Table of Contents
1. Overview 7
- 1.1 Objective of Report 7
- 1.2 Scope of Report 7
- 1.3 Methodology 8
- 1.4 Executive Summary 9
2. Veterinary Biological Products 11
- 2.1 Overview of Health Products Market 11
- 2.1.1 World Products Markets 11
- 2.1.2 U.S. Animal Health Products Market 14
- 2.1.3 European Animal Health Markets 15
- 2.1.4 Asian Animal Health Products Markets 16
- 2.1.5 Rest of World 23
- 2.1.6 World Market Share 23
- 2.1.7 Common Animal Diseases 24
- 2.1.8 Companion Animals 54
- 2.2 Veterinary Vaccines 57
- 2.2.1 Major Canine Vaccines 59
- 2.2.2 Major Feline Vaccines 61
- 2.3 Agricultural Animals 67
- 2.3.1 Major Cattle Vaccines 69
- 2.3.2 Major Poultry Vaccines 74
- 2.3.3 Major Sheep Vaccines 81
- 2.3.4 Major Swine Vaccines 84
- 2.3.5 Horses 89
- 2.4 Trends in the Biologicals Market 92
- 2.5 Nutraceuticals 94
- 2.5.1 Nutraceutical Market for Companion Animals 94
- 2.6 OTC Animal Health Global Market Opportunity 98
3. Veterinary Pharmaceutical Products 99
- 3.1 Overview 99
- 3.1.1 Pharmaceutical Products for Dogs and Cats 104
- 3.1.1.1 Antiparasitics 108
- 3.1.1.2 Antibiotics 110
- 3.1.1.3 Anti-Inflammatories 114
- 3.1.1.4 Chronic Care Products 117
- 3.1.1.5 Cardiovasculars 117
- 3.1.1.6 GI Products 118
- 3.1.1.7 Endocrine Products 118
- 3.1.1.8 Anti-Infectives 119
- 3.1.1.9 Behavior Modifiers 120
- 3.1.1.10 Anthelminitics 120
- 3.1.1.11 Antifungals 121
- 3.1.1.12 Cancer and Chemotherapy in Companion Animals 121
- 3.1.2 Pharmaceutical Products for Agricultural Animals 131
- 3.1.2.1 Antiparasites 131
- 3.1.2.2 Antibiotics 132
- 3.1.2.3 Insecticides 133
- 3.2 Leading Products and Competitors 134
- 3.2.1 Elanco 134
- 3.2.2 Novartis 135
- 3.2.3 Alpharma 136
- 3.2.4 Wyeth 138
- 3.2.5 Pfizer Animal Health 138
- 3.3 Veterinary Pharmaceutical Market Trends 139
- 3.4 Companion-Animal Crossover Products 140
- 3.5 Generics in the Animal Health Sector 141
4. Veterinary Feed Additive Products 142
- 4.1 Overview 142
- 4.2 U.S. Feed Additives Market 147
- 4.3 Leading Feed Additives and Competitors 147
- 4.4 Feed Additives Market Trends 149
- 4.4.1 Livestock Performance Enhancers 150
- 4.5 Pet Food Additives and Contaminants 152
- 4.5.1 Pet Deaths 153
- 4.5.2 The FDA Response 153
5. Veterinary Diagnostic Test Products 154
- 5.1 Introduction 154
- 5.2 Veterinary Diagnostic Market Size and Growth Rates 156
- 5.2.1 Market Drivers 159
- 5.2.2 Immunodiagnostic and Nucleic Acid Testing Markets 159
- 5.2.2.1 Market Size and Growth 159
- 5.2.3 Technological Developments in the Diagnostic Industry 159
- 5.3 Competitive Situation 161
- 5.4 Estimate of Units Sold and Pricing 162
- 5.5 PCR Applications for Veterinary Use 162
- 5.6 Companion-Animal Diagnostics 166
- 5.6.1 Feline Leukemia Virus 166
- 5.7 Agricultural Animal Diagnostics 167
- 5.8 U.S. Diagnostic Test Market 168
- 5.9 Leading Competitors in Diagnostic Testing 169
- 5.10 Veterinary Diagnostic Market Trends 172
- 5.11 Collaborative Licensing 173
- 5.12 BSE Diagnostic Tests 173
- 5.13 West Nile Virus Diagnostic Tests 174
- 5.14 Avian Flu Diagnostic Tests 174
6. Overview of the Veterinary Health Market 175
- 6.1 Regulatory Environment 175
- 6.1.1 International Bodies for Regulation of Animal Health Products 176
- 6.1.1.1 Regulation of Animal Health Products in the E.U. 178
- 6.1.1.2 Regulation of Animal Health Products in the U.S. 180
- 6.1.1.3 Regulation of Animal Health Products in Japan 181
- 6.1.2 Proposed Regulation of Animal Antibiotics 182
- 6.2 The European Animal Health Industry 183
- 6.2.1 Trends Driving Demand 183
- 6.2.1.1 European, International and U.S. Oversight of Veterinary
Medicines 183
