Table of Contents
Introduction
Worldwide Market and Technology Overview
A. Cancer Statistics and Etiology
- 1. Bladder
- 2. Breast
- 3. Cervical
- 4. Colon and Rectum
- 5. Endometrial
- 6. Esophagus
- 7. Head and Neck
- 8. Leukemia
- 9. Lung
- 10. Lymphoma
- 11. Oral
- 12. Ovarian
- 13. Prostate
- 14. Renal Cell Carcinoma
- 15. Skin
- 16. Stomach
- 17. Uterine
B. Major Current And Emerging Cancer Diagnostic Tests
- 1. Introduction
- 2. Tumor Marker Classification
- 3. ACTH
- 4. Alpha-Fetoprotein (AFP)
- 5. Beta-2 Microglobulin
- 6. CA 15-3/27.29
- 7. CA 19-9
- 8. CA-125
- 9. Calcitonin
- 10. Carcinoembrionic Antigen (CEA)
- 11. Estrogen and Progesterone Receptors
- 12. Ferritin
- 13. Gastrin
- 14. Human Chorionic Gonadotropin (HCG)
- 15. Insulin
- 16. Lymphocytes CD4/CD8
- 17. NSE
- 18. Occult Blood
- 19. PAP Smear/HPV
- 20. Prostatic Acid Phosphatase (PAP)
- 21. Prostate-Specific Antigen (PSA)
- 22. Squamous Cell Carcinoma Antigen (SCC)
- 23. TdT
- 24. Thyroglobulin
- 25. Tissue Polypeptide Antigen (TPA)
- 26. Biochemical Tumor Markers
- ADA
- B-Protein
- PNP
- 5' -Nucleotidase
- 27. Oncogenes
- Abl/Abl-bcr
- AIB1
- APC
- BTA 26
- BCL-2
- bcr-Abl
- B-raf
- BRCA
- CD44
- CDK
- C-abl
- C-fos
- C-myb
- C-myc
- CYCD1
- CYP-17
- DPC
- E-myc
- Erb-B
- HER-2/neu
- HPC1
- HSTF
- L-myc
- MET
- MSH
- neu
- N-myc
- N-telopeptide
- PCA3
- PIK3CA
- PTI-1
- P10
- P40
- P51
- P53
- Ras
- Reg
- RET
- sFas
- Sis
- Src
- 28. Polypeptide Growth Factors
- Basic Fibroblast Growth Factor
- Beta-TGF
- Cachectin (TNT)
- Calmodulin
- ECFR
- Nerve Growth Factor (NGF)
- Epidermal Growth Factor (EGF)
- Ornithine Decarboxylase
- Transferrin
- Transforming Growth Factor-Alpha
- 29. Ectopic Hormones
- 30. Colony Stimulating Factors
- 31. Lymphokines
- Alpha-Interferon
- B Cell Growth Factors
- B Cell Growth Factor (BCGF)
- Gamma-Interferon
- Interleukin-1 (IL-1)
- Macrophage Activating Factor
- 32. Immunohistochemical Stains
- 33. Emerging Tumor Markers
- N-Acetylglucosamine
- Actin
- Alpha-Actin
- Angiogenin
- Angiostatin
- Antineuronal Antibodies
- 7B2
- B72.3
- B-Protein
- Bax
- BCD-F9
- BLCA-4
- Blood Group Antigens A,B,H
- BTA
- CA 50
- CA 72-4/TAG-72
- CA 195
- CA-242
- CA-549
- Cadherin
- CAM 26
- CAR-3
- CD105
- Cathepsin-D
- Chromogranin A and B
- Cluster 1 Antigen
- Cluster-5/5A Antigen
- COX Antigen
- CTA
- CU18
- Cyclin
- DR-70
- DU-PAN-2
- Endometrial Bleeding Associated Factor
- Endostatin
- Epithelial Membrane Antigen
- FDP
- Feulgen Hydrolysis
- Fibronectin
- FSH
- (1->3)-L-fucosyltransferase
- Gastrin-Releasing Peptide (GRP)
- GDCFP-15
- Glucagon
- Glycoamines
- H23
- HAAH
- HK3
- HPA
- HSP27
- Human Carcinoma Antigen
- ICAM
- Intermediate Filaments
- Cytokeratins/CK18/Cyfra 21-1
- Desmin
- Gliofibrillary Acid Protein
- Neurofilaments
- Vimentin
- KA 93
- Kallikrein
- Kinases
- KP16D3
- LAI
- Leukocyte Common Antigen
- Lewis Antigens
- Lysophosphatidic Acid (LPA)
- Ma 695/Ma 552
- MABDF3
- MAG
- ME1
- Minactivin
- MN/CA9
- MSA
- Mucin Cancer Antigen (MCA)
- Multiple Tumor Suppressor 1
- Myosin
- NEA-130
- NMP22
- Nucleolar
- OA-519
- Opiod Peptides
- P-glycoprotein
- Pancreatic Oncofetal Antigen (POA)
- Parathyrcoid Hormone
- Placental Lactogen
- PR92
- Proliferative Index, Ki-67
- Px
- RB Inactivation/Deletion
- RET
- S-100 Protein
- SCCL 175
- Selectin
- Serotonin
- Sialic Acid
- Sialyl SSEA-1/SLX
- SN10
- Somatostatin
- TA-90
- TABA
- Tachykinin
- TAG 12
- TPS
- Troponin
- Tubulin
