Table of Contents
1 EXECUTIVE SUMMARY
- Introduction
- Introduction
- Technology Primer
- Scope and Methodology
2 TECHNOLOGY AND APPLICATIONS VIEWPOINT
- Application Analysis and Trends
- Microbial Fermentation
- Glycomics and Biopharmaceuticals
- Diagnostic Applications
- Therapeutic Applications
- Biopolymers
- Cell Culture
- Sensors in Biotechnology Processing
- Other Applications
- Industry Trends and Assessment
- Industry Trends
- Mergers and Acquisitions
- Regulatory Issues
- Funding Analysis
3 ASSESSMENT OF INNOVATIONS IN UPSTREAM PROCESSING: NORTH AMERICA ASIA AND
EUROPE
- Antibodies
- Enhanced Genetic Evolution--USA
- Phage Display and Humanized Antibodies--USA
- RNA Synthesis and Delivery of Antibodies--USA
- Humanized Antibodies from Yeast--USA
- Comparing Polyclonal Humanized Antibodies with Monoclonals--USA
- High-Throughput High-Diversity Generation of Antibody Platform--UK
- Fucose Increases Antibody-Dependent Cellular Cytotoxicity--Japan
- Production of Fully Human Antibodies through Human Combinatorial
Antibody Libraries--Germany
- Phage Display Technique Targets Bacterial Haptens--UK
- Other Companies
- Vaccines
- Flu Vaccine from Cell Culture Instead of Eggs--USA
- Potato Vaccine for Hepatitis B--USA
- Antibiotics
- Antimicrobial Peptide from Fungus Kills Resistant Infections--Denmark
- Metabolic Pathway Engineering Simplifies Antibiotic
Preparation--Netherlands
- Other Biopharmaceuticals
- Improved Recombinant Interferon--USA
- Bioconversion for Production of Chiral Compounds--Japan
- Biocatalysis and Metabolic Engineering for Vitamin and Nutrient
Production--Germany
- Modified E. Coli Make Human Glycoproteins--USA
- Enzymes
- Fungal Genome Sequence for Better Enzymes--USA
- Directed Evolution: Increased Mutation Rate Yields Enhanced Enzymes--USA
- Solid-Phase Massively-Parallel Screening System for Improved Enzyme
Mutants--USA
- Rearranging DNA to Improve Variants--USA
- Genetic Engineering to Boost Xylanase Output--Canada
- Plants and Algae
- Lack of Financing Shuts down Large-Scale Biology--USA
- Transgenic Duckweed for Protein Manufacture--USA
- Tobacco Plant-Based Monoclonal Antibodies against Tumor Cells--USA
- Cotton Roots Produce Gossypol Antibiotic--USA
- Metabolomics Changes Plants to Chemical Factories--USA
- Insulin Production in Plants--Canada
- Polysaccharide from Immobilized Callus Cultures--India
- Transgenic Animals
- Human Antibodies and Other Therapeutic Proteins from Chicken Eggs--USA
- Transgenic Mice for Production of Fully Human Antibodies--USA
- Human Antithrombin from Transgenic Goat Milk--USA
- Transgenic Rabbits Produce C1 Inhibitor for Hereditary Angioedema--Spain
- Biopolymers
- Stabilized Gene Transfer for Producing Recombinant PHA--USA
- Yeast Produces Tailor-Made PHA Polymers--USA
- Limiting Nitrogen Boosts Bacterial PHA Synthesis--Ireland
- Bioreactors and Fermenters
- Eliminating Cryptic Plasmid Improves Fermentation--USA
- Microreactor Regenerates Enzyme Cofactors--USA
- Boost Cobalamin to Improve Fermentation Microbes--USA
- Novel Two-Phase Fermenter Process--Netherlands
- Tubular versus Bubble Column Photobioreactors--Spain
- Cell Culture
- Stable Analog of Poly D-Lysine for Fastidious Cells--USA
- Nanofiber-Based Cell-Culture Platform--USA
