Advances in Signal Transduction based Drug Discovery

Table of Contents

1 EXECUTIVE SUMMARY

• Scope and Methodology
  • Scope and Segmentation of the Research Service
  • Research Methodology
• Role of Signal Transduction in Drug Discovery
  • Drug Discovery--The Changing Paradigm
  • Industry Scenario in Signal Transduction
  • Signal Transduction-Based Drug Discovery--Technology

2 TECHNICAL DEVELOPMENTS

• Technology Primer
  • Major Families of Signal Transducing Molecules
  • Rationale of Pathway Maps in Drug Discovery
  • Cell-Based Assay Approach to Drug Discovery
• Assessment of Enabling Technologies - Informatics or Cell-Based Approach
  • An Informatics-Based Discovery Engine for GPCRs--Israel
  • Distinct Activated Checkpoint Therapy Platform For Drug Discovery--USA
  • Biological Illustration and Biopathway Modeling Software Tool--Japan
  • SureFire Technology Assists in Cell-Based Screening--USA
  • Functional Protein Arrays Assist in Detecting Kinases--UK
  • Nanoprobes Can Identify Cells in Action--USA
  • Platform to Assist in Protein Kinase Analysis--USA
  • Biosensor Dye to Study Signaling in Live Cells--USA
  • Pathway Analysis Tool to Assist in Drug Discovery--India
  • Cell-Based Screening Assisted with a Flexible Tag--USA
  • Proteomics Platform to Discover Protein Phosphorylation--USA
  • Signal Transduction Protein Array--First of its Kind--USA
  • A High-Throughput Ion Channel Screening Service--UK
  • Cell-Based Technology Hastens Drug Discovery Process--USA
  • A GPCR Internalization Assay--Denmark

3 TECHNOLOGY ADOPTION FACTOR ANALYSIS

• Competitive Landscape
  • Drivers
  • Challenges
• Industry Insights
  • Analysis of the Druggable Genome And Explorable Targets
  • Stakeholder Analysis
  • Geographic Trend Analysis

4 PATENTS AND DATABASE OF KEY INDUSTRY PARTICIPANTS

• Patents
  • Kinase Patents
  • G-protein Coupled Receptor Patents
  • Ion-channel Receptor Patents
  • Patent Analysis
• Key Industry Participants; Glossary
  • Key Participants
  • Glossary of Signaling Molecules

5 DECISION SUPPORT DATABASE

• Database Tables
  • Global R&D Expenditure for Biotechnology (2002-2012)
  • Percent Government R&D Investment in Biotechnology (2002-2012)
  • Global Pharmaceutical R&D Expenditure (2002-2012)
  • Global Percentage Pharmaceutical R&D Expenditure (2002-2012)