US Markets for Orthopedic Soft Tissue Solutions 2009

Table of Contents

TABLE OF CONTENTS

LIST OF EXHIBITS

EXECUTIVE SUMMARY

METHODOLOGY

1.0 ORTHOPEDIC SOFT TISSUE SOLUTIONS BACKGROUND

• 1.1 Shoulder Fixation and Rotator Cuff Reinforcement Overview
  • 1.1.1 Procedure Overview
    • 1.1.1.1 Rotator Cuff Repair
    • 1.1.1.2 Glenohumeral Joint Repair
• 1.2 Knee Ligament Reconstruction Overview
  • 1.2.1 Procedure Overview
    • 1.2.1.1 Anterior Cruciate Ligament - Only Reconstruction
    • 1.2.1.2 Multiple Ligament Reconstruction
  • 1.2.2 Graft Overview
    • 1.2.2.1 Autografts
    • 1.2.2.2 Allografts
• 1.3 Knee Cartilage Repair Overview
  • 1.3.1 Procedure Overview
    • 1.3.1.1 Debridement and Microfracture
    • 1.3.1.2 Osteochondral Autograft Transplantation
    • 1.3.1.3 Autologous Chondrocyte Implantation
    • 1.3.1.4 Osteochondral Allograft Transplantation
• 1.4 Meniscus Repair Overview
  • 1.4.1 Procedure Overview
    • 1.4.1.1 Meniscectomy
    • 1.4.1.2 Meniscus Tear Repair

2.0 US ORTHOPEDIC SOFT TISSUE SOLUTIONS MARKET

• 2.1 Market Overview
• 2.2 Market Analysis
  • 2.2.1 Economic Assumptions for the Forecast Period
  • 2.2.2 Procedures
  • 2.2.3 Market Forecast
    • 2.2.3.1 Shoulder Fixation Market
    • 2.2.3.2 Knee Ligament Reconstruction Market
    • 2.2.3.3 Knee Cartilage Repair Market
    • 2.2.3.4 Meniscus Repair Market
    • 2.2.3.5 Rotator Cuff Reinforcement Graft Market
    • 2.2.3.6 Hip Arthroscopy Market
• 2.3 Competitive Analysis
  • Arthrex
  • DePuy Mitek
  • Smith & Nephew
  • ConMed Linvatec
  • Joint Restoration Foundation

3.0 SHOULDER FIXATION MARKET

• 3.1 Market Overview
• 3.2 Market Analysis
  • 3.2.1 Procedures
  • 3.2.2 Market Forecast
    • Suture Anchor Market, by Type
    • Suture Anchor Market, by Material
  • 3.2.3 Market Drivers and Limiters
    • 3.2.3.1 Market Drivers
    • 3.2.3.2 Market Limiters
• 3.3 Competitive Analysis
  • Arthrex
  • DePuy Mitek
  • Smith & Nephew
  • ArthroCare
  • ConMed Linvatec

4.0 KNEE LIGAMENT RECONSTRUCTION MARKET

• 4.1 Market Overview
• 4.2 Market Analysis
  • 4.2.1 Procedures
  • 4.2.2 Market Forecast
    • 4.2.2.1 Knee Ligament Reconstruction Device Market
      • Disposables Market
      • Bone - Patellar Tendon - Bone Fixation Device Market
      • Soft Tissue Fixation Device Market
    • 4.2.2.2 Knee Ligament Reconstruction Graft Market
  • 4.2.3 Market Drivers and Limiters
    • 4.2.3.1 Market Drivers
    • 4.2.3.2 Market Limiters
  • 4.2.4 Emerging Trends
    • 4.2.4.1 Graft Alternatives
      • Pegasus Biologics
      • Serica Technologies
    • 4.2.4.2 Biomaterials
      • Bone Solutions
      • BioMimetic Therapeutics
    • 4.2.4.3 Surgical Techniques
• 4.3 Competitive Analysis
  • Arthrex
  • Smith & Nephew
  • Musculoskeletal Transplant Foundation
  • DePuy Mitek
  • LifeNet Health
  • ConMed Linvatec
  • Joint Restoration Foundation
  • Biomet Sports Medicine

