Report: Worldwide Surgical Sealants, Glues, Wound Closure and Anti-Adhesion Markets, 2009-2013 TOC

Executive Summary

Introduction
Demographic trends
Consumer-Driven Product Selection
Mechanisms of Tissue Repair
Commercial Imperatives
Industry Consolidation
Clinical Caseload
Market Segmentation and Dynamics
New Surgical Techniques Drive Market Opportunity
The Uses of Adjunctive Surgical Closure and Securement Products
Product Development History
Evolution of Commercial Markets for Sealants and Adhesives
Company Strategies - Overview

Section 1: CLINICAL NEED, CASELOAD, AND PROCEDURE VOLUME

1.1 Anatomy and Physiology of Tissue Repair
1.2 The Skin
1.3 Internal Tissues and Organs
1.4 Wound Classification and Types
- 1.4.1 Classification by Morphology and Severity
- 1.4.2 Wound Classification by Cause
- 1.4.3 Surgical Wounds
1.5 Caseload
- 1.5.1 Cardiovascular
- 1.5.1.1 Coronary Heart Disease
- 1.5.1.2 Dysfunctional Heart Valves
- 1.5.1.3 Peripheral Vascular Disorders
- 1.5.1.4 Abnormal Aortic Aneurysms
- 1.5.1.5 Drivers of Caseloads for Cardiac Surgery
- 1.5.2 Neurological
- 1.5.2.1 Stroke
- 1.5.2.2 Parkinson' s Disease
- 1.5.2.3 Epilepsy
- 1.5.2.4 Traumatic Injury
- 1.5.2.5 Peripheral Nerve Treatment
- 1.5.2.6 Neurology Drivers
- 1.5.3 Orthopedic
- 1.5.3.1 Hip Replacements
- 1.5.3.2 Knee Replacements
- 1.5.3.3 Cartilage Repair
- 1.5.3.4 Ligament Damage
- 1.5.3.5 Bone Grafting
- 1.5.3.6 Vertebral Disc Repair
- 1.5.3.7 Drivers of Orthopedic Surgery
- 1.5.4 Urological
- 1.5.4.1 Incontinence
- 1.5.4.2 Drivers of Urological Surgery
- 1.5.5 Skin
- 1.5.5.1 Burns
- 1.5.5.2 Pressure Ulcers
- 1.5.5.3 Diabetic Ulcers
- 1.5.5.4 Venous Ulcers
- 1.5.5.5 Plastic Surgery
1.6 The Role of Modern Sealant, Securement and Hemostatic Products in Surgery
- 1.6.1 Fibrin Sealants
- 1.6.2 High-Strength Glues

Section 2: SCIENCE, TECHNOLOGY, DEVELOPMENT, CLINICAL AND REGULATORY CHALLENGES

2.1 Tissue Healing
- 2.1.1 Hemostasis
- 2.1.2 Proliferation and Maturation
- 2.1.3 Factors That Affect Healing
2.2 Product Development
2.3 Development Timelines
- 2.3.1 Collagen and Thrombin Combination
- 2.3.2 Polyethylene Glycol Polymer (PEG)
- 2.3.3 Albumin Cross-Linked with Glutaraldehyde
- 2.3.4 Delivery Systems
2.4 Cost Effectiveness
2.5 Regulatory Challenges
- 2.5.1 Approval Processes
- 2.5.2 History of Product Development
- 2.5.3 Regulatory Aspects