- Single Cell from Embryo Can Generate Stem Cell Lines--USA
- Feeder-Free Derivation of Embryonic Stem Cells--USA
- Artificial Intelligence Controls Cell-Culture Parameters--Finland
- Special Culture Dish for Both Long-Term Cell Culture and Imaging--Germany
- Additional Companies
- Growing Bone Cells on Carbon Nanotubes--USA
- 3D Capillary Channeled Fibers for Scaffolds--USA
- Sensors and Detectors
- Universal Detector for HPLC--USA
- CCD Technology-Based Image Sensors for Process Control--UK
- Augmenting Cell Culture Optimization Using Optical Sensors--USA
- Biosensor Dye Aids Viewing Proteins in Live Cells--USA
- Biocompatible Poly (Dimethylsiloxane) Coatings for Sensors and
Microfluidic Devices--USA
- Fiber-Optic Sensor Measures pH--USA
- Novel Ultrasonic Sensor for In Situ Detection of Protein Fouling--China
4 ASSESSMENT OF INNOVATIONS IN DOWNSTREAM PROCESSING: NORTH AMERICA ASIA AND
EUROPE
- Nucleic Acid Purification
- RNA Manufacturing In cGMP Facility--USA
- ChargeSwitch Technology to Purify Nucleic Acids--USA
- Convoluted Polymer-Coated Beads for High-Yield mRNA
Purification--Netherlands
- Column To Purify Plasmid DNA--Slovenia
- Chromatography
- High Speed Ultraperformance Liquid Chromatography (UPLC)--USA
- Removal of Abundant Proteins Allows Purification of Low-Abundance
Proteins--USA
- Liquid-Liquid Counter-Current Chromatography Saves Time and Money--UK
- Molecularly Imprinted Polymers for Large-Scale Specific
Separations--Sweden
- Additional Companies
- Membrane and Filter Separations
- Nanofilter Traps Micron-Sized Particles--USA
- Portfolio of Specialized Filters--USA
- Membrane Processing Improves Enzyme Production Pharmaceutical
Applications--Sweden
- Multichannel Membranes for Microfiltration--France
- Additional Companies
- Manufacture and Scale-Up
- Large-Scale Process for Ricin Vaccine Production--USA
- True Micro-Bioreactor Scale-Up--USA
- Step-Wise Scale-Up of Pharma Protein Production Up to 25000
Liters--Netherlands
- Additional Companies
- Process Design and Management Software
- Enhancements to Execution Software--USA
- Software for Enhanced Asset Performance--USA
- Software Portfolio for Process Manufacturers--USA
- Computer Modeling Platform Predicts Cellular Metabolism and Behavior--USA
5 TECHNOLOGY ADOPTION FACTOR ANALYSIS
- Technology Development Restraints And Market Challenges
- Technology Restraints
- Technology Challenges
- Competing Technologies
- Technology Adoption Drivers and Benefits
- Adoption Drivers
- Technology Benefits
6 DATABASE OF KEY INDUSTRY PARTICIPANTS AND SELECTED PATENTS
- Patents
- US Patents
- International Patents
- Key Industry Participants
7 FROST & SULLIVAN 2006 SCIENCE & TECHNOLOGY AWARDS
- Technology Leadership Award
- Award Description
- Award Recipient
- Technology Innovation Award
- Award Description
- Award Recipient
- Excellence in Technology Award
- Award Description
- Award Recipient
8 DECISION SUPPORT DATABASE
- Database Tables
- Biotech Companies (1999-2006)
- Biotech Employees (1999-2006)
- Biotech Private Investment (1999-2006)
- EPO Biotech Patents (1999-2006)
- Government Biotech R&D Investment (1999-2006)
- USPTO Biotech Patents (1999-2006)
- Percent Government Biotech Investment (1999-2006)
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