5.0 KNEE CARTILAGE REPAIR MARKET

• 5.1 Market Overview
• 5.2 Market Analysis
  • 5.2.1 Procedures
  • 5.2.2 Market Forecast
    • 5.2.2.1 Graft Market
    • 5.2.2.2 Device Market
  • 5.2.3 Market Drivers and Limiters
    • 5.2.3.1 Market Drivers
    • 5.2.3.2 Market Limiters
  • 5.2.4 Emerging Trends
    • 5.2.4.1 Next - Generation Autologous Chondrocyte Implantation Products
      • Arthro Kinetics' CaReS
      • TETEC Tissue Engineering Technologies' Novocart 3D
      • BioTissue Technologies' Bio - Seed - C
      • Fidia Advanced Biopolymers' s Hyalograft C and TiGenix' s ChondroCelect
      • Geistlich Pharma, Cell Matrix, and CellGenix' s Chondro - Gide and CartiGro
      • Genzyme Biosurgery' s Matrix - induced Autologous Chondrocyte Implantation (MACI)
      • Histogenics' VeriCart/NeoCart
      • co.don' s chondrosphere
      • DePuy Mitek' s Cartilage Autograft Implantation System (CAIS)
      • Zimmer and ISTO Technologies' DeNovo ET Engineered Tissue Graft (Neocartilage)
  • 5.2.4.2 Biomaterials
    • BioMimetic Therapeutics' GEM 21S
    • BioSyntech' s BST - CarGel
    • Kensey Nash
    • Scil Technology' s ST03
  • 5.2.4.3 Stem Cells
    • PrimeGen Biotech' s PrimeCell and ChondroCell
  • 5.2.4.4 Synthetic Implants
    • SaluMedica' s SaluCartilage
• 5.3 Competitive Analysis
  • Genzyme Biosurgery
  • Joint Restoration Foundation
  • Arthrex
  • DePuy Mitek
  • Smith & Nephew

6.0 MENISCUS REPAIR MARKET

• 6.1 Market Overview
• 6.2 Market Analysis
  • 6.2.1 Procedures
  • 6.2.2 Market Forecast
    • 6.2.2.1 Device Market
    • 6.2.2.2 Graft Market
  • 6.2.3 Market Drivers and Limiters
    • 6.2.3.1 Market Drivers
    • 6.2.3.2 Market Limiters
  • 6.2.4 Emerging Trends
    • 6.2.4.1 Graft Alternatives
      • ReGen Biologics
    • 6.2.4.2 Stem Cells
      • Osiris Therapeutics
• 6.3 Competitive Analysis
  • Smith & Nephew
  • DePuy Mitek
  • Arthrex
  • ConMed Linvatec
  • Biomet Sports Medicine

7.0 ROTATOR CUFF REINFORCEMENT GRAFT MARKET

• 7.1 Market Overview
• 7.2 Market Analysis
  • 7.2.1 Procedures
  • 7.2.2 Market Forecast
    • 7.2.2.1 Graft Market
      • Xenograft Market
      • Allograft Market
      • Synthetic Implant Market
  • 7.2.3 Market Drivers and Limiters
    • 7.2.3.1 Market Drivers
    • 7.2.3.2 Market Limiters
• 7.3 Competitive Analysis
  • Wright Medical Technology
  • DePuy Mitek
  • Stryker
  • Pegasus Biologics
  • Biomet Sports Medicine
  • Zimmer

