Lung Cancer Drug Pipeline Update 2008

Abstract

Executive Summary

Non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) comprises over 95% of all lung cancers. High unmet needs still persist for this tumor type and despite two decades of extensive R&D and chemotherapy use, the median overall survival of NSCLC patient' s remains below 12 months. More than 80,000 new SCLC cases are expected to be diagnosed in 2007 in the seven major markets, although it is set to decrease due to changing smoking habits. Mesothelioma is rarer, although incidence is expected to increase in the coming years in Europe and Japan given the heavy use of asbestos in the 1970s and long latency period of the disease.

There are today more than 335 therapeutics targeting lung cancer, from early preclinical to marketed drugs. Lung Cancer Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 169 different targets. These targets are further categorized on the CD-ROM by 50 classifications of molecular function and with pathway referals to BioCarta, KEGG and NetPath. Read more below on how the Lung Cancer Drug Pipeline Update is organized.

How May Drug Pipeline Update Be of Use?

• Show investors/board/management that you are right on top of drug development progress in your therapeutic area.
• Find competitors, collaborations partners, M&A candidates etc.
• Jump start competitive drug intelligence operations
• Excellent starting point for world wide benchmarking
• Compare portfolio and therapy focus with your peers
• Speed up pro-active in-/out licensing strategy work
• Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug.

Drug Pipeline Update is delivered to you as a CD-ROM application, which requires no installation on your computer. Please read more about application features and system requirements below.