Section 3: PRODUCTS, TECHNOLOGIES, AND FORECAST OPPORTUNITY

3.1 Overview
3.2 Development Timeline
3.3 Sutures, Staples, and Other Mechanical Closure Devices
- 3.3.1 Competitors and Products
- 3.3.2 Suppliers
- 3.3.3 Product Development
- 3.3.4 Market Analysis and Forecast
3.4 Tapes
- 3.4.1 Competitors and Products
- 3.4.2 Products in Development
- 3.4.3 Market Analysis and Forecast
3.5 Hemostats
- 3.5.1 Competitors and Products
- 3.5.2 Products in Development
- 3.5.3 Market Analysis and Forecasts
3.6 Fibrin and Other Sealant Products
- 3.6.1 Competitors and Products
- 3.6.2 Products in Development
- 3.6.3 Fibrin and Sealant Market and Competitive Activity
3.7 High-Strength Medical Adhesives
- 3.7.1 Competitors and Products
- 3.7.2 Products in Development
- 3.7.3 Market Analysis and Forecasts
3.8 Post-Surgical Adhesion Prevention
- 3.8.1 Competitors and Products
- 3.8.2 Products in Development
- 3.8.3 Market Analysis and Forecasts
3.9 Wound Closure and Securement Markets: Global and Regional Analysis
- 3.9.1 Americas
- 3.9.1.1 United States
- 3.9.1.2 Latin America
- 3.9.2 Japan
- 3.9.3 Europe
- 3.9.4 Rest of World
3.10 Worldwide Markets By Country and Segment