- 6.2.1.2 Antibiotic Usage 184
- 6.3 Mergers and Acquisitions 184
- 6.4 New Product Launches 186
- 6.5 Bioterrorism and Foodborne Pathogens-WHO Guidelines 187
- 6.5.1 The U.S. Bioterrorism Preparedness and Response Act, 2002 188
- 6.6 Generic Products 188
7. Emerging Markets 191
- 7.1 Biotechnology and Veterinary Health 191
- 7.1.1 Biotechnology and Biologics 191
- 7.1.1.1 Recombinant DNA Vaccines 191
- 7.1.1.2 Plant-derived Vaccines 192
- 7.1.2 DNA Probes 192
- 7.1.3 Biotechnology and Pharmaceuticals 193
- 7.1.3.1 Immunodiagnostic Applications 193
- 7.1.3.2 Growth Enhancers 194
- 7.2 Impact of Genomics on Veterinary Health 194
- 7.2.1 Autosomal Dominant Traits 197
- 7.2.2 X-Linked Traits 197
- 7.2.3 Autosomal Recessive Traits 198
- 7.2.4 Current DNA Testing in Animals 199
- 7.2.5 Direct DNA Testing: Mutation-based Tests 200
- 7.2.6 Indirect DNA Testing: Linkage-based or Marker-Based Tests 200
- 7.3 Companion-Animal Markets 200
- 7.4 Alternative Medicine in Veterinary Practice 201
- 7.5 Generics in the Animal Health Market 201
- 7.6 Pet Insurance 207
- 7.7 Orthotics and Prosthetics for Animals 209
- 7.8 Pet Cloning 211
8. Company Profiles 212
- 8.1 Abaxis, Inc. 212
- 8.2 Abbott Laboratories 214
- 8.3 Adiagene 215
- 8.4 Agricultural Research Service 215
- 8.5 Alpharma, Inc. 216
- 8.6 Avian Biotech 218
- 8.7 BASF 218
- 8.8 Bayer Animal Health 219
- 8.9 Biobest Laboratories 220
- 8.10 BioVet, Inc. 221
- 8.11 Boehringer Ingelheim Corp. 222
- 8.12 CEVA Sante Animale 222
- 8.13 Cypress Diagnostics 224
- 8.14 Dabaco Viet Nam Corporation 225
- 8.15 DayMoon Industries, Inc. 225
- 8.16 Dow AgroSciences LLC 226
- 8.17 Dupont Qualicon 226
- 8.18 Egyptian International Pharmaceutical Industries Company 227
- 8.19 Elanco Animal Health 227
- 8.20 Eurofins Medigenomix GmbH 228
- 8.21 Fort Dodge Animal Health 228
- 8.22 Gene Check, Inc. 229
- 8.23 Heska 230
- 8.24 Huvepharma 232
- 8.25 IDEXX Laboratories, Inc. 232
- 8.26 Intervet/Schering-Plough Animal Health 235
- 8.27 IWAKI & Co., Ltd. 235
- 8.28 Janssen Pharmaceutica 236
- 8.29 Laboklin 237
- 8.30 Medika d.d. 237
- 8.31 Merial 237
- 8.32 MetaMorphix, Inc. 238
- 8.33 Microbix Biosystems, Inc. 240
- 8.34 Momina krepost AD Veliko Tarnovo 240
- 8.35 Monsanto 240
- 8.36 Mosaic Company 241
- 8.37 Neogen Corporation 242
- 8.38 Novartis Animal Health 244
- 8.39 OptiGen 245
- 8.40 Orion Corporation 246
- 8.41 PETCO Animal Supplies, Inc. 247
- 8.42 PetSmart, Inc. 248
- 8.43 Pfizer Animal Health 249
- 8.44 Phylaxia Pharma NyRt. 255
- 8.45 Sanofi-Aventis 255
- 8.46 Schering-Plough Animal Health Corporation 256
- 8.47 Skystar Bio-Pharmaceutical Company 257
- 8.48 Sunwin International Nutraceuticals 257
- 8.49 Synbiotics Corporation 257
- 8.50 Teva Pharmaceutical Industries Ltd. 258
- 8.51 The Arab Pesticides and Veterinary Drugs Mfg. Co. 259
- 8.52 ThermoGenesis Corp. 260
- 8.53 VCA Antech, Inc. 260
- 8.54 Velefarm ad Beograd 262
- 8.55 Veterinarski Zavod Subotica ad Subotica 262
- 8.56 Vetoquinol 262
- 8.57 Virbac SA 262
- 8.58 WooGene B&G Co., Ltd 263
- 8.59 Wyeth 263
9. Business Trends in the Industry 265
- 9.1 Animal Health Additive Growth Trends 265
- 9.2 Move to Complete Product Portfolio 265
- 9.3 Reduced Antibiotic Usage in Animal Feeds 265
- 9.4 European Animal Health Industry 265
- 9.5 Licensing and Partnership Opportunities in Animal Health R&D 266
10. Company Directory 267
Appendix 1: Dosages for Selected Drugs Alphabetical Listing 276
Appendix 2: Trade Names 289
Appendix 3: Abbreviations 301
INDEX OF FIGURES
- Figure 2.1: Global Animal Health Market by Product Category, 2007 11
- Figure 2.2: Worldwide Sales of Animal Health Products by Product Class,
