[Report] Commercial Biotechnology Review TOC

Title

INTRODUCTION/SUMMARY

CONFERENCE REPORT

RECORD ATTENDANCE AT BIO 2000

BASIC RESEARCH

THE SMALLEST MOVING MACHINE
HARBINGER OF DEATH TRAVELS TO NUCLEUS
FRAGMENT SERVES AS NUCLEAR MESSENGER
SUGAR STRUCTURES PROMOTE METASTASES
MAST CELLS LINKED TO MULTIPLE SCLEROSIS
CONTROLLING TRANSCRIPTION IN SPECIFIC TISSUES
END-JOINING PROTEIN PROTECTS BRAINS CELLS
COMPLEMENT NECESSARY FOR ARTHRITIS
COMPLEMENT’S ROLE IN CARDIOVASCULAR DISEASE

BASIC SCIENCE

PRIONS IN YEAST, MICE AND MAN
SMAD6 REPORTS LATEST RESULTS
BITTER TASTE RECEPTORS IDENTIFIED
METHYLATION FACILITATES TUMOR PROGRESSION
CALPAIN IMPLICATED IN ALZHEIMER’S
38,000 PRODUCTS FROM ONE GENE
MITOCHONDRIAL DEFECTS LINKED TO ALZHEIMER’S
NEW THEORY OF HIV ACTION PROPOSED
GATEKEEPER CONTROLS PROTEIN INSERTION
"ONE HIT" MODEL OF NEURON DEATH
MUTANT PROTEINS IN HUNTINGTON’S DISEASE
CALCIUM MODULATOR FENDS OFF ALZHEIMER’S
GENETIC PATHWAY IN CARDIAC DEATH
ORPHAN RECEPTORS CONTROL CHOLESTEROL
BUILDING BLOOD VESSELS FOR TUMORS
SV40, ASBESTOS CAUSE MESOTHELIOMA
MOUSE MODEL OF MULTIPLE NEOPLASIA
PROPERTIES OF A STEM CELL NURSERY
MOLECULE HELPS PREVENT ALZHEIMER’S
MUSCLE SEEKS COMPATIBLE NERVE
RIBAVIRIN MUTATES RNA VIRUSES
PLASMINOGEN BINDS PRIONS
RNA EDITING NEEDED FOR EMBRYOGENESIS

GENE THERAPY

PROTEINS DELIVERED BY DISAGGREGATION
NAKED GENE DELIVERY SERVICE
DNA EDITING PATENT GRANTED
FGF-4 HELPS FIX DAMAGED HEARTS
A TB STRAIN THAT CAN’T CAUSE TB
UV-INDUCED APOPTOSIS GENES IDENTIFIED
CIRCADIAN RHYTHM MUTATION EXPLAINED
SUSCEPTIBILITY GENE FOR SCHIZOPHRENIA
SUPPRESSOR GENES ARE PATENTED
DEL-1 INDUCES ANGIOGENESIS
BETTER ALTERNATIVE TO NAKEDNESS
HEAT-ACTIVATED GENE THERAPY
HIV ANTISENSE GENE THERAPY
ENBREL GENE USED AGAINST RHEUMATOID ARTHRITIS
FILAMENTOUS PHAGE VECTORS PATENTED
GDNF GENE FOR PARKINSON’S DISEASE
E1A GENE/CHEMOTHERAPY COMBINATION PATENTED
CANAVAN TRIAL CALLED PROMISING
NAKED DNA FOR AUTOIMMUNE DISEASES
BACULOVIRUS VECTOR USED IN MAMMALS
REOVIRUS PATENTED AS CANCER REMEDY
TARGETED GENETICS WINS PATENT
GENE THERAPY CHAIR AT UCSD
STENTS USED TO DELIVER GENES
GENE THERAPY HALTS CARDIAC ARRHYTHMIA

GENOMICS

GENOMICS MARKET SOARING IN THE NEXT DECADE
CHANGING WHITE HAIRS TO BLACK
TYPE-2 DIABETES GENE DISCOVERED
UNIVERSAL CLONING TECHNOLOGY PATENTED
GENE EXPRESSED IN LUNG CANCER
WATCH THE DNA DANCE
MUTATIONS CAUSE EYE DISORDER
DUPLICATED REGIONS INDICATE AUTISM
GENE DEFECTS PRECEDE DEGENERATION
CHIP DISTINGUISHES LYMPHOMA TYPES
PATENTS FILED ON 10,000 SEQUENCES
INTERLEUKIN-1 VARIANTS LINKED TO ALZHEIMER’S
PANNING FOR GOLD IN THEM THAREGENOMES
HOT SPOTS LEAD TO DELETIONS
NEWFOUND PLUMBS NEWFOUNDLAND GENES
ANALYZING HGSI’S GENE COLLECTION
HUMAN GENOME SEQUENCING COMPLETED
GENETIC MUTATIONS LINKED TO EPILEPSY
CORRELATING SNPS WITH BREAST CANCER
GENETICS AND GENOMICS CHANNEL ON WEBMD
INTERLEUKIN-1 VARIATIONS INCREASE RISK OF RESTENOSIS
OLFACTORY RECEPTOR GENES IDENTIFIED
CHILDREN RELEASED FROM BUBBLE
LIPID DELIVERY OF GENES
APOE EXPRESSION LINKED TO STROKES
GENE BLOCKS BREAST CANCER METASTASIS
GENE LINKED TO ENDOTOXIN RESPONSE
INFECTED FROGS REVEAL TB TRICKS
FROZEN MITOCHONDRIA TO BE SEQUENCED
CASPASE 8 SILENCED IN NEUROBLASTOMA
GENE FOUND FOR LYMPHEDEMA
APOE-4 PREVENTS KIDNEY DAMAGE
CHECKPOINT GENE DISCOVERED
BARDET-BIEDLE GENE IDENTIFIED
CARDIOVASCULAR DRUG TARGET IDENTIFIED
TISSUE BANK FOR GENOMICS RESEARCHERS
LATE-ONSET PARKINSON’S DISEASE GENE FOUND
BRCA MUTATIONS ENHANCE RISK
SUSCEPTIBILITY GENE FOR TYPE-2 DIABETES
INSULIN, OBESITY, INFERTILITY LINKED
IGA NEPHROPATHY IS INHERITED
DETECTING ABNORMALITIES IN CHROMOSOMES
ZINC FINGER REGULATES LIPIDS
TOUCH DETECTOR DISCOVERED
ALZHEIMER’S-RELATED GENES FOUND
TOXIN-LOVING BACTERIA SEQUENCED
SITOSTEROLEMIA GENES DISCOVERED
REGIONS MAPPED FOR ARTERY DISEASE
ATM LINKED TO ATAXIA-TELANGIECTASIA
GENETIC CAUSE OF TYPE-1 DIABETES
SCREENING FOR DISEASE GENES

ANTIBODIES

THE AGE OF THE ANTIBODY HAS COMMENCED
BIOLOGICS LICENSE FILED FOR CAMPATH
MARYLAND WINS GRANT FOR HEART RESEARCH
MACROPHAGE MONOCLONAL FIGHTS INFLAMMATION
SEARLE AND CAMBRIDGE COMBINE EFFORTS
SYNTHETIC ANTIBODY SUBSTITUTES PRODUCED
ANTI-ANGIOGENIC THERAPY REDUCES TUMORS
ANTI-PROPERDIN ANTIBODY REDUCES INFLAMMATION
ZONULIN ELEVATED IN CELIAC DISEASE
ABGENIX, GENZYME GET TOGETHER
ALLIANCE COMBINES ANTIBODY TECHNOLOGIES
BLENDED IMMUNE SYSTEM ESTABLISHED IN HUMANS
BLYS TO ENTER CLINICAL TRIALS
ANTI-CD18 FAILS AS HEART TREATMENT
ANTI-FACTOR D FOR BYPASS TREATMENT
ANTI-GNRH PATENT GRANTED
ANTIBODY/RECEPTOR STRUCTURE SOLVED
MODIFIED ANTIBODIES CROSS CELL BARRIERS
ABGENIX GETS PRODRUG TECHNOLOGY
ANTIBODIES TO PROSTATE ANTIGEN PATENTED
PLANTIBODIES TO PREVENT STDS
CAT LICENSES ANTIBODY TECHNOLOGY
PREVENTING PSEUDOMONAS-INDUCED PNEUMONIA
NATURAL ANTIBODIES REGENERATE NERVES
ALLIANCE CREATES 250 ANTIBODIES
SCREENING IMPROVES ANTIBODY GENERATION
RIBONUCLEASE KILLS LYMPHOMA CELLS
THERAPY FOR RARE STOMACH ILLNESS

ANTISENSE AND RIBOZYMES

PATENTS GRANTED FOR ANTISENSE
RIBOZYMES ADVANCE DOWN THE PIPELINE
ANTISENSE POTENT AGAINST P53
ANTIBODIES USED TO DELIVER DRUGS
ISIS PROMULGATES PATENT PLETHORA
ORALLY ADMINISTERED ANTISENSE DRUGS
NEW GENERATION OF RIBOZYMES UNLEASHED
BAYLOR, CYTOGENIX TO COLLABORATE
FAS ANTISENSE BENEFITS HEPATITIS PATIENTS
INHIBITION OF PTP-1B REDUCES GLUCOSE LEVELS
TELOMERASE COMPOUND EFFECTIVE AGAINST TUMORS
HERE’S HOW RNA INTERFERENCE WORKS

BIOMANUFACTURING

U.S. MARKETS FOR MEDIA, SERA AND REAGENTS SHOWING POSITIVE TRENDS
HIGH YIELDS OF A FUSION PROTEIN
RADIOLABELING PATENT GRANTED
NEW VENTURE IS EGG-ZITING
CHLOROPLASTS MAKE HUMAN PROTEINS
PEPTIDES HARVESTED FROM CULTURE MEDIUM
CATALYTICA FORMS INDUSTRIAL UNIT
HYPERSPEED EVOLUTION OF ENZYMES
PURIFYING ANTIBODIES DERIVED FROM PLANTS
PLANT PROTEASES WIN PATENT
MICROORGANISMS TO PRODUCE CHEMICALS
CHICKENS TO LAY GOLDEN EGGS

EVOLUTION

RNA MAY REGULATE DEVELOPMENT
BIPED REPTILE PRECEDED DINOSAURS
LONG LIVE THE METHUSELAH BUG

CELL THERAPY

MIXED CHIMERISM PATENT AWARDED
GRANT AWARDED TO CELL BASED DELIVERY
PATENT FOR ENGRAFTABLE NEURAL STEM CELLS
ORTEC, MIT IN TISSUE-ENGINEERING PACT
STEM CELLS REVERSE DIABETES IN MICE
GROWING A BLADDER REPLACEMENT
REPLICATING BONE FORMING CELLS
PREVENTING BONE MARROW TRANSPLANT RELAPSE
DERMAGRAFT STIMULATES ANGIOGENESIS IN HEARTS
CORD BLOOD CELLS FOR LEUKEMIA VICTIMS
REGULATING STEM-CELL DIFFERENTIATION
LIVER CELLS FROM BLOOD STEM CELLS
NEURAL STEM CELLS MAKE MORE THAN NERVES
CORD BLOOD STEM CELLS EXPAND IN CULTURE
GROWING A NEW HEART
GROWING LIVER CELLS IN VITRO
PRIMATE GETS MISMATCHED PANCREATIC ISLETS
UNLIMITED PRODUCTION BETA CELLS ENVISIONED
APLIGRAF APPROVED FOR DIABETIC FOOT ULCERS
HUMAN STEM CELL COLLABORATION
LIVER CELLS COME FROM THE MARROW
T-CELLS HELP PREVENT REJECTION
DENDRITIC CELLS TO BE MASS-PRODUCED
ISLET TRANSPLANTATION TO BE SUPPORTED
NEW GUIDELINES FOR STEM CELL RESEARCH
PIG CELLS FIX RAT SPINAL CORDS
ENDOGENOUS RETROVIRUS NOT TRANSMITTED
ANGIOBLASTS RESTORE DIABETIC CIRCULATION
3D BIOREACTOR PATENT ISSUED
ALTERED CD4+ CELLS ENGRAFT INTO MARROW
FETAL CELLS ENGRAFT INTO THE MOTHER
SAVE YOUR TUMOR CELLS
EXPANSION OF HEPATIC STEM CELLS REPORTED
STEM CELLS REPAIR SPINAL CORD INJURIES
GROWTH SWITCH PRODUCES DIFFERENTIATION

HORMONES AND CYTOKINES

ANGIOPOIETINS INDUCE BLOOD VESSEL REPAIR
RELAXIN MAY TREAT INFERTILITY
HEPATITIS-B VACCINE PREVENTS LIVER CANCER
NICOTINE VACCINE APPEARS EFFECTIVE
CULTIVATION OF A TICK-BORNE PATHOGEN
GROWING BONES IN SPACE
IL-1 ANTAGONIST LINKED TO CORONARY DISEASE
ANTI-ANGIOGENIC AGENTS ABOUND
ALTERNATIVE PROTEIN EXPORT PATHWAY
CAUSING GENETIC ANXIETY IN MICE
IMMUNOSUPPRESSION IN LUPUS MODEL
RELAXIN IS POTENTIAL HYPERTENSION DRUG
ACTIVATED PROTEIN C SHOWS PROWESS
IL-6 POLYMORPHISM OSTEOPOROSIS LINKED
BONZO GETS A MATE
"SLIPPY" HEALS WHAT AILS YOU
BLYS LEVELS ELEVATED IN LUPUS
INTERLEUKIN-21 CRITICAL FOR IMMUNE RESPONSES
NEUROTROPHIN ACTIVE AGAINST OBESITY
VEGF-138 STIMULATES ENDOTHELIAL CELLS

