Orthopedic Drugs, Implants and Devices

TABLE OF CONTENTS

INTRODUCTION

• STUDY OBJECTIVES
• REASONS FOR DOING THIS STUDY
• CONTRIBUTIONS TO THE STUDY
• SCOPE OF THE STUDY
• METHODOLOGY
• INFORMATION SOURCES
• ABOUT THE AUTHOR
• BCC ON-LINE SERVICES
• DISCLAIMER

SUMMARY

• Summary Table:
  GLOBAL SALES OF ORTHOPAEDIC DRUGS, IMPLANTS, AND DEVICES, THROUGH 2009 ($ BILLIONS)
• Summary Figure:
  GLOBAL SALES OF ORTHOPAEDIC DRUGS, IMPLANTS, AND DEVICES, 2002-2009 ($ BILLIONS)

OVERVIEW

• WHAT IS ORTHOPAEDICS?
• COMMON ORTHOPAEDIC DISORDERS
• Table 1 COMMON ORTHOPAEDIC DISORDERS
  • ANKYLOSING SPONDYLITIS
    • Cause and Symptoms
    • Treatment
  • BONE INFECTIONS
    • Cause and Symptoms
    • Treatment
  • GOUT
    • Cause and Symptoms
    • Treatment
  • HYPOPHOSPHATASIA
    • Cause and Symptoms
    • Treatment
  • OSTEOARTHRITIS
    • Cause and Symptoms
    • Treatment
  • OSTEOPOROSIS
    • Cause and Symptoms
    • Treatment
  • OSTEITIS DEFORMANS (PAGETS DISEASE)
    • Cause and Symptoms
    • Treatment
  • PSORATIC ARTHRITIS
    • Cause and Symptoms
    • Treatment
  • REACTIVE ARTHRITIS
    • Cause and Symptoms
    • Treatment
  • RHEUMATOID ARTHRITIS
    • Cause and Symptoms
    • Treatment
  • SCOLIOSIS
    • Cause and Symptoms
    • Treatment
  • SOME OTHER RELATED ORTHOPAEDIC DISORDERS
    • ACHONDROPLASIA
    • ANKLE PAIN
    • ANKLE SPRAINS
    • ARTHRITIS MUTILANS
    • ARTHROGRYPOSIS
    • BONE TUMOR
    • BURSITIS
    • CERVICAL ARTHRITIS
      • Symptoms
      • Treatment
    • DOWAGERS HUMP
    • FIBROUS DYSPLASIA
      • Cause and Symptoms
      • Treatment
        • Nonsurgical Treatments
    • HEEL SPURS
      • Cause and Symptoms
      • Treatment
    • JOINT INFECTIONS
    • JUVENILE ARTHRITIS
      • Causes and Symptoms
    • LUMBAR ARTHRITIS
      • Cause and Symptoms
      • Treatment
    • OSTEOPENIA
    • SAPHO SYNDROME
    • TENDINITIS
      • Treatment
    • VANISHING BONE SYNDROME
  • FRACTURES
    • TYPES OF FRACTURES
    • CLASSIFICATION OF FRACTURES
    • TREATMENT FOR FRACTURES
• Table 2 TYPES OF TREATMENTS FOR FRACTURES

