US Markets for Orthopedic Biomaterials 2009

Table of Contents

LIST OF EXHIBITS

EXECUTIVE SUMMARY

METHODOLOGY

1.0 ORTHOPEDIC BIOMATERIALS BACKGROUND

• 1.1 Bone Graft Overview
  • 1.1.1 Autograft
  • 1.1.2 Nonproprietary Allograft
  • 1.1.3 Demineralized Bone Matrix
  • 1.1.4 Synthetics
  • 1.1.5 Growth Factors
  • 1.1.6 Orthopedic Stem Cell Products
• 1.2 Osteoarthritis and Hyaluronic Acid Viscosupplementation
  • 1.2.1 Incidence
  • 1.2.2 Treatment Alternatives
    • 1.2.2.1 Nonpharmacologic Treatments
    • 1.2.2.2 Nonsteroidal Anti - Inflammatory Drugs
    • 1.2.2.3 Cyclooxygenase - 2 (COX - 2) Inhibitors
    • 1.2.2.4 Hyaluronic Acid Viscosupplementation
• 1.3 Machined Bone Interbody Devices Overview
• 1.4 Cell Concentration Systems Overview
  • 1.4.1 Platelet Concentration Systems
  • 1.4.2 Bone Marrow Aspirate Concentrate Systems
  • 1.4.3 Bone Marrow Aspirate Systems
• 1.5 Knee Cartilage Repair Overview
  • 1.5.1 Treatment Alternatives
    • 1.5.1.1 Debridement and Microfracture
    • 1.5.1.2 Osteochondral Flap Repair
    • 1.5.1.3 Osteochondral Autograft Transplantation
    • 1.5.1.4 Osteochondral Allograft Transplantation
    • 1.5.1.5 Autologous Chondrocyte Implantation

2.0 US ORTHOPEDIC BIOMATERIAL MARKET

• 2.1 Market Overview
• 2.2 Market Analysis
  • 2.2.1 Key Report Updates
  • 2.2.2 Economic Assumptions for the Forecast Period
  • 2.2.3 Procedures
  • 2.2.4 Market Forecast
    • 2.2.4.1 Bone Graft Substitute Market
    • 2.2.4.2 Hyaluronic Acid Viscosupplementation Market
    • 2.2.4.3 Machined Bone Interbody Device Market
    • 2.2.4.4 Cell Concentration System Market
    • 2.2.4.5 Knee Cartilage Repair Market
• 2.3 Competitive Analysis
  • 2.3.1 Market Shares
  • 2.3.2 Competitor Discussion (in Alphabetical Order)
    • Biomet
    • DePuy
    • Ferring Pharmaceuticals
    • Genzyme Biosurgery
    • Medtronic Spinal and Biologics
    • Orthovita
    • Osteotech
    • sanofi - aventis
    • Smith & Nephew
    • Stryker
    • Synthes
    • Other