CLONING

PATENT AWARDED FOR DOLLY’S TECHNOLOGY
DUMB HUMAN PET TRICKS
PIGS CLONED FOR THE FIRST TIME
SOME PIGS ARE MORE EQUAL THAN OTHERS
RETURN TO THE FUTURE
HAPPY BIRTHDAY TO SECOND CHANCE
BRINGING BACK ENDANGERED SPECIES
JAPANESE BAN HUMAN CLONING

ENZYMES

ENZYME IS TARGET FOR CANCER DRUG
RIBONUCLEASE KILLS LYMPHOMA CELLS
SERINE RACEMASE IS A DRUG TARGET
PTEN PHOSPHATASE DIABETES DRUG TARGET
PHARMING PATENTS ALPHA-GLUCOSIDASE
UNCLOG YOUR CATHETER WITH ALTEPLASE
HURLER SYNDROME ENZYME PATENTED

INDUSTRY NEWS

WORLDWIDE MARKET FOR APOPTOSIS-RELATED PRODUCTS TO CROSS $529 MILLION BY 2005
WORLDWIDE MARKET FOR MOLECULAR DIAGNOSTIC AND CYTOGENETIC DISEASE TESTING ON THE RISE
BURRILL SUMS UP THE FOURTH QUARTER
IMMORTALITY IS AT HAND
TECHNOLOGY TAX TRANSFER BEGINS IN NEW JERSEY
OSTEOPOROSIS GENOMICS ALLIANCE FORGED
TAISHO LICENSES INVESTIGATIONAL DRUGS
UN SAFETY PROTOCOL REACHED
GENENTECH PATENT RULED INVALID
ALL GOD’S CREATURES IN ONE DATABASE
THREE BOSTON BIOTECH COMPANIES TO MERGE
VALIGENE, KIMERAGEN TO FORM VALIGEN
HUMAN GENOME SCIENCES GETS INTO PEPTIDES
NOVALON ACQUIRED BY KARO BIO
GRANTS FOR CANADA, LATIN AMERICA
GM AWARDS FOR CANCER RESEARCH
BIOPROSPECTING AGREEMENT UPHELD
DUESBERG AND RASNICK ON AIDS ADVISORY BOARD
NEURO-ONCOLOGY CENTER CREATED
APOPTOGEN, EXOGEN COMPLETE MERGER
NEWSFLASH: HIV CAUSES AIDS
M.I.N.D. INSTITUTE AWARDED $34 MILLION
THE SCIENTIFIC WORLD EMERGES ON THE WEB
UNIGENE FORGES CHINESE CONNECTION
AVAX BUYS GENOPOIETIC
INVITROGEN LICENSES POLYMERASES
TARGETED GENETICS MAKES SOME MOVES
TISSUE SEALANT COLLABORATION
ANTIGENICS ACQUIRES AQUILA BIOPHARM
IBM BECOMES LIFE SCI COMPANY
GLOBAL BIODIVERSITY INFORMATION FACILITY
NEUROSCIENCE FIRM NAMED NEUROME
IMMUNE RESPONSE SUES OVER PUBLICATION
VENTURE CAPITAL REMAINS PLENTIFUL
DNA TESTING FOR THE DEAD
ABGENIX ACQUIRES INTRAIMMUNE THERAPIES
DIVERSA TO SAMPLE SOUTH AFRICA

PUBLICATIONS

THE GOOD OLD DAYS
BATTLE OVER BONE, JOINT THERAPIES

AG-BIOTECH

TEST KITS FOR GM CORN ON THE WAY
ZENECA, CAMBRIDGE TO COLLABORATE
HYSEQ AND CYANAMID FORGE GENE AGREEMENT
ARGENTINIAN AG COMPANY FORMED
EVOLVING BETTER CO2 FIXATION
GENE THERAPY FOR CHICKENS
SEPARATING GENES FROM CHAFF
LEAF LIFE IS EXTENDED
TRACKING THE TASTIEST PIGS
NEW MODE OF CROP PROTECTION OFFERED
RICE GENOME MAPPED
DOMESTIC MARKET NIXING GM FOOD
FRIENDLY FUNGI HELP TREES GROW
CHICKENS HAVE STEM CELLS, TOO
GROWING THE VIRTUAL ARABIDOPSIS
THE SEQUENCING OF USTILAGO MAYDIS
TURNING ON DISEASE RESISTANCE
ARABIDOPSIS GENECHIP PROBE ARRAY LAUNCHED
WHICH CAME FIRST, STEM CELL OR THE EGG?
DOW AGROSCIENCES GETS BRAZILIAN UNIT
METAMORPHIX ACQUIRES BIOSTAR ASSETS
HERBICIDE TOLERANT CROPS MAY AFFECT BIRDS
BT CROPS DO NOT ENDANGER MONARCHS
OF COWS AND MEN
PCR TESTS FOR FOOD-BORNE PATHOGENS
HIGH-THROUGHPUT GENOTYPING
PLANT-DERIVED ANIMAL VACCINES
GOLDEN MUSTARD OIL TO PROVIDE VITAMIN A
CORN GROWERS DON’T WANT STARLINK

