Table of Contents
1. Introduction
- 1.1 Statement of Report
- 1.2 Objectives and Goals of Study
- 1.3 Methodology
- 1.4 Executive Summary
- 1.4.1 Market Drivers
- 1.4.2 Market Restraints
- 1.4.3 Market Size and Growth Projections
- 1.5 What Is a Gene?
- 1.6 Gene Expression
- 1.7 Genetic Variability
- 1.8 The Human Genome Project (HGP)
- 1.9 Gene Databases
- 1.10 Sequencing and Resequencing
- 1.11 RNA Interference (RNAi)
- 1.12 DNA Tags
2. Genomics Technology and Industry
- 2.1 The Development of a Genomics Market
- 2.1.1 Market Size and Growth Projections
- 2.1.2 The U.S. Genomics Market
- 2.2 DNA Microarray Technology
- 2.2.1 Biochips
- 2.2.2 Photolithography
- 2.2.3 Instrumentation for DNA Microarray Analysis
- 2.2.4 Lab-on-a-Chip
- 2.2.5 DNA Microarrays
- 2.3 Applications of DNA Microarrays
- 2.3.1 DNA Sequence Analysis
- 2.3.2 Gene Expression Analysis
- 2.3.3 Effect of DNA Sequence and Gene Expression Monitoring on the
Genomics Market
- 2.4 Bioinformatics
- 2.5 Functional Genomics
- 2.5.1 Gene Knockdown
- 2.5.2 Protein-Protein Interactions
- 2.5.3 Bioinformatics
- 2.5.4 Strategies of Functional Genomics Companies
- 2.5.5 Frontiers in Functional Genomics
- 2.6 Comparative Genomics
- 2.7 Pharmacogenomics
- 2.8 Proteomics
- 2.9 Structural Genomics
- 2.10 Disease Targets
- 2.10.1 Paradigm Shift in Drug Development: The Evolution of Targeted
Therapies
- 2.10.2 Personalized Warfarin Therapy
3. How Genomics Is Revolutionizing Healthcare
- 3.1 Pharmaceutical Applications
- 3.2 Diagnostics
- 3.3 Toxicogenomics
- 3.4 The Market for DNA Microarrays
- 3.5 DNA Chip Technology Competition
- 3.6 Expression Profiling
- 3.7 Gene Sequencing-Advantages of Chip Array Technology
- 3.8 Applied Markets for Genomics
- 3.9 Genomics and the Pharmaceutical Companies
- 3.10 Cancer Markets
- 3.11 Agricultural Markets
- 3.11.1 Plant Genomics
- 3.11.2 Food Processing
- 3.11.3 Animal Husbandry
4. Proprietary Applications and Patents
- 4.1 What is Patentable?
- 4.2 Patents and Litigation
5. Business Analysis
- 5.1 Facilitation and Capitalization of the Convergence of Gene Expression
Analysis and Proteomics
- 5.2 Competition
- 5.3 Market Opportunities for Functional Genomics
- 5.3.1 Metabolic Profiling
- 5.3.2 Anti-Fungal Targets
- 5.3.3 Nutrition
- 5.3.4 Crop Production
- 5.4 The Highly-Competitive Nature of the Genomics Industry
- 5.4.1 First-Generation Biotech
- 5.4.2 Second-Generation Genomics Companies
- 5.4.3 Next-Generation DNA Sequencing Companies
- 5.5 Strategic Alliances
6. Genomics Company Profiles
- 6.1 Affymetrix, Inc.
- 6.2 Agendia
- 6.3 Agilent Technologies, Inc.
- 6.4 Applied Biosystems Group
- 6.5 Bayer, AG
- 6.6 Biotage
- 6.7 Caliper Life Sciences
- 6.8 Celera Group
- 6.9 Cepheid
- 6.10 CLC bio
- 6.11 Clinical Data, Inc.
- 6.12 CuraGen Corporation
- 6.13 Cytocell Ltd.
- 6.14 diaDexus, Inc.
- 6.15 Enzo Biochem, Inc.
- 6.16 Exiqon A/S
- 6.17 GE Healthcare
- 6.18 Gene Link, Inc.
- 6.19 Gene Logic, Inc.
- 6.20 Genentech, Inc.
- 6.21 Genisphere, Inc.
- 6.22 Genomatix Software, Inc.
- 6.23 Genomic Solutions, Inc.
- 6.24 Gen-Probe, Inc.
- 6.25 Harvard Bioscience, Inc.
- 6.26 Helicos Biosciences Corporation
- 6.27 Human Genome Sciences, Inc.
- 6.28 Illumina, Inc.
- 6.29 Interleukin Genetics
- 6.30 LI-COR Biosciences
- 6.31 Luminex Corporation
- 6.32 Millennium Pharmaceuticals, Inc.
- 6.33 Monogram Biosciences, Inc.
- 6.34 Motorola, Inc.
- 6.35 MWG Biotech AG
- 6.36 Myriad Genetics, Inc.
- 6.37 Nanogen, Inc.
- 6.38 Nuvelo, Inc.
