Innovations in Diagnostics: Next generation molecular and point-of-care diagnostics driving personalized healthcare

Table of Contents

Executive Summary

• Introduction to diagnostics
• Challenges and opportunities in diagnostic innovation
• Molecular technology innovations
• Innovation in infectious disease diagnostics
• Personalized medicine
• Point-of-care testing
• Competitive landscape

Chapter 1 Introduction to diagnostics

• Summary
• Introduction
• The global IVD market
  • Market segments
  • Market dynamics
  • Market growth
• Key IVD players
  • Industry profile
• Overview of diagnostic technologies
  • Immunoassays
  • Nucleic acid (NA) assays
  • Biosensors
  • Microarrays
• Future trends

Chapter 2 Challenges and opportunities in diagnostic innovation

• Summary
• Introduction
• A changing healthcare environment
• Challenges & opportunities
  • Regulatory hurdles
  • Reimbursement
  • Technology requirements
  • Connectivity
  • Communication
  • New partnerships/new players

Chapter 3 Molecular technology innovations

• Summary
• Introduction
• IVD technologies
  • PCR
  • FISH
  • Arrays
  • Nanotechnology
  • DNA methylation
  • DNA biosensors

Chapter 4 Innovation in infectious disease diagnostics

• Summary
• Introduction
• Emerging infections
  • Avian influenza H5N1
  • SARS
• Multiple detection of infectious agents
• Future challenges
  • Hospital-acquired infections
  • Gonorrhea
  • Early onset sepsis
  • Other infections

Chapter 5 Personalized medicine

• Summary
• Introduction
  • Imaging: part of the Dx+PGx+Rx equation
• Pharmacogenomics
  • Clinical application of pharmacogenomics
  • Pharmacogenetic tests
    • Case Study: AmpliChip CYP450
    • Other pharmacogenetic tests
  • Biomarkers
    • Case study: Diabetes
    • Case study: Heart disease
• Oncology
  • Breast cancer
  • Colorectal cancer
  • Leukemia
  • Lung cancer
  • Prostate cancer
• Future challenges

Chapter 6 Point-of-care testing

• Summary
• Introduction
• Blood glucose tests
  • Case study: Scout test for diabetes screening
• Infectious diseases
  • Rapid Step B test
  • Urinary tract infection (UTI) biosensor
  • Active tuberculosis (TB)
• Cardiac diagnostics
  • Blood coagulation
  • Cardiac markers
  • Direct LDL cholesterol test
  • Stroke
• Bladder cancer rapid test
• HIV home tests
• Future challenges

Chapter 7 Competitive landscape

• Summary
• Introduction
• Key mergers & acquisitions
• Competitive landscape
• Pharma companies with Dx divisions
  • Roche Diagnostics
    • Diabetes Care
    • Centralized Diagnostics
    • Molecular Diagnostics
    • Near Patient Testing
    • Applied Science
    • Product Pipeline
  • Abbott
    • Diabetes Care
    • Immunodiagnostics, clinical chemistry and hematology
    • Molecular Diagnostics
    • Point-of-Care
• MedTech companies with Dx divisions
  • Becton Dickinson
    • Diagnostics
    • Biosciences
• Dx Specialists
  • Gen-Probe
    • Clinical Diagnostics
    • Blood Screening
    • Molecular Diagnostics
  • Inverness Medical Innovations (IMI)
    • Consumer Diagnostics Products
    • Professional Diagnostics Products
    • Research & Development
    • Acquisitions
  • Tm Bioscience
    • Human Genetics
    • Infectious disease
    • PGx
• Technology specialists
  • Affymetrix
    • Collaborations
    • Competition
  • Nanogen

Chapter 8 Appendix

• Index