APPENDIX A: MRG ACRONYMS AND INITIALISMS

APPENDIX B: OSTEOARTHRITIS EPIDEMIOLOGY

APPENDIX C: SUPPLEMENTAL EXHIBITS

List of Exhibits

EXECUTIVE SUMMARY

• Exhibit 1: Orthopedic Soft Tissue Solutions Market, US (US$), 2007 - 2013
• Exhibit 2: Suture Anchor Sales, by Material, as a % of Total, US, 2007 - 2013
• Exhibit 3: Knee Ligament Reconstruction Market, by Segment, US (US$), 2007 - 2013
• Exhibit 4: Knee Cartilage Repair Market, by Segment, US (US$), 2007 - 2013
• Exhibit 5: Meniscus Repair Market, US (US$), 2007 - 2013
• Exhibit 6: Rotator Cuff Reinforcement Graft Market, by Segment, US (US$), 2007 - 2013
• Exhibit 7: Leading Competitors in the Orthopedic Soft Tissue Solutions Market, US, 2008

CHAPTER 1: ORTHOPEDIC SOFT TISSUE SOLUTIONS BACKGROUND

• Exhibit 8: BTB Autograft Advantages and Disadvantages
• Exhibit 9: Soft Tissue Autograft Advantages and Disadvantages

CHAPTER 2: US ORTHOPEDIC SOFT TISSUE SOLUTIONS MARKET

• Exhibit 10: Orthopedic Soft Tissue Solutions Market, US (US$), 2007 - 2013
• Exhibit 11: Orthopedic Soft Tissue Procedures, by Type, US, 2007 - 2013
• Exhibit 12: Orthopedic Soft Tissue Solutions Market, by Segment, US (US$), 2007 - 2013
• Exhibit 13: Leading Competitors in the Orthopedic Soft Tissue Solutions Market, as a % of Total, US, 2008
• Exhibit 14: Leading Competitors in the Orthopedic Soft Tissue Solutions Market, by Segment, as a % of Total, US, 2008

CHAPTER 3: SHOULDER FIXATION MARKET

• Exhibit 15: Shoulder Fixation Market, by Segment, US (US$), 2007 - 2013
• Exhibit 16: Shoulder Fixation Procedures, by Type US, 2007 - 2013
• Exhibit 17: Rotator Cuff Repairs, by Method, US, 2007 - 2013
• Exhibit 18: Rotator Cuff Repairs, by Technique, US, 2007 - 2013
• Exhibit 19: Glenohumeral Joint Repairs, by Method, US, 2007 - 2013
• Exhibit 20: Shoulder Fixation Market, by Segment, US (US$), 2007 - 2013
• Exhibit 21: Suture Anchor Units, by Type, US, 2007 - 2013
• Exhibit 22: Suture Anchor Market, by Type, US (US$), 2007 - 2013
• Exhibit 23: Suture Anchor Market Growth, by Type, US, 2008 - 2013
• Exhibit 24: Suture Anchor Market, by Type, as a % of Total, US, 2007 - 2013
• Exhibit 25: Suture Anchor Sales, by Material, as a % of Total, US, 2007 - 2013
• Exhibit 26: Suture Anchor Market, by Material, US (US$), 2007 - 2013
• Exhibit 27: Suture Anchor Market Growth, by Material, US, 2008 - 2013
• Exhibit 28: Suture Anchor Market, by Material, as a % of Total, US, 2007 - 2013
• Exhibit 29: Drivers and Limiters of the Shoulder Fixation Market, US
• Exhibit 30: Leading Competitors in the Shoulder Fixation Market, by Segment, as a % of Total, US, 2008
• Exhibit 31: Leading Competitors in the Suture Anchor Market, by Material, as a % of Total, US, 2008

