Abstract
Executive Summary
Cancer vaccines offer an attractive therapeutic addition, delivering treatment
of high specificity, low toxicity and prolonged activity. However, despite
years of R&D, a reproducible survival benefit has proved elusive, leaving the
market wide open.
There are today more than 235 cancer vaccines, from early preclinical to
marketed drugs. Cancer Vaccines Drug Pipeline Update lists all drugs and gives
you a progress analysis on each one of them. Identified drugs are linked to 91
different targets. These targets are further categorized on the CD-ROM by 40
classifications of molecular function and with pathway referals to BioCarta,
KEGG and NetPath. Read more below on how the Cancer Vaccines Drug Pipeline
Update is organized.
How May Drug Pipeline Update Be of Use?
- Show investors/board/management that you are right on top of drug
development progress in your therapeutic area.
- Find competitors, collaborations partners, M&A candidates etc.
- Jump start competitive drug intelligence operations
- Excellent starting point for world wide benchmarking
- Compare portfolio and therapy focus with your peers
- Speed up pro-active in-/out licensing strategy work
- Fast and easy way of tracking drugs using search engines; just one click
from inside the application and you may search the World Wide Web and PubMed
for any drug.
Drug Pipeline Update is delivered to you as a CD-ROM application, which
requires no installation on your computer. Please read more about application
features and system requirements below.
Drug Pipeline Update at a Glance
- Investigators
- Includes more than 170 principal investigators plus their collaborators.
There is direct access from inside the application to web pages of all
principal investigators.
- Note: You are able to sort and find drugs according to investigators and
partners from drop-down menus in the application. You may also sort and find
drugs according to country of investigator.
- Drug name & Synonyms
- Lists commercial, generic and code names for drugs. In all more than 400
names
- Developmental stage This Drug Pipeline Update contains more than 235
cancer vaccine drugs in active development and more than 440 developmental
projects:
- 9 marketed drugs
- > 25 projects in Phase III
- > 140 projects in Phase II
- > 90 projects in Phase I
- > 130 projects in Preclinical
- Note: You are able to sort and find drugs according to developmental
stage from drop-down menu in the application.
- Indications
- Included vaccine drugs are in development for over 65 indications, where
of 40+ are different cancer indications. All drugs are in development for
the treatment of cancer.
- Note: You are able to sort and find drugs according to type of
indication from drop-down menu in the application.
- Targets
- Identified drugs are linked to more than 138 different targets,
divided into 40 classifications of molecular function:
- - Acid phosphatase activity
- - Carboxypeptidase activity
- - Catalytic activity
- - Cell adhesion molecule activity
- - Chaperone activity
- - Cofactor binding
- - Complement activity
- - Cytokine activity
- - DNA binding
- - DNA topoisomerase activity
- - DNA-directed DNA polymerase activity
- - Growth factor activity
- - Heat shock protein activity
- - Hormone activity
- - Hydrolase activity
- - Intracellular ligand-gated ion channel activity
- - Isomerase activity
- - Kinase binding
- - Kinase regulator activity
- - Metallopeptidase activity
- - MHC class I receptor activity
- - Molecular function unknown
- - Oxidoreductase activity
- - Peptidase activity
- - Peptide hormone
- - Protein binding
- - Protein serine/threonine kinase activity
- - Protein-tyrosine kinase activity
- - Receptor activity
- - Receptor binding
- - Receptor signaling complex scaffold activity
- - Receptor signaling protein serine/threonine kinase activity
- - RNA-directed DNA polymerase activity
- - Serine-type peptidase activity
- - T cell receptor activity
- - Transcription factor activity
- - Transcription regulator activity
- - Transmembrane receptor activity
- - Transmembrane receptor protein tyrosine kinase activity
- - Transporter activity
- Identified targets are categorized into 22 different primary and
alternate sub-cellular localizations:
- - Apical membrane
- - Cell surface
- - Centrosome
- - Clathrin-coated vesicle
- - Cytoplasm
- - Cytoskeleton
- - Endoplasmic reticulum
- - Endosome
- - Extracellular
- - Extracellular matrix
- - Golgi apparatus
- - Integral to membrane
- - Lysosome
- - Mitochondrial matrix
- - Mitochondrion
- - Nucleolus
- - Nucleus
- - Peroxisomal matrix
- - Plasma membrane
- - Sarcoplasmic reticulum
- - Secreted
- - Secretory granule
- Note: You are able to sort and find drugs according to target gene name,
molecular function of target, and target localization from drop-down menus
in the application.
- Target Expression Profile
- Direct links are provided from inside the application to 51 protein
expression profiles of 39 drug targets in various human tissues and cancer
types, cell lines and primary cells, including up to:
- - 48 different normal tissue types
- - 20 different types of cancer
- - 47 cell lines
- - 12 samples of primary blood cells
- Pathway Referals
- Identified targets have been cross referenced against their invovlement
in different cellular pathways, according to BioCarta, KEGG and NetPath.
- - BioCarta 121 Pathways
- - KEGG 64 Pathways
- - NetPath 17 Signaling Pathways
- Note: You are able to sort and find drugs according to targeted pathways
from drop-down menues in the application.
- Mechanism
- In total there are more than 65 different drug mechanism of action
represented in this Drug Pipeline Update.
- Note: You are able to sort and find drugs according to mechanism of
action from drop-down menu in the application.
- Compound
- Identified drug compounds are described by:
- Compound type, Chemical name, CAS Number and molecular weight
- Note: You are able to sort and find drugs according to compound type
from drop-down menu in the application.
- Drug Profile
- Progress analysis and review of drug development. A typical drug profile
reports on, depending on stage of development and available information:
- Drug Name & Synonyms
- Presentation of drug name and synonyms
- Principal Investigator & Partners
- Presentation of principal investigator and partners
- Target and Molecular Function of Target
- Described target(s) is/are presented with:
- Official Gene Symbol - Official Gene Name [Species/Homo Sapiens] -
Molecular Function
- Target Localization
- Described target(s) is/are presented with primary and alternate
localizations.
- Target Expression Profiles
- Links to protein expression profile(s) of target(s) in various human
tissues, cell lines and primary cells, including up to:
- 48 different normal tissue types
- 20 different types of cancer
- 47 cell lines
- 12 samples of primary blood cells
- Targeted Pathways
- Described target(s) is/are matched for the involvement in cellular
pathways according to BioCarta, KEGG, and NetPath.
- Mechanism
- Developmental Projects
- Summary field of developmental projects for the drug, including
indication, developmental stage and status.
- Example:
- Cancer, myeloma - Phase II Clinical Trial - Active
- Cancer, prostate - Phase III Clinical Trial - Ceased
- Drug Description
- Short introduction to drug
- Compound Data
- Compound type, Chemical name, CAS Number and molecular weight
- Patent Data
- Available patent information related to the drug is presented here.
- Business & Markets
- Collaborations and deals
- Approvals and submissions
- Analyst comments
- Phase III Data
- Available Phase III development data, developmental history and
scientific data.
- Phase II Data
- Available Phase II development data, developmental history and
scientific data.
- Phase I Data
- Available Phase I development data, developmental history and
scientific data.
- Preclinical Data
- Available preclinical development data, developmental history and
scientific data.
- Licensing Information
- Availability for licensing
- Application Features
- Use 13 different parameters, available in drop-down menus, to find
and sort among drugs
- - Drug status
- - Clinical Trial Status
- - Principle Investigator
- - Partners
- - Indication
- - Developmental Stage
- - Compound Type
- - Mechanism
- - Target
- - Molecular Function of Target
- - Target Localization
- - Targeted Pathways
- - Free text search of entire drug profile contents
- Direct linkage from inside the application to related internet
resources
- - Drug data is linked to search engines like Google and PubMed
- - Drug target data is linked directly to BioCarta, Human Protein
Atlas, KEGG, and NetPath
- - Direct links to company web pages of principal investigators
- Export and sharing of information
- - Found information is easily shared with others over e-mail, file
export (xls) or in print
- System Requirements
- - AMD-Athlon/Pentium II PC
- - Windows 98/NT4/2000/ME/XP/VISTA
- - 8x-speed CD Rom drive
- - SVGA 16 bit display. (32 bit recommended)
- - 32 MB of available RAM (128 MB recommended)
- - Internet access (for related internet resources)
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