- VCAM
- VEGF
- Villen
- White Blood Cell Markers
C. Instrumentation Review And Market Needs
- Abbott Architect
- Abbott AxSYM
- Abbott IMx
- Amersham Amerlite
- Bayer ACS: 180
- Bayer ADVIA Centaur
- Bayer Immuno 1
- Beckman Coulter Access
- bioMerieux Vidas Series
- -Biotrol System 7000
- Dade Behring Dimension
- DPC Immulite
- DiaSorin ETI-Max
- Ortho-Clinical Diagnostics Vitros
- Olympus PK Series
- Roche Elecsys
- Roche Modular
- Tosoh AIA Series
D. Current and Emerging Technologies
- 1. Monoclonal and Polyclonal Antibodies
- 2. Immunoassays
- a. Technological Principle
- b. Radioimmunoassay (RIA)
- c. Enzyme Immunoassays (EIA)
- Overview
- ELISA
- Immunofiltration
- Particle-Membrane Capture Immunoassay
- Enzyme Amplification
- d. Fluorescent Immunoassays
- e. Luminescence
- Chemiluminescence
- Bioluminescence
- 3. Molecular Diagnostics
- a. Technology Overview
- b. Amplification Methods
- PCR
- DAP-PCR
- Immuno-PCR
- QC-PCR
- CAR
- DNA
- HPA
- LCR
- NASBA
- QBR
- SDA
- 3 SR, and others
- 4. Biochips/Microarrays
- 5. Chromosome Analysis
- a. Chronic Myelogenous Leukemia (CML)
- b. Acute Myeloid Leukemia (AML)
- c. Acute Lymphoblastic Leukemia (ALL)
- d. Malignant Lymphomas
- e. Chronic Lymphocytic Leukemia (CLL)
- f. Solid Cancers
- g. Chromosomal Translocation and Oncogenes
- 6. Microcomputers and Automation
- 7. Artificial Intelligence
- 8. Flow Cytometry
- 9. Biosensors
E. Competing/Complementing Technologies
- 1. CT
- 2. MRI
- 3. NMR
- 4. PET
- 5.Photonics Spectroscopy
F. Business Environment
- 1. Worldwide Market Structure
- 2. Worldwide Market Size and Growth
- G. Personal Testing
Japan
- A. Executive Summary
- B. Business Environment
- C. Market Structure
- D. Market Size, Growth and Major Suppliers
Major Product Development Opportunities
- A. Reagent Kits and Test Systems/Panels
- B. Instrumentation
- C. Computers, Software and Automation
- D. Auxiliary Products
Design Criteria for Decentralized Testing Products
Alternative Market Penetration Strategies
- A. Internal Development
- B. Collaborative Arrangements
- C. University Contracts
- D. Distribution Strategies
- 1. Marketing Approaches
- 2. Product Complexity
- 3. Customer Preference
- 4. Established Suppliers
- 5. Emerging Suppliers
- 6. Major Types of Distributors
- 7. Market Segmentation Factor
Potential Market Entry Barriers and Risks
- A. Market Maturity
- B. Cost Containment
- C. Competition
- D. Technological Edge and Limitations
- E. Patent Protection
- F. Regulatory Constraints
- G. Decentralized Testing Market Challenges
Competitive Profiles
- Abbott
- AdnaGen
- Agensys
- Altana
- Ambrilia Biopharma
- AMDL
- BD
- Beckman Coulter
- Biofield
- Biomedical Diagnostics
- bioMerieux
- Bio-Rad
- Biotrol/B. Braun
- CeMines
- Cepheid
- CIS/Bio
- Cliniqa
- Correlogic Systems
- Cytyc
- Daiichi
- DakoCytomation
- diaDexus
- DiagnoCure
- Diagnostic Systems
- Dianon
- DiaSorin
- Digene
- Eiken
- Enterix
- Enzo Biochem
- Epigenomics
- Exact Sciences
- Fujirebio
- Gen-Probe
- Gene Logic
- Green Cross
- Grifols-Quest
- Guided Therapeutics
- Ibex Technologies
- Immunicon
- Ipsogen
- Kyowa Medex
- Matritech
- Molecular Diagnostics
- Myriad Genetics
- Nippon Flour Mills
- OncoLab
- Ortho-Clinical Diagnostics
- Panacea Pharmaceuticals
- Polartechnics
- Polymedco
- PreMD
- Quest Diagnostics Nichols Institute
- Roche Diagnostics
- Scantibodies
- Siemens
- Targeted Diagnostics
- Tosoh
- Trylon
- Wako Chemicals