CLASSIFICATION OF DRUGS BASED ON THERAPEUTIC CATEGORY

• ANALGESICS, ANTI-INFLAMMATORIES AND ANTIPYRETICS (NON-OPIOD) (NON-STEROIDAL ANTI-INFLAMMATORY DRUGS, NSAIDs)
• Table 3 NON-OPIOID DRUGS USED AS ANALGESICS, ANTI-INFLAMMATORIES, AND ANTIPYRETICS
  • ASPIRIN
  • ACETAMINOPHEN
  • ZOSTRIX
  • DICLOFENAC
  • FLURBIPROFEN
  • IBUPROFEN
  • INDOMETHACIN
  • HYDROXYCHLOROQUINE
  • KETOPROFEN
  • KETOROLAC TROMETHAMINE
  • MECLOFENAMATE SODIUM
  • NABUMETONE
  • NAPROXEN
  • DAYPRO
  • VIOXX
  • AZULFIDINE
  • TOLMETIN/TOLECTIN
  • BEXTRA
  • OPIOID ANALGESICS
• Table 4 OPIOID DRUGS USED AS ANALGESICS
  • ALFENTA
  • BUPRENEX
  • FENTANYL
  • HYDROMORPHONE
  • DEMEROL
  • METHADONE
  • NUBAIN
  • OXYCODONE
  • NUMORPHAN
  • PROPXYPHENE
  • CODEINE
  • CORTICOSTEROIDS
• Table 5 CLASSIFICATION OF CORTICOSTEROIDS
• Table 6 CORTICOSTERIOD DRUGS USED AS ANTI-INFLAMMATORYS
  • CYCLOCORT
  • COLBETASOL
  • DESONIDE
  • DEXAMETHASONE
  • FLUOCINOLONE ACETONIDE
  • FML
  • FLURANDRENOLIDE
  • FLONASE
  • HYDROCORTISONE
  • MEDROL
  • PREDNISONE
  • ARISTOCORT
  • BONE STABILIZERS
• Table 7 DRUGS USED AS BONE STABILIZERS
  • FOSAMAX
  • ETIDRONATE DISODIUM
  • AREDIA
  • ACTONEL
  • EVISTA
  • ACTONEL
  • SKELID
  • ZOMETA
  • SKELETAL MUSCLE RELAXANTS
• Table 8 DRUGS USED AS SKELETAL MUSCLE RELAXANTS
  • BACLOFEN
  • SOMA
  • PARAFON FORTE DSC
  • FLEXERIL
  • VALIUM
  • THERAPEUTIC VITAMINS AND MINERALS
• Table 9 DRUGS USED AS VITAMIN SUPPLEMENTS
  • DIHYDROTACHYSTEROL
  • NASCOBAL
  • FOLIC ACID
  • CALCIFEDIOL
  • ROCALTROL
  • ZEMPLAR
  • CALCIUM SUPPLEMENTS
• Table 10 DRUGS USED AS CALCIUM SUPPLEMENTS
  • ANTIBIOTICS
• Table 11 DRUGS USED AS ANTIBIOTICS
• Table 11 (CONTINUED)
• Table 11 (CONTINUED)
  • DISEASE-MODIFYING AGENTS
• Table 12 DISEASE-MODIFYING AGENTS
  • AZATHRIOPIN
  • CALCITONIN
  • ENBREL
  • HYALURONATE
  • HYLAN-G-F20
  • REMICADE
  • ARAVA
  • METHOTREXATE
  • PENICILLAMINE
  • FORTEO

IMPLANTS AND DEVICES

• JOINT REPLACEMENT
  • KNEE REPLACEMENT
  • HIP REPLACEMENT
  • SHOULDER REPLACEMENT
  • OTHER JOINT IMPLANTS
• DEVICES FOR FIXATION
  • WIRES
  • PLATES
  • NAILS OR RODS
  • SCREWS
• CARTILAGE TRANSPLANTATION
• SYNOVIAL FLUID REPLACEMENT
• ALLOGRAFTS
• OTHER MATERIALS

REGULATORY ASPECTS

• REGULATION OF BONE AND JOINT THERAPIES
  • REGULATION IN THE U.S.
    • Devices
• Table 13 FOOD AND DRUG ADMINISTRATION AGENCIES INVOLVED IN IMPLANT REGULATION
  • Drugs and Biologicals
    • Drugs and Biologicals (Continued)
  • Orphan Product Status
  • INTERNATIONAL ISSUES
    • ISO 9000
• Table 14 ISO STANDARDS FOR ORTHOPAEDIC IMPLANTS
• Table 14 (CONTINUED)
  • DRUG APPROVALS
    • DEVICES AND IMPLANTS
• Table 15 DEVICES AND IMPLANTS APPROVED BY THE FDA, 2000-2004
  • Humanitarian-Use Devices
• Table 16 LISTING OF CDRH HUMANITARIAN DEVICE EXEMPTION SUMMARIES OF SAFETY AND POSSIBLE BENEFITS, 2000-2004
• Table 16 (CONTINUED)
  • DRUGS
• Table 17 DRUGS APPROVED BY THE FDA, 2000-2004

INDUSTRY STRUCTURE

• ORTHOPAEDIC INDUSTRY - MARKET BY COMPANY
  • DRUG COMPANIES
    • NSAIDs
• Table 18 MARKET SHARES OF NSAIDs IN THE ORTHOPAEDIC INDUSTRY, 2003
• Figure 1 MARKET SHARES OF NSAIDs IN THE ORTHOPAEDIC INDUSTRY, 2003
  • Opioid Analgesics
• Table 19 MARKET SHARES OF OPIOID ANALGESICS IN THE ORTHOPAEDIC INDUSTRY, 2003
• Figure 2 MARKET SHARES OF OPIOID ANALGESICS IN THE ORTHOPAEDIC INDUSTRY, 2003
  • Corticosteroids
• Table 20 MARKET SHARE OF CORTICOSTEROIDS IN ORTHOPAEDIC INDUSTRY IN 2003
• Figure 3 MARKET SHARES OF CORTICOSTEROIDS IN THE ORTHOPAEDIC INDUSTRY, 2003
  • Bone Stabilizers
• Table 21 MARKET SHARES OF BONE STABILIZERS, 2003
• Figure 4 MARKET SHARES OF BONE STABILIZERS, 2003
  • Skeletal Muscle Relaxants
• Table 22 MARKET SHARES OF SKELETAL MUSCLE RELAXANTS USED IN ORTHOPAEDICS, 2003
• Figure 5 MARKET SHARES OF SKELETAL MUSCLE RELAXANTS USED IN ORTHOPAEDICS, 2003
  • Therapeutic Vitamins and Supplements
• Table 23 MARKET SHARE OF THERAPEUTIC VITAMINS AND SUPPLEMENTS USED IN ORTHOPAEDICS, 2003
• Figure 6 MARKET SHARE OF THERAPEUTIC VITAMINS AND MINERALS USED IN ORTHOPAEDICS, 2003
  • Antibiotics
    • Cephalosporins
• Table 24 MARKET SHARES OF CEPHALOSPORINS USED IN ORTHOPAEDICS, 2003
• Figure 7 MARKET SHARES OF CEPHALOSPORINS USED IN ORTHOPAEDICS, 2003
  • Macrolides
• Table 25 MARKET SHARES FOR MACROLIDES USED IN ORTHOPAEDICS, 2003
• Figure 8 MARKET SHARES FOR MACROLIDES USED IN ORTHOPAEDICS, 2003
  • Penicillins
• Table 26 MARKET SHARES FOR PENICILLINS USED IN ORTHOPAEDICS, 2003
• Figure 9 MARKET SHARES FOR PENICILLINS USED IN ORTHOPAEDICS, 2003
  • Quinolones
• Table 27 MARKET SHARES FOR QUINOLONES USED IN ORTHOPAEDICS, 2003
• Figure 10 MARKET SHARES FOR QUINOLONES USED IN ORTHOPAEDICS, 2003
  • Tetracyclines
• Table 28 MARKET SHARES OF TETRACYCLINES USED IN ORTHOPAEDICS, 2003
• Figure 11 MARKET SHARES OF TETRACYCLINES USED IN ORTHOPAEDICS, 2003
  • Other Antibiotics
• Table 29 MARKET SHARES FOR OTHER ANTIBIOTICS USED IN ORTHOPAEDICS, 2003
• Figure 12 MARKET SHARES FOR OTHER ANTIBIOTICS USED IN ORTHOPAEDICS, 2003
  • Disease-Modifying Agents
• Table 30 MARKET SHARES FOR DISEASE-MODIFYING AGENTS USED IN ORTHOPAEDICS, 2003
• Figure 13 MARKET SHARES FOR DISEASE-MODIFYING AGENTS USED IN ORTHOPAEDICS, 2003
  • IMPLANTS AND DEVICES USED IN ORTHOPAEDICS
• Table 31 MARKET SHARES FOR IMPLANTS AND DEVICES USED IN ORTHOPAEDICS, 2003
• Figure 14 MARKET SHARES FOR IMPLANTS AND DEVICES USED IN ORTHOPAEDICS, 2003

THE MARKET BY PRODUCT

• ORTHOPAEDIC DRUGS
• Table 32 WORLDWIDE SALES OF DRUGS USED IN ORTHOPAEDICS, THROUGH 2009 ($ BILLIONS)
• Figure 15 WORLDWIDE SALES OF DRUGS USED IN ORTHOPAEDICS, 2002-2009 ($ BILLIONS)
• Table 33 SHARES OF DRUGS USED IN ORTHOPAEDICS IN 2003
• Figure 16 SHARES OF DRUGS USED IN ORTHOPAEDICS, 2003
  • NON-OPIOID ANALGESIC, ANTI-INFLAMMATORY, AND ANTIPYRETIC NSAIDS
• Table 34 WORLDWIDE SALES OF NSAIDS FOR ORTHOPAEDICS, THROUGH 2009 ($ BILLIONS)
• Figure 17 WORLDWIDE SALES OF NSAIDS FOR ORTHOPAEDICS, 2002-2009 ($ BILLIONS)
  • OPIOID ANALGESICS
• Table 35 WORLDWIDE SALES OF OPIOID ANALGESICS FOR ORTHOPAEDICS, THROUGH 2009 ($ BILLIONS)
• Figure 18 WORLDWIDE SALES OF OPIOID ANALGESICS FOR ORTHOPAEDICS, 2002-2009 ($ BILLIONS)
  • CORTICOSTEROIDS
• Table 36 WORLDWIDE SALES OF CORTICOSTEROIDS USED IN ORTHOPAEDICS, THROUGH 2009 ($ BILLIONS)
• Figure 19 WORLDWIDE SALES OF CORTICOSTEROIDS IN ORTHOPAEDICS, 2002-2009 ($ BILLIONS)
  • BONE STABILIZERS
• Table 37 WORLDWIDE SALES OF BONE STABILIZERS, THROUGH 2009 ($ BILLIONS)
• Figure 20 WORLDWIDE SALES OF BONE STABILIZERS, 2002-2009 ($ BILLIONS)
  • SKELETAL MUSCLE RELAXANTS
• Table 38 WORLDWIDE SALES OF SKELETAL MUSCLE RELAXANTS USED IN ORTHOPAEDICS, THROUGH 2009 ($ BILLIONS)
• Figure 21 WORLDWIDE SALES OF SKELETAL MUSCLE RELAXANTS USED IN ORTHOPAEDICS, 2002-2009 ($ BILLIONS)
  • THERAPEUTIC VITAMINS AND MINERALS
• Table 39 WORLDWIDE SALES OF THERAPEUTIC VITAMINS AND MINERALS USED IN ORTHOPAEDICS, THROUGH 2009 ($ BILLIONS)
• Figure 22 WORLDWIDE SALES OF THERAPEUTIC VITAMINS AND MINERALS USED IN ORTHOPAEDICS, 2002-2009 ($ BILLIONS)
  • ANTIBIOTICS
    • Antibiotics (Continued)
• Table 40 WORLDWIDE SALES OF ANTIBIOTICS USED IN ORTHOPAEDICS, THROUGH 2009 ($ BILLIONS)
• Figure 23 WORLDWIDE SALES OF ANTIBIOTICS USED IN ORTHOPAEDICS, 2002-2009 ($ BILLIONS)
  • DISEASE-MODIFYING AGENTS
• Table 41 WORLDWIDE SALES OF DISEASE-MODIFYING AGENTS IN ORTHOPAEDICS, THROUGH 2009 ($ BILLIONS)
• Figure 24 WORLDWIDE SALES OF DISEASE-MODIFYING AGENTS USED IN ORTHOPAEDICS, 2002-2009 ($ BILLIONS)
  • ORTHOPAEDIC IMPLANTS AND DEVICES
    • HIP REPLACEMENT
    • RESEARCH AND DEVELOPMENT
• Table 42 IMPLANTS AND DEVICES USED IN THE ORTHOPAEDIC INDUSTRY
• Table 42 (CONTINUED)
• Table 42 (CONTINUED)
• Table 42 (CONTINUED)
• Table 42 (CONTINUED)
• Table 42 (CONTINUED)
• Table 42 (CONTINUED)
• Table 43 WORLDWIDE SALES OF IMPLANTS AND DEVICES USED IN ORTHOPAEDICS, THROUGH 2009 ($ BILLIONS)
• Figure 25 WORLDWIDE SALES OF IMPLANTS AND DEVICES USED IN ORTHOPAEDICS, 2002-2009 ($ BILLIONS)
• Table 44 MARKET SHARES OF IMPLANTS AND DEVICES USED IN ORTHOPAEDICS, 2003
• Figure 26 MARKET SHARES OF IMPLANTS AND DEVICES USED IN ORTHOPAEDICS, 2003 (%)
  • KNEE
• Table 45 WORLDWIDE SALES OF THERAPEUTIC PRODUCTS TO REPAIR THE KNEE, THROUGH 2009 ($ BILLIONS)
• Figure 27 WORLDWIDE SALES OF THERAPEUTIC PRODUCTS TO REPAIR THE KNEE, 2002-2009 ($ BILLIONS)
  • HIP
• Table 46 WORLDWIDE SALES OF THERAPEUTIC PRODUCTS TO REPAIR THE HIP, THROUGH 2009 ($ BILLIONS)
• Figure 28 WORLDWIDE SALES OF THERAPEUTIC PRODUCTS TO REPAIR THE HIP, 2002-2009 ($ BILLIONS)
  • SHOULDER
• Table 47 WORLDWIDE SALES OF THERAPEUTIC PRODUCTS TO REPAIR THE SHOULDER, THROUGH 2009 ($ BILLIONS)
• Figure 29 WORLDWIDE SALES OF THERAPEUTIC PRODUCTS TO REPAIR THE SHOULDER, 2002-2009 ($ BILLIONS)
  • SPINE
• Table 48 WORLDWIDE SALES OF THERAPEUTIC PRODUCTS TO REPAIR THE SPINE, THROUGH 2009 ($ BILLIONS)
• Figure 30 WORLDWIDE SALES OF THERAPEUTIC PRODUCTS TO REPAIR THE SPINE, 2002-2009 ($ BILLIONS)
  • INTERNAL AND EXTERNAL FIXATION DEVICES
• Table 49 WORLDWIDE SALES OF INTERNAL AND EXTERNAL FIXATION DEVICES, THROUGH 2009 ($ BILLIONS)
• Figure 31 WORLDWIDE SALES OF INTERNAL AND EXTERNAL FIXATION DEVICES, 2002-2009 ($ BILLIONS)

NEW DEVELOPMENTS

• Abbott Laboratories
• AstraZeneca
• Table 50 NEW DRUGS BY ASTRAZENECA
  • DePuy
  • Elan Pharmaceuticals
• Table 51 NEW DRUGS BY ELAN PHARMACEUTICALS
  • Endo Pharmaceuticals
• Table 52 NEW DRUGS BY ENDO PHARMACEUTICALS
  • Genzyme
• Table 53 NEW DRUGS BY GENZYME
  • Merck
• Table 54 NEW DRUGS BY MERCK
  • Nastech
• Table 55 NEW DRUGS BY NASTECH
  • Novartis
• Table 56 NEW DRUGS BY NOVARTIS
  • Orthologic
• Table 57 NEW DRUGS BY ORTHOLOGIC
  • Pfizer
  • Orthovita
  • Roche
• Table 58 NEW DRUGS BY ROCHE

PATENTS

• PATENTS BY YEAR
• Table 59 NUMBER OF PATENTS IN EACH YEAR, 2000-2004
• Figure 32 NUMBER OF PATENTS IN EACH YEAR, 2000-2004
• Table 60 SIGNIFICANT PATENTS FOR DRUGS USED IN ORTHOPAEDICS, 2004
• Table 60 (CONTINUED)
• Table 60 (CONTINUED)
• Table 60 (CONTINUED)
• Table 60 (CONTINUED)
• Table 60 (CONTINUED)
• Table 60 (CONTINUED)
• Table 60 (CONTINUED)
• Table 60 (CONTINUED)
• Table 60 (CONTINUED)
• Table 60 (CONTINUED)
• Table 61 SIGNIFICANT PATENTS FOR DRUGS USED IN ORTHOPAEDICS, 2002-2003
• Table 61 (CONTINUED)
• Table 61 (CONTINUED)
• Table 61 (CONTINUED)
• Table 61 (CONTINUED)
• Table 61 (CONTINUED)
• Table 61 (CONTINUED)
• Table 61 (CONTINUED)
• Table 61 (CONTINUED)
• Table 61 (CONTINUED)
• Table 61 (CONTINUED)
• Table 62 PATENTS FOR DEVICES AND IMPLANTS USED IN ORTHOPAEDICS, 2004
• Table 62 (CONTINUED)
• Table 62 (CONTINUED)
• Table 63 SIGNIFICANT PATENTS FOR DEVICES AND IMPLANTS USED IN ORTHOPAEDICS, 2002-2003
• Table 63 (CONTINUED)
  • PATENTS BY COMPANY
• Table 64 U.S. PATENTS BY COMPANY, 2000-2004
• Figure 33 U.S. PATENTS BY COMPANY, 2000-2004
  • PATENTS BY COUNTRY
• Table 65 U.S. PATENTS BY COUNTRY, 2000-2004
• Figure 34 U.S. PATENTS BY COUNTRY, 2000-2004
• Table 66 TRENDS OF PATENTS ISSUED BY COUNTRY, 2004-2000
• Figure 35 TRENDS OF PATENTS ISSUED BY COUNTRY, 2000-2004
• Figure 36 TRENDS OF PATENTS ISSUED BY COUNTRY, 2000-2004
  • PATENTS BY ASSIGNEE
• Table 67 SHARES OF U.S. PATENTS BY ASSIGNEE, 2000-2004
• Figure 37 NUMBER OF U.S. PATENTS BY ASSIGNEE, 2000-2004
• Figure 38 PERCENT OF U.S. PATENTS BY ASSIGNEE, 2000-2004

INTERNATIONAL ASPECTS

• Table 68 SALES OF ORTHOPAEDIC DRUGS, IMPLANTS, AND DEVICES, BY REGION, THROUGH 2009 ($ BILLIONS)
• Figure 39 SALES OF ORTHOPAEDIC DRUGS, IMPLANTS, AND DEVICES, BY REGION, 2002-2009 ($ BILLIONS)
• Figure 40 SHARE OF EACH REGION FOR ORTHOPAEDIC DRUGS, IMPLANTS, AND DEVICES, 2003 (PERCENT (%) OF TOTAL)

COMPANY PROFILES

• ABBOTT LABORATORIES
• ARTHROCARE
• AKORN, INC.
• ALCON LABORATORIES
• ALLERGAN, INC.
• ALEMBIC LTD.
• ALPHARMA, INC.
• ASTRAZENECA
• AVENTIS PHARMACEUTICALS, INC.
• BAXTER INTERNATIONAL, INC.
• BAYER AG
• BIOMET ORTHOPAEDIC, INC.
• BRISTOL-MYERS SQUIBB
• BIOGLAN PHARMACEUTICALS
• BLACKSTONE MEDICAL, INC.
• CEPHALON
• CONNETICS CORP.
• DERMIK LABORATORIES, INC.
• DEPUY, A JOHNSON & JOHNSON COMPANY
• ELAN PHARMACEUTICALS, PLC
• ELI LILLY AND COMPANY
• ENCORE MEDICAL CORP.
• ENDO PHARMACEUTICALS
• FUJISAWA HEALTHCARE, INC.
• GALDERMA LABORATORIES
• GENZYME BIOSURGERY
• GLAXOSMITHKLINE, PLC
• INNOMED, INC.
• INTERPORE CROSS INTERNATIONAL
• JOHNSON & JOHNSON
• Table 69 THE JOHNSON & JOHNSON GROUP OF COMPANIES
• Table 69 (CONTINUED)
  • KING PHARMACEUTICALS
  • KYPHON, INC.
  • MERCK & COMPANY, INC.
  • MITEK SURGICAL PRODUCTS
  • MURO PHARMACEUTICALS, INC.
  • NASTECH PHARMACEUTICAL CO., INC.
  • NOVARTIS PHARMACEUTICAL CORP.
  • OCLASSEN PHARMACEUTICALS, INC.
  • ORTHOFIX, INC.
  • OSTEOTECH
  • PFIZER, INC.
  • PROCTER & GAMBLE
  • PURDUE PHARMA
  • ROCHE
  • ROXANE LABORATORIES, INC.
  • RUSH/BERIVON, INC.
  • SANOFI-SYNTHELABO
  • SANTEN, INC.
  • SCHERING-PLOUGH
  • SMITH & NEPHEW ORTHOPAEDICS
    • SMITH & NEPHEW ORTHOPAEDICS (CONTINUED)
  • STRYKER ORTHOPAEDICS
  • VALEANT PHARMACEUTICALS
  • WYETH PHARMACEUTICALS
  • WRIGHT MEDICAL TECHNOLOGY
  • ZIMMER HOLDINGS, INC.

LIST OF TABLES

Summary Table:
GLOBAL SALES OF ORTHOPAEDIC DRUGS, IMPLANTS, AND DEVICES, THROUGH 2009 ($ BILLIONS)

Table 1 COMMON ORTHOPAEDIC DISORDERS

Table 2 TYPES OF TREATMENTS FOR FRACTURES

Table 3 NON-OPIOID DRUGS USED AS ANALGESICS, ANTI-INFLAMMATORIES, AND ANTIPYRETICS

Table 4 OPIOID DRUGS USED AS ANALGESICS

Table 5 CLASSIFICATION OF CORTICOSTEROIDS

Table 6 CORTICOSTERIOD DRUGS USED AS ANTI-INFLAMMATORYS

Table 7 DRUGS USED AS BONE STABILIZERS

Table 8 DRUGS USED AS SKELETAL MUSCLE RELAXANTS

Table 9 DRUGS USED AS VITAMIN SUPPLEMENTS

Table 10 DRUGS USED AS CALCIUM SUPPLEMENTS

Table 11 DRUGS USED AS ANTIBIOTICS

Table 12 DISEASE-MODIFYING AGENTS

Table 13 FOOD AND DRUG ADMINISTRATION AGENCIES INVOLVED IN IMPLANT REGULATION

Table 14 ISO STANDARDS FOR ORTHOPAEDIC IMPLANTS

Table 15 DEVICES AND IMPLANTS APPROVED BY THE FDA, 2000-2004

Table 16 LISTING OF CDRH HUMANITARIAN DEVICE EXEMPTION SUMMARIES OF SAFETY AND POSSIBLE BENEFITS, 2000-2004

Table 17 DRUGS APPROVED BY THE FDA, 2000-2004

Table 18 MARKET SHARES OF NSAIDs IN THE ORTHOPAEDIC INDUSTRY, 2003

Table 19 MARKET SHARES OF OPIOID ANALGESICS IN THE ORTHOPAEDIC INDUSTRY, 2003

Table 20 MARKET SHARE OF CORTICOSTEROIDS IN ORTHOPAEDIC INDUSTRY IN 2003

Table 21 MARKET SHARES OF BONE STABILIZERS, 2003

Table 22 MARKET SHARES OF SKELETAL MUSCLE RELAXANTS USED IN ORTHOPAEDICS, 2003

Table 23 MARKET SHARE OF THERAPEUTIC VITAMINS AND SUPPLEMENTS USED IN ORTHOPAEDICS, 2003

Table 24 MARKET SHARES OF CEPHALOSPORINS USED IN ORTHOPAEDICS, 2003

Table 25 MARKET SHARES FOR MACROLIDES USED IN ORTHOPAEDICS, 2003

Table 26 MARKET SHARES FOR PENICILLINS USED IN ORTHOPAEDICS, 2003

Table 27 MARKET SHARES FOR QUINOLONES USED IN ORTHOPAEDICS, 2003

Table 28 MARKET SHARES OF TETRACYCLINES USED IN ORTHOPAEDICS, 2003

Table 29 MARKET SHARES FOR OTHER ANTIBIOTICS USED IN ORTHOPAEDICS, 2003

Table 30 MARKET SHARES FOR DISEASE-MODIFYING AGENTS USED IN ORTHOPAEDICS, 2003

Table 31 MARKET SHARES FOR IMPLANTS AND DEVICES USED IN ORTHOPAEDICS, 2003

Table 32 WORLDWIDE SALES OF DRUGS USED IN ORTHOPAEDICS, THROUGH 2009 ($ BILLIONS)

Table 33 SHARES OF DRUGS USED IN ORTHOPAEDICS IN 2003

Table 34 WORLDWIDE SALES OF NSAIDS FOR ORTHOPAEDICS, THROUGH 2009 ($ BILLIONS)

