Post-Genomic Target Validation: Next-Generation Approaches and Tools for Optimizing Target Selection

TABLE OