[Report] Drug Discovery Technologies TOC

Drug Discovery Technologies
Chapter 1 - EXECUTIVE SUMMARY
- Summary Table: REVENUES FOR SELECTED DRUG DISCOVERY-RELATED PRODUCTS, WORLDWIDE FORECAST, THROUGH 2012 ($ MILLIONS)
- Summary Figure: REVENUES FOR SELECTED DRUG DISCOVERY-RELATED PRODUCTS, WORLDWIDE FORECAST, 2006-2012 ($ MILLIONS)
  - DRUG DISCOVERY TECHNOLOGIES AND R&D EFFORTS
  - OVERALL DRUG DISCOVERY MARKET TO 2012
Chapter 2 - OVERVIEW
- OVERVIEW
- GOVERNMENT REGULATIONS
  - INTRODUCTION
  - DRUG DISCOVERY
  - PRECLINICAL TESTING AND SUBMISSION OF AN IND
  - CLINICAL TRIALS
  - TIMELINE AND COSTS
  - SUBMISSION OF NDA OR BLA
  - POST-FDA APPROVAL
  - NEW DRUG APPROVALS
- Figure 1 FDA APPROVALS OF NEW MOLECULAR ENTITIES SINCE 1993
- Table 1 NEW MOLECULAR ENTITIES APPROVED BY THE FDA, 1990-OCTOBER 2007
  - DO CURRENT CORPORATE MANAGEMENT PRACTICES HAVE A ROLE IN R&D SHORTFALLS?
    - Blockbuster Drugs
- Table 2 NME APPROVALS BY DISORDER, 2004-OCTOBER 30, 2007
  - Other Successful Therapeutic Agents
- Table 3 BOTOX SALES, 1993-2012 ($ MILLIONS)
  - IS THE NIH FUNDING CRISIS CONTRIBUTING TO SHORTFALLS IN DRUG DISCOVERY?
  - IS THE NIH FUNDING CRISIS CONTRIBUTINGý(CONTINUED)
Chapter 3 - TRENDS IN BIG PHARMA DRUG DISCOVERY AND INVESTMENTS IN DRUG DISCOVERY
- BIG PHARMA
- Table 4 THE WORLD PHARMACEUTICALS MARKET, THROUGH 2012 ($ BILLIONS)
- Figure 2 THE WORLD PHARMACEUTICALS MARKET, 2005-2012 ($ BILLIONS)
  - BIG PHARMA (CONTINUED)
- Table 5 COMPARATIVE PERCENTAGES OF REVENUES AT THE SIX LARGEST U.S. PHARMACEUTICAL COMPANIES
- Table 6 COMPARISON OF FDA APPOVED NME DRUGS DEVELOPED IN HOUSE OR THROUGH IN-LICENSING, 2006 AND H1 2007
  - VENTURE CAPITAL
    - VENTURE CAPITAL (CONTINUED)
Chapter 4 - LIQUID CHROMATOGRAPHY (LC)
- Table 7 WORLD MARKETS FOR HPLC, THROUGH 2012 ($ MILLIONS)
- Figure 3 WORLD MARKETS FOR HPLC, 2006-2012 ($ MILLIONS)
  - HPLC AND UHPLC: THEORY
    - HPLC AND UHPLC: THEORY (CONTINUED)
  - ULTRA-HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (UHPLC, UPLC)
  - HPLC & UPLC INSTRUMENTS
    - Sample Injection Systems
    - Pumps
    - Columns
  - DRIVERS OF GROWTH IN LIQUID CHROMATOGRAPHY SYSTEMS
    - Proteomics Research
    - FDA and Other Regulatory Body Requirements
    - Drug Discovery Research in Small and Medium Sized Companies
    - The Growth of the Research Enterprise Overseas
    - New Instrument Designs
  - CHALLENGES TO GROWTH IN LIQUID CHROMATOGRAPHY SYSTEMS
    - Technology Maturity
    - Throughput Speed
    - Stagnation and/or Reduction of the NIH Budget
  - MARKET LEADERS
- Table 8 MARKET LEADERS IN HPLC, 2006 (%)
Chapter 5 - MASS SPECTROMETRY (MS)
- Table 9 MARKETS FOR MASS SPECTROMETRY, THROUGH 2012 ($ MILLIONS)
- Figure 4 MARKETS FOR MASS SPECTROMETRY, 2006-2012 ($ MILLIONS)
  - MASS SPECTROMETRY (CONTINUED)
- Table 10 MARKET LEADERS IN MASS SPECTROMETRY, 2006 (%)
  - MASS SPECTROMETRY: THEORY AND INSTRUMENT TYPES
    - IONIZATION SOURCES
      - Matrix-assisted Laser Desorption/Ionization (MALDI)
      - Electropsray Ionization (ESI)
      - Atmospheric Pressure Chemical Ionization (APCI)
    - MASS ANALYZERS
- Table 11 TYPES OF MASS SPECTROMETRY ANALYZERS USED IN PHARMACEUTICAL APPLICATIONS
  - Quadrupole
  - Time-of-Flight Mass Spectrometry
  - Quadrupole-Time-of-Flight (Q-TOF)
- Table 12 SELECTED Q-TOF MODELS
  - ION TRAP MASS SPECTROSCOPY
- Table 13 SELECTED ION TRAP MASS SPECTROMETER MODELS
  - DRIVERS OF GROWTH AND CHALLENGES IN MASS SPECTROMETRY
    - Drivers of Growth and Challengesý(Continued)
Chapter 6 - COMPANY PROFILES: LIQUID CHROMATOGRAPHY AND MASS SPECTROMETRY
- COMPANY PROFILES
  - DETAILED PROFILES
    - Agilent Technologies
    - Applera Corp.
