Innovations in Medical Imaging: Technological advances, growth opportunities and future market outlook

Table of Contents

Executive Summary

• Introduction
• Current issues in medical imaging & recent breakthroughs
• Challenges, opportunities & regulations
• Market, trends & future directions

Chapter 1 - Introduction

• What does medical imaging encompass?
• Anatomical & functional imaging

• Why is medical imaging of value to the pharmaceutical industry?
• Applications of medical imaging in drug R&D

• Leading imaging modalities
• X-Ray
• Computed tomography
• Magnetic resonance imaging
  • Functional MRI
• Optical near-infrared fluorescence imaging
• Ultrasound

• Nuclear medicine
• Positron Emission Tomography
• Single Photon Emission Computed Tomography
• Other imaging modalities
  • Video imaging

• Comparison of imaging modalities: in vivo & ex vivo applications
• Advantages & disadvantages of imaging modalities

• Therapeutic applications
• Cancer
  • Breast cancer
  • Colorectal cancer
• Cardiovascular disease
  • Coronary artery disease
  • Stroke
  • Other cardiovascular conditions
• Gastrointestinal conditions
• Orthopedics & osteoporosis
• CNS and thoracic trauma
• Therapeutic conclusions

Chapter 2 - Current issues in medical imaging & recent breakthroughs

• Pre-processing & post-processing issues
• Artifacts
• Noise
• Noise & artifact reduction
• Raw data acquisition & image reconstruction
• Image enhancement & portioning

• Conclusions on imaging issues

• Breakthroughs in medical imaging
• Novel imaging agents
  • CT imaging agents
  • MRI imaging agents
  • Ultrasound imaging agents
  • PET & SPECT imaging agents
• Imaging agent conclusions
• Novel scintillator & detectors
• Multimodality imaging devices
  • SPECT-CT & PET-CT hybrids
• Spectral CT
• High field MRI

• Conclusions on imaging breakthroughs

Chapter 3 - Challenges, opportunities & regulations

• Geographical challenges & opportunities
• US market growth & legislative impact
• International markets and changing dynamics
• Urbanization and rise of the emerging markets
• Patient demographics: therapeutic dynamics

• Technical Challenges & Opportunities
• Molecular imaging
  • Molecular imaging probes
  • Regulatory support
  • Molecular imaging consortia
  • Imaging task forces

• Targeted and multifunctional imaging agents
• Nanotechnology
  • Nano-enabled delivery
  • Nano imaging materials
• Targeted contrast agents
• Multifunctional imaging agents

• Novel imaging modalities
• Magnetic Particle Imaging
• PET-MRI
• Real-time whole animal imaging
  • Multi-spectral opto-acoustic tomography

• Computer assisted imaging & virtual surgery
• Virtual surgery
• Breakthrough conclusions

• Reimbursement & regulations
• Overall conclusions

Chapter 4 - Market trends & future directions

• The medical imaging market
• Leading manufacturers of medical imaging equipment

• Leading healthcare companies
• GE Healthcare, New York, US
• Hitachi Medical Corporation, Tokyo, Japan
• Philips Medical Systems, Amsterdam, The Netherlands
• Siemens Medical Solutions, Berlin & Munich, Germany
• Toshiba Medical Systems Corporation, Tokyo, Japan

• M&A activity

• Recent market trends
• Global trends in medical imaging
• Technological trends in imaging equipment
• Imaging agents & nanotechnology
• Image-guided radiation therapy and patient selection

• Future directions
• Molecular imaging & diagnostics
• Medical imaging informatics and networking
• Medical imaging and virtual reality

• Summary & overall conclusions

Chapter 5 - Appendices

• Primary research methodology
• Companies involved in medical imaging
• Glossary
• Acknowledgements
• Index
• Bibliography & Endnotes

List of Figures

• Figure 1.1: Medical imaging uses a spectrum of wavelengths
• Figure 1.2: Medical imaging technologies
• Figure 1.3: Imaging techniques and their uses
• Figure 1.4: Medical imaging in the drug discovery & development process
• Figure 1.5: X-ray of a skull a) anterior-posterior and b) lateral view
• Figure 1.6: Computed tomography of the head a) coronal section and b) sagittal section
• Figure 1.7: X-ray imagers
• Figure 1.8: Evolution of CT imaging
• Figure 1.9: Magnetic resonance imaging of the head
• Figure 1.10: Functional magnetic resonance imaging of the brain
• Figure 1.11: Multispectral imaging of the arm (700-900 nm range)
• Figure 1.12: Ultrasound image of a baby in-utero
• Figure 1.13: Principles of PET imaging
• Figure 1.14: Fused PET/CT image of anatomy and function
• Figure 1.15: SPECT detection
• Figure 1.16: video imaging
• Figure 1.17: Therapeutic application of medical imaging
• Figure 1.18: Therapeutic applications of medical imaging
• Figure 2.19: Medical imaging workflow
• Figure 2.20: CT imaging artifacts
• Figure 2.21: US imaging artifacts
• Figure 2.22: US imaging artifacts
• Figure 2.23: Recent technological breakthroughs in medical imaging
• Figure 2.24: New scintillator materials
• Figure 2.25: Opportunities in PET & SPECT for better energy resolution
• Figure 2.26: Advances collimators focus and maximize SPECT-CT
• Figure 2.27: Schematic of Spectral CT technology
• Figure 2.28: Diffusion MRI - CNS
• Figure 3.29: Historical and future outlook of MR/CT revenues in the US (1997-2011)
• Figure 3.30: Global Population (2008)
• Figure 3.31: Population over 60: world and developed regions (1950-2050)
• Figure 3.32: Projected global deaths for selected conditions (2005-2030)
• Figure 3.33: Application of molecular imaging
• Figure 3.34: Delivery platforms for contrast agent
• Figure 3.35: Multifunctional agents
• Figure 3.36: Schematic of MPI technology
• Figure 3.37: IVIS Kinetic images in small animal models
• Figure 3.38: Real-time whole body optical imaging of Zebrafish

List of Tables

• Table 1.1: Examples of image-related biomarkers with application in a variety of disease areas
• Table 1.2: Common PET positron-emitting tracer isotopes
• Table 1.3: Common SPECT radionuclides
• Table 1.4: Ex vivo imaging modalities
• Table 1.5: In vivo imaging modalities
• Table 1.6: Advantages & disadvantages of imaging modalities
• Table 3.7: Impact of American Recovery & Reinvestment Act (ARRA) on healthcare & medical imaging
• Table 3.8: Recent impact of investment & regulation on international healthcare & medical imaging markets
• Table 3.9: Typical effective radiation doses for medical imaging procedures
• Table 3.10: Leading manufacturers of small animal imaging equipment and probes
• Table 4.11: The medical imaging market - market leaders
• Table 4.12: Leading manufacturers of medical imaging equipment
• Table 4.3: Leading manufacturers of medical imaging equipment (cont)
• Table 4.4: Recent M&A activity in the medical imaging field
• Table 4.5: Recent M&A activity in the medical imaging field (continued)
• Table 5.16: The medical imaging market - leading companies in the US