Section 4: Company Profiles

4.1 3DM, Inc. (3D-Matrix, Ltd.)
4.2 3M
- 4.2.1 Products
- 4.2.1.1 Steri-Strip and Other Wound Closure Products
- 4.2.2 Financial
4.3 Abbott Vascular
- 4.3.1 Products
- 4.3.1.1 Perclose A-T, Perclose ProGlide and Prostar XL
- 4.3.1.2 StarClose
- 4.3.1.3 Chito-Seal
- 4.3.2 Financials
4.4 AccessClosure, Inc.
- 4.4.1 Product
- 4.4.1.1 Mynx
4.5 Adhezion Biomedical, LLC
4.6 Advanced Medical Solutions plc
- 4.6.1 Products
- 4.6.1.1 LiquiBand
- 4.6.2 Financials
4.7 Allerderm
4.8 Angiotech Pharmaceuticals, Inc.
- 4.8.1 Products
- 4.8.1.1 CoSeal
- 4.8.1.2 Vitagel
- 4.8.1.3 Adhibit
- 4.8.1.4 Quill
- 4.8.1.5 LOOK Sutures
- 4.8.1.6 Sharpoint
- 4.8.2 Financials
4.9 Anika Therapeutics, Inc.
- 4.9.1 Products
- 4.9.1.1 Incert-S
- 4.9.2 Financials
4.10 ARC Pharmaceuticals
- 4.10.1 Product
- 4.10.1.1 ARCAD
4.11 Arch Therapeutics, Inc.
4.12 ArthroCare Corporation
- 4.12.1 Products
- 4.12.1.1 MagnumWire
- 4.12.2 Financials
4.13 Aso LLC
4.14 Aspen Surgical Products
4.15 Atrax Medical Group
4.16 Avery Dennison
4.17 B. Braun Melsungen AG
- 4.17.1 Products
- 4.17.1.1 Histoacryl
- 4.17.1.2 Lysostypt
- 4.17.1.3 Gelita Local Hemostat
- 4.17.2 Financials
4.18 Bastos Viegas, s.a.
4.19 Baxter International Inc.
- 4.19.1 Products
- 4.19.1.1 Tisseel/Tissucol
- 4.19.1.2 FloSeal
- 4.19.1.3 CoSeal
- 4.19.1.4 TissuFleece E
- 4.19.1.5 ARTISS
- 4.19.2 Financials
4.20 Bayer HealthCare
4.21 BD (Becton, Dickinson and Company)
- 4.21.1 Products
- 4.21.1.1 Autoclip
4.22 Berlin Heart GmbH
- 4.22.1 Products
- 4.22.1.1 Gluetiss
4.23 Bernsco Surgical Supply
4.24 Biocoral Inc.
- 4.24.1 Products
- 4.24.1.1 Autologous Biological Glue
4.25 BioCore Medical Technologies, Inc.
4.26 Biogentis, Inc.
- 4.26.1 Products
- 4.26.1.1 SkinLink
4.27 Biomet Inc.
- 4.27.1 Product
- 4.27.1.1 GPS III System
- 4.27.1.2 Pro Osteon/BioPlex (Interpore Cross)
4.28 BIOSTER a.s.
4.29 BioSyntech Canada Inc.
4.30 BSN Medical
4.31 C.R. Bard
- 4.31.1 Bard Medical
- 4.31.2 Davol Inc.
- 4.31.3 Financials
4.32 Cardiovascular Sciences, Inc.
4.33 Carl Auffarth GmbH & Co. KG
4.34 Cardiva Medical, Inc.
4.35 Ceremed, Inc.
4.36 Chemence Ltd.
4.37 Chemopharma, s.a.
4.38 Cohera Medical, Inc.
- 4.38.1 Products
- 4.38.1.1 TissuGlu
4.39 Collagen Matrix, Inc.
- 4.39.1....... Products
- 4.39.1.1 Porous Collagen Dental Dressings
- 4.39.1.2 Collatene Fibrillar Collagen Dental Dressing
4.40 Coloplast A/S
4.41 ConvaTec
4.42 Covidien Ltd.
- 4.42.1 Products
- 4.42.1.1 DuraSeal
- 4.42.1.2 SprayGel
- 4.42.1.3 Indermil (Syneture)
- 4.42.1.4 PleuraSeal
- 4.42.1.5 VascuSeal
- 4.42.1.6 SprayShield
- 4.42.2 Financials
4.43 CryoLife Inc.
- 4.43.1 Products
- 4.43.1.1 BioGlue Surgical Adhesive
- 4.43.1.2 BioFoam Adhesive
- 4.43.1.3 Hemostase MPH
- 4.43.2 Financials
4.44 CSIRO PhotoMedical Technologies
- 4.44.1 Products
- 4.44.1.1 PhotoSeal
4.45 CSL Behring
- 4.45.1 Products
- 4.45.1.1 Beriplast P Combi-Set (Fibrin Sealant)
- 4.45.1.2 Beriplex P/N, Confidex
- 4.45.1.3 Fibrogammin P
- 4.45.1.4 Haemocomplettan P
- 4.45.1.5 Kybernin P
4.46 CSMG Technologies, Inc.
- 4.46.1 Live Tissue Connect, Inc.
4.47 CuraMedical BV
- 4.47.1 Products
- 4.47.1.1 Curacel
- 4.47.1.2 Curacoll
- 4.47.1.3 Curaspon
4.48 Cypress Medical Products
4.49 Derma Sciences, Inc.
4.50 Distrex Iberica S.A.
4.51 DuPont Applied BioSciences
4.52 Entegrion, Inc.
- 4.52.1 Products
- 4.52.1.1 Stasilon FR
- 4.52.1.2 Stasix
- 4.52.1.3 Resusix
4.53 FibroGen, Inc.
4.54 Fidia Advanced Biopolymers
- 4.54.1 Products
4.55 Flamel Technologies SA
4.56 Forticell Bioscience
- 4.56.1 Products
- 4.56.1.1 Fibrin MB
4.57 FzioMed Inc.
- 4.57.1 Products
- 4.57.1.1 Oxiplex/SP Gel
- 4.57.1.2 MediShield
- 4.57.1.3 Intercoat
- 4.57.1.4 Laresse Dermal Filler
4.58 Gelita Medical BV
- 4.58.1 Products
- 4.58.1.1 Gelita-Spon
- 4.58.1.2 Gelitacel
- 4.58.1.3 Geli Putty
4.59 GEM srl
4.60 Genzyme Biosurgery Inc.