2007 12
- Figure 2.3: Worldwide Animal Health Industry Revenues by Species, 2007 13
- Figure 2.4: Worldwide Animal Health Products Market by Region, 2007 13
- Figure 2.5: Market Share for the Top Ten Animal Health Companies, 2007 14
- Figure 2.6: U.S. Companion Animal Healthcare Products Share of Overall
Animal Health Product Sales, 2007 15
- Figure 2.7: Pet Population in Japan, 1996 and 2006 17
- Figure 2.8: Swine Population in Japan, 2006-2008 18
- Figure 2.9: Cattle Population in Japan, 2006-2008 19
- Figure 2.10: The Indian Biologicals Industry by Product Category, 2007 21
- Figure 2.11: South African Animal Health Market by Product Category, 2007
23
- Figure 2.12: Global Incidence of Avian H5N1, 2008 76
- Figure 2.13: Global incidence of Equine Herpesvirus Type 1, 2008 89
- Figure 2.14: Global Outbreaks of Equine Viral Arteritis, 2008 92
- Figure 3.1: Animal Health Product Sales in the U.S., 2005-2014 103
- Figure 3.2: Expenditure on Pets in Australia by Pet Type, 2005 108
- Figure 3.3: Pet care Expenditure in Australia by Category, 2005 108
- Figure 3.4: The European Parasiticide Market by Product Category, 2007 110
- Figure 3.5: Growth in Global Sales of Antibiotic Products, 2005-2012 132
- Figure 3.6: Novartis Animal Health Division: Business Split, 2007 135
- Figure 3.7: Novartis Animal Health Division: Product Split, 2007 136
- Figure 3.8: Novartis Animal Health Division: Sales by Geographic Region,
2007 136
- Figure 4.1: Global Market for Livestock Performance Enhancers, 2006 152
- Figure 5.1: Growth of the Lateral Flow Diagnostic Tests in the Veterinary
Market, 2005-2015 160
- Figure 7.1: The U.S. Market for Companion Animal Pharmaceuticals, 2007 201
- Figure 7.2: U.S. Companion Animal Pharmaceuticals: Percentage of New
Generics, 2007 204
- Figure 7.3: U.S. Market for FDA-approved Pharmaceuticals for Companion
Animals, 2007 205
LIST OF TABLES
- Table 2.1: World Market for Animal Health Products, 2002-2012 11
- Table 2.2: Global Sales of Animal Health and Nutrition Products, 2004-2012
12
- Table 2.3: Worldwide Animal Health Products Market by Region, 2007 13
- Table 2.4: U.S. Animal Health Product Sales, 2005-2014 14
- Table 2.5: Animal Health Market: Sales Statistics-Europe, 2007 15
- Table 2.6: E.U. Animal Health Market, 2004-2014 16
- Table 2.7: Japanese Animal Health Market, 2000-2012 17
- Table 2.8: Chinese Animal Health Products Market, 2005-2012 19
- Table 2.9: Indian Animal Health Market, 2003-2010 20
- Table 2.10: Institutions Involved in Manufacturing Vaccines and Other
Biological Products for Livestock 22
- Table 2.11: Worldwide Animal Health Product Sales for Leading Producers,
2007 23
- Table 2.12: Common Animal Diseases 25
- Table 2.13: Cattle Diseases 25
- Table 2.14: Sheep and Goat Diseases 26
- Table 2.15: Equine Diseases 26
- Table 2.16: Swine Diseases 26
- Table 2.17: Avian Diseases 27
- Table 2.18: Fish Diseases 27
- Table 2.19: Other Veterinary Diseases 27
- Table 2.20: Leading Companion-Animal Prescription Drugs by Sales, 2007 55
- Table 2.21: Worldwide Veterinary Vaccine Market, 2005-2012 57
- Table 2.22: U.S. Veterinary Vaccine Market, 2004-2013 58
- Table 2.23: Second-Generation Licensed/Commercialized Veterinary Viral
Vaccines 59
- Table 2.24: Canine Vaccinations 61
- Table 2.25: Dog Vaccine Price List 61
- Table 2.26: American Association of Feline Practitioners 2006 Feline
Vaccination Guidelines: Summary of Vaccination in General Practice. 62
- Table 2.27: Recently Commercialized Veterinary Bacterial Vaccines 67
- Table 2.28: Available Veterinary Live Protozoal Vaccines 68