    - Applied Biosystems
    - Beckman Coulter
    - Bruker Daltonics
    - Dionex
    - Eksigent
    - ESA Biosciences
    - Jasco, Inc.
    - JEOL USA
    - MDS Sciex
    - PerkinElmer Corporation
    - Phenomenex Corporation
    - Shimadzu
    - Thermo Fisher Scientific
    - Varian, Inc.
    - Waters Corp.
  - BRIEF PROFILES
    - Aapttec LLC
    - Advanced Chemistry Development, Inc. (ACD/Labs)
    - Advanced Chromatography Technologies (ACE)
    - Advanced Scientific Instruments: See Knauer
    - Advanced Separation Technologies (Astec)
    - Advion
    - Alpha Omega Technologies
    - Ametek Process and Analytical Instruments (Ametek PI)
    - Ampersand International, Inc.
    - Analytical Scientific Instruments, Inc. (ASI)
    - Applied Research Europe GmbH
    - Ardara Technologies, LP
    - B/R Instrument Corporation
    - Bischoff Chromatography
    - BioTrove
    - BSG, Inc.
    - Burle Electro-Optics/ Photonis Group
    - Cecil Instruments Ltd.
    - Cerno Bioscience
    - Chrom Tech, Inc.
    - Dychrom
    - ES Industries
    - Gilson
    - International Equipment Trading (IET) Ltd.
    - IonSense, Inc.
    - Ion Square Technology, Inc.
    - Isolation Technologies, Inc.
    - Justrite Manufacturing Co.
    - Knauer/Advanced Scientific Instruments
    - Konik Instruments
    - Kromasil/Akzo Nobel
    - Lab Alliance/Scientific Systems Inc. (SSI)
    - Macherey-Nagel, GmbH & Co. KG
    - Moeller Medical GmbH
    - Molnar Institute
    - NCSRT Inc.
    - Nova Biotech
    - Ocean Optics Inc.
    - Optimize Technologies Inc.
    - Phytronix Technologies, Inc.
    - Quantum Analytics
    - Sonntek
    - Spark Holland BV
    - SRI Instruments
    - VICI Valco Instruments Company Inc.
    - YMC Ltd.
    - Zinsser Analytic GmbH
Chapter 7 - HIGH CONTENT SCREENING (HCS)
- Table 14 MARKETS FOR HCS, THROUGH 2012 ($ MILLIONS)
- Figure 5 MARKETS FOR HCS, 2006-2012 ($ MILLIONS)
  - HCS: THEORY
- Table 15 HCS INSTRUMENT LINES
- Table 16 MARKET LEADERS IN HCS INSTRUMENTS, 2006
  - DRIVERS OF GROWTH IN HCS
    - Information Output
    - The Growth of Contract Research Organizations (CROs)
    - The Growth of the Research Enterprise Overseas
    - Requirements for Pathway Knowledge
  - CHALLENGES TO GROWTH IN HCS
    - Costs
    - Drug Discovery Research in Small- and Medium Sized Companies
    - Stagnation and/or Reduction of the NIH Budget
    - Complexity
  - COMPANY PROFILES
    - CELLOMICS/THERMO FISHER
    - GE HEALTHCARE
    - COMPUCYTE CORPORATION
    - TTP LABTECH
    - EVOTEC TECHNOLOGIES/PERKINELMER
    - IMSTAR SA
Chapter 8 - BIOINFORMATICS
- BIOINFORMATICS
- Table 17 THE U.S. MARKET FOR BIOINFORMATICS SOFTWARE APPLICATIONS AND DATABASES/KNOWLEDGE BASES, THROUGH 2012 ($ MILLIONS)
- Figure 6 THE U.S. MARKET FOR BIOINFORMATICS SOFTWARE APPLICATIONS AND DATABASES/KNOWLEDGE BASES, 2006-2012 ($ MILLIONS)
  - WHAT IS BIOINFORMATICS?