- 4.60.1 Products
- 4.60.1.1 Sepraflm
- 4.60.1.2 Seprapack and Sepragel ENT
- 4.60.1.3 SeprameshIP
- 4.60.1.4 Epicel
- 4.60.1.5 FocalSeal
- 4.60.2 Financial
4.61 GluStitch, Inc.
- 4.61.1 Products
- 4.61.1.1 GluStitch
- 4.61.1.2 GluSeal
- 4.61.1.3 PeriAcryl
- 4.61.1.4 GluShield
- 4.61.1.5 GluSite
4.62 Graceduty Company Limited
4.63 GramsMed, LLC
4.64 Haemacure Corporation
- 4.64.1 Products
- 4.64.1.1 Hemaseel HMN
- 4.64.1.2 Hemaseel Thrombin
- 4.64.2 Financial Data
4.65 HAPTO Biotech Israel Ltd.
4.66 Hartmann Group
4.67 Harvest Technologies Corporation
4.68 HemCon Medical Technologies, Inc.
- 4.68.1 Products
- 4.68.1.1 HemCon Bandage
- 4.68.1.2 ChitoFlex
- 4.68.1.3 HemCon Dental Dressing
- 4.68.1.4 KytoStat
- 4.68.1.5 m" doc
4.69 Hemostasis, LLC
4.70 HyperBranch Medical Technology, Inc.
4.71 Incisive Surgical, Inc.
4.72 Innovasa Corporation
4.73 Integra Lifesciences Corporation
- 4.73.1 Products
- 4.73.2 Financials
4.74 I-Therapeutix, Inc.
4.75 Johnson & Johnson
- 4.75.1 Ethicon, Inc. and Ethicon Endo-Surgery, Inc.
- 4.75.1.1 Evicel/Quixil
- 4.75.1.2 Dermabond
- 4.75.1.3 Omnex
- 4.75.1.4 Gynecare Interceed
- 4.75.1.5 Hemostasis Products
- 4.75.1.6 Surgical Sutures and Skin Closures
- 4.75.2 DePuy Spine
- 4.75.3 Financials
4.76 Kaketsuken (Chemo-Sero-Therapeutic Research Institute)
4.77 Kensey Nash Corporation
- 4.77.1 Product
- 4.77.1.1 Angio-Seal
4.78 Kimberly-Clark Health Care
- 4.78.1 Products
- 4.78.1.1 InteguSeal
- 4.78.2 Financials
4.79 Kinetic Concepts, Inc.
4.80 King Pharmaceuticals, Inc.
- 4.80.1 Products
- 4.80.1.1 Thrombin-JMI
- 4.80.2 Financials
4.81 Kookbo Chemicals Co., Ltd. (KB Chem.)
4.82 Laboratoires Urgo (Urgo Medical)
4.83 Lewis Medical Supplies
4.84 LifeBond Ltd.
4.85 Lifecore Biomedical, Inc.
4.86 Lohmann & Rauscher
4.87 Marine Polymer Technologies
4.88 Medafor, Inc.
4.89 Medi Surgichem Pvt. Ltd.
4.90 MedTrade Products, Ltd.
4.91 Meyer-Haake GmbH Medical Innovations
4.92 Molnlycke Health Care AB
4.93 Morris Innovative
4.94 Motex Healthcare Corp.
4.95 Myco Medical
4.96 NeatStitch Ltd.
4.97 Neose Technologies Inc. (Novo Nordisk)
4.98 Nycomed
- 4.98.1 Products
4.99 Omrix Biopharmaceuticals Inc.
- 4.99.1 Products
- 4.99.1.1 Evicel/Quixil
- 4.99.1.2 Fibrin Patch
- 4.99.1.3 Evithrom
- 4.99.1.4 Adhexil
- 4.99.2 Financials
4.100 Pac-Kit Safety Equipment
4.101 Pfizer Inc.
- 4.101.1 Product
- 4.101.1.1 Gelfoam
- 4.101.2 Financials
4.102 Pharming Group NV
- 4.102.1 Financials
4.103 Plasma Technologies, Inc.
4.104 PlasmaSeal
4.105 Pluromed, Inc.
4.106 Polyganics
4.107 Polyheal Ltd.
4.108 ProFibrix BV
4.109 Progressive Surgical, Ltd.
4.110 Protein Polymer Technologies, Inc.
4.111 Radi Medical Systems AB
- 4.111.1 Products
- 4.111.1.1 FemoSeal
4.112 Resorba Wundversorgung GmbH & Co. KG
4.113 Scapa Group plc
4.114 Scion Cardio-Vascular, Inc.
4.115 Sea Run Holdings
4.116 Seton
4.117 Smith & Nephew plc
4.118 Starch Medical, Inc.
- 4.118.1 Products
- 4.118.1.1 PerClot
- 4.118.1.2 StarFoam
- 4.118.1.3 SuperClot
4.119 Stereoplast Ltd.
4.120 Sutura, Inc.
- 4.120.1 Products
- 4.120.1.1 SuperStitch
4.121 Synovis Life Technologies
4.122 SyntheMed, Inc.
4.123 Teleflex Medical
- 4.123.1 Products
- 4.123.1.1 Deknatel Sutures
- 4.123.1.2 Weck
- 4.123.2 Financial
4.124 ThermoGenesis Corporation
- 4.124.1 Products
- 4.124.1.1 CryoSeal FS System
- 4.124.1.2 Thrombin Processing Device (TPD)
4.125 Therus Corporation
4.126 Thrombotargets Corp.
- 4.126.1 Products
- 4.126.1.1 TT-103MH
4.127 Tissuemed Ltd.
- 4.127.1 Products
4.128 TraumaCure, Inc.
- 4.128.1 Products
- 4.128.1.1 WoundStat
4.129 TyRx Pharma Inc.
4.130 Vascular Solutions, Inc.
4.131 Vectura Group plc
- 4.131.1 Product
- 4.131.1.1 Adept
4.132 Vivostat A/S
- 4.132.1 Products
- 4.132.1.1 Vivostat
4.133 Z-Medica Corporation
4.134 Zimmer
4.135 ZymoGenetics, Inc.
- 4.135.1 Products
- 4.135.1.1 Recothrom
- 4.135.2 Financials

