Biocompatible Materials for the Human Body

Table of Contents

• INTRODUCTIONSTUDY GOAL AND OBJECTIVES
  • REASONS FOR DOING THE STUDY
  • INTENDED AUDIENCE
  • SCOPE OF REPORT
  • INFORMATION SOURCES
  • ANALYST' S CREDENTIALS
  • RELATED BCC REPORTS
  • BCC ONLINE SERVICES
  • DISCLAIMER
  • SUMMARY
• Summary Table:
  • U.S. MARKET FORECAST FOR BIOCOMPATIBLE MATERIALS BY SEGMENT, THROUGH 2012 ($ MILLIONS)
  • Summary Figure:
  • U.S. MARKET FOR BIOCOMPATIBLE MATERIALS, BY SEGMENT 2004-2012 ($ MILLIONS)
• OVERVIEW
  • INTRODUCTION TO BIOCOMPATIBLE MATERIALS
  • TYPES OF MATERIALS
    • CERAMICS
      • Ceramics (Continued)
  • Table 1 COMMON BIOCOMPATIBLE CERAMICS
    • METALS
      • Titanium
      • Gold
      • Platinum
  • Table 2 COMMON BIOCOMPATIBLE METALS
    • POLYMERS
      • PLA and PGA
      • PTFE
  • Table 3 COMMON BIOCOMPATIBLE POLYMERES
    • NATURAL MATERIALS
      • Collagen
      • Chitosan
      • Alginate
  • Table 4 COMMON BIOCOMPATIBLE NATURAL MATERIALS
• TECHNOLOGY
  • ADVANCES IN BIOACTIVE MATERIALS
    • GROWTH FACTORS
    • DRUG-ELUTING SURFACES
    • HYDROGELS
      • Hydrogels for Growth Factor Delivery
      • Mechanoresponsive Hydrogels
      • Poly(HEMA)
  • DEGRADABLE OR BIORESORBABLE MATERIALS
    • Chitosan
    • Polyethylene Oxide
    • Ethylene-vinyl Acetate
• THE CHALLENGES OF BIOCOMPATIBILITY
  • BLOOD COMPATIBILITY AND PROTEIN ADSORPTION
    • Albumin
    • Immunoglobulins
    • Fibrinogen
  • CALCIFICATION
  • INFECTION AND BIOFILMS
  • HOST IMMUNE RESPONSE
    • Wound Healing and Inflammation
    • Foreign Body Immune Reaction and Rejection
    • Complement Immune Response
  • RECENT ADVANCES IN ENABLING TECHNOLOGIES
    • BIOMIMETICS
    • NANOTECHNOLOGY
    • TISSUE ENGINEERING
    • STEM CELLS
    • BIOREACTOR TECHNOLOGY
• PATENT ANALYSIS
  • PATENTS BY TECHNOLOGY
    • Table 5 BIOCOMPATIBLE MATERIALS, ISSUED PATENTS BY TECHNOLOGY, JANUARY 2006-JANUARY 2007
    • Figure 1 BIOCOMPATIBLE MATERIALS, ISSUED PATENTS BY TECHNOLOGY, JANUARY 2006-JANUARY 2007 (%)
  • PATENTS BY MEDICAL APPLICATION
    • Table 6 BIOCOMPATIBLE MATERIALS, ISSUED PATENTS BY MEDICAL APPLICATION, JANUARY 2006-JANUARY 2007
    • Figure 2 BIOCOMPATIBLE MATERIALS, ISSUED PATENTS BY MEDICAL APPLICATION, JANUARY 2006-JANUARY 2007 (%)
  • PATENTS BY REGION/OR COUNTRY (DEPENDING ON DISTRIBUTION)
    • Table 7 BIOCOMPATIBLE MATERIALS, ISSUED PATENTS BY REGION, JANUARY 2006-JANUARY 2007
    • Figure 3 BIOCOMPATIBLE MATERIALS, ISSUED PATENTS BY COUNTRY, JANUARY 2006-JANUARY 2007 (%)
  • PATENTS BY ASSIGNEE
    • Table 8 BIOCOMPATIBLE MATERIALS, ISSUED PATENTS BY ASSIGNEE AFFILIATION, JANUARY 2006-JANUARY 2007
    • Figure 4 BIOCOMPATIBLE MATERIALS, ISSUED PATENTS BY ASSIGNEE AFFILIATION, JANUARY 2006-JANUARY 2007 (%)
    • Table 9 BIOCOMPATIBLE MATERIALS ISSUED PATENTS BY ASSIGNEE, JANUARY 2006-JANUARY 2007
    • Table 9 (CONTINUED)
