The CRO Market Outlook: Emerging markets, leading players and future trends

Table of Contents

Executive Summary

• The global contract research organization market
• CRO market analysis
• Established regions in the global CRO market
• Emerging regions in the global CRO market
• Leading players in the global CRO market
• The future of contract research

Chapter 1 - The global contract research organization market

• Summary
• Introduction
• The CRO contribution to drug development
• Market overview
• Key market drivers
• Key market restraints
• Conclusions and key findings

• Overview of the global CRO market
• Total revenue forecasts
• Global R&D expenditure and CRO market size
• Global clinical development outsourcing
• The contribution of CRO to drug development

• Current market drivers
• Growth of R&D expenditure from biotech and pharma
• Cost pressures encourage R&D outsourcing
• Long term growth and R&D expenditure of biotechnology companies
• Growing regulatory burden and safety concerns
  • US
  • EU
• Patient recruitment
• Increasing number of products in development
• The development of biomarkers

• Current market restraints
• Near term reductions in biotech R&D spending
• Growing competition and customer consolidation
• New financial realities alter biopharmaceutical outsourcing landscape
• Shortage of clinical research personnel
• Electronic data capture: a threat to CRO revenue

• Key market trends
• Globalization
• EDC evolution
• Strategic alliances

Chapter 2 - CRO market analysis

• Summary
• Introduction
• Market conditions

• Competitive analysis
• Market share analysis
• Competitive dynamics
  • Academic medical centers
  • Site management organizations
  • Laboratory analytical services
  • Non-CRO niche service providers
  • Conclusion

• CRO service models
• Introduction
• The full service model
  • SWOT analysis
• The niche model
  • SWOT analysis

• Industry strategies
• Consolidation: Mergers & acquisitions in the CRO industry
• Expanding the continuum of services: vertical integration
  • Forward integration
  • Backward integration

• Industry challenges
• Consolidation within the CRO industry: a threat to close customer relationships
• Strategic outsourcing: demonstrating clear value to clients
• Co-development: sharing the risk

Chapter 3 - Established regions in the global CRO market

• Summary
• Introduction

• The US CRO market
• Overview
• Drivers of the US CRO market
• Challenges of the US CRO market
• Competitive dynamics

• The CRO market in Western Europe
• Overview
• Infrastructure and local regulations
• Drivers of the CRO market in Western Europe
• Challenges of the CRO market in Western Europe
• Competitive dynamics

Chapter 4 - Emerging regions in the global CRO market

• Summary
• Introduction

• The Central and Eastern European CRO market
• Overview
• Infrastructure and local regulations
• Benefits of outsourcing to CEE
• Challenges of outsourcing to CEE
• Competitive dynamics

• The CRO market in China
• Overview
• Infrastructure and local regulations
• Benefits of outsourcing to China
• Challenges of outsourcing to China
• Competitive dynamics

• The CRO market in India
• Overview
• Infrastructure and local regulations
  • Intellectual property
  • Legislative reforms
• Benefits of outsourcing to India
• Challenges of outsourcing to India
• Competitive dynamics

• The CRO market in Latin America
• Overview
• Infrastructure and local regulations
  • Argentina
  • Brazil
  • Mexico
• Benefits of outsourcing to Latin America
• Challenges of outsourcing to Latin America
• Competitive dynamics

• The CRO markets in South Korea and Turkey
• Overview
• Infrastructure and local regulations
• Benefits of outsourcing to South Korea
• Challenges of outsourcing to South Korea
• Benefits of outsourcing to Turkey
• Challenges of outsourcing to Turkey
• Competitive dynamics

Chapter 5 - Leading players in the global CRO market

• Summary

• Introduction
• The client perspective
• Capabilities of leading CROs

• Quintiles Transnational Corp
• Company profile
• Business description
• Partnering collaborations and recent deals

• Covance
• Company profile
• Business description
• Partnering collaborations and recent deals