Drug Pipeline Update at a Glance

• Investigators
  • Includes more than 240 principal investigators plus their collaborators. There is direct access from inside the application to web pages of all principal investigators.
  • Note: You are able to sort and find drugs according to investigators and partners from drop-down menus in the application. You may also sort and find drugs according to country of investigator.
• Drug name & Synonyms
  • Lists commercial, generic and code names for drugs. In all more than 500 names
  • Developmental stage This Drug Pipeline Update contains more than 335 drugs in active development for the treatment of lung cancer:
  • 36 marketed drugs
  • > 20 projects in Phase III
  • > 150 projects in Phase II
  • > 80 projects in Phase I
  • > 65 projects in Preclinical
  • Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.
• Indications
  • Included lung cancer drugs are also in development for over 100 other listed indications
  • Note: You are able to sort and find drugs according to type of indication from drop-down menu in the application.
• Targets
  • Identified drugs are linked to more than 165 different targets, divided into 50 classifications of molecular function:
    • - Carboxy-lyase activity
    • - Catalytic activity
    • - Cell adhesion molecule activity
    • - Chaperone activity
    • - Chemokine activity
    • - Complement activity
    • - Cysteine-type peptidase activity
    • - Cytokine activity
    • - DNA binding
    • - DNA repair protein
    • - DNA topoisomerase activity
    • - DNA-directed DNA polymerase activity
    • - DNA-methyltransferase activity
    • - Extracellular matrix structural constituent
    • - G-protein coupled receptor activity
    • - Glutathione transferase activity
    • - Growth factor activity
    • - Hormone activity
    • - Hydrolase activity
    • - Kinase activity
    • - Kinase regulator activity
    • - Ligand-dependent nuclear receptor activity
    • - Ligase activity
    • - Lipase activity
    • - Metallopeptidase activity
    • - Molecular function unknown
    • - Motor activity
    • - Oxidoreductase activity
    • - Peptidase activity
    • - Phosphoric diester hydrolase activity
    • - Protein binding
    • - Protein serine/threonine kinase activity
    • - Protein threonine/tyrosine kinase activity
    • - Protein-tyrosine kinase activity
    • - Receptor activity
    • - Receptor binding
    • - Receptor signaling complex scaffold activity
    • - Receptor signaling protein serine/threonine kinase activity
    • - RNA binding
    • - RNA-directed DNA polymerase activity
    • - Serine-type peptidase activity
    • - Structural constituent of cytoskeleton
    • - T cell receptor activity
    • - Transcription factor activity
    • - Transcription regulator activity
    • - Transferase activity
    • - Translation regulator activity
    • - Transmembrane receptor activity
    • - Transmembrane receptor protein tyrosine kinase activity
    • - Transporter activity
  • Identified targets are categorized into 23 different primary and alternate sub-cellular localizations:
    • - Centrosome
    • - Clathrin-coated vesicle
    • - Cytoplasm
    • - Cytoplasmic vesicle
    • - Cytoskeleton
    • - Cytosol
    • - Endoplasmic reticulum
    • - Endosome
    • - Extracellular
    • - Golgi apparatus
    • - Integral to membrane
    • - Lysosome
    • - Microtubule
    • - Mitochondrial membrane
    • - Mitochondrion
    • - Nuclear membrane
    • - Nucleolus
    • - Nucleus
    • - Perinuclear region
    • - Perinuclear vesicle
    • - Plasma membrane
    • - Secreted
    • - Secretory granule
  • Note: You are able to sort and find drugs according to target gene name, molecular function of target, and target localization from drop-down menus in the application.
• Target Expression Profile
  • Direct links are provided from inside the application to 111 protein expression profiles of 96 drug targets in various human tissues and cancer types, cell lines and primary cells, includin u to:
    • - 48 different normal tissue types
    • - 20 different types of cancer
    • - 47 cell lines
    • - 12 samples of primary blood cells
• Pathway Referals
  • Identified targets have been cross referenced against their invovlement in different cellular pathways, according to BioCarta, KEGG and NetPath.
    • - BioCarta 229 Pathways
    • - KEGG 67 Pathways
    • - NetPath 20 Signaling Pathways
  • Note: You are able to sort and find drugs according to targeted pathways from drop-down menues in the application.
• Mechanism
  • In total there are more than 190 different drug mechanism of action represented in this Drug Pipeline Update.
  • Note: You are able to sort and find drugs according to mechanism of action from drop-down menu in the application.
• Compound
  • Identified drug compounds are described by:
  • Compound type, Chemical name, CAS Number and molecular weight
  • Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.
• Drug Profile
  • Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:
  • Drug Name & Synonyms
    • Presentation of drug name and synonyms
  • Principal Investigator & Partners
    • Presentation of principal investigator and partners
  • Target and Molecular Function of Target
    • Described target(s) is/are presented with:
    • Official Gene Symbol - Official Gene Name [Species/Homo Sapiens] - Molecular Function
  • Target Localization
    • Described target(s) is/are presented with primary and alternate localizations.
  • Target Expression Profiles
    • Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:
    • 48 different normal tissue types
    • 20 different types of cancer
    • 47 cell lines
    • 12 samples of primary blood cells
  • Targeted Pathways
    • Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, and NetPath.
  • Mechanism
    • Drug mechanism of action
  • Developmental Projects
    • Summary field of developmental projects for the drug, including indication, developmental stage and status.
    • Example:
    • Cancer, myeloma - Phase II Clinical Trial - Active
    • Cancer, prostate - Phase III Clinical Trial - Ceased
  • Drug Description
    • Short introduction to drug
  • Compound Data
    • Compound type, Chemical name, CAS Number and molecular weight
  • Patent Data
    • Available patent information related to the drug is presented here.
  • Business & Markets
    • Collaborations and deals
    • Approvals and submissions
    • Analyst comments
  • Phase III Data
    • Available Phase III development data, developmental history and scientific data.
  • Phase II Data
    • Available Phase II development data, developmental history and scientific data.
  • Phase I Data
    • Available Phase I development data, developmental history and scientific data.
  • Preclinical Data
    • Available preclinical development data, developmental history and scientific data.
  • Licensing Information
    • Availability for licensing
• Application Features
  • Use 13 different parameters, available in drop-down menus, to find and sort among drugs
    • - Drug status
    • - Clinical Trial Status
    • - Principle Investigator
    • - Partners
    • - Indication
    • - Developmental Stage
    • - Compound Type
    • - Mechanism
    • - Target
    • - Molecular Function of Target
    • - Target Localization
    • - Targeted Pathways
    • - Free text search of entire drug profile contents
  • Direct linkage from inside the application to related internet resources
    • - Drug data is linked to search engines like Google and PubMed
    • - Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, and NetPath
    • - Direct links to company web pages of principal investigators
  • Export and sharing of information
    • - Found information is easily shared with others over e-mail, file export (xls) or in print
• System Requirements
  • - AMD-Athlon/Pentium II PC
  • - Windows 98/NT4/2000/ME/XP/VISTA
  • - 8x-speed CD Rom drive
  • - SVGA 16 bit display. (32 bit recommended)
  • - 32 MB of available RAM (128 MB recommended)
  • - Internet access (for related internet resources)