Global Markets for Atrial Fibrillation Treatment Devices 2009

Table of Contents

TABLE OF CONTENTS I

LIST OF EXHIBITS V

EXECUTIVE SUMMARY XII

METHODOLOGY XVII

1.0 GLOBAL ATRIAL FIBRILLATION TREATMENT DEVICE PROCEDURES 1

• 1.1 Procedure Overview 1
• 1.2 Atrial Fibrillation 2
  • 1.2.1 Cardiac Arrhythmias 2
  • 1.2.2 Atrial Fibrillation 2
    • 1.2.2.1 Classification of Atrial Fibrillation 6
    • 1.2.2.2 Effects of Atrial Fibrillation 6
    • 1.2.2.3 Diagnosing Atrial Fibrillation 7
• 1.3 Treatments for Atrial Fibrillation 9
  • 1.3.1 EP Catheter Ablations 12
    • 1.3.1.1 Electrophysiology Diagnostic Procedures 12
    • 1.3.1.2 Electrophysiology Catheter Ablations 13
  • 1.3.2 Surgical Ablations 14
    • 1.3.2.1 Surgical Ablation Energy Sources 16
  • 1.3.3 Cardiac Rhythm Management Procedures 16

2.0 GLOBAL ATRIAL FIBRILLATION TREATMENT DEVICE MARKET 18

• 2.1 Market Overview 18
• 2.2 Market Analysis 19
  • 2.2.1 Economic Assumptions for the Forecast Period 19
  • 2.2.2 Procedures 19
  • 2.2.3 Market Forecast 24
  • 2.2.4 Market Drivers and Limiters 29
    • 2.2.4.1 Market Drivers 29
    • 2.2.4.2 Market Limiters 30
• 2.3 Competitive Analysis 33
  • 2.3.1 Competitor Discussions (in Alphabetical Order) 33
    • 2.3.1.1 Electrophysiology Device Market Competitors 33
      • Biosense Webster 33
      • Boston Scientific 34
      • C. R. Bard 35
      • EP MedSystems (Acquired by St. Jude Medical) 35
      • GE Healthcare 36
      • Hansen Medical 36
      • Japan Lifeline 37
      • Medtronic 37
      • Philips Healthcare 38
      • Siemens Healthcare 39
      • Stereotaxis 39
      • St. Jude Medical 40
      • Other 41
      • 2.3.1.2 Surgical Ablation Device Market Competitors 42
      • AtriCure 42
      • ATS Medical 42
      • Cardima 43
      • ESTECH 43
      • MAQUET Cardiovascular (A Business Unit of Getinge Group) 43
      • Medtronic 43
      • St. Jude Medical 44
    • 2.3.1.3 Cardiac Rhythm Management Device Market Competitors 45
      • BIOTRONIK 45
      • Boston Scientific 45
      • Medtronic 45
      • Sorin Group 46
      • St. Jude Medical 46
      • Other 47

3.0 US ATRIAL FIBRILLATION TREATMENT DEVICE MARKET 48

• 3.1 Market Overview 48
• 3.2 Market Analysis 49
  • 3.2.1 Procedures 50
    • 3.2.1.1 Electrophysiology Atrial Fibrillation Treatment Device Procedures 52
    • 3.2.1.2 Surgical Ablation Atrial Fibrillation Treatment Device Procedures 53
    • 3.2.1.3 Cardiac Rhythm Management Atrial Fibrillation Treatment Device Procedures 55
  • 3.2.2 Market Forecast 56
    • 3.2.2.1 Electrophysiology Atrial Fibrillation Treatment Device Market 58
    • 3.2.2.2 Surgical Ablation Atrial Fibrillation Treatment Device Market 70
    • 3.2.2.3 Cardiac Rhythm Management Atrial Fibrillation Treatment Device Market
  • 3.2.3 Market Drivers and Limiters 77
• 3.3 Competitive Analysis 78