3.0 BONE GRAFT SUBSTITUTE MARKET

• 3.1 Market Overview
• 3.2 Market Analysis
  • 3.2.1 Procedures and Units
    • 3.2.1.1 Procedures by Application
      • Thoracolumbar and Cervical Spinal Fusions
      • Trauma Surgeries
      • Joint Revision and Reconstruction Procedures
      • Craniomaxillofacial Surgeries
    • 3.2.1.2 Units by Material
      • Autograft - Only
      • Growth Factors
      • Demineralized Bone Matrices
      • Synthetics
      • Nonproprietary Allografts
      • Orthopedic Stem Cell Products
  • 3.2.2 Market Forecast
    • 3.2.2.1 Bone Graft Substitute Market by Application (Thoracolumbar and Cervical
      • Spinal Fusion, Trauma Surgery, Joint Revision and Reconstruction, and
      • Craniomaxillofacial Surgery)
    • 3.2.2.2 Bone Graft Substitute Market by Material (Autograft, Nonproprietary
      • Allograft, Growth Factors, Demineralized Bone Matrices, Synthetics, and
      • Orthopedic Stem Cell Products)
  • 3.2.3 Market Drivers and Limiters
    • 3.2.3.1 Market Drivers
    • 3.2.3.2 Market Limiters
• 3.3 Competitive Analysis
  • 3.3.1 Market Shares
  • 3.3.2 Competitor Discussions (in Alphabetical Order)
    • 3.3.2.1 Leading Competitors
      • Allograft Tissue Providers
      • Biomet Osteobiologics
      • DePuy Spine
      • Integra LifeSciences
      • Medtronic Spinal and Biologics
      • Orthofix
      • Orthovita
      • Osteotech
      • Stryker
      • Synthes
      • Wright Medical Technology
      • Other
    • 3.3.2.2 Emerging Competitors and Technologies
      • 3DM' s PuraMatrix
      • Aastrom Biosciences' Tissue Repair Cell
      • BioMimetic Therapeutics' Augment Bone Graft
      • Bone Biologics' UCS - 1 and UCB - 1 (NELL - 1)
      • Cerapedics' i - FACTOR
      • Pioneer Surgical Technology' s FortrOss
• 3.4 Spinal Fusion Bone Graft Substitute Market
  • 3.4.1 Spinal Fusion Bone Graft Substitute Market by Application (Thoracolumbar and Cervical)
  • 3.4.2 Spinal Fusion Bone Graft Substitute Market by Material (Autografts, Growth Factors, Demineralized Bone Matrices, Synthetics, Nonproprietary Allografts, and
    • Orthopedic Stem Cell Products)
  • 3.4.3 Thoracolumbar Fusion Bone Graft Substitute Market
  • 3.4.4 Cervical Fusion Bone Graft Substitute Market
• 3.5 Trauma Surgery Bone Graft Substitute Market
  • 3.5.1 Trauma Surgery Bone Graft Substitute Market by Application (Fresh Fracture and Nonunion)
  • 3.5.2 Trauma Surgery Bone Graft Substitute Market by Material (Autografts, Growth Factors, Demineralized Bone Matrices, Synthetics, Nonproprietary Allografts, and
    • Orthopedic Stem Cell Products)
  • 3.5.3 Fresh Fracture Surgery Bone Graft Substitute Market
  • 3.5.4 Nonunion Surgery Bone Graft Substitute Market
• 3.6 Joint Revision and Reconstruction Bone Graft Substitute Market
  • 3.6.1 Joint Revision and Reconstruction Bone Graft Substitute Market by Application (Hip Revision, Knee Revision, Primary Total Knee, and Primary Total Hip)
  • 3.6.2 Joint Revision and Reconstruction Bone Graft Substitute Market by Material (Autografts, Demineralized Bone Matrices, Synthetics, and Nonproprietary Allografts)
  • 3.6.3 Hip Revision Bone Graft Substitute Market
  • 3.6.4 Knee Revision Bone Graft Substitute Market
  • 3.6.5 Primary Total Knee Reconstruction Bone Graft Substitute Market
  • 3.6.6 Primary Total Hip Reconstruction Bone Graft Substitute Market
• 3.7 Craniomaxillofacial Surgery Bone Graft Substitute Market
  • 3.7.1 Craniomaxillofacial Surgery Bone Graft Substitute Market by Material (Autografts, Growth Factors, Demineralized Bone Matrices, Synthetics, and Nonproprietary Allografts)