- Worldwide Medical
- Zila
Appendixes
- Appendix I: Major Companies Developing or Marketing Cancer Diagnostic
Reagents and Instruments
- Appendix II: Major Universities and Research Centers Developing Cancer
Diagnostic Technology and Applications
- Appendix III: Assumed Currency Exchange Rates
List of Tables
- Tumor Marker Classification
- Major Companies Developing or Marketing ACTH Tests
- Major Companies Developing or Marketing AFP Tests
- Major Companies Developing or Marketing Beta-2 Microglobulin Tests
- Major Companies Developing or Marketing CA 15-3/27.29 Tests
- Major Companies Developing or Marketing CA 19-9 Tests
- Major Companies Developing or Marketing CA 125 Tests
- Major Companies Developing or Marketing Calcitonin Tests
- Major Companies Developing or Marketing CEA Tests
- Major Companies Developing or Marketing Estrogen Receptor Tests
- Major Companies Developing or Marketing Progesterone Receptor Tests
- Major Companies Developing or Marketing Ferritin Tests
- Major Companies Developing or Marketing Gastrin Tests
- Major Companies Developing or Marketing HCG Tests
- Major Companies Developing or Marketing Insulin Tests
- Major Companies Developing or Marketing NSE Tests
- Major Companies Developing or Marketing Occult Blood Tests
- Major Companies Developing or Marketing PAP Smear/HPV Tests
- Major Companies Developing or Marketing PAP Tests
- Major Companies Developing or Marketing PSA Tests
- Major Companies Developing or Marketing Lymphocyte Subclassification Tests
- Biochemical Markers Potential Applications In Cancer Diagnosis
- Oncogenes Potential Applications In Cancer Diagnosis
- Major Companies Developing or Marketing Oncogene Tests
- Growth Factors Potential Applications In Cancer Diagnosis
- Colony Stimulating Factors Potential Applications in Cancer Diagnosis
- Lymphokines Potential Applications In Cancer Diagnosis
- Immunohistochemical Stains Potential Applications in Cancer Diagnosis
- Executive Summary Table: Japan, Total Tumor Marker Test Volume and Sales
Forecast by Market Segment
- Japan, Estimated Cancer Death Rates Per 100,000 Population
- Japan, Laboratories Performing Tumor Marker Tests by Market Segment
- Japan, Hospital Laboratories Performing Tumor Marker Tests by Bed Size
- Commercial/Private Laboratories Performing Tumor Marker Tests By Annual
Test Volume
- Japan, Total Tumor Marker Testing Volume Forecast by Market Segment
- Japan, All Market Segments Major Tumor Marker Test Volume Forecast
- Japan, Hospital Laboratories Major Tumor Marker Test Volume Forecast by
Test
- Japan, Commercial/Private Laboratories Major Tumor Marker Test Volume
Forecast
- Japan, Total Tumor Marker Sales Forecast by Market Segment
- Japan, All Market Segments Major Tumor Marker Sales Forecast by Test
- Japan, Hospital Laboratories Major Tumor Marker Sales Forecast by Test
- Japan, Commercial/Private Laboratories Major Tumor Marker Sales Forecast
by Test
- Japan, ACTH Test Volume and Diagnostics Sales Forecast by Market Segment
- Japan, AFP Test Volume and Diagnostics Sales Forecast by Market Segment
- Japan, Beta-2 Microglobulin Test Volume and Diagnostics Sales Forecast by
Market Segment
- Japan, CA 15-3/27.29 Test Volume and Diagnostics Sales Forecast by Market
Segment
- Japan, CA 19-9 Test Volume and Diagnostics Sales Forecast by Market Segment
- Japan, CA-125 Test Volume and Diagnostics Sales Forecast by Market Segment
