Cancer Vaccines: Drug Pipeline Update 2007

Executive Summary

Cancer vaccines offer an attractive therapeutic addition, delivering treatment of high specificity, low toxicity and prolonged activity. However, despite years of R&D, a reproducible survival benefit has proved elusive, leaving the market wide open.

There are today more than 235 cancer vaccines, from early preclinical to marketed drugs. Cancer Vaccines Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 91 different targets. These targets are further categorized on the CD-ROM by 40 classifications of molecular function and with pathway referals to BioCarta, KEGG and NetPath. Read more below on how the Cancer Vaccines Drug Pipeline Update is organized.

How May Drug Pipeline Update Be of Use?

• Show investors⁄board⁄management that you are right on top of drug development progress in your therapeutic area.
• Find competitors, collaborations partners, M&A candidates etc.
• Jump start competitive drug intelligence operations
• Excellent starting point for world wide benchmarking
• Compare portfolio and therapy focus with your peers
• Speed up pro-active in-⁄out licensing strategy work
• Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug.

Drug Pipeline Update at a Glance

Includes more than 170 principal investigators plus their collaborators. There is direct access from inside the application to web pages of all principal investigators.

Note: You are able to sort and find drugs according to investigators and partners from drop-down menus in the application. You may also sort and find drugs according to country of investigator.

Lists commercial, generic and code names for drugs. In all more than 400 names

This Drug Pipeline Update contains more than 235 cancer vaccine drugs in active development and more than 440 developmental projects:9 marketed drugs

• > 25 projects in Phase III
• > 140 projects in Phase II
• > 90 projects in Phase I
• > 130 projects in Preclinical

Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.

Included vaccine drugs are in development for over 65 indications, where of 40+ are different cancer indications. All drugs are in development for the treatment of cancer.

Note: You are able to sort and find drugs according to type of indication from drop-down menu in the application.

Identified drugs are linked to more than 138 different targets, divided into 40 classifications of molecular function:

• Acid phosphatase activity
• Carboxypeptidase activity
• Catalytic activity
• Cell adhesion molecule activity
• Chaperone activity
• Cofactor binding
• Complement activity
• Cytokine activity
• DNA binding
• DNA topoisomerase activity
• DNA-directed DNA polymerase activity
• Growth factor activity
• Heat shock protein activity
• Hormone activity
• Hydrolase activity
• Intracellular ligand-gated ion channel activity
• Isomerase activity
• Kinase binding
• Kinase regulator activity
• Metallopeptidase activity
• MHC class I receptor activity
• Molecular function unknown
• Oxidoreductase activity
• Peptidase activity
• Peptide hormone
• Protein binding
• Protein serine/threonine kinase activity
• Protein-tyrosine kinase activity
• Receptor activity
• Receptor binding
• Receptor signaling complex scaffold activity
• Receptor signaling protein serine/threonine kinase activity
• RNA-directed DNA polymerase activity
• Serine-type peptidase activity
• T cell receptor activity
• Transcription factor activity
• Transcription regulator activity
• Transmembrane receptor activity
• Transmembrane receptor protein tyrosine kinase activity
• Transporter activity

Identified targets are categorized into 22 different primary and alternate sub-cellular localizations:

• Apical membrane
• Cell surface
• Centrosome
• Clathrin-coated vesicle
• Cytoplasm
• Cytoskeleton
• Endoplasmic reticulum
• Endosome
• Extracellular
• Extracellular matrix
• Golgi apparatus
• Integral to membrane
• Lysosome
• Mitochondrial matrix
• Mitochondrion
• Nucleolus
• Nucleus
• Peroxisomal matrix
• Plasma membrane
• Sarcoplasmic reticulum
• Secreted
• Secretory granule

Note: You are able to sort and find drugs according to target gene name, molecular function of target, and target localization from drop-down menus in the application.

Direct links are provided from inside the application to 51 protein expression profiles of 39 drug targets in various human tissues and cancer types, cell lines and primary cells, including up to:

• 48 different normal tissue types
• 20 different types of cancer
• 47 cell lines
• 12 samples of primary blood cells

Identified targets have been cross referenced against their invovlement in different cellular pathways, according to BioCarta, KEGG and NetPath.

• BioCarta 121 Pathways
• KEGG 64 Pathways
• NetPath 17 Signaling Pathways

Note: You are able to sort and find drugs according to targeted pathways from drop-down menues in the application.

In total there are more than 65 different drug mechanism of action represented in this Drug Pipeline Update.

Note: You are able to sort and find drugs according to mechanism of action from drop-down menu in the application.

Identified drug compounds are described by:

Compound type, Chemical name, CAS Number and molecular weight

Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.

Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:

Drug Name & Synonyms

Presentation of drug name and synonyms

Principal Investigator & Partners

Presentation of principal investigator and partners

Target and Molecular Function of Target

Described target(s) is/are presented with:

Official Gene Symbol - Official Gene Name [Species/Homo Sapiens] - Molecular Function

Target Localization

Described target(s) is/are presented with primary and alternate localizations.

Target Expression Profiles

Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:

• 48 different normal tissue types
• 20 different types of cancer
• 47 cell lines
• 12 samples of primary blood cells

Targeted Pathways

Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, and NetPath.

Mechanism

Drug mechanism of action

Developmental Projects

Summary field of developmental projects for the drug, including indication, developmental stage and status.

Example:

• Cancer, myeloma - Phase II Clinical Trial - Active
• Cancer, prostate - Phase III Clinical Trial - Ceased

Drug Description

Short introduction to drug

Compound Data

Compound type, Chemical name, CAS Number and molecular weight

Patent Data

Available patent information related to the drug is presented here.

Business & Markets

• Collaborations and deals
• Approvals and submissions
• Analyst comments

Phase III Data

Available Phase III development data, developmental history and scientific data.

Phase II Data

Available Phase II development data, developmental history and scientific data.

Phase I Data

Available Phase I development data, developmental history and scientific data.

Preclinical Data

Available preclinical development data, developmental history and scientific data.

Licensing Information

Availability for licensing

Use 13 different parameters, available in drop-down menus, to find and sort among drugs

• Drug status
• Clinical Trial Status
• Principle Investigator
• Partners
• Indication
• Developmental Stage
• Compound Type
• Mechanism
• Target
• Molecular Function of Target
• Target Localization
• Targeted Pathways
• Free text search of entire drug profile contents

Direct linkage from inside the application to related internet resources

• Drug data is linked to search engines like Google and PubMed
• Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, and NetPath
• Direct links to company web pages of principal investigators

Export and sharing of information

• Found information is easily shared with others over e-mail, file export (xls) or in print

• AMD-Athlon/Pentium II PC
• Windows 98/NT4/2000/ME/XP/VISTA
• 8x-speed CD Rom drive
• SVGA 16 bit display. (32 bit recommended)
• 32 MB of available RAM (128 MB recommended)
• Internet access (for related internet resources)