Table of Contents
CHAPTER 1: INTRODUCTION TO PROTEOMICS
- The human genome versus the proteome
- Identification of human genome
- Applications to proteomics
- The relationship between the proteome and the genome
- The genome
- Proteins
- From genes to proteins
- Proteomics
CHAPTER 2: PROTEOMIC TECHNOLOGIES
- Laboratory methods used in proteomics
- Separation techniques
- Identification techniques
- Interactions techniques
- Separation techniques
- Identification techniques
- Protein-protein interaction techniques
- Automation
- Pre-fractionation
- Separation
- Identification
- Complete proteomics solutions
- Bioinformatics and databases
- Data Analysis
- Databases
- Laboratory information management systems (LIMS)
CHAPTER 3: PROTEOMIC APPLICATIONS IN DRUG DISCOVERY
- Optimizing the R&D process
- Early selection of efficacious and non-toxic drug targets
- Toxicoproteomics
- Pharmacoproteomics
- Accelerating the discovery of new targets for therapeutic candidates
- Therapeutic proteins
- Protein targets
- Mining the proteome is an alternative approach for drug discovery
CHAPTER 4: PROTEOMIC APPLICATIONS IN CLINICAL TRIAL DESIGN AND
PERSONALIZED MEDICINE
- Development of new biomarkers
- Biomarkers as clinical endpoints
- Responders and non-responders
- Patients with adverse reactions
- Patients in different stages of a disease, or other subsets of patients
- Monitor clinical responses in new and comparator drugs - allowing
potential strategic alliances
- Patients with disease resistance
- Niche markets
- Application of biomarkers in different therapy areas
- Oncoproteomics
- Application in the diagnosis of: ovarian
- cancer, prostate cancer, breast cancer and
- esophageal cancer
- Neuroproteomics Application in the diagnosis of:
- Alzheimers diseases and amyotrophic lateral sclerosis (ALS)
- Cardioproteomics
- Cardiovascular markers
- Respiratory markers
- Application in organ transplantation
- Post-marketing applications of biomarkers
CHAPTER 5: PHARMACEUTICAL AND PROTEOMIC COMPANY ALLIANCES
- Recent collaborations and alliances of pharmaceutical and proteomic based
companies
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