4.0 EUROPEAN ATRIAL FIBRILLATION TREATMENT DEVICE MARKET 79

• 4.1 Market Overview 79
• 4.2 Market Analysis 80
  • 4.2.1 Procedures 81
    • 4.2.1.1 Electrophysiology Atrial Fibrillation Treatment Device Procedures 83
    • 4.2.1.2 Surgical Ablation Atrial Fibrillation Treatment Device Procedures 85
    • 4.2.1.3 Cardiac Rhythm Management Atrial Fibrillation Treatment Device Procedures 89
  • 4.2.2 Market Forecast 91
    • 4.2.2.1 Electrophysiology Atrial Fibrillation Treatment Device Market 94
    • 4.2.2.2 Surgical Ablation Atrial Fibrillation Treatment Device Market 131
    • 4.2.2.3 Cardiac Rhythm Management Atrial Fibrillation Treatment Device Market 137
  • 4.2.3 Market Drivers and Limiters 155
• 4.3 Competitive Analysis 156

5.0 JAPANESE ATRIAL FIBRILLATION TREATMENT DEVICE MARKET 157

• 5.1 Market Overview 157
• 5.2 Market Analysis 158
  • 5.2.1 Procedures 159
    • 5.2.1.1 Electrophysiology Atrial Fibrillation Treatment Device Procedures 161
    • 5.2.1.2 Surgical Ablation Atrial Fibrillation Treatment Device Procedures 162
    • 5.2.1.3 Cardiac Rhythm Management Atrial Fibrillation Treatment Device Procedures 164
  • 5.2.2 Market Forecast 165
    • 5.2.2.1 Electrophysiology Atrial Fibrillation Treatment Device Market 167
    • 5.2.2.2 Surgical Ablation Atrial Fibrillation Treatment Device Market 178
    • 5.2.2.3 Cardiac Rhythm Atrial Fibrillation Treatment Management Device Market
  • 5.2.3 Market Drivers and Limiters 187
• 5.3 Competitive Analysis 188

APPENDIX A: MRG ACRONYMS AND INITIALISMS 189

APPENDIX B: SUPPLEMENTAL EXHIBITS 190

List of Exhibits

EXECUTIVE SUMMARY XII

• Exhibit 1: AF Treatment Device Market, by Segment, Global (US$), 2007 - 2013 XII
• Exhibit 2: EP AF Treatment Device Procedures, Global, 2007 - 2013 XIII
• Exhibit 3: Surgical Ablation AF Treatment Device Market, Global (US$), 2007 - 2013 XIV
• Exhibit 4: AF Treatment Device Market, by Segment, as a % of Total, Global, 2008 XV
• Exhibit 5: Leading Competitors in the AF Treatment Device Market, Global, 2008 XVI

METHODOLOGY XVII

• Exhibit 6: Currency Exchange Rates, 2008 XXI

CHAPTER 1: GLOBAL ATRIAL FIBRILLATION TREATMENT DEVICE PROCEDURES 1

• Exhibit 7: AF Prevalence, Global, 2007 - 2013 1
• Exhibit 8: AF Prevalence, by Country, Global, 2007 - 2013 4
• Exhibit 9: AF Prevalence, by Country, as a % of Total, Global, 2007 - 2013 5
• Exhibit 10: Methods of AF Diagnosis and Evaluation 8
• Exhibit 11: AF Treatment Comparison 11

CHAPTER 2: GLOBAL ATRIAL FIBRILLATION TREATMENT DEVICE MARKET 18

• Exhibit 12: AF Treatment Device Market, Global (US$), 2007 - 2013 18
• Exhibit 13: AF Treatment Device Market Segmentation, Global 19
• Exhibit 14: AF Treatment Device Procedures, Global, 2007 - 2013 21
• Exhibit 15: AF Treatment Device Procedures, by Segment, Global, 2007 - 2013 22
• Exhibit 16: AF Treatment Device Procedures, by Region, Global, 2007 - 2013 23
• Exhibit 17: AF Treatment Device Market, by Segment, Global (US$), 2007 - 2013 25
• Exhibit 18: AF Treatment Device Market, by Segment and Region, Global (US$), 2007 - 2013 26
• Exhibit 19: AF Treatment Device Market Growth, by Segment and Region, Global, 2008 - 2013 27
• Exhibit 20: AF Treatment Device Market, by Segment and Region, as a % of Total, Global, 2007 - 2013 28
• Exhibit 21: Drivers and Limiters of the AF Treatment Device Market, Global 29