4.0 HYALURONIC ACID VISCOSUPPLEMENTATION MARKET

• 4.1 Market Overview
• 4.2 Market Analysis
  • 4.2.1 Procedures
    • 4.2.1.1 Hyaluronic Acid Viscosupplementation Procedures by Number of Injections (1, 3, and 5)
    • 4.2.1.2 Hyaluronic Acid Viscosupplementation Procedures by Application (Knee, Shoulder, Hip, and Other)
    • 4.2.1.3 Hyaluronic Acid Viscosupplementation Procedures by Site (Sports Medicine Clinic, Rheumatology Clinic, Primary Care Clinic, Other)
  • 4.2.2 Market Forecast
  • 4.2.3 Market Drivers and Limiters
    • 4.2.3.1 Market Drivers
    • 4.2.3.2 Market Limiters
• 4.3 Competitive Analysis
  • 4.3.1 Market Shares
  • 4.3.2 Competitor Discussions (in Alphabetical Order)
    • 4.3.2.1 Leading Competitors
      • DePuy Mitek (Anika Therapeutics)
      • Ferring Pharmaceuticals
      • Genzyme Biosurgery
      • sanofi - aventis (Fidia Farmaceutici)
      • Smith & Nephew (Seikagaku)
    • 4.3.2.2 Emerging Competitors and Technologies
      • Carbylan BioSurgery' s ActaVisc and ActaVisc Mx
      • Orthogen' s Orthokine
      • Seikagaku' s Gel - 200

5.0 MACHINED BONE INTERBODY DEVICE MARKET

• 5.1 Market Overview
• 5.2 Market Analysis
  • 5.2.1 Market Forecast
  • 5.2.2 Market Drivers and Limiters
    • 5.2.2.1 Market Drivers
    • 5.2.2.2 Market Limiters
• 5.3 Competitive Analysis
  • 5.3.1 Market Shares
  • 5.3.2 Competitor Discussions (in Alphabetical Order)
    • DePuy Spine
    • Medtronic Spinal and Biologics
    • Osteotech
    • Stryker Spine
    • Synthes Spine
    • Zimmer Spine
    • Other

6.0 CELL CONCENTRATION SYSTEM MARKET

• 6.1 Market Overview
• 6.2 Market Analysis
  • 6.2.1 Procedures
    • 6.2.1.1 Cell Concentration Procedures by Application (Thoracolumbar Fusion, Cervical Fusion, Other Orthopedic Surgery, and Soft Tissue Repair)
    • 6.2.1.2 Cell Concentration Procedures by Type
      • Platelet Concentration System Procedures
      • Bone Marrow Aspirate Concentrate Procedures
      • Bone Marrow Aspirate Procedures
  • 6.2.2 Market Forecast
    • 6.2.2.1 Cell Concentration System Market by Type (Platelet Concentration System Disposable Kit, Platelet Concentration System Applicator, Bone Marrow Aspirate Concentrate, and Bone Marrow Aspirate)
  • 6.2.3 Market Drivers and Limiters
    • 6.2.3.1 Market Drivers
    • 6.2.3.2 Market Limiters
• 6.3 Competitive Analysis
  • 6.3.1 Market Shares
  • 6.3.2 Competitor Discussions (in Alphabetical Order)
    • Arteriocyte Medical Systems/Medtronic Spinal and Biologics
    • Biomet Biologics
    • DePuy Spine (Harvest Technologies)
    • Exactech
    • Harvest Technologies
    • Other