CHAPTER 4: KNEE LIGAMENT RECONSTRUCTION MARKET

• Exhibit 32: Knee Ligament Reconstruction Market, US (US$), 2007 - 2013
• Exhibit 33: Knee Ligament Reconstruction Procedures, by Scope, US, 2007 - 2013
• Exhibit 34: Knee Ligament Reconstruction Procedures, by Graft, US, 2007 - 2013
• Exhibit 35: Knee Ligament Reconstruction Market, by Segment, US (US$), 2007 - 2013
• Exhibit 36: Knee Ligament Reconstruction Device Market, by Segment, US (US$), 2007 - 2013
• Exhibit 37: Knee Ligament Reconstruction Disposables Market, US (US$), 2007 - 2013
• Exhibit 38: BTB Fixation Device Market, by Material, US (US$), 2007 - 2013
• Exhibit 39: BTB Fixation Device Market Growth, by Material, US, 2008 - 2013
• Exhibit 40: BTB Fixation Device Market, by Material, as a % of Total, US, 2007 - 2013
• Exhibit 41: Soft Tissue Fixation Device Market, by Segment, US (US$), 2007 - 2013
• Exhibit 42: Soft Tissue Femoral Fixation Device Market, by Type, US (US$), 2007 - 2013
• Exhibit 43: Soft Tissue Femoral Fixation Device Market Growth, by Type, US, 2008 - 2013
• Exhibit 44: Soft Tissue Femoral Fixation Device Market, by Type, as a % of Total, US, 2007 - 2013
• Exhibit 45: Soft Tissue Tibial Fixation Device Market, by Type, US (US$), 2007 - 2013
• Exhibit 46: Soft Tissue Tibial Fixation Device Market Growth, by Type, US, 2008 - 2013
• Exhibit 47: Soft Tissue Tibial Fixation Device Market, by Type, as a % of Total, US, 2007 - 2013
• Exhibit 48: Knee Ligament Reconstruction Graft Market, by Type, US (US$), 2007 - 2013
• Exhibit 49: Knee Ligament Reconstruction Graft Market Growth, by Type, US, 2008 - 2013
• Exhibit 50: Knee Ligament Reconstruction Graft Market, by Type, as a % of Total, US, 2007 - 2013
• Exhibit 51: Drivers and Limiters of the Knee Ligament Reconstruction Market, US
• Exhibit 52: Leading Competitors in the Knee Ligament Reconstruction Market, by Segment, as a % of Total, US, 2008
• Exhibit 53: Leading Competitors in the Knee Ligament Reconstruction Device Market, by Segment, as a % of Total, US, 2008
• Exhibit 54: Leading Competitors in the BTB Fixation Device Market, by Material, as a % of Total, US, 2008
• Exhibit 55: Leading Competitors in the Soft Tissue Femoral Fixation Device Market, by Type, as a % of Total, US, 2008

CHAPTER 5: KNEE CARTILAGE REPAIR MARKET

• Exhibit 56: Knee Cartilage Repair Market, by Segment, US (US$), 2007 - 2013
• Exhibit 57: Knee Cartilage Repair Procedures, by Type, US, 2007 - 2013
• Exhibit 58: Knee Cartilage Repair Market, by Segment, US (US$), 2007 - 2013
• Exhibit 59: Knee Cartilage Repair Graft Market, by Type, US (US$), 2007 - 2013
• Exhibit 60: Knee Cartilage Repair Graft Market Growth, by Type, US, 2008 - 2013
• Exhibit 61: Knee Cartilage Repair Graft Market, by Type, as a % of Total, US, 2007 - 2013
• Exhibit 62: Knee Cartilage Repair Device Market, by Type, US (US$), 2007 - 2013
• Exhibit 63: Knee Cartilage Repair Device Market Growth, by Type, US, 2008 - 2013
• Exhibit 64: Knee Cartilage Repair Device Market, by Type, as a % of Total, US, 2007 - 2013
• Exhibit 65: Drivers and Limiters of the Knee Cartilage Repair Market, US
• Exhibit 66: Selected Next - Generation ACI Products
• Exhibit 67: Leading Competitors in the Knee Cartilage Repair Market, by Segment, as a % of Total, US, 2008
• Exhibit 68: Leading Competitors in the Knee Cartilage Repair Graft Market, by Type, as a % of Total, US, 2008
• Exhibit 69: Leading Competitors in the Knee Cartilage Repair Device Market, by Type, as a % of Total, US, 2008