CHAPTER 3: US ATRIAL FIBRILLATION TREATMENT DEVICE MARKET 48

• Exhibit 22: AF Treatment Device Market, US (US$), 2007 - 2013 48
• Exhibit 23: AF Treatment Device Market Segmentation, US 49
• Exhibit 24: AF Treatment Device Procedures, by Segment, US, 2007 - 2013 (Graphical Format) 50
• Exhibit 25: AF Treatment Device Procedures, by Segment, US, 2007 - 2013 (Tabular Format) 51
• Exhibit 26: Surgical Ablation AF Treatment Device Procedures, by Type, US, 2007 - 2013 54
• Exhibit 27: AF Treatment Device Market, by Segment, US (US$), 2007 - 2013 (Graphical Format) 56
• Exhibit 28: AF Treatment Device Market, by Segment, US (US$), 2007 - 2013 (Tabular Format) 57
• Exhibit 29: EP AF Treatment Device Market, US (US$), 2007 - 2013 59
• Exhibit 30: EP AF Treatment Device Market, by Segment, US (US$), 2007 - 2013 60
• Exhibit 31: AF EP Diagnostic Catheter Market, by Type, US (US$), 2007 - 2013 61
• Exhibit 32: AF EP Diagnostic Catheter Market Growth, by Type, US, 2008 - 2013 62
• Exhibit 33: AF EP Diagnostic Catheter Market, by Type, as a % of Total, US, 2007 - 2013 63
• Exhibit 34: AF EP Ablation Catheter Market, by Type, US (US$) 2007 - 2013 64
• Exhibit 35: AF EP Ablation Catheter Market Growth, by Type, US, 2008 - 2013 65
• Exhibit 36: AF EP Ablation Catheter Market, by Type, as a % of Total, US, 2007 - 2013 66
• Exhibit 37: AF EP Advanced Ablation Catheter Market, by Type, US (US$) 2007 - 2013 67
• Exhibit 38: AF EP Advanced Ablation Catheter Market Growth, by Type, US, 2008 - 2013 68
• Exhibit 39: AF EP Advanced Ablation Catheter Market, by Type, as a % of Total, US, 2007 - 2013 69
• Exhibit 40: Surgical Ablation AF Treatment Device Market, US (US$), 2007 - 2013 (Graphical Format) 70
• Exhibit 41: Surgical Ablation AF Treatment Device Market, US (US$), 2007 - 2013 (Tabular Format) 71
• Exhibit 42: Surgical Ablation AF Treatment Device Market Growth, US, 2008 - 2013 72
• Exhibit 43: CRM AF Treatment Device Market, US (US$), 2007 - 2013 74
• Exhibit 44: CRM AF Treatment Device Market, by Segment, US (US$), 2007 - 2013 75
• Exhibit 45: CRM AF Treatment Device Market Growth, by Type, US, 2008 - 2013 76
• Exhibit 46: Drivers of the AF Treatment Device Market, US 77
• Exhibit 47: Limiters of the AF Treatment Device Market, US 77
• Exhibit 48: Leading Competitors in the AF Treatment Device Market, US, 2008 78

CHAPTER 4: EUROPEAN ATRIAL FIBRILLATION TREATMENT DEVICE MARKET 79

• Exhibit 49: AF Treatment Device Market, Europe (US$), 2007 - 2013 79
• Exhibit 50: AF Treatment Device Market Segmentation, Europe 80
• Exhibit 51: AF Treatment Device Procedures, by Segment, Europe, 2007 - 2013 (Graphical Format) 81
• Exhibit 52: AF Treatment Device Procedures, by Segment, Europe, 2007 - 2013 (Tabular Format) 82
• Exhibit 53: EP AF Treatment Device Procedures, by Country, Europe, 2007 - 2013 84
• Exhibit 54: Surgical Ablation AF Treatment Device Procedures, by Country, Europe, 2007 - 2013 87
• Exhibit 55: Surgical Ablation AF Treatment Device Procedures, by Type, Europe, 2007 - 2013 88
• Exhibit 56: CRM AF Treatment Device Procedures, by Country, Europe, 2007 - 2013 90
• Exhibit 57: AF Treatment Device Market, by Segment, Europe (US$), 2007 - 2013 91
• Exhibit 58: AF Treatment Device Market, by Segment, Europe (US$ and € ), 2007 - 2013 92
• Exhibit 59: AF Treatment Device Market, by Country, Europe (US$ and € ), 2007 - 2013 93
• Exhibit 60: EP AF Treatment Device Market, Europe (US$), 2007 - 2013 95
• Exhibit 61: EP AF Treatment Device Market, by Segment, Europe (US$ and € ), 2007 - 2013 96
• Exhibit 62: EP AF Treatment Device Market, by Country, Europe (US$, € , and £), 2007 - 2013 97
• Exhibit 63: EP AF Treatment Device Market Growth, by Country, Europe, 2008 - 2013 98
• Exhibit 64: EP AF Treatment Device Market, by Country, as a % of Total, Europe, 2007 - 2013 98
• Exhibit 65: AF EP Diagnostic Catheter Market, by Type, Europe (US$), 2007 - 2013 99
• Exhibit 66: AF EP Diagnostic Catheter Market, by Type, Europe (€ ), 2007 - 2013 100
• Exhibit 67: AF EP Diagnostic Catheter Market Growth, by Type, Europe, 2008 - 2013 101
• Exhibit 68: AF EP Diagnostic Catheter Market, by Type, as a % of Total, Europe, 2007 - 2013 102
• Exhibit 69: AF EP Diagnostic Catheter Market, by Country, Europe (US$), 2007 - 2013 103
• Exhibit 70: AF EP Diagnostic Catheter Market, by Country, Europe (€ and £), 2007 - 2013 104
• Exhibit 71: AF EP Diagnostic Catheter Market Growth, by Country, Europe, 2008 - 2013 105
• Exhibit 72: AF EP Diagnostic Catheter Market, by Country, as a % of Total, Europe, 2007 - 2013 106
• Exhibit 73: Conventional AF EP Diagnostic Catheter Market, by Country, Europe (US$), 2007 - 2013 107
• Exhibit 74: Conventional AF EP Diagnostic Catheter Market, by Country, Europe (€ and £), 2007 - 2013 108
• Exhibit 75: Conventional AF EP Diagnostic Catheter Market Growth, by Country, Europe, 2008 - 2013 109
• Exhibit 76: Conventional AF EP Diagnostic Catheter Market, by Country, as a % of Total, Europe, 2007 - 2013 110
• Exhibit 77: Advanced AF EP Diagnostic Catheter Market, by Country, Europe (US$), 2007 - 2013 111
• Exhibit 78: Advanced AF EP Diagnostic Catheter Market, by Country, Europe (€ and £), 2007 - 2013 112
• Exhibit 79: Advanced AF EP Diagnostic Catheter Market Growth, by Country, Europe, 2008 - 2013 113
• Exhibit 80: Advanced AF EP Diagnostic Catheter Market, by Country, as a % of Total, Europe, 2007 - 2013 114
• Exhibit 81: AF EP Ablation Catheter Market, by Type, Europe (US$), 2007 - 2013 115
• Exhibit 82: AF EP Ablation Catheter Market, by Type, Europe (€ ), 2007 - 2013 116
• Exhibit 83: AF EP Ablation Catheter Market Growth, by Type, Europe, 2008 - 2013 117
• Exhibit 84: AF EP Ablation Catheter Market, by Type, as a % of Total, Europe, 2007 - 2013 118
• Exhibit 85: AF EP Ablation Catheter Market, by Country, Europe (US$), 2007 - 2013 119
• Exhibit 86: AF EP Ablation Catheter Market, by Country, Europe (€ and £), 2007 - 2013 120
• Exhibit 87: AF EP Ablation Catheter Market Growth, by Country, Europe, 2008 - 2013 121
• Exhibit 88: AF EP Ablation Catheter Market, by Country, as a % of Total, Europe, 2007 - 2013 122
• Exhibit 89: Conventional AF EP Ablation Catheter Market, by Country, Europe (US$), 2007 - 2013 123
• Exhibit 90: Conventional AF EP Ablation Catheter Market, by Country, Europe (€ and £), 2007 - 2013 124
• Exhibit 91: Conventional AF EP Ablation Catheter Market Growth, by Country, Europe, 2008 - 2013 125
• Exhibit 92: Conventional AF EP Ablation Catheter Market, by Country, as a % of Total, Europe, 2007 - 2013 126
• Exhibit 93: Advanced AF EP Ablation Catheter Market, by Country, Europe (US$), 2007 - 2013 127
• Exhibit 94: Advanced AF EP Ablation Catheter Market, by Country, Europe (€ and £), 2007 - 2013 128
• Exhibit 95: Advanced AF EP Ablation Catheter Market Growth, by Country, Europe, 2008 - 2013 129
• Exhibit 96: Advanced AF EP Ablation Catheter Market, by Country, as a % of Total, Europe, 2007 - 2013 130
• Exhibit 97: Surgical Ablation AF Treatment Device Market, Europe (US$), 2007 - 2013 132
• Exhibit 98: Surgical Ablation AF Treatment Device Market, by Country, Europe (US$), 2007 - 2013 133
• Exhibit 99: Surgical Ablation AF Treatment Device Market, by Country, Europe (€ and £), 2007 - 2013 134
• Exhibit 100: Surgical Ablation AF Treatment Device Market Growth, by Country, Europe, 2008 - 2013 135
• Exhibit 101: Surgical Ablation AF Treatment Device Market, by Country, as a % of Total, Europe, 2007 - 2013 136
• Exhibit 102: CRM AF Treatment Device Market, Europe (US$), 2007 - 2013 138
• Exhibit 103: CRM AF Treatment Device Market, by Type, Europe (US$), 2007 - 2013 139
• Exhibit 104: CRM AF Treatment Device Market, by Type, Europe (€ ), 2007 - 2013 140
• Exhibit 105: CRM AF Treatment Device Market Growth, by Type, Europe, 2008 - 2013 141
• Exhibit 106: CRM AF Treatment Device Market, by Type, as a % of Total, Europe, 2007 - 2013 142
• Exhibit 107: CRM AF Treatment Device Market, by Country, Europe (US$), 2007 - 2013 143
• Exhibit 108: CRM AF Treatment Device Market, by Country, Europe (€ and £), 2007 - 2013 144
• Exhibit 109: CRM AF Treatment Device Market Growth, by Country, Europe, 2008 - 2013 145
• Exhibit 110: CRM AF Treatment Device Market, by Country, as a % of Total, Europe, 2007 - 2013 146
• Exhibit 111: AF Pacemaker Market, by Country, Europe (US$), 2007 - 2013 147
• Exhibit 112: AF Pacemaker Market, by Country, Europe (€ and £), 2007 - 2013 148
• Exhibit 113: AF Pacemaker Market Growth, by Country, Europe, 2008 - 2013 149
• Exhibit 114: AF Pacemaker Market, by Country, as a % of Total, Europe, 2007 - 2013 150
• Exhibit 115: AF Defibrillator Market, by Country, Europe (US$), 2007 - 2013 151
• Exhibit 116: AF Defibrillator Market, by Country, Europe (€ and £), 2007 - 2013 152
• Exhibit 117: AF Defibrillator Market Growth, by Country, Europe, 2008 - 2013 153
• Exhibit 118: AF Defibrillator Market, by Country, as a % of Total, Europe, 2007 - 2013 154
• Exhibit 119: Drivers of the AF Treatment Device Market, Europe 155
• Exhibit 120: Limiters of the AF Treatment Device Market, Europe 155
• Exhibit 121: Leading Competitors in the AF Treatment Device Market, Europe, 2008 156

