Drug Delivery Systems: US Market Outlook, Advances for Pharma, Biotech & Medical Devices

Table of Contents

1.Introduction

• About This Report
• Overview
  • Drug Delivery Systems: Some Definitions
  • Drug Delivery Systems: What They Can Do
• Highlights of Pharma Issues Driving the Need for Drug
• Delivery
  • Declining Pharmaceutical Industry Productivity
  • Patent Expirations and Declining Branded Drug Sales
  • Pharmas Use Patent Extension Strategies
• Many Pharmas Will Seek Partners for Drug Delivery
  • New Crop of Drugs Will Reach the Market in Near Term
  • Limited Pharma Resources: Its Difficult to Invent New Drugs
• Every Drug Needs a Drug Delivery System
• Key Motivators for Developing Drug Delivery Systems
  • Business Considerations
  • Genomics, Proteomics and Targeted Therapies
  • Protein and Peptide Drugs
  • Expanding Knowledge About Disease Mechanisms
• Commercial and Technical Challenges of Drug Delivery
• Companies
  • Market is Diverse and Dynamic
  • An Expanding Industry
  • Companies Migrating to Become Specialty or Generic Pharmas
• Business Trends
  • A Market Snapshot
  • The Pharma Industry Wants Drug Delivery Systems
  • Changing Business Models

2.Drug Delivery Technology Developments

• Delivery by Controlled Release Approaches
• Oral Drug Delivery
• New Formulations and Packaging
  • Chewable Tablets
  • Orally Disintegrating Tablets (ODTs)
  • Orally Disintegrating Film Strips (ODFs)
  • Enhancing Drug Bioavailability or Solubility
• Injection Drug Delivery
  • Needle-free Injection
  • Drug Delivery by Implantable Infusion Pump
  • Intraosseous Injection
• Drug Delivery to Specific Organs
  • Lung Drug Delivery
  • Drug Delivery via the Nose
  • Delivery to the Cardiovascular System
  • Delivery to the Gastrointestinal Tract
  • Delivery to the Urogenital Tract
  • Drug Delivery into the Eye
• Drug Delivery by Transdermal Methods
• Drug Delivery to Mucosal Membranes
• Targeting Selected Disease Sites
  • Drug Delivery by Polymers and Proteins
  • Drug Delivery by Small Particles
    • Monoclonal Antibodies
    • Drug Delivery by Liposomes
    • Drug Delivery by Heat-Activated Liposomes
    • Drug Delivery by Microparticles
    • Drug Delivery by Modified Blood Cells
    • Drug Delivery by Nanoparticles
    • Viral Vectors for Gene Delivery
    • Non-Viral Vectors for Gene Delivery

3.Survey of Changing DDS Developments

• Inhalation System
• Polymer Development
• Protein Drug Delivery
• Therapeutic MAbs
• Developments in Polyethylene Glycol (PEG)
• Vaccines
• Nanotech
• Buccal Development
• Drug Delivery to the Eye
• Analyst Opinion: Next Generation Companies

4.Recent Strategic Alliances and M&As

• Alliance Analysis: Deals Through 2006
• Summaries of Drug Delivery Alliance Deals

5.Drug Delivery Systems Market Forecast

• The US Drug Delivery Market
  • A Large Market
  • New Innovations Help Drugs Work Better
  • Demand for Less Invasive Drugs and Treatments
  • Pharmaceutical Firms Can Differentiate Products
• The US Drug Delivery Market, 2005-2010E
  • Market Segments Defined by Route of Administration
  • Oral Delivery Segment
  • Injectable Delivery Segment
  • Injection Devices Delivery Segment
  • Inhaled Delivery Segment
  • Inhaler Devices Segment
  • Transdermal Delivery Segment
  • Implant Delivery Segment
  • Transmucosal Delivery Segment
  • Therapeutic Antibodies Segment
  • Therapeutic & Cancer Vaccine Segment
  • Targeted Therapy/Delivery Segment
  • Other Delivery Segment
  • Market Shares of the US Drug Delivery Market, 2005 and 2010
• Market Map: DDS Companies by Technology Categories