- Japan, Calcitonin Test Volume and Diagnostics Sales Forecast by Market
Segment
- Japan, Cathepsin Test Volume and Diagnostics Sales Forecast by Market
Segment
- Japan, CEA Test Volume and Diagnostics Sales Forecast by Market Segment
- Japan, Chromogranin Test Volume and Diagnostics Sales Forecast by Market
Segment
- Japan, Colon-Specific Antigen Test Volume And Diagnostics Sales Forecast
by Market Segment
- Japan, Cytokeratins Test Volume and Diagnostics Sales Forecast by Market
Segment
- Japan, Estrogen Receptor Test Volume and Diagnostics Sales Forecast by
Market Segment
- Japan, Ferritin Test Volume and Diagnostics Sales Forecast by Market
Segment
- Japan, Gastrin Test Volume and Diagnostics Sales Forecast by Market egment
- Japan, HCG Test Volume and Diagnostics Sales Forecast by Market Segment
- Japan, Insulin Test Volume and Diagnostics Sales Forecast by Market Segment
- Japan, Interferons Test Volume and Diagnostics Sales Forecast by Market
Segment
- Japan, Interleukins Test Volume and Diagnostics Sales Forecast by Market
Segment
- Japan, Lymphocyte Subtyping Test Volume and Diagnostics Sales Forecast by
Market Segment
- Japan, NSE Test Volume and Diagnostics Sales Forecast by Market Segment
- Japan, Nucleolar Test Volume and Diagnostics Sales Forecast by Market
Segment
- Japan, Occult Blood Test Volume and Diagnostics Sales Forecast by Market
Segment
- Japan, Oncogenes Test Volume and Diagnostics Sales Forecast by Market
Segment
- Japan, Pancreatic Oncofetal Antigen Test Volume and Diagnostics Sales
Forecast by Market Segment
- Japan, PAP Smear Test Volume and Diagnostics Sales Forecast by Market
Segment
- Japan, Parathyroid Hormone Test Volume and Diagnostics Sales Forecast by
Market Segment
- Japan, Progesterone Receptor Test Volume and Diagnostics Sales Forecast by
Market Segment
- Japan, PAP Test Volume and Diagnostics Sales Forecast by Market Segment
- Japan, PSA Test Volume and Diagnostics Sales Forecast by Market Segment
- Japan, S-100 Protein Test Volume and Diagnostics Sales Forecast by Market
Segment
- Japan, Serotonin Test Volume and Diagnostics Sales Forecast by Market
Segment
- Japan, Sialic Acid Test Volume and Diagnostics Sales Forecast by Market
Segment
- Japan, Squamous Cell Carcinoma Antigen Test Volume and Diagnostics Sales
Forecast by Market Segment
- Japan, TDT Test Volume and Diagnostics Sales Forecast by Market Segment
- Japan, Thymidine Kinase Test Volume and Diagnostics Sales Forecast by
Market Segment
- Japan, Thyroglobulin Test Volume and Diagnostics Sales Forecast by Market
Segment
- Japan, TPA, Test Volume and Diagnostics Sales Forecast by Market Segment
- Japan, Total Tumor Marker Sales by Major Suppliers
- Japan, AFP Testing Market Diagnostics Sales by Major Supplier
- Japan, CA 15-3/27.29 Testing Market Diagnostics Sales by Major Supplier
- Japan, CA 19-9 Testing Market Diagnostics Sales by Major Supplier
- Japan, CA 125 Testing Market Diagnostics Sales by Major Supplier
- Japan, Calcitonin Testing Market Diagnostics Sales by Major Supplier
- Japan, CEA Testing Market Diagnostics Sales by Major Supplier
- Japan, NSE Testing Market Diagnostics Sales by Major Supplier
- Japan, PAP Testing Market Diagnostics Sales by Major Supplier
- Japan, PSA Testing Market Diagnostics Sales by Major Supplier
- Japan, Tumor Marker Testing Instrumentation, Major Systems Estimated
Placements and Installed Base By Supplier and Model
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