    - The First Wave of Bioinformatics Companies: Lessons Learned
- Table 18 ANNUAL BIOINFORMATICS-RELATED REVENUES AT SELECTED COMPANIES, 2000-2007 ($ MILLIONS, ROUNDED)
- Table 19 FREE MAJOR ONLINE SOURCES OF GENOMIC AND PROTEOMIC INFORMATION
- Table 20 SOME COMMERICAL SOURCES OF GENOMIC AND PROTEOMIC INFORMATION
- Table 20 (CONTINUED)
  - The Second Wave of Bioinformatics Companies: Lessons Applied in a Difficult Market
- Table 21 BIOINFORMATICS: MARKET LEADERS AND STRUGGLING COMPANIES
  - The Second Wave ofý(Continued)MICROARRAYS: COMBINING BIOINFORMATICS AND BENCH RESEARCH
- Table 22 MARKETS FOR COMMERCIAL MICROARRAYS ($ MILLIONS)
  - Microarrays: Combiningý(Continued)
- OPEN SOURCE TOOLS AND IN-HOUSE BIOINFORMATICS
  - Bioinformatics Software Not Related to Drug Discovery
- EMPLOYMENT OUTLOOK IN BIOINFORMATICS
  - Employment Outlook in ý (Continued)
- TYPICAL DEVELOPMENT PATTERNS IN BIOINFORMATICS
- GAPS IN BIOINFORMATICS
  - GAPS IN BIOINFORMATICS (CONTINUED)
- FUTURE TRENDS IN BIOINFORMATICS
- COMPANY PROFILES
  - ACCELRYS, INC. (NASDAQ: ACCL)
  - AFFYMETRIX, INC.
  - GENE LOGIC, INC.
  - GEOSPIZA
  - INCYTE
  - PROTEOME SYSTEMS
  - SPOTFIRE
  - VIZX LABS, INC.
  - VLST CORPORATION
  - VLST Corporation (Continued)
Chapter 9 - SYSTEMS BIOLOGY
- SYSTEMS BIOLOGY
- Table 23 THE MARKET FOR SYSTEMS BIOLOGY ($ MILLIONS)
  - CATEGORIES OF SYSTEMS BIOLOGY COMPANIES
    - Pathway providers
    - Model Makers
  - USES OF SYSTEMS BIOLOGY
    - Uses of Systems Biology (Continued)
- Table 24 SYSTEMS BIOLOGY COMPANIES ($ MILLIONS)
  - CHALLENGES IN SYSTEMS BIOLOGY
  - COMPANY PROFILES
  - ARIADNE GENOMICS
  - BG MEDICINE
  - BIOSEEK
  - ENTELOS (LONDON AIM: ENTL)
  - GENEGO
  - GENE NETWORK SCIENCES (GNS)
  - GENOMATICA
  - GENSTRUCT
  - INGENUITY SYSTEMS
Chapter 10 - U.S. PATENT ANALYSIS
- INTRODUCTION
- HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC)
- GENERAL TRENDS
- Table 25 HPLC-RELATED TECHNOLOGY: U.S. PATENT TRENDS, 5/2002-8/2007
- Table 26 MS-RELATED PATENTS BY USE CATEGORY
  - TRENDS BY ASSIGNEE
- Table 27 HPLC-RELATED PATENTS BY ASSIGNEE CATEGORY
- Table 28 HPLC-RELATED PATENTS BY COMPANY
  - PATENT APPLICATION TRENDS
- Table 29 HPLC-RELATED TECHNOLOGY, U.S. PATENT APPLICATION TRENDS, 2001-8/2/2007
- Table 30 HPLC-RELATED TECHNOLOGY: U.S. PATENT APPLICATION TRENDS BY FILING DATE, 1997-8/2007
- Table 31 MS-RELATED PATENTS BY USE CATEGORY
  - MASS SPECTROMETRY (MS)
- Table 32 MS-RELATED TECHNOLOGY: U.S. PATENT TRENDS, 1976-8/7/2007
  - GENERAL TRENDS
- Table 33 MS-RELATED PATENTS BY USE CATEGORY
  - TRENDS BY ASSIGNEE
- Table 34 MS-RELATED PATENTS BY ASSIGNEE CATEGORY
- Table 35 MS-RELATED PATENTS BY COMPANY
  - PATENT APPLICATION TRENDS
- Table 36 MS-RELATED TECHNOLOGY, U.S. PATENT APPLICATION TRENDS, 2001-8/2/2007
- Table 37 MS-RELATED TECHNOLOGY, U.S. PATENT APPLICATION TRENDS BY FILING DATE, 1997-8/2007
- Table 38 MS-RELATED PATENTS BY USE CATEGORY
  - PATENT APPLICATION TRENDS (CONTINUED)
Chapter 11 - APPENDIX A: SELECTION OF OPEN-ACCESS AND FEE-BASED SOURCES FOR GENOMIC AND PROTEOMIC DATA
- GENOMICS-RELATED DATABASES
- PROTEOMICS DATABASES
  - PROTEIN INTERACTION DATABASES (INTERACTOME DATABASES)
    - Other Proteomics Databases
  - SYSTEMS BIOLOGY
  - OTHER DATABASES USEFUL FOR DRUG DISCOVERY:

Drug Discovery Technologies

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