Global Markets for Heart Defect Closure Devices 2009

Table of Contents

TABLE OF CONTENTS

LIST OF EXHIBITS

EXECUTIVE SUMMARY

METHODOLOGY

1.0 GLOBAL HEART DEFECT CLOSURE DEVICE MARKET

• 1.1 Market Overview
• 1.2 Condition Overview
  • 1.2.1 Atrial Septal Defect
  • 1.2.2 Patent Foramen Ovale
  • 1.2.3 Patent Ductus Arteriosus
  • 1.2.4 Ventricular Septal Defect
• 1.3 Market Analysis
  • 1.3.1 Major Events and Assumptions
  • 1.3.2 Procedures
    • 1.3.2.1 Atrial Septal Defect Closure Device Procedures
    • 1.3.2.2 Patent Foramen Ovale Closure Device Procedures
    • 1.3.2.3 Patent Ductus Arteriosus Closure Procedures
    • 1.3.2.4 Ventricular Septal Defect Closure Device Procedures
  • 1.3.3 Patent Foramen Ovale Randomized Control Trial Review
    • 1.3.3.1 Trial Summaries for Cryptogenic Strokes and Transient Ischemic Attack Indications
    • 1.3.3.2 Trial Summaries for Migraine Indications
      • Completed Trials for Migraine Indications
      • Ongoing Trials for Migraine Indications
  • 1.3.4 Physician Feedback Regarding Patent Foramen Ovale Closure
  • 1.3.5 Market Forecast
    • 1.3.5.1 Atrial Septal Defect Closure Device Market
    • 1.3.5.2 Patent Foramen Ovale Closure Device Market
    • 1.3.5.3 Patent Ductus Arteriosus Closure Device Market
    • 1.3.5.4 Ventricular Septal Defect Closure Device Market
  • 1.3.6 Market Drivers and Limiters
    • 1.3.6.1 Market Drivers
    • 1.3.6.2 Market Limiters
• 1.4 Competitive Analysis
  • 1.4.1 Competitive Landscape
  • 1.4.2 Emerging Competitors

2.0 US HEART DEFECT CLOSURE DEVICE MARKET

• 2.1 Market Overview
• 2.2 Market Analysis
  • 2.2.1 Major Events and Assumptions
  • 2.2.2 Procedures
    • 2.2.2.1 Atrial Septal Defect Closure Device Procedures
    • 2.2.2.2 Patent Foramen Ovale Closure Device Procedures
      • Physician Feedback Regarding Patent Foramen Ovale Closure
    • 2.2.2.3 Patent Ductus Arteriosus Closure Device Procedures
    • 2.2.2.4 Ventricular Septal Defect Closure Device Procedures
  • 2.2.3 Market Forecast
    • 2.2.3.1 Atrial Septal Defect Closure Device Market
    • 2.2.3.2 Patent Foramen Ovale Closure Device Market
    • 2.2.3.3 Patent Ductus Arteriosus Closure Device Market
    • 2.2.3.4 Ventricle Septal Defect Closure Device Market
  • 2.2.4 Market Drivers and Limiters
• 2.3 Competitive Analysis

3.0 EUROPEAN HEART DEFECT CLOSURE DEVICE MARKET

• 3.1 Market Overview
• 3.2 Market Analysis
  • 3.2.1 Major Events and Assumptions
  • 3.2.2 Procedures
    • 3.2.2.1 Atrial Septal Defect Closure Device Procedures
    • 3.2.2.2 Patent Foramen Ovale Closure Device Procedures
      • Physician Feedback Regarding Patent Foramen Ovale Closure
    • 3.2.2.3 Patent Ductus Arteriosus Closure Device Procedures
    • 3.2.2.4 Ventricular Septal Defect Closure Device Procedures
  • 3.2.3 Market Forecast
    • 3.2.3.1 Atrial Septal Defect Closure Device Market
    • 3.2.3.2 Patent Foramen Ovale Closure Device Market
    • 3.2.3.3 Patent Ductus Arteriosus Closure Device Market
    • 3.2.3.4 Ventricle Septal Defect Closure Device Market
  • 3.2.4 Market Drivers and Limiters
• 3.3 Competitive Analysis

4.0 JAPANESE HEART DEFECT CLOSURE DEVICE MARKET

• 4.1 Market Overview
• 4.2 Market Analysis
  • 4.2.1 Major Events and Assumptions
  • 4.2.2 Procedures
  • 4.2.3 Market Forecast
  • 4.2.4 Market Drivers and Limiters
• 4.3 Competitive Analysis

APPENDIX A: MRG ACRONYMS AND INITIALISMS

APPENDIX B: SUPPLEMENTAL EXHIBITS

List of Exhibits

EXECUTIVE SUMMARY

• Exhibit 1: Heart Defect Closure Device Market, Global (US$), 2007 - 2013
• Exhibit 2: PFO Closure Device Procedures, by Device Type, US, 2007 - 2013
• Exhibit 3: Heart Defect Closure Device Market, by Country, Europe, 2007 - 2013
• Exhibit 4: Heart Defect Closure Device Market, by Indication, Japan, (US$), 2007 - 2013
• Exhibit 5: Leading Competitors in the Global Heart Defect Closure Device Market,2008

METHODOLOGY

• Exhibit 6: Currency Exchange Rates, 2008

CHAPTER 1: GLOBAL HEART DEFECT CLOSURE DEVICE MARKET

• Exhibit 7: Heart Defect Closure Device Market, Global (US$), 2007 - 2013
• Exhibit 8: Transcatheter Heart Defect Closure Procedures, by Region, Global, 2007 - 2013
• Exhibit 9: Transcatheter Heart Defect Closure Procedures, by Indication, Global, 2007 - 2013
• Exhibit 10: Transcatheter Heart Defect Closure Procedures, by Indication and Region, 2007 - 2013
• Exhibit 11: Transcatheter Heart Defect Closure Procedure Growth, by Indication and Region, 2008 - 2013
• Exhibit 12: CLOSE Clinical Trial Summary, 2008
• Exhibit 13: CLOSURE I Clinical Trial Summary, 2008
• Exhibit 14: PC-Trial Summary, 2008
• Exhibit 15: REDUCE Clinical Trial Summary, 2008
• Exhibit 16: RESPECT Clinical Trial Summary, 2008
• Exhibit 17: MIST I Clinical Trial Summary, 2008
• Exhibit 18: PREMIUM Clinical Trial Summary, 2008
• Exhibit 19: PRIMA Clinical Trial Summary, 2008
• Exhibit 20: Heart Defect Closure Device Market, by Region, Global (US$), 2007 - 2013
• Exhibit 21: Heart Defect Closure Device Market, by Indication, Global (US$), 2007 - 2013
• Exhibit 22: Heart Closure Device Market, by Indication and Region, Global (US$), 2007 - 2013
• Exhibit 23: Heart Defect Closure Device Market Growth, by Indication and Region, 2008 - 2013
• Exhibit 24: Drivers and Limiters of the Heart Defect Closure Device Market, Global
• Exhibit 25: Key Facts in the Competitive Landscape of the Heart Defect Closure Device Market, Country, 2008
• Exhibit 26: Leading Competitors in the Heart Defect Closure Device Market, as a % of Total, Global, 2008
• Exhibit 27: Leading Competitors in the Heart Defect Closure Device Market, by Segment, as a % of Total, Global, 2008
• Exhibit 28: Leading Competitors in the Heart Defect Closure Device Market, by Region, as a % of Total, Global, 2008

CHAPTER 2: US HEART DEFECT CLOSURE DEVICE MARKET

• Exhibit 29: Heart Defect Closure Device Market, US (US$), 2007 - 2013
• Exhibit 30: Transcatheter Heart Defect Closure Procedures, by Indication, US, 2007 - 2013 (Graphical Format)
• Exhibit 31: Transcatheter Heart Defect Closure Procedures, by Indication, US, 2007 - 2013 (Tabular Format)
• Exhibit 32: PFO Closure Device Procedures, by Indication, US, 2007 - 2013
• Exhibit 33: PFO Closure Device Procedures, by Device Type, US, 2007 - 2013
• Exhibit 34: PDA Closure Procedures, by Type, US, 2007 - 2013
• Exhibit 35: Heart Defect Closure Device Market, by Indication, US (US$), 2007 - 2013 (Graphical Format)
• Exhibit 36: Heart Defect Closure Device Market, by Indication, US (US$), 2007 - 2013 (Tabular Format)
• Exhibit 37: Heart Defect Closure Device Market Growth, by Indication, US, 2008 - 2013
• Exhibit 38: Heart Defect Closure Device Market, by Indication, as a % of Total, US, 2007 - 2013
• Exhibit 39: ASD Closure Device Units, by Indication, US, 2007 - 2013 (Graphical Format)
• Exhibit 40: ASD Closure Device Units, by Indication, US, 2007 - 2013 (Tabular Format)
• Exhibit 41: Drivers of the Heart Defect Closure Device Market, US
• Exhibit 42: Limiters of the Heart Defect Closure Device Market, US
• Exhibit 43: Leading Competitors in the Heart Defect Closure Device Market, as a % of Total, US, 2007
• Exhibit 44: Leading Competitors in the Heart Defect Closure Device Market, by Indication, as a % of Total, US, 2007

CHAPTER 3: EUROPEAN HEART DEFECT CLOSURE DEVICE MARKET

• Exhibit 45: Heart Defect Closure Device Market, Europe (US$), 2007 - 2013
• Exhibit 46: Transcatheter Heart Defect Closure Procedures, by Country, Europe, 2007 - 2013
• Exhibit 47: Transcatheter Heart Defect Closure Procedures, by Indication, Europe, 2007 - 2013
• Exhibit 48: Transcatheter Heart Defect Closure Procedures, by Indication and Country, Europe, 2007 - 2013
• Exhibit 49: Transcatheter Heart Defect Closure Procedures, by Indication and Country, Europe, 2007 - 2013 (Continued)
• Exhibit 50: Transcatheter Heart Defect Closure Procedure Growth, by Indication and Country, Europe, 2008 - 2013
• Exhibit 51: Transcatheter Heart Defect Closure Procedure Growth, by Indication and Country, Europe, 2008 - 2013 (Continued)
• Exhibit 52: PDA Closure Procedures, by Type and Country, Europe, 2007 - 2013
• Exhibit 53: PDA Closure Procedure Growth, by Type and Country, Europe, 2008 - 2013
• Exhibit 54: PDA Closure Procedure, by Country and Type, as a % of total, Europe, 2007 - 2013
• Exhibit 55: Heart Defect Closure Device Market, by Country, Europe (US$), 2007 - 2013 (Graphical Format)
• Exhibit 56: Heart Defect Closure Device Market, by Indication, Europe (US$), 2007 - 2013 (Graphical Format)
• Exhibit 57: Heart Defect Closure Device Market, by Country, Europe (US$), 2007 - 2013 (Tabular Format)
• Exhibit 58: Heart Defect Closure Device Market, by Country, Europe (€ and £), 2007 - 2013
• Exhibit 59: Heart Defect Closure Device Market Growth, by Country, Europe, 2008 - 2013
• Exhibit 60: Heart Defect Closure Device Market, by Indication, Europe (US$), 2007 - 2013 (Tabular Format)
• Exhibit 61: Heart Defect Closure Device Market, by Indication, Europe (€ and £), 2007 - 2013
• Exhibit 62: Heart Defect Closure Device Market Growth, by Indication, Europe, 2008 - 2013
• Exhibit 63: ASD Closure Device Market, by Country, Europe (US$), 2007 - 2013 (Graphical Format)
• Exhibit 64: ASD Closure Device Market, by Country, Europe (US$), 2007 - 2013 (Tabular Format)
• Exhibit 65: ASD Closure Device Market, by Country, Europe, (€ and £), 2007 - 2013
• Exhibit 66: ASD Closure Device Market Growth, by Country, Europe, 2008 - 2013
• Exhibit 67: PFO Closure Device Market, by Country, Europe (US$), 2007 - 2013 (Graphical Format)
• Exhibit 68: PFO Closure Device Market, by Country, Europe (US$), 2007 - 2013 (Tabular Format)
• Exhibit 69: PFO Closure Device Market, by Country, Europe (€ and £), 2007 - 2013
• Exhibit 70: PFO Closure Device Market Growth, by Country, Europe, 2008 - 2013
• Exhibit 71: PDA Closure Device Market, by Country, Europe, (US$), 2007 - 2013 (Graphical Format)
• Exhibit 72: PDA Closure Device Market, by Country, Europe (US$), 2007 - 2013 (Tabular Format)
• Exhibit 73: PDA Closure Device Market, by Country, Europe (€ and £), 2007 - 2013
• Exhibit 74: PDA Closure Device Market Growth, by Country, Europe, 2008 - 2013
• Exhibit 75: VSD Closure Device Market, by Country, Europe (US$), 2007 - 2013 (Graphical Format)
• Exhibit 76: VSD Closure Device Market, by Country, Europe (US$), 2007 - 2013 (Tabular Format)
• Exhibit 77: VSD Closure Device Market, by Country, Europe, (€ and £), 2007 - 2013
• Exhibit 78: VSD Closure Device Market Growth, by Country, Europe, 2008 - 2013
• Exhibit 79: Drivers of the Heart Defect Closure Device Market, Europe
• Exhibit 80: Limiters of the Heart Defect Closure Device Market, Europe
• Exhibit 81: Leading Competitors in the Heart Defect Closure Device Market, as a % of Total, Europe, 2008
• Exhibit 82: Leading Competitors in the Heart Defect Closure Device Market, by Country, as a % of Total, Europe, 2008
• Exhibit 83: Leading Competitors in the Heart Defect Closure Device Market, by Indication, as a % of Total, Europe, 2007

CHAPTER 4: JAPANESE HEART DEFECT CLOSURE DEVICE MARKET

• Exhibit 84: Heart Defect Closure Device Market, Japan (US$), 2007 - 2013
• Exhibit 85: Transcatheter Heart Defect Closure Procedures, by Indication, Japan, 2007 - 2013 (Graphical Format)
• Exhibit 86: Transcatheter Heart Defect Closure Procedures, by Indication, Japan, 2007 - 2013 (Graphical Format)
• Exhibit 87: PDA Closure Procedures, by Type, Japan, 2007 - 2013
• Exhibit 88: Heart Defect Closure Device Market, by Indication, Japan (US$), 2007 - 2013 (Graphical Format)
• Exhibit 89: Heart Defect Closure Device Market, by Indication, Japan (US$), 2007 - 2013 (Tabular Format)
• Exhibit 90: Heart Defect Closure Device Market, by Indication, Japan (¥), 2007 - 2013
• Exhibit 91: Heart Defect Closure Device Market Growth, by Indication, Japan, 2008 - 2013
• Exhibit 92: Heart Defect Closure Device Market, by Indication, as a % of Total, Japan, 2007 - 2013
• Exhibit 93: Drivers of the Heart Defect Closure Device Market, Japan
• Exhibit 94: Limiters of the Heart Defect Closure Device Market, Japan

APPENDIX B: SUPPLEMENTAL EXHIBITS

• Exhibit 95: Heart Defect Closure Device Market, Global (US$), 2007 - 2013 (Detailed Format)
• Exhibit 96: PFO Closure Device Procedures, by Device Type, US, 2007 - 2013 (Detailed Format)
• Exhibit 97: Heart Defect Closure Device Market, by Country, Europe, 2007 - 2013 (Detailed Format)
• Exhibit 98: Heart Defect Closure Device Market, by Indication, Japan, (US$), 2007 - 2013 (Detailed Format)