- 6.39 Orchid Cellmark
- 6.40 Pacific Biosciences, Inc.
- 6.41 QIAGEN, Inc.
- 6.42 Roche Diagnostics
- 6.43 Sequenom, Inc.
- 6.44 Third Wave Technologies, Inc.
- 6.45 Verenium Corporation
- 6.46 Visigen Technologies, Inc.
- 6.47 Brief Profiles of Companies Marketing Personalized Genomics Products
- 6.47.1 23andMe, Inc.
- 6.47.2 deCODE Genetics, Inc.
- 6.47.3 Navigenics, Inc.
- 6.48 Brief Profiles of Other Selected Genomics Firms
- 6.48.1 Aber Genomic Computing
- 6.48.2 Spotfire, Inc.
7. Genomics Challenges and Growth Factors
- 7.1 Market Drivers
- 7.1.1 Product Pipeline: Need for More Drug Candidates
- 7.1.2 Need for Increased Research and Development Productivity
- 7.2 A Genomics Market Bottleneck-Bioinformatics
- 7.3 Strategic Recommendations-Market Opportunities
- 7.3.1 More Comprehensive Tools Are Needed
- 7.3.2 Resolving Bottlenecks in Functional Genomics Market
- 7.4 Key Trends of Recent Mergers and Acquisition Deals
- 7.5 Chemogenomics
- 7.6 Pharmacogenomics
- 7.7 Biomarkers
- 7.8 Additional Genomics Market Opportunities
8. Bioinformatics
- 8.1 Types of Data and Bioinformatics Applications
- 8.1.1 Validated Core Modeling Technology
- 8.1.2 Broad Applicability
- 8.1.3 Data Management Compliant with Industry Standards
- 8.1.4 Open Architecture
- 8.1.5 Ease of Use
- 8.1.6 Increased Access
- 8.2 Functions of Informatics Software
- 8.2.1 Data Management
- 8.2.2 Transformation of Data into Knowledge
- 8.2.3 Collaboration Among Researchers
- 8.2.4 Interface for Online Data Sources
- 8.3 Target Markets for Informatics Software
- 8.3.1 Pharmaceutical Companies
- 8.3.2 Biotechnology Companies
- 8.3.3 Academic and Government Research Institutions
- 8.3.4 Agricultural, Environmental and Industrial Biotechnology Companies
- 8.4 Products of Bioinformatics
- 8.4.1 Sequences and Structure of Genes and Proteins
- 8.4.2 3-D Molecular Structures
- 8.4.3 Genome Structures and Functions
- 8.4.4 Bibliographic Data
- 8.5 Bioinformatics Processes
- 8.6 Informatics Tools and Functionalities
- 8.6.1 Sequence to Structure
- 8.6.2 Lead Identification and Optimization
- 8.6.3 Development and Formulation
- 8.6.4 Improving Materials and Processes in the Chemicals Industry
- 8.6.5 Other Materials-Based Industries
- 8.7 Role of Bioinformatics in the Value Chain
- 8.8 Bioinformatics Market Segments
- 8.8.1 Database
- 8.8.2 Hardware
- 8.8.3 Software
- 8.8.4 Bioinformatics Services
- 8.9 Bioinformatics Business Models
- 8.9.1 Changing Business Models
- 8.9.2 Selected Business Strategies
Glossary
INDEX OF FIGURES
- Figure 2.1: Major Areas of Functional Genomics and Their Relationship to
Bioinformatics and Industry
- Figure 8.1: Role of Bioinformatics in the Biotechnology Value Chain
INDEX OF TABLES
- Table 2.1: Genomics Sector Global Market Size, 2001 to 2010
- Table 2.2: Companies Marketing DNA Microarray Software
- Table 2.3: Selected Competitors in the DNA Microarray Market
- Table 2.4: Companies Offering DNA Sequencing Products
- Table 2.5: Competitors in the SNP-Genotyping Segment
- Table 2.6: Companies that Market MAQC-tested Gene Expression Microarrays
- Table 2.7: Worldwide Market for Bioinformatics, 2005 to 2010
- Table 2.8: Selected Companies Marketing New Functional Genomics Tools
- Table 3.1: Genomics Pharmaceutical Market Sector Leaders and Promising
Newcomers
- Table 3.2: Summary of Assays for HIV Viral Load Testing
- Table 3.3: Global Market for HIV Diagnostic Testing, 2000 to 2012
- Table 3.4: Summary of Molecular Diagnostics Testing
- Table 3.5: Global Market for Molecular Diagnostics Testing, 2000 to 2012
- Table 3.6: U.S. Market for Molecular Diagnostics Testing, 2004 to 2012
- Table 3.7: Applied Markets for Genomics
- Table 3.8: Competitors in the Field of Identity Genomics Testing
- Table 3.9: Opportunities for Molecular-Targeting Therapeutics for Cancer
- Table 3.10: Emerging Companies in the Anti-Cancer Sector
- Table 8.1: Data Source and Bioinformatic Investigations
- Table 8.2: Bioinformatics Activities, Subactivities and Key Players
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