APPENDIX: LIST OF COMPANIES

List of Exhibits

Exhibit ES-1: Recent Acquisitions in the Securement Segment
Exhibit ES-2: Introducers of New Securement Technologies to the U.S. Market
Exhibit ES-3: Definition of Surgical Closure and Securement Products
Exhibit ES-4: Incidence of Two Example Surgical Procedures with High Requirement for Adjunctive Products for Surgical Closure and Securement
Exhibit ES-5: U.S. FDA Approved Uses of Sealants, Glues, and Hemostats
Exhibit ES-6: Synthetic and Biological Sealant Competitors (Non-Fibrin Sealants)
Exhibit ES-7: Selected High-Strength Adhesive Companies and Their Strategies
Exhibit ES-8: Selected Sealant Product Companies and Their Strategies
Exhibit ES-9: Worldwide Growth in the Securement and Closure Market, 2006 - 2013

Exhibit 1-1: Skin Structure Illustrating Major Organelles and Skin Layers
Exhibit 1-2: Classification of Wounds by Morphology
Exhibit 1-3: Severity Classification of Wounds
Exhibit 1-4: Wound Classification by Etiology
Exhibit 1-5: Prevalence of Different Wound Types, 2008
Exhibit 1-6: Criteria for Adjunctive Use of Hemostats, Sealants, Glues and Adhesion Prevention Products in Surgery
Exhibit 1-7: Surgical Procedures with Potential for the Use of Hemostats, Sealants, Glues and Adhesion Prevention Products, Worldwide
Exhibit 1-8: Potential for Cardiovascular Applications, Prevalence of Applicable Surgical Applications
Exhibit 1-9: Potential for Neurological Applications, Prevalence of Applicable Disorders
Exhibit 1-10: Potential for Orthopedic Applications, Frequency of Major Surgical Interventions
Exhibit 1-11: Potential for Urological Applications, Prevalence of Applicable Disorders
Exhibit 1-12: Potential for Dermal Repair, Prevalence of Applicable Disorders
Exhibit 1-13: Applications of Fibrin and Other Sealants
Exhibit 1-14: Surgical Procedures Using Fibrin and Other Sealant Products (2009 - 2013)
Exhibit 1-15: Surgical Indications for High-Strength Glues (Europe, 2008)

Exhibit 2-1: Factors That Affect Wound Healing
Exhibit 2-2: Timescales for Development of Closure and Sealant Products
Exhibit 2-3: Variables Associated With Clinical Evaluation of Closure and Securement and Related Products