CHAPTER 5: JAPANESE ATRIAL FIBRILLATION TREATMENT DEVICE MARKET 157

• Exhibit 122: AF Treatment Device Market, Japan (US$), 2007 - 2013 157
• Exhibit 123: AF Treatment Device Market Segmentation, Japan 158
• Exhibit 124: AF Treatment Device Procedures, by Segment, Japan, 2007 - 2013 (Graphical Format) 159
• Exhibit 125: AF Treatment Device Procedures, by Segment, Japan, 2007 - 2013 (Tabular Format) 160
• Exhibit 126: Surgical Ablation AF Treatment Device Procedures, by Type, Japan, 2007 - 2013 163
• Exhibit 127: AF Treatment Device Market, by Segment, Japan (US$), 2007 - 2013 165
• Exhibit 128: AF Treatment Device Market, by Segment, Japan (US$ and ¥), 2007 - 2013 166
• Exhibit 129: EP AF Treatment Device Market, Japan (US$), 2007 - 2013 168
• Exhibit 130: EP AF Treatment Device Market, by Segment, Japan (US$ and ¥), 2007 - 2013 169
• Exhibit 131: AF EP Diagnostic Catheter Market, by Type, Japan (US$), 2007 - 2013 170
• Exhibit 132: AF EP Diagnostic Catheter Market, by Type, Japan (¥), 2007 - 2013 171
• Exhibit 133: AF EP Diagnostic Catheter Market Growth, by Type, Japan, 2008 - 2013 172
• Exhibit 134: AF EP Diagnostic Catheter Market, by Type, as a % of Total, Japan, 2007 - 2013 173
• Exhibit 135: AF EP Ablation Catheter Market, by Type, Japan (US$) 2007 - 2013 174
• Exhibit 136: AF EP Ablation Catheter Market, by Type, Japan (¥), 2007 - 2013 175
• Exhibit 137: AF EP Ablation Catheter Market Growth, by Type, Japan, 2008 - 2013 176
• Exhibit 138: AF EP Ablation Catheter Market, by Type, as a % of Total, Japan, 2007 - 2013 177
• Exhibit 139: Surgical Ablation AF Treatment Device Market, Japan (US$), 2007 - 2013 (Graphical Format) 178
• Exhibit 140: Surgical Ablation AF Treatment Device Market, Japan (US$), 2007 - 2013 (Tabular Format) 179
• Exhibit 141: Surgical Ablation AF Treatment Device Market, Japan (¥), 2007 - 2013 179
• Exhibit 142: Surgical Ablation AF Treatment Device Market Growth, Japan, 2008 - 2013 180
• Exhibit 143: CRM AF Treatment Device Market, Japan (US$), 2007 - 2013 182
• Exhibit 144: CRM AF Treatment Device Market, by Type, Japan (US$), 2007 - 2013 183
• Exhibit 145: CRM AF Treatment Device Market, by Type, Japan (¥), 2007 - 2013 184
• Exhibit 146: CRM AF Treatment Device Market Growth, by Type, Japan, 2008 - 2013 185
• Exhibit 147: CRM AF Treatment Device Market, by Type, as a % of Total, Japan, 2007 - 2013 186
• Exhibit 148: Drivers of the AF Treatment Device Market, Japan 187
• Exhibit 149: Limiters of the AF Treatment Device Market, Japan 187
• Exhibit 150: Leading Competitors in the AF Treatment Device Market, Japan, 2008 188

APPENDIX B: SUPPLEMENTAL EXHIBITS 190

• Exhibit 151: AF Treatment Device Market, by Segment, Global (US$), 2007 - 2013 (Detailed Format) 190
• Exhibit 152: EP AF Treatment Device Procedures, Global, 2007 - 2013 (Detailed Format) 191
• Exhibit 153: Surgical Ablation AF Treatment Device Market, Global (US$), 2007 - 2013 (Detailed Format) 191
• Exhibit 154: AF Treatment Device Market, by Segment, as a % of Total, Global, 2008 (Detailed Format) 192