    • Table 9 (CONTINUED)
    • Table 9 (CONTINUED)
    • Table 9 (CONTINUED)
      • PATENTS OF INTEREST
        • Patent Title: Triggered Release Hydrogel Drug Delivery System
        • Patent Title: Adaptive Memory Prioritization for Implanted Medical Devices
        • Patent Title: Coumarin Endcapped Absorbable Polymers
        • Bioabsorbable Polymeric Implants and a Method Of Using The Same to Create Occlusions
      • SPECIAL ISSUES IN CARDIAC STENT PATENTING
        • Special Issues in Cardiac ...(Continued)
• GOVERNMENT REGULATION
  • FDA REGULATION OF MEDICAL DEVICES
    • BIOMATERIALS ACCESS ASSURANCE ACT OF 1998
    • REGULATION OF TISSUE ENGINEERED PRODUCTS
    • FDA REGULATION OF GOOD TISSUE PRACTICES
    • GOVERNMENT REGULATION OF NANOMATERIALS
    • NEW FDA APPROVALS
      • Novel Hernia Repair Material
      • Low Pressure Perfusion Catheter
      • Real-Time Continuous Glucose Monitor
      • Omega-3 Fatty Acid Coated Mesh
      • Wireless Telemetry and Cardiac Rhythm Management Implants
        • Wireless Telemetry ... (Continued)
• MARKET FOR BIOCOMPATIBLE MATERIALS
  • Table 10 U.S. MARKET FORECAST FOR BIOCOMPATIBLE MATERIALS BY SEGMENT, THROUGH 2012 ($ MILLIONS)
    • IMPLANTABLE MEDICAL DEVICES
  • Table 11 U.S. MARKET FORECAST FOR IMPLANTABLE MEDICAL DEVICES BY SEGMENT, THROUGH 2012 ($ MILLIONS)
  • Figure 5 U.S. MARKET FOR IMPLANTABLE MEDICAL DEVICES, BY SEGMENT 2004-2012 ($ MILLIONS)
    • TISSUE REPLACEMENTS
  • Table 12 U.S. MARKET FORECAST FOR TISSUE REPLACEMENTS BY SEGMENT, THROUGH 2012 ($ MILLIONS)
  • Table 12 (CONTINUED)
  • Figure 6 U.S. MARKET FOR TISSUE REPLACEMENTS, BY SEGMENT 2004-2012 ($ MILLIONS)
    • SURFACE COATINGS
  • Table 13 U.S. MARKET FORECAST FOR BIOCOMPATIBLE SURFACE COATINGS BY SEGMENT, THROUGH 2012 ($ MILLIONS)
  • Figure 7 U.S. MARKET FOR BIOCOMPATIBLE SURFACE COATINGS BY SEGMENT, 2004-2012 ($ MILLIONS)
    • SURFACE COATINGS (CONTINUED)
• U.S. MARKET FOR BIOMATERIALS, BY APPLICATION
  • Table 14 U.S. MARKET FORECAST FOR BIOMATERIALS BY APPLICATION, THROUGH 2012 ($ MILLIONS)
  • Figure 8 U.S. MARKET FOR BIOMATERIALS, BY MEDICAL APPLICATION 2004-2012 ($ MILLIONS)
    • ORTHOPEDIC APPLICATIONS
  • Table 15 U.S. MARKET FOR ORTHOPEDIC BIOMATERIALS, BY SEGMENT THROUGH 2012 ($ MILLIONS)
  • Figure 9 U.S. MARKET FOR ORTHOPEDIC BIOMATERIALS, BY SEGMENT, 2004-2012 ($ MILLIONS)
    • BONE-PLATE MATERIALS
      • Bone-Plate Materials (Continued)
• HIP REPLACEMENTS
  • Hip Resurfacing
    • KNEE REPLACEMENTS
      • Non-constrained Implants
      • Semi-constrained Implants
      • Constraint or Hinged Implants
      • Unicondylar Knee Replacement
  • SPINAL IMPLANTS
    • Types of Spinal Implants
    • Disc Arthroplasty
  • THE MARKET FOR ORTHOPEDIC BIOMATERIALS
• CARDIOVASCULAR APPLICATIONS
  • Table 16 U.S. MARKET FORECAST FOR CARDIOVASCULAR BIOMATERIALS BY SEGMENT, THROUGH 2012 ($ MILLIONS)