6.Patent Litigation Examples

• University of Alabama v. Nektar Therapeutics
• IVAX, Teva Pharmaceutical Industries Ltd., et al v.
• Eli Lilly
• Johnson & Johnson v. Boston Scientific
• Chiron Corporation v. Corus Pharma, Inc.
• Novartis Pharmaceuticals Corp., et al v. Sun
• Pharmaceutical Industries Ltd.
• GlaxoSmithKline Plc v. Par Pharmaceutical Companies,
• Inc. (Kali Laboratories, Inc.)
• Santarus, Inc. v. TAP Pharmaceutical Products, Inc.
• Travanti Pharma Inc. v. IOMED

7.Drug Delivery With Nanotechnology

• Nanotechnology
• Companies Using Nanotechnology for Drug Delivery
• Commercializing Nanotechnology
• Selected Nanotech R&D Companies

Activities of Selected Drug Delivery Companies

• Abgenix, Inc. (Amgen)
• Alkermes, Inc.
• Alnylam Pharmaceuticals, Inc.
• Antigenics, Inc.
• Aradigm Corporation
• Cima Laboratories (Cephalon)
• Elan Corporation
• Intradigm Corporation
• Medarex, Inc.
• NanoBio Corporation
• NanoMed Pharmaceuticals, Inc.
• Nastech Pharmaceutical Company, Inc.
• Nektar Therapeutics
• Nexmed, Inc.
• Noven Pharmaceuticals, Inc.
• Palatin Technologies, Inc.
• Raven Biotechnologies, Inc.
• Sanofi Pasteur SA (Vaccines)
• Sirna Therapeutics, Inc.
• Skyepharma PLC
• Sontra Medical Corporation
• Watson Pharmaceuticals, Inc.
• Wyeth

8.Appendices

• Appendix A: Top Drug Delivery Companies
• Appendix B: Drug Delivery Industry Websites
  • Pharmaceutical Industry Sites
  • Government Office Sites
  • Industry News Sites
• Appendix C: Glossary of Terms
• About the Publisher and Authors
  • About Takeda Pacific
  • About the Authors

List of Tables

• Table 1. Drug Delivery Systems Market in US, 2005-2010
• Table 2. Survey Results: Emerging Drug Delivery Technologies
• Table 3. Previous Survey Results: Top New DDS Technologies (2004)
• Table 4. DDS Technology Review
• Table 5. Strategic Alliance and M&A Analysis, 2004 through Mid-2006
• Table 6. Alliances in 2006
• Table 7. Alliances in 2005
• Table 8. Alliances in 2004
• Table 9. Drug Delivery Market in the US by Segments, 2005- 2010E
• Table 10. US DDS Market Revenues by Share, 2005 and 2010E
• Table 11. Competing DDS Companies by Technology Categories
• Table 12. Examples of Drug Delivery Litigations
• Table 13. Drug Delivery Companies Using Nanotechnology
• Table 14. The Top Drug Delivery Companies by Total Revenues (2005)

List of Illustrations

• Figure 1. Drug Delivery Systems Market in the US, 2005-2010
• Figure 2. Controlled Release Drug Delivery System
• Figure 3. The Oral Drug Delivery Route
• Figure 4. Products Featuring Orally Disintegrating Film Strips
• Figure 5. Injection Drug Delivery by Needle Size
• Figure 6. Implantable Insulin Delivery System
• Figure 7. Inserting a Needle for Bone Marrow Infusion
• Figure 8. Airway Delivery by Nektar
• Figure 9. Close-up of Drug Delivery Mechanism to the Lung
• Figure 10. Two Leading Drug-Coated Stents
• Figure 11. Urogenital Drug Delivery For Men
• Figure 12. Drug Delivery Mechanism for a Transdermal Patch
• Figure 13. The DOT Matrix Patch by Noven
• Figure 14. Drug Delivery Market in the US by Segments, 2005-2010E
• Figure 15. US DDS Market Revenues by Share, 2005 and 2010E