7.0 KNEE CARTILAGE REPAIR MARKET

• 7.1 Market Overview
• 7.2 Market Analysis
  • 7.2.1 Procedures
    • Debridement and Microfracture Procedures
    • Osteochondral Flap Repairs
    • Osteochondral Autograft Procedures
    • Osteochondral Allograft Procedures
    • Autologous Chondrocyte Implantation
  • 7.2.2 Market Forecast
    • 7.2.2.1 Knee Cartilage Repair Graft Market
      • Autologous Chondrocyte Implantation Market
      • Osteochondral Allograft Market
    • 7.2.2.2 Knee Cartilage Repair Device Market
      • Osteochondral Flap Repair
      • Osteochondral Autograft
  • 7.2.3 Market Drivers and Limiters
    • 7.2.3.1 Market Drivers
    • 7.2.3.2 Market Limiters
  • 7.2.4 Emerging Competitors and Technologies
    • 7.2.4.1 Next - Generation Autologous Chondrocyte Implantation Products
      • Arthro Kinetics' CaReS
      • BioTissue Technologies' Bio - Seed - C
      • co.don' s chondrosphere
      • DePuy Mitek' s Cartilage Autograft Implantation System (CAIS)
      • Fidia Advanced Biopolymers' Hyalograft C and TiGenix' s ChondroCelect
      • Geistlich Pharma, Cell Matrix, and CellGenix' s Chondro - Gide and CartiGro
      • Genzyme Biosurgery' s Matrix - induced Autologous Chondrocyte
      • Implantation (MACI)
      • Histogenics' VeriCart/NeoCart
      • TETEC Tissue Engineering Technologies' Novocart 3D
      • Zimmer and ISTO Technologies' DeNovo ET Engineered Tissue Graft (Neocartilage)
    • 7.2.4.2 Biomaterials
      • BioMimetic Therapeutics' GEM 21S
      • BioSyntech' s BST - CarGel
      • Kensey Nash
      • Scil Technology' s ST03
    • 7.2.4.3 Stem Cells
      • PrimeGen Biotech' s PrimeCell and ChondroCell
    • 7.2.4.4 Synthetic Implants
      • SaluMedica' s SaluCartilage
• 7.3 Competitive Analysis
  • 7.3.1 Market Shares
  • 7.3.2 Competitor Discussions (in Alphabetical Order)
    • Arthrex
    • DePuy Mitek
    • Genzyme Biosurgery
    • Joint Restoration Foundation
    • Smith & Nephew
    • Other

APPENDIX A: MRG ACRONYMS AND INITIALISMS

APPENDIX B: OSTEOPOROSIS EPIDEMIOLOGY

APPENDIX C: OSTEOARTHRITIS EPIDEMIOLOGY

APPENDIX D: SUPPLEMENTAL EXHIBITS

List of Exhibits

EXECUTIVE SUMMARY XVI

• Exhibit 1: Orthopedic Biomaterial Market, by Segment, US (US$), 2007 - 2013 XVI
• Exhibit 2: Bone Graft Units, by Material, as a % of Total, US, 2007 - 2013 XVII
• Exhibit 3: HA Viscosupplementation Treatments, by Number of Injections, US,
• 2008 and 2013 XVIII
• Exhibit 4: Machined Bone IBD Market, by Approach, US (US$), 2007 - 2013 XIX
• Exhibit 5: Cell Concentration System Market, by Type, US (US$), 2007 - 2013 XX
• Exhibit 6: Knee Cartilage Repair Market, by Segment, US (US$), 2007 - 2013 XXI
• Exhibit 7: Leading Competitors in the Orthopedic Biomaterial Market, US, 2008 XXII

CHAPTER 1: ORTHOPEDIC BIOMATERIALS BACKGROUND 1

• Exhibit 8: Characteristics of Bone Graft Materials 2
• Exhibit 9: Advantages and Disadvantages of Various Bone Graft Materials 3
• Exhibit 10: Select NP Allograft Providers, US, 2008 4
• Exhibit 11: Select DBM Companies and Products, US, 2008 5
• Exhibit 12: Select Synthetic BGS Companies and Products, US, 2008 7
• Exhibit 13: Select Synthetic BGS Materials 8
• Exhibit 14: Select HA Viscosupplementation Companies and Products, US, 2008 14

CHAPTER 2: US ORTHOPEDIC BIOMATERIAL MARKET 22

• Exhibit 15: Orthopedic Biomaterial Market, US (US$), 2007 - 2013 22
• Exhibit 16: Key Report Updates, 2009 23
• Exhibit 17: Orthopedic Biomaterial Market, by Segment, US (US$), 2007 - 2013 29
• Exhibit 18: Leading Competitors in the Orthopedic Biomaterial Market, as a % of Total, US, 2008 30
• Exhibit 19: Leading Competitors in the Orthopedic Biomaterial Market, by Segment, as a % of Total, US, 2008 31