Table 35 WORLDWIDE SALES OF OPIOID ANALGESICS FOR ORTHOPAEDICS, THROUGH 2009 ($ BILLIONS)

Table 36 WORLDWIDE SALES OF CORTICOSTEROIDS USED IN ORTHOPAEDICS, THROUGH 2009 ($ BILLIONS)

Table 37 WORLDWIDE SALES OF BONE STABILIZERS, THROUGH 2009 ($ BILLIONS)

Table 38 WORLDWIDE SALES OF SKELETAL MUSCLE RELAXANTS USED IN ORTHOPAEDICS, THROUGH 2009 ($ BILLIONS)

Table 39 WORLDWIDE SALES OF THERAPEUTIC VITAMINS AND MINERALS USED IN ORTHOPAEDICS, THROUGH 2009 ($ BILLIONS)

Table 40 WORLDWIDE SALES OF ANTIBIOTICS USED IN ORTHOPAEDICS, THROUGH 2009 ($ BILLIONS)

Table 41 WORLDWIDE SALES OF DISEASE-MODIFYING AGENTS IN ORTHOPAEDICS, THROUGH 2009 ($ BILLIONS)

Table 42 IMPLANTS AND DEVICES USED IN THE ORTHOPAEDIC INDUSTRY

Table 43 WORLDWIDE SALES OF IMPLANTS AND DEVICES USED IN ORTHOPAEDICS, THROUGH 2009 ($ BILLIONS)

Table 44 MARKET SHARES OF IMPLANTS AND DEVICES USED IN ORTHOPAEDICS, 2003

Table 45 WORLDWIDE SALES OF THERAPEUTIC PRODUCTS TO REPAIR THE KNEE, THROUGH 2009 ($ BILLIONS)

Table 46 WORLDWIDE SALES OF THERAPEUTIC PRODUCTS TO REPAIR THE HIP, THROUGH 2009 ($ BILLIONS)

Table 47 WORLDWIDE SALES OF THERAPEUTIC PRODUCTS TO REPAIR THE SHOULDER, THROUGH 2009 ($ BILLIONS)

Table 48 WORLDWIDE SALES OF THERAPEUTIC PRODUCTS TO REPAIR THE SPINE, THROUGH 2009 ($ BILLIONS)

Table 49 WORLDWIDE SALES OF INTERNAL AND EXTERNAL FIXATION DEVICES, THROUGH 2009 ($ BILLIONS)

Table 50 NEW DRUGS BY ASTRAZENECA

Table 51 NEW DRUGS BY ELAN PHARMACEUTICALS

Table 52 NEW DRUGS BY ENDO PHARMACEUTICALS

Table 53 NEW DRUGS BY GENZYME

Table 54 NEW DRUGS BY MERCK

Table 55 NEW DRUGS BY NASTECH

Table 56 NEW DRUGS BY NOVARTIS

Table 57 NEW DRUGS BY ORTHOLOGIC

Table 58 NEW DRUGS BY ROCHE

Table 59 NUMBER OF PATENTS IN EACH YEAR, 2000-2004

Table 60 SIGNIFICANT PATENTS FOR DRUGS USED IN ORTHOPAEDICS, 2004

Table 61 SIGNIFICANT PATENTS FOR DRUGS USED IN ORTHOPAEDICS, 2002-2003

Table 62 PATENTS FOR DEVICES AND IMPLANTS USED IN ORTHOPAEDICS, 2004

Table 63 SIGNIFICANT PATENTS FOR DEVICES AND IMPLANTS USED IN ORTHOPAEDICS, 2002-2003

Table 64 U.S. PATENTS BY COMPANY, 2000-2004

Table 65 U.S. PATENTS BY COUNTRY, 2000-2004

Table 66 TRENDS OF PATENTS ISSUED BY COUNTRY, 2004-2000

Table 67 SHARES OF U.S. PATENTS BY ASSIGNEE, 2000-2004

Table 68 SALES OF ORTHOPAEDIC DRUGS, IMPLANTS, AND DEVICES, BY REGION, THROUGH 2009 ($ BILLIONS)

Table 69 THE JOHNSON & JOHNSON GROUP OF COMPANIES