• PPD Inc.
• Company profile
• Business description
• Partnering collaborations and recent deals

• Charles River Laboratories
• Company Profile
• Business description
• Partnering collaborations and recent deals

• PAREXEL International
• Company profile
• Business description
• Partnering collaborations and recent deals

• ICON plc.
• Company profile
• Business description
• Partnering collaborations and recent deals

• MDS Inc.
• Company profile
• Business description
• Partnering collaborations and recent deals

• Kendle International
• Company profile
• Business description
• Partnering collaborations and recent deals

• PRA International
• Company profile
• Business description
• Partnering collaborations and recent deals

• PharmaNet Development Group
• Company profile
• Business description
• Partnering collaborations and recent deals

Chapter 6 - The future of contract research

• vSummary
• Introduction
• The shift towards a strategic model
• Emerging markets
• Phases I and IV growth activity
• Electronic data capture

• Biomarkers
• Selected acquisitions/partnerships
• Conclusion

• Key findings and conclusions

Chapter 7 - Appendix

• Selected bibliography
• Index

List of Figures

• Figure 1.1: Estimated CRO market ($bn), 2003-2015e
• Figure 1.2: Global development expenditure and CRO market forecast ($bn), 2008-2014e
• Figure 1.3: Global outsourcing market by phase, 2006
• Figure 1.4: CRO usage and number of days by which projects overrun
• Figure 1.5: Global pharmaceutical R&D expenditure ($bn), 2000-2014e
• Figure 1.6: Number of FDA approvals 1990-2008
• Figure 1.7: Comparison of drug development cost estimates
• Figure 1.8: Global biotech R&D expenditure ($bn), 2004-2012e
• Figure 1.9: Number of products in development by phase 1998-2009
• Figure 1.10: CRO/Sponsor relationship models
• Figure 2.11: Market share of major players, 2008
• Figure 2.12: Typical full service CRO model
• Figure 3.13: R&D expenditures of PhRMA members and non-member companies ($bn), 1980-2009
• Figure 3.14: Overall indexed clinical trial costs by region, 2006-2008
• Figure 3.15: The European CRO market - revenue forecast ($bn), 2008-2012e
• Figure 3.16: Pharmaceutical R&D expenditure in Europe ($bn), 1990-2008
• Figure 4.17: Geographic distribution of clinical trials, 2005 to 2009f
• Figure 4.18: Clinical trial costs of European countries compared to the UK
• Figure 4.19: Comparison of trial registration periods in CEE countries (days)
• Figure 4.20: CRO market in China ($m), 2007-2012e
• Figure 4.21: China' s capabilities across the value chain
• Figure 4.22: India' s capabilities across the value chain
• Figure 4.23: Number of clinical trials in Latin America, 2000-2008
• Figure 4.24: Clinical trials in South Korea, 2005-2009e
• Figure 5.25: Revenue growth of top public CROs in 2007-2008
• Figure 5.26: Capabilities of leading CROs, 2009
• Figure 6.27: Regional presence of major CROs
• Figure 6.28: Attractiveness of selected countries for clinical trials
• Figure 6.29: Global numbers of phase IV trials 2006-2009e
• Figure 6.30: Electronic data capture market size ($m), 2006E-2012e
• Figure 6.31: Clinical trials using predictive biomarkers, 2005-2009

List of Tables

• Table 1.1: Functions commonly performed by CROs
• Table 2.2: The global R&D outsourcing market: five major segments
• Table 2.3: SWOT analysis: the full service model
• Table 2.4: SWOT analysis: the niche model
• Table 2.5: Key deals in the CRO sector
• Table 4.6: Major CROs operating in Eastern Europe, 2009
• Table 4.7: Domestic Chinese CROs
• Table 4.8: Major domestic CROs operating in Latin America, 2009
• Table 4.9: Selected domestic CROs in South Korea and Turkey
• Table 5.10: Revenues ($m) and growth of major CROs, 2007-2008