- Table 2.29: Available Veterinary Killed/Subunit Protozoal Vaccines 68
- Table 2.30: Commercialized Reproduction Control Vaccines 68
- Table 2.31: Global Market for Nutraceutical in Companion Animals,
2005-2012 97
- Table 3.1: Veterinary Drugs Listed by Therapeutic Class 99
- Table 3.2: Sales of Pharmaceutical Products for Animal Health in the U.S.,
2000-2008 104
- Table 3.3: Number of Dogs in the U.S., 1996-2008 105
- Table 3.4: Number of Pet Dogs by Geographical Region, 2008 105
- Table 3.5: Number of Cats in the U.S., 1996-2008 105
- Table 3.6: Number of Pet Cats by Geographical Region, 2008 105
- Table 3.7: U.S. Spending on Pet Care, 1996-2008 105
- Table 3.8: American Veterinary Specialists 106
- Table 3.9: Companion-Animal Products Sales, 2008 106
- Table 3.10: U.S. Antiparistic Animal Health Product Sales, 2005-2012 109
- Table 3.11: Global Antiparistic Animal Health Product Sales, 2005-2012 109
- Table 3.12: Worldwide Sales of Animal Health Antibiotics, 2005-2012 111
- Table 3.13: U.S. Volume of Animal Health Antibiotics Used, 2000-2006 111
- Table 3.14: U.S. Sales of Animal Health Antibiotics, 2005-2012 111
- Table 3.15: European Sales of Animal Health Antibiotics, 2005-2012 112
- Table 3.16: Common Veterinary Anti-Inflammatories 115
- Table 3.17: U.S. Pet Anti-Inflammatory Market, 2003-2012 115
- Table 3.18: Retail Pricing of Rimadyl 115
- Table 3.19: EtoGesic Pricing 116
- Table 3.20: Therapy for Various Pet Cancers 122
- Table 3.21: Mechanisms of Action, Indications and Toxicities of Selected
Antineoplastic Agents 125
- Table 3.22: Treatment Options for Canine or Feline Lymphomas 127
- Table 3.23: Chemotherapeutic Agents Commonly Used in Veterinary Medicine,
and the Associated Risks 129
- Table 3.24: Bacterial and Protozoal Threats to Poultry 133
- Table 3.25: Bacterial and Protozoal Threats to Pigs 133
- Table 3.26: Elanco Veterinary Products Summary 134
- Table 3.27: Wyeth Fort Dodge Animal Health Products 138
- Table 4.1: Global Sales of Feed Additives for Animal Health, 2005-2014 142
- Table 4.2: Target Species and Brand Names for Probiotics 146
- Table 4.3: Feed Additives-antimicrobials and Growth Promotants 148
- Table 4.4: Feed Additives-anthelmintics 148
- Table 4.5: U.S. Beef Exports, 2002-2007 148
- Table 4.6: Retail Equivalent Value of U.S. Beef Industry, 2002-2007 148
- Table 4.7: U.S. Revenues from Animal Agriculture by State, 2006 149
- Table 4.8: Use of Antibiotics as Growth Promotants 150
- Table 4.9: Global Market for Livestock Performance Enhancers, 2004-2010 151
- Table 5.1: Veterinary Diagnostics World Market, 2005-2012 156
- Table 5.2: Veterinary Immunodiagnostic Testing World Markets, 2005-2012 159
- Table 7.1: Labs that Perform Canine DNA Testing 197
- Table 7.2: DNA (Mutation) Tests for Canine Inherited Diseases 198
- Table 7.3: DNA (Marker) Tests for Canine Inherited Diseases 199
- Table 7.4: U.S. Companion Animal Prescription Drug Revenue, 2006 202
- Table 7.5: Companies Producing Generic Pharmaceuticals for Animal Health
203
- Table 7.6: Generics vs. Branded Animal Health Pharmaceuticals, 2005 204
- Table 7.7: U.S. Animal Health Generic Pharmaceuticals in the Pipeline,
2007 206
- Table 7.8: Veterinary Pet Insurance Rates and Coverage in the U.S., 2008
209
- Table 8.1: Pfizer Animal Health Products 250
- Table 8.2: Pfizer Products Patents 252
- Table 8.3: Key Pfizer Animal Health Products 254
- Table 8.4: Pfizer Livestock Products 254
- Table 8.5: Pfizer Equine Products 255
- Table 8.6: Pfizer Companion Animal Products 255
- Table 9.1: European Animal Health Market Sales, 2005-2012 266
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