  • CARDIAC PACEMAKERS
• IMPLANTABLE CARDIOVERTER DEFIBRILLATORS
  • Implantable Cardioverter ... (Continued)
• CARDIAC STENTS
  • Metal Stents
  • Drug-Eluting Stents (DES)
  • Rapamycin and Related Immunosuppressants
  • Paclitaxel
  • Drug-Eluting Stents And Complications
• HEART VALVES
  • Percutaneous Implant
• VASCULAR ACCESS DEVICES
  • Midline Catheter
• Peripherally Inserted Central Catheter (PICC)
  • Tunneled Catheter
  • Subcutaneous Port
• PERIPHERAL VASCULAR GRAFTS
  • Figure 10 U.S. MARKET FOR CARDIOVASCULAR BIOMATERIALS, BY SEGMENT 2004-2012 ($ MILLIONS)
    • WOUND MANAGEMENT APPLICATIONS
  • Table 17 U.S. MARKET FORECAST FOR WOUND MANAGEMENT BIOMATERIALS BY SEGMENT, THROUGH 2012 ($ MILLIONS)
  • Figure 11 U.S. MARKET FOR WOUND MANAGEMENT BIOMATERIALS BY SEGMENT, 2004-2012 ($ MILLIONS)
    • TISSUE SEALANTS AND HEMOSTATS
      • Bovine Serum/ Albumin/ Glutaraldehyde
      • Fibrin
      • Gelatin Matrix/ Thrombin Sealants
      • Polyethylene Glycol Hydrogels
  • ADHESION BARRIERS
• Table 18 TYPES OF ADHESION BARRIERS AND MANUFACTURERS
  • SKIN SUBSTITUTES
    • Skin Substitutes (Continued)
• Table 19 MAJOR SKIN SUBSTITUTE PRODUCTS
  • Skin Substitutes (Continued)
    • Genetically Modified Skin Cells
• GASTROINTESTINAL APPLICATIONS
  • Table 20 U.S. MARKET FORECAST FOR GASTROINTESTINAL BIOMATERIALS BY SEGMENT, THROUGH 2012 ($ MILLIONS)
  • Figure 12 U.S. MARKET FOR GASTROINTESTINAL BIOMATERIALS, BY SEGMENT, 2004-2012 ($ MILLIONS)
    • UROLOGICAL BIOMATERIALS
  • Table 21 U.S. MARKET FORECAST FOR UROLOGY BIOMATERIALS BY SEGMENT, THROUGH 2012 ($ MILLIONS)
    • URETERAL STENTS
    • URETHRAL STENTS
    • URINARY CATHETERS
      • Removal
      • Resistance to Encrustation
      • Biofilms
• Figure 13 U.S. MARKET FOR UROLOGY BIOMATERIALS BY SEGMENT, 2004-2012 ($ MILLIONS)
  • THE MARKET FOR UROLOGY BIOMATERIALS
    • PLASTIC SURGERY
• Table 22 U.S. MARKET FORECAST FOR PLASTIC SURGERY BIOMATERIALS BY SEGMENT, THROUGH 2012 ($ MILLIONS)
  • BREAST IMPLANTS
    • Saline-Filled Implants
    • Silicone Gel Implants
    • Safety Considerations
      • Breakage and Leakage
        • Breakage and Leakage (Continued)
  • Scarring
  • Platinum
  • INJECTABLE FILLERS
    • Zyderm and Zyplast Collagen
    • Fibrel
    • Artecoll
    • Hylan B Gel
    • Resoplast
    • Autologen
    • Isolagen
    • Dermalogen
    • AlloDerm
    • Fat Injections
• Table 23 COLLAGEN FILLERS
  • FACIAL IMPLANTS
    • Teflon
    • Polyethylene
    • Hydroxyapatite
• Figure 14 U.S. MARKET FOR PLASTIC SURGERY BIOMATERIALS, BY SEGMENT 2004-2012 ($ MILLIONS)
  • THE MARKET FOR PLASTIC SURGERY BIOMATERIALS
    • The Market for Plastic ... (Continued)
• ON THE HORIZON
  • BIOMATERIALS FOR GENE AND PROTEIN DELIVERY
  • ELECTROSPINNING SCAFFOLDS
• COMPANY PROFILES
  • ABIOMED, INC
  • ADVANCED BIONICS CORPORATION
  • ALLERGAN INC.
  • BAXTER INTERNATONAL INC.
  • BIOINTERACTIONS LTD.
  • BIOMET, INC
  • COCHLEAR CORPORATION
  • CONMED CORPORATION
  • DEPUY ORTHOPAEDICS, INC.
  • ENCORE ORTHOPEDICS
  • GUIDANT CORP.
  • INTERPORE CROSS INTERNATIONAL
  • JOHNSON & JOHNSON MEDICAL, INC
  • MEDICAL ELECTRONICS (MED-EL)
  • MEDTRONIC, INC.
  • MENTOR CORPORATION
  • MIV THERAPEUTICS
  • SOFAMOR DANEK GROUP
  • STAAR SURGICAL COMPANY
  • STRYKER CORPORATION
  • SULZER MEDICA
    • SULZER MEDICA (CONTINUED)
  • SYNTHES CORPORATION
  • THORATEC LABORATORIES
  • ZIMMER CORP.
• MARKET SHARE
  • MARKET SHARE OF MAJOR COMPANIES' IMPLANTABLE MEDICAL DEVICES
• Table 24 MARKET SHARE OF MAJOR COMPANIES' IMPLANTABLE MEDICAL DEVICES (%)
• Figure 15 MARKET SHARE OF MAJOR COMPANIES IN IMPLANTABLE MEDICAL DEVICES (%)
  • MARKET SHARE OF MAJOR COMPANIES IN TISSUE REPLACEMENTS BIOMATERIALS
• Table 25 MARKET SHARE OF MAJOR COMPANIES IN TISSUE REPLACEMENTS (%)
• Figure 16 MARKET SHARE OF MAJOR COMPANIES IN TISSUE REPLACEMENTS (%)
  • MARKET SHARE OF MAJOR COMPANIES IN SURFACE COATINGS
• Table 26 MARKET SHARE OF MAJOR COMPANIES IN SURFACE COATINGS (%)
• Figure 17 MARKET SHARE OF MAJOR COMPANIES IN SURFACE COATINGS (%)
• LIST OF TABLES
  • Summary Table:
  • U.S. MARKET FORECAST FOR BIOCOMPATIBLE MATERIALS BY SEGMENT, THROUGH 2012 ($ MILLIONS)
  • Table 1 COMMON BIOCOMPATIBLE CERAMICS
  • Table 2 COMMON BIOCOMPATIBLE METALS
  • Table 3 COMMON BIOCOMPATIBLE POLYMERES
  • Table 4 COMMON BIOCOMPATIBLE NATURAL MATERIALS
  • Table 5 BIOCOMPATIBLE MATERIALS, ISSUED PATENTS BY TECHNOLOGY, JANUARY 2006-JANUARY 2007
  • Table 6 BIOCOMPATIBLE MATERIALS, ISSUED PATENTS BY MEDICAL APPLICATION, JANUARY 2006-JANUARY 2007
  • Table 7 BIOCOMPATIBLE MATERIALS, ISSUED PATENTS BY REGION, JANUARY 2006-JANUARY 2007
  • Table 8 BIOCOMPATIBLE MATERIALS, ISSUED PATENTS BY ASSIGNEE AFFILIATION, JANUARY 2006-JANUARY 2007
  • Table 9 BIOCOMPATIBLE MATERIALS ISSUED PATENTS BY ASSIGNEE, JANUARY 2006-JANUARY 2007
  • Table 10 U.S. MARKET FORECAST FOR BIOCOMPATIBLE MATERIALS BY SEGMENT, THROUGH 2012 ($ MILLIONS)
  • Table 11 U.S. MARKET FORECAST FOR IMPLANTABLE MEDICAL DEVICES BY SEGMENT, THROUGH 2012 ($ MILLIONS)
  • Table 12 U.S. MARKET FORECAST FOR TISSUE REPLACEMENTS BY SEGMENT, THROUGH 2012 ($ MILLIONS)
  • Table 13 U.S. MARKET FORECAST FOR BIOCOMPATIBLE SURFACE COATINGS BY SEGMENT, THROUGH 2012 ($ MILLIONS)
  • Table 14 U.S. MARKET FORECAST FOR BIOMATERIALS BY APPLICATION, THROUGH 2012 ($ MILLIONS)
  • Table 15 U.S. MARKET FOR ORTHOPEDIC BIOMATERIALS, BY SEGMENT THROUGH 2012 ($ MILLIONS)
  • Table 16 U.S. MARKET FORECAST FOR CARDIOVASCULAR BIOMATERIALS BY SEGMENT, THROUGH 2012 ($ MILLIONS)
  • Table 17 U.S. MARKET FORECAST FOR WOUND MANAGEMENT BIOMATERIALS BY SEGMENT, THROUGH 2012 ($ MILLIONS)
  • Table 18 TYPES OF ADHESION BARRIERS AND MANUFACTURERS
  • Table 19 MAJOR SKIN SUBSTITUTE PRODUCTS
  • Table 20 U.S. MARKET FORECAST FOR GASTROINTESTINAL BIOMATERIALS BY SEGMENT, THROUGH 2012 ($ MILLIONS)
  • Table 21 U.S. MARKET FORECAST FOR UROLOGY BIOMATERIALS BY SEGMENT, THROUGH 2012 ($ MILLIONS)
  • Table 22 U.S. MARKET FORECAST FOR PLASTIC SURGERY BIOMATERIALS BY SEGMENT, THROUGH 2012 ($ MILLIONS)
  • Table 23 COLLAGEN FILLERS
  • Table 24 MARKET SHARE OF MAJOR COMPANIES' IMPLANTABLE MEDICAL DEVICES (%)
  • Table 25 MARKET SHARE OF MAJOR COMPANIES IN TISSUE REPLACEMENTS (%)
  • Table 26 MARKET SHARE OF MAJOR COMPANIES IN SURFACE COATINGS (%)
• LIST OF FIGURES
  • Summary Figure:
  • U.S. MARKET FOR BIOCOMPATIBLE MATERIALS, BY SEGMENT 2004-2012 ($ MILLIONS)
  • Figure 1 BIOCOMPATIBLE MATERIALS, ISSUED PATENTS BY TECHNOLOGY, JANUARY 2006-JANUARY 2007 (%)
  • Figure 2 BIOCOMPATIBLE MATERIALS, ISSUED PATENTS BY MEDICAL APPLICATION, JANUARY 2006-JANUARY 2007 (%)
  • Figure 3 BIOCOMPATIBLE MATERIALS, ISSUED PATENTS BY COUNTRY, JANUARY 2006-JANUARY 2007 (%)
  • Figure 4 BIOCOMPATIBLE MATERIALS, ISSUED PATENTS BY ASSIGNEE AFFILIATION, JANUARY 2006-JANUARY 2007 (%)
  • Figure 5 U.S. MARKET FOR IMPLANTABLE MEDICAL DEVICES, BY SEGMENT 2004-2012 ($ MILLIONS)
  • Figure 6 U.S. MARKET FOR TISSUE REPLACEMENTS, BY SEGMENT 2004-2012 ($ MILLIONS)
  • Figure 7 U.S. MARKET FOR BIOCOMPATIBLE SURFACE COATINGS BY SEGMENT, 2004-2012 ($ MILLIONS)
  • Figure 8 U.S. MARKET FOR BIOMATERIALS, BY MEDICAL APPLICATION 2004-2012 ($ MILLIONS)
  • Figure 9 U.S. MARKET FOR ORTHOPEDIC BIOMATERIALS, BY SEGMENT, 2004-2012 ($ MILLIONS)
  • Figure 10 U.S. MARKET FOR CARDIOVASCULAR BIOMATERIALS, BY SEGMENT 2004-2012 ($ MILLIONS)
  • Figure 11 U.S. MARKET FOR WOUND MANAGEMENT BIOMATERIALS BY SEGMENT, 2004-2012 ($ MILLIONS)
  • Figure 12 U.S. MARKET FOR GASTROINTESTINAL BIOMATERIALS, BY SEGMENT, 2004-2012 ($ MILLIONS)
  • Figure 13 U.S. MARKET FOR UROLOGY BIOMATERIALS BY SEGMENT, 2004-2012 ($ MILLIONS)
  • Figure 14 U.S. MARKET FOR PLASTIC SURGERY BIOMATERIALS, BY SEGMENT 2004-2012 ($ MILLIONS)
  • Figure 15 MARKET SHARE OF MAJOR COMPANIES IN IMPLANTABLE MEDICAL DEVICES (%)
  • Figure 16 MARKET SHARE OF MAJOR COMPANIES IN TISSUE REPLACEMENTS (%)
  • Figure 17 MARKET SHARE OF MAJOR COMPANIES IN SURFACE COATINGS (%)