CHAPTER 3: BONE GRAFT SUBSTITUTE MARKET 37

• Exhibit 20: BGS Market, by Material, US (US$), 2007 - 2013 (Graphical Format) 37
• Exhibit 21: Bone Graft Procedures, by Application, US, 2007 - 2013 40
• Exhibit 22: Average Volume of Bone Graft per Procedure, by Application, US, 2008 41
• Exhibit 23: Bone Graft Units, by Material, US, 2007 - 2013 45
• Exhibit 24: Bone Graft Units, by Material, as a % of Total, US, 2007 - 2013 46
• Exhibit 25: BGS Market, by Application, US (US$), 2007 - 2013 49
• Exhibit 26: BGS ASPs, by Material and Volume, US (US$), 2008 50
• Exhibit 27: BGS Market, by Material, US (US$), 2007 - 2013 (Tabular Format) 51
• Exhibit 28: Drivers and Limiters of the BGS Market, US 52
• Exhibit 29: Leading Competitors in the BGS Market, by Material, as a % of Total, US, 2008 56
• Exhibit 30: Spinal Fusion Bone Graft Procedures, by Application, US, 2007 - 2013 68
• Exhibit 31: Spinal Fusion Bone Graft Units, by Material, US, 2007 - 2013 69
• Exhibit 32: Spinal Fusion Bone Graft Units, by Material, as a % of Total, US, 2007 - 2013 70
• Exhibit 33: Spinal Fusion BGS Market, by Material, US (US$), 2007 - 2013 71
• Exhibit 34: Thoracolumbar Fusion Bone Graft Procedures, by Level, US, 2007 - 2013 73
• Exhibit 35: Thoracolumbar Fusion Bone Graft Units, by Material, US, 2007 - 2013 74
• Exhibit 36: Thoracolumbar Fusion Bone Graft Units per Procedure, by Material, US, 2007 - 2013 75
• Exhibit 37: Single - Level Thoracolumbar Fusion Bone Graft Units, by Material, US, 2007 - 2013 76
• Exhibit 38: Two - Level Thoracolumbar Fusion Bone Graft Units, by Material, US, 2007 - 2013 77
• Exhibit 39: Multilevel Thoracolumbar Fusion Bone Graft Units, by Material, US, 2007 - 2013 78
• Exhibit 40: Thoracolumbar Fusion BGS ASPs, by Material, US (US$), 2007 - 2013 79
• Exhibit 41: Single - Level Thoracolumbar Fusion BGS ASPs, by Material, US (US$), 2007 - 2013 80
• Exhibit 42: Two - Level Thoracolumbar Fusion BGS ASPs, by Material, US (US$), 2007 - 2013 81
• Exhibit 43: Multilevel Thoracolumbar Fusion BGS ASPs, by Material, US (US$), 2007 - 2013 82
• Exhibit 44: Thoracolumbar Fusion BGS Market, by Material, US (US$), 2007 - 2013 83
• Exhibit 45: Single - Level Thoracolumbar Fusion BGS Market, by Material, US (US$), 2007 - 2013 84
• Exhibit 46: Two - Level Thoracolumbar Fusion BGS Market, by Material, US (US$), 2007 - 2013 85
• Exhibit 47: Multilevel Thoracolumbar Fusion BGS Market, by Material, US (US$), 2007 - 2013 86
• Exhibit 48: Cervical Fusion Bone Graft Procedures, by Level, US, 2007 - 2013 89
• Exhibit 49: Cervical Fusion Bone Graft Units, by Material, US, 2007 - 2013 90
• Exhibit 50: Cervical Fusion Bone Graft Units per Procedure, by Material, US, 2007 - 2013 91
• Exhibit 51: Single - Level Cervical Fusion Bone Graft Units, by Material, US, 2007 - 2013 92
• Exhibit 52: Two - Level Cervical Fusion Bone Graft Units, by Material, US, 2007 - 2013 93
• Exhibit 53: Multilevel Cervical Fusion Bone Graft Units, by Material, US, 2007 - 2013 94
• Exhibit 54: Cervical Fusion BGS ASPs, by Material, US (US$), 2007 - 2013 95
• Exhibit 55: Single - Level Cervical Fusion BGS ASPs, by Material, US (US$), 2007 - 2013 96
• Exhibit 56: Two - Level Cervical Fusion BGS ASPs, by Material, US (US$), 2007 - 2013 97
• Exhibit 57: Multilevel Cervical Fusion BGS ASPs, by Material, US (US$), 2007 - 2013 98
• Exhibit 58: Cervical Fusion BGS Market, by Material, US (US$), 2007 - 2013 99
• Exhibit 59: Single - Level Cervical Fusion BGS Market, by Material, US (US$), 2007 - 2013 100
• Exhibit 60: Two - Level Cervical Fusion BGS Market, by Material, US (US$), 2007 - 2013 101
• Exhibit 61: Multilevel Cervical Fusion BGS Market, by Material, US (US$), 2007 - 2013 102
• Exhibit 62: Trauma Surgery Bone Graft Procedures, by Application, US, 2007 - 2013 105
• Exhibit 63: Trauma Surgery Bone Graft Units, by Material, US, 2007 - 2013 106
• Exhibit 64: Trauma Surgery Bone Graft Units, by Material, as a % of Total, US, 2007 - 2013 107
• Exhibit 65: Trauma Surgery BGS Market, by Material, US (US$), 2007 - 2013 108
• Exhibit 66: Fresh Fracture Procedures, by Type, US, 2007 - 2013 111
• Exhibit 67: Fresh Fracture Surgery Bone Graft Units, by Material, US, 2007 - 2013 112
• Exhibit 68: Fresh Fracture Bone Graft Units per Procedure, by Material, US, 2007 - 2013 113
• Exhibit 69: Fresh Fracture Surgery BGS ASPs, by Material, US (US$), 2007 - 2013 114
• Exhibit 70: Fresh Fracture Surgery BGS Market, by Material, US (US$), 2007 - 2013 115
• Exhibit 71: Nonunion Surgery Bone Graft Units, by Material, US, 2007 - 2013 116
• Exhibit 72: Nonunion Bone Graft Units per Procedure, by Material, US, 2007 - 2013 117
• Exhibit 73: Nonunion Surgery BGS ASPs, by Material, US (US$), 2007 - 2013 118
• Exhibit 74: Nonunion Surgery BGS Market, by Material, US (US$), 2007 - 2013 119
• Exhibit 75: Joint Revision and Reconstruction Bone Graft Procedures, by Application, US, 2007 - 2013 122
• Exhibit 76: Joint Revision and Reconstruction Bone Graft Units, by Material, US, 2007 - 2013 123
• Exhibit 77: Joint Revision and Reconstruction BGS Market, by Material, US (US$), 2007 - 2013 124
• Exhibit 78: Hip Revisions, by Type, US, 2007 - 2013 125
• Exhibit 79: Hip Revision Bone Graft Units, by Material, US, 2007 - 2013 126
• Exhibit 80: Hip Revision BGS ASPs, by Material, US (US$), 2007 - 2013 127
• Exhibit 81: Hip Revision BGS Market, by Material, US (US$), 2007 - 2013 128
• Exhibit 82: Knee Revisions, by Type, US, 2007 - 2013 129
• Exhibit 83: Knee Revision Bone Graft Units, by Material, US, 2007 - 2013 130
• Exhibit 84: Knee Revision BGS ASPs, by Material, US (US$), 2007 - 2013 131
• Exhibit 85: Knee Revision BGS Market, by Material, US (US$), 2007 - 2013 132
• Exhibit 86: Primary Total Knee Reconstructions, by Type, US, 2007 - 2013 133
• Exhibit 87: Primary Total Knee Reconstruction Bone Graft Units, by Material, US, 2007 - 2013 134
• Exhibit 88: Primary Total Knee Reconstruction BGS ASPs, by Material, US (US$), 2007 - 2013 135
• Exhibit 89: Primary Total Knee Reconstruction BGS Market, by Material, US (US$), 2007 - 2013 136
• Exhibit 90: Primary Total Hip Reconstructions, by Type, US, 2007 - 2013 137
• Exhibit 91: Primary Total Hip Reconstruction Bone Graft Units, by Material, US, 2007 - 2013 138
• Exhibit 92: Primary Total Hip Reconstruction BGS ASPs, by Material, US (US$), 2007 - 2013 139
• Exhibit 93: Primary Total Hip Reconstruction BGS Market, by Material, US (US$), 2007 - 2013 140
• Exhibit 94: CMF Procedures, by Type, US, 2007 - 2013 143
• Exhibit 95: CMF Surgery Bone Graft Units, by Material, US, 2007 - 2013 144
• Exhibit 96: CMF Surgery Bone Graft Units per Procedure, by Material, US, 2007 - 2013 145
• Exhibit 97: CMF Surgery BGS ASPs, by Material, US (US$), 2007 - 2013 146
• Exhibit 98: CMF Surgery BGS Market, by Material, US (US$), 2007 - 2013 147

CHAPTER 4: HYALURONIC ACID VISCOSUPPLEMENTATION MARKET 148

• Exhibit 99: HA Viscosupplementation Market, US (US$), 2007 - 2013 (Graphical Format) 148
• Exhibit 100: HA Viscosupplementation Treatments and Injections, US, 2007 - 2013 152
• Exhibit 101: HA Viscosupplementation Treatments, by Number of Injection, US, 2007 - 2013 153
• Exhibit 102: HA Viscosupplementation Treatments and Injections, by Application, US, 2007 - 2013 154
• Exhibit 103: HA Viscosupplementation Treatment and Injection Growth, by Application, US, 2008 - 2013 155
• Exhibit 104: HA Viscosupplementation Treatment and Injections, by Application, as a % of Total, US, 2007 - 2013 156
• Exhibit 105: Estimated HA Viscosupplementation Procedures, by Site, as a % of Total, US, 2008 157
• Exhibit 106: HA Viscosupplementation Market, US (US$), 2007 - 2013 (Tabular Format) 159
• Exhibit 107: Drivers and Limiters of the HA Viscosupplementation Market, US 160
• Exhibit 108: Leading Competitors in the HA Viscosupplementation Market, as a % of Total, US, 2008 165

CHAPTER 5: MACHINED BONE INTERBODY DEVICE MARKET 170

• Exhibit 109: Machined Bone IBD Market, by Segment, US (US$), 2007 - 2013 (Graphical Format) 170
• Exhibit 110: Machined Bone Lumbar IBD Market, by Approach, US (US$), 2007 - 2013 173
• Exhibit 111: Machined Bone Lumbar IBD Market Growth, by Approach, 2008 - 2013 174
• Exhibit 112: Machined Bone IBD Market, by Segment, US (US$), 2007 - 2013 (Tabular Format) 175
• Exhibit 113: Machined Bone IBD Market Growth, by Segment, 2008 - 2013 176
• Exhibit 114: Machined Bone IBDs per Procedure, by Approach, US, 2007 - 2013 177
• Exhibit 115: Drivers and Limiters of the Machined Bone IBD Market, US 178
• Exhibit 116: Leading Competitors in the Machined Bone IBD Market, as a % of Total, US, 2008 181

CHAPTER 6: CELL CONCENTRATION SYSTEM MARKET 185

• Exhibit 117: Cell Concentration System Market, by Type, as a % of Total, US, 2007 - 2013 (Graphical Format) 185
• Exhibit 118: Cell Concentration System Procedures, by Type, US, 2007 - 2013 189
• Exhibit 119: Cell Concentration System Procedures, by Application, US, 2007 - 2013 190
• Exhibit 120: PCS Procedures, by Application, US, 2007 - 2013 191
• Exhibit 121: BMAC Procedures, by Application, US, 2007 - 2013 192
• Exhibit 122: BMA Procedures, by Application, US, 2007 - 2013 193
• Exhibit 123: Cell Concentration System Market, by Type, US (US$), 2007 - 2013 195
• Exhibit 124: Cell Concentration System Market Growth, by Type, US, 2008 - 2013 196
• Exhibit 125: Cell Concentration System Market, by Type, as a % of Total, US, 2007 - 2013 (Tabular Format) 197
• Exhibit 126: Drivers and Limiters of the Cell Concentration System Market, US 198
• Exhibit 127: Leading Competitors in the Cell Concentration System Market, by Type, as a % of Total, US, 2008 201

CHAPTER 7: KNEE CARTILAGE REPAIR MARKET 204

• Exhibit 128: Knee Cartilage Repair Market, by Segment, US (US$), 2007 - 2013
• (Graphical Format) 204
• Exhibit 129: Knee Cartilage Repair Procedures, by Type, US, 2007 - 2013 208
• Exhibit 130: Knee Cartilage Repair Market, by Segment, US (US$), 2007 - 2013 (Tabular Format) 209
• Exhibit 131: Knee Cartilage Repair Graft Market, by Type, US (US$), 2007 - 2013 211
• Exhibit 132: Knee Cartilage Repair Graft Market Growth, by Type, US, 2008 - 2013 212
• Exhibit 133: Knee Cartilage Repair Graft Market, by Type, as a % of Total, US, 2007 - 2013 213
• Exhibit 134: Knee Cartilage Repair Device Market, by Type, US (US$), 2007 - 2013 215
• Exhibit 135: Knee Cartilage Repair Device Market Growth, by Type, US, 2008 - 2013 216
• Exhibit 136: Knee Cartilage Repair Device Market, by Type, as a % of Total, US, 2007 - 2013 217
• Exhibit 137: Drivers and Limiters of the Knee Cartilage Repair Market, US 218
• Exhibit 138: Selected Next - Generation ACI Products 222
• Exhibit 139: Leading Competitors in the Knee Cartilage Repair Market, by Segment, as a % of Total, US, 2008 230
• Exhibit 140: Leading Competitors in the Knee Cartilage Repair Graft Market, by Type, as a % of Total, US, 2008 231
• Exhibit 141: Leading Competitors in the Knee Cartilage Repair Device Market, by Type, as a % of Total, US, 2008 231

APPENDIX B: OSTEOPOROSIS EPIDEMIOLOGY 237

• Exhibit 142: Prevalence of Osteoporosis, US, 2007 - 2013 237

APPENDIX C: OSTEOARTHRITIS EPIDEMIOLOGY 238

• Exhibit 143: Prevalence of Osteoarthritis, US, 2007 - 2013 238

APPENDIX D: SUPPLEMENTAL EXHIBITS 239

• Exhibit 144: Orthopedic Biomaterial Market, by Segment, US (US$), 2007 - 2013 (Detailed Format) 239
• Exhibit 145: Bone Graft Units, by Material, as a % of Total, US, 2007 - 2013 (Detailed Format) 240
• Exhibit 146: HA Viscosupplementation Treatments, by Number of Injections, US, 2008 and 2013 (Detailed Format) 241
• Exhibit 147: Machined Bone IBD Market, by Approach, US (US$), 2007 - 2013 242
• Exhibit 148: Cell Concentration System Market, by Type, US (US$), 2007 - 2013 (Detailed Format) 243
• Exhibit 149: Knee Cartilage Repair Market, by Segment, US (US$), 2007 - 2013 (Detailed Format) 244