CHAPTER 6: MENISCUS REPAIR MARKET

• Exhibit 70: Meniscus Repair Market, US (US$), 2007 - 2013
• Exhibit 71: Meniscus Procedures, by Type, US, 2007 - 2013
• Exhibit 72: Meniscus Repairs, by Method, US, 2007 - 2013
• Exhibit 73: Meniscus Repair Market, by Segment, US (US$), 2007 - 2013
• Exhibit 74: Meniscus Repair Device Sales, by Segment, US, 2007 - 2013
• Exhibit 75: Meniscus Repair Device Market, by Segment, US (US$), 2007 - 2013
• Exhibit 76: Meniscus Repair Device Market Growth, by Segment, US, 2008 - 2013
• Exhibit 77: Meniscus Repair Device Market, by Segment, as a % of Total, US, 2007 - 2013
• Exhibit 78: Meniscus Repair Graft Market, US (US$), 2007 - 2013
• Exhibit 79: Drivers and Limiters of the Meniscus Repair Market, US
• Exhibit 80: Leading Competitors in the Meniscus Repair Market, by Segment, as a % of Total, US, 2008
• Exhibit 81: Leading Competitors in the Meniscus Repair Device Market, by Type, as a % of Total, US, 2008

CHAPTER 7: ROTATOR CUFF REINFORCEMENT GRAFT MARKET

• Exhibit 82: Rotator Cuff Reinforcement Graft Market, by Segment, US (US$), 2007 - 2013
• Exhibit 83: Rotator Cuff Repair Procedures, by Scope, US, 2007 - 2013
• Exhibit 84: Rotator Cuff Reinforcement Graft Market, by Segment, as a % of Total, US, 2007 - 2013 (Graphical Format)
• Exhibit 85: Rotator Cuff Reinforcement Graft Market, by Segment, US (US$), 2007 - 2013 (Tabular Format)
• Exhibit 86: Rotator Cuff Reinforcement Xenograft Market, by Type, US (US$), 2007 - 2013 (Graphical Format)
• Exhibit 87: Rotator Cuff Reinforcement Xenograft Market, by Type, US (US$), 2007 - 2013 (Tabular Format)
• Exhibit 88: Rotator Cuff Reinforcement Xenograft Market Growth, by Type, US, 2008 - 2013
• Exhibit 89: Rotator Cuff Reinforcement Xenograft Market, by Type, as a % of Total, US, 2007 - 2013
• Exhibit 90: Rotator Cuff Reinforcement Allograft Market, US (US$), 2007 - 2013
• Exhibit 91: Rotator Cuff Reinforcement Synthetic Implant Market, US (US$), 2007 - 2013
• Exhibit 92: Drivers and Limiters of the Rotator Cuff Reinforcement Graft Market, US
• Exhibit 93: Leading Competitors in the Rotator Cuff Reinforcement Graft Market, by Segment, as a % of Total, US, 2008
• Exhibit 94: Leading Competitors in the Rotator Cuff Reinforcement Xenograft Market, by Type, as a % of Total, US, 2008

APPENDIX B: OSTEOARTHRITIS EPIDEMIOLOGY

• Exhibit 95: Prevalence of Osteoarthritis, US, 2007 - 2013

APPENDIX C: SUPPLEMENTAL EXHIBITS

• Exhibit 96: Orthopedic Soft Tissue Solutions Market, US (US$), 2007 - 2013 (Detailed Format)
• Exhibit 97: Suture Anchor Sales, by Material, as a % of Total, US, 2007 - 2013 (Detailed Format)
• Exhibit 98: Knee Ligament Reconstruction Market, by Segment, US (US$), 2007 - 2013 (Detailed Format)
• Exhibit 99: Knee Cartilage Repair Market, by Segment, US (US$), 2007 - 2013 (Detailed Format)
• Exhibit 100: Meniscus Repair Market, US (US$), 2007 - 2013 (Detailed Format)
• Exhibit 101: Rotator Cuff Reinforcement Graft Market, by Segment, US (US$), 2007 - 2013 (Detailed Format)