VACCINES AND ANTI-INFECTIVES

PROTEINS KICK START IMMUNE SYSTEM
BACTERIAL SUICIDE PATHWAY FOUND
IMMUNOSTIMULATORY DNA FOR VACCINES
ALPHA-GALACTOSE SUPERCHARGES VACCINES
HOW HIV INVADES US
MELANOMA VACCINE FOUND EFFECTIVE
LINK BETWEEN HEART DISEASE, INFECTION
PAPILLOMA VACCINE TO BE DEVELOPED
TELOMERASE USED AS CANCER VACCINE
NEW DRUG TARGET FOR ANTIBIOTICS
PAPILLOMA LINKED TO HEAD, NECK CANCER
HEPATITIS B MAY HAVE PRIMATE ORIGIN
DOUBLE-STRANDED RNA AS DRUG TARGET
MICROPARTICULATE VACCINES PATENTED
HIV VACCINE TO BE EVALUATED
TOXIN BINDER BLOCKS CLOSTRIDIUM DISEASE
PEPTIDES PROTECT AGAINST PATHOGENS
INDIVIDUALIZED CANCER VACCINE MARKETED
HIV RESISTANCE EMERGES IN AFRICA
EAT YOUR VACCINE, DEAR
ROTAVIRUS VACCINES TRIGGER DIABETES
EPIMMUNE WINS AIDS VACCINE GRANT
IS A UNIVERSAL CANCER VACCINE POSSIBLE?
GENE VACCINE FOR MALARIA
SHIGA SUBUNIT REPLACES ADJUVANT
FUSION PROTEIN AS PAPILLOMA VACCINE
PROTECTION AGAINST RODENT MALARIA
INFECTIOUS DISEASE GRANTS AWARDED
TARGETING MUCOSAL INDUCTION SITES

INDUSTRIAL BIOTECHNOLOGY

BACTERIA MAKE GOOD EMPLOYEES

SEQUENCING

GENOME’S SEQUENCED: NOW WHAT?

LIST OF TABLES
SUMMARY TABLE:
MARKET FOR SELECTED BIOTECHNOLOGY ENABLING TECHNOLOGIES AND STAR PRODUCTS, THROUGH 2005
1 APPLICATION MARKETS FOR GENOMIC-BASED PRODUCTS AND SERVICES, 1999-2004
2 WORLDWIDE SALES OF THERAPEUTIC AND DIAGNOSTIC IMAGING ANTIBODIES, 1999-2004
3 MARKET FOR MEDIA, SERA, REAGENTS, 2000-2005
4 WORLDWIDE REVENUES FOR APOPTOSIS-RELATED PRODUCTS, 1999-2005
5 WORLDWIDE MARKET FOR MOLECULAR DIAGNOSTIC AND CYTOGENETIC DISEASE TESTING, 2000-2005
6 TOP SELLING PEPTIDE DRUGS, 2000
7 MARKET FOR BONE AND JOINT THERAPIES BY TYPE, 2000-2005

LIST OF FIGURES
SUMMARY FIGURE:
MARKET FOR SELECTED BIOTECHNOLOGY ENABLING TECHNOLOGIES AND STAR PRODUCTS, 2000-2005
1 APPLICATION MARKETS FOR GENOMIC-BASED PRODUCTS AND SERVICES, 1999-2004
2 WORLDWIDE SALES OF THERAPEUTIC AND DIAGNOSTIC IMAGING ANTIBODIES, 1999-2004
3 MARKET FOR MEDIA, SERA, REAGENTS, 2000-2005
4 WORLDWIDE REVENUES FOR APOPTOSIS-RELATED PRODUCTS, 1999-2005
5 WORLDWIDE MARKET FOR MOLECULAR DIAGNOSTIC AND CYTOGENETIC DISEASE TESTING, 2000-2005
6 MARKET FOR BONE AND JOINT THERAPIES BY TYPE, 2000-2005