Exhibit 3-1: Manufacturers of Surgical Sutures, Staples, Clips, and Other Mechanical Closure Devices
Exhibit 3-2: Worldwide Sutures and Staples Market Forecast, 2006 - 2013
Exhibit 3-3: Worldwide Suture and Staples Market 2007, Share by Supplier
Exhibit 3-4: Companies Commercializing First Aid Technologies Often Used as Tapes for Closure
Exhibit 3-5: Worldwide Tapes Market Forecast, 2006-2013
Exhibit 3-6: Worldwide Tapes for Closure Market Share, 2007, by Supplier
Exhibit 3-7: Companies Commercializing Technologies in the Hemostat Category
Exhibit 3-8: Worldwide Hemostats Market Forecast, 2009 - 2013
Exhibit 3-9: Worldwide Hemostats Market Share, 2007, by Supplier
Exhibit 3-10: Companies Commercializing Technologies in the Sealants Category
Exhibit 3-11: Worldwide Sealants Market Forecast, 2006-2013
Exhibit 3-12: Worldwide Sealants Market Share, 2007, by Supplier
Exhibit 3-13: Companies Commercializing Cyanoacrylate-based High-Strength Medical Adhesives
Exhibit 3-14: Worldwide High-Strength Glues Market Forecast, 2006 - 2013
Exhibit 3-15: Worldwide High-Strength Glues Market Share 2007, by Supplier
Exhibit 3-16: Companies Commercializing Technologies in the Post-Surgical Adhesion Prevention Category
Exhibit 3-17: Worldwide Post-Operative Adhesion Prevention Market Forecast, 2006 - 2013
Exhibit 3-18: Worldwide Post Operative Adhesion Prevention Market Share, 2007, by Supplier
Exhibit 3-19: Size and Growth of Wound Closure and Securement Market, World and Selected Countries, 2007
Exhibit 3-20: Wound Closure Market 2007, by Product Segments: The Major American Countries
Exhibit 3-21: Wound Closure Market 2007, by Product Segments: Japan
Exhibit 3-22: Wound Closure Market 2007, by Product Segments: Major European Countries
Exhibit 3-23: Wound Closure Market 2007, by Product Segments: Rest of World
Exhibit 3-24: Growth Forecast for Closure and Securement Market, 2006 - 2013

Exhibit 4-1: 3M, Selected Financial Data for 2007
Exhibit 4-2: Abbott Laboratories, Selected Financial Data for the First Nine Months of 2008
Exhibit 4-3: Advanced Medical Solutions' Selected Financial Data for 2006 and 2007
Exhibit 4-4: Angiotech Pharmaceuticals' Statement of Income for 2nd Quarter, 2008 (Ending June 30)
Exhibit 4-5: Anika Therapeutics' Financial Results for 2006 and 2007
Exhibit 4-6: ArthroCare Corporation Financial Data
Exhibit 4-7: B. Braun Financial Data
Exhibit 4-8: Baxter International Financial Data
Exhibit 4-9: C.R. Bard, Inc. Financial Data for Nine Months Ending Sept. 30
Exhibit 4-10: Cardiovascular Sciences, Inc. Financial Data
Exhibit 4-11: Covidien, Selected Financial Data, 2007
Exhibit 4-12: CryoLife Financial Results, 2006 and 2007
Exhibit 4-13: Haemacure Corporation, Selected Financial Data
Exhibit 4-14: Integra Lifesciences, Financial Data
Exhibit 4-15: Johnson & Johnson Key Financial Data, 2006 and 2007
Exhibit 4-16: Kimberly-Clark Health Care Financial Data
Exhibit 4-17: King Pharmaceuticals Financial Data
Exhibit 4-18: Overview of Omrix' Biosurgical Product Pipeline
Exhibit 4-19: Omrix Biopharmaceuticals Financial Data
Exhibit 4-20: Pfizer Financial Data for 2007 and 2006
Exhibit 4-21: Pharming Financial Data
Exhibit 4-22: Teleflex Inc. Financial Data
Exhibit 4-23: Vascular Solutions Financial Results
Exhibit 4-24: ZymoGenetics Financial Data, 3rd Quarter, 2008

Worldwide Surgical Sealants, Glues, Wound Closure and Anti-Adhesion Markets, 2009-2013

Table of Contents

Executive Summary

Section 1: CLINICAL NEED, CASELOAD, AND PROCEDURE VOLUME

Section 2: SCIENCE, TECHNOLOGY, DEVELOPMENT, CLINICAL AND REGULATORY CHALLENGES

Section 3: PRODUCTS, TECHNOLOGIES, AND FORECAST OPPORTUNITY

Section 4: Company Profiles

APPENDIX: LIST OF COMPANIES

List of Exhibits