EMMA09 - Emerging Markets for Microfluidic Appliations in Life Sciences and In-Vitro Diagnostics

Table of Contents

1 - Executive Summary

2 - Introduction

• Introduction
• Methodology

3-Microfluidic markets 2009-2014

• Microfluidic markets
• Markets considered in this report
• Market geographical distribution
• Market distribution
• Impact of microfluidics
• Microfluidic applications
• Microfluidic components market value and forecast - Data
• Microfluidic components market value nd forecast - Market in M$
• Microfluidic components market value nd forecast - Market in Munits
• Compound Annual Growth Rates 2006-2008 and 2009-2014
• Market analysis

4- What Happened since 2007

• Microfluidics, a structured market
• Market data versus EMMA2007 forecasts
• Total diagnostics & Drug Delivery Markets 2006-2008; in M$
• Microfluidic Devices Market Evolution 2006-2008, in M$
• Market Breakdown in 2008
• Materials by Application
• Some product introduction 1/3)
• Some product introduction (2/3)
• Some product introduction (3/3)
• Investments in microfluidics since 2007
• M&A in microfluidics since 2007
• Life & Death

5- Microfluidic Applications

• Microfluidics Applications
• Microfluidic Applications description
• Microfluidics for Analytical devices
  • Microfluidics for Analytical devices (1/2)
  • Microfluidics for Analytical devices (2/2)
  • Agilent - HPLC-Chip/MS Technologies (US) HPLC Eksigent Technologies (US) - nanoLC™ HPLC systems
  • Nanostream (US) : Veloce Micro Parallel Liquid Chromatography (μPLC) System
  • Advion Biosciences (US) - NanoMate System for MS sample electrospray
• Cartridges for clinical and veterinary diagnostics
  • Cartridges for clinical and veterinary diagnostics (1/2)
  • Cartridges for clinical and veterinary diagnostics (2/2)
    • MicroParts/ Merlin Diagnostik Lilliput chip
  • Directif GmbH - November AG Lab on a Chip
  • Abaxis - Piccolo® Xpress
• Microfluidic devices for Pharmaceutical and life science applications
  • Microfluidic devices for Pharmaceutical and life science applications (1/2)
  • Microfluidic devices for Pharmaceutical and life science applications (2/2)
  • Gyros Gyrolab Bioaffy™ CD
  • Fluidigm Dynamic Array for Single Cell Gene Expression
  • CEA Leti Smartdrop
  • Miniaturized cell based assays
  • Cell based assays
  • Miniaturized cell based assays Applications
    • Ion channel drug discovery and screening
    • Patch-clamp
    • Cell transfection
    • Living or fixed cells
    • Primary cells and stem cells
    • Drug discovery programs
    • Toxicology and initial ADME studies
    • Shear flow analysis
  • ACEA Bioscience's real-time cell assay technology
  • ADVALYTIX - AmpliGrid™ Platform
  • Advanced Liquid logic
  • Applied Biophysics
  • Bellbrooks Laboratories
  • Bionas - Adcon plate & reader
  • Cellectricon
  • Cellix
  • Cytoo
  • Evotec - High Throughput Screening
  • Fluxion Bioscience: BioFlux
  • Nanion Technologies GmbH
  • Nanopoint
  • Raindance Technologies
  • SpinX Technologies (CH) - gCards™ and SpinX Lab™ for HTS
• Microfluidic devices for Point of Care
  • Microfluidic devices for Point of Care (1/2)
  • Microfluidic devices for Point of Care (2/2)
  • Abbott / I stat
  • Abbott / I stat
  • Biosite POC system
  • STmicroelectronics:In-Check platform
  • In STmicroelectronics:In-Check platform
  • Clondiag Chip Technology AssayProcessor
  • POC ongoing developments: Siemens Medical Solutions
  • POC ongoing developments: Philips Magnetic Biosensor
  • POC ongoing developments: DALSA Semiconducteur BioMEMS (1/2)
  • POC ongoing developments: DALSA Semiconducteur BioMEMS (2/2)
• Capillary Electrophoresis chips
  • Capillary Electrophoresis chips (1/2)
  • Capillary Electrophoresis chips (2/2)
  • CALIPER Life Sciences (US) (1/2)
  • CALIPER Life Sciences (US) (2/2)
  • Shimazu Biotech
  • Qiagen Qiaxcel
  • Capilix Capella platform
• Microfluidic devices for Industrial and environmental testing
  • Microfluidic devices for Industrial and environmental testing (1/2)
  • Microfluidic devices for Industrial and environmental testing (2/2)
  • Cepheid - GeneXpert™ Systems (1/2)
  • Cepheid - GeneXpert™ Systems (2/2)
  • Genesystems (Pall Life Sciences)
• Microdispensers
  • Microdispensing (1/2)
  • Microdispensing (2/2)
  • Microfluidics positioning in the Liquid Handling market
    • Microdispensers and workflow platforms
  • Overview of low liquid-handling systems
  • LabCyte Echo 550 Liquid handler
  • Biodot
  • BioFluidix TopSpot 5
  • GeSim Nano- Nano Plotters Perkin Elmer PiezoArray
  • MicroDrop microdosing System
  • Scienion FlexArrayer
  • Agilent - Ink Jet SurePrint technology
  • Shimatzu Biotech: Chemical Inkject Printer CHIP 1000
• Microfluidic devices for drug delivery
  • Microfluidic devices for drug delivery (1/2)
  • Microfluidic devices for drug delivery (2/2)
    • Boehringer MicroParts Respimat®
  • Medspray: spray nozzles Micro Infusion pumps
  • Medtronic Minimed Inc.
  • Debiotech Nanopump™
  • MicroCHIPS
  • ChipRx Inc.
  • Active needle-free transdermal systems
  • Transdermal Microneedle developments (1/2)
  • Transdermal Microneedle developments (2/2)

6- Microfluidic Technologies

• Microfluidics technologies Overview
• Microfluidic Fluid motion strategy
• Microfluidic Prototyping and Production
• Materials by Application
  • Silicon as a substrate for Life Science applications
  • Glass as a substrate for Life Science applications
  • Polymers as a substrate for Life Science applications
  • Microfluidic technologies and materials Synthesis
• Microfluidic technologies: Main trends and conclusion
• Functions integration
• Functions integration, a main challenge
  • Functions needed for Life Science applications
  • A multi-disciplinary challenge
  • Material combination, a main challenge
• Packaging techniques and their evolution
  • Packaging evolution
  • Advanced packaging: The challenges
  • From 2D to 3D...
  • Packaging for Life Science applications
  • Capillary DALSA Semiconducteur: Electrophoresis (CE) and DNA Separation

7- Microfluidic supply chain

• Introduction
• Competences required along the microfluidic industrial chain
• Expectations of the microfluidic customers
• Glass industrial supply chain
• Polymer industrial supply chain
• Silicon Industrial supply chain

8- Microfluidic Value chain

• Value chain analysis
  • Case Study: Microarray component value chain (1/2)
  • Case Study: Microarray component value chain (2/2)
  • Case Study: CALIPER Life Sciences LabChip
  • Case Study: Cost Analysis Caliper Labchip
  • Case Study: Caliper Labchip; Material Variation
  • Case Study: Caliper Labchip; Production location
• Conclusion on the value chain

9- Conclusion

• Conclusion (1/3)
• Conclusion (2/3)
• Conclusion (3/3)

APPENDIX

• APPENDIX 1 : Manufacturing Technologies
• Microfluidic technologies
  • Chemical etching (1/2)
  • Chemical etching (2/2)
  • Photo-etching of glass
  • Sand blasting/Powder blasting
  • Electro Discharge Machining (EDM)
  • Mechanical micromachining
  • Laser Micromachining
  • Micromolding - Injection molding
  • Soft Lithography
  • Hot Embossing
• Polymer chip manufacturing techniques
  • Polymer microfluidic components
  • Polymer microtechnologies flowchart
  • Polymer microcomponents technology
  • Prototyping / Production : Polymer microtechnologies
  • Prototyping / Production Lamination / PCB techniques Post processing Bonding
  • Post processing Surface functionalization

APPENDIX 2 :Yole Developpement Presentation