Abstract
Kinases are a ubiquitous group of enzymes that catalyze the phosphoryl
transfer reaction from a phosphate donor (usually ATP) to a receptor
substrate, which can be protein, lipid, or a small molecule (e.g. sugar).
Phosphorylation of protein substrates is a fundamental and reversible
mechanism for regulating protein activity in eukaryotes. In addition to
protein kinases, many other kinases play important roles in cellular
phosphorylation reactions. Aberrant kinase activity has been directly
implicated in the etiology of a wide spectrum of human pathologies. As a
result of their importance, approximately 30% of current discovery and
development spending focuses on kinases, especially in the fields of oncology,
inflammation and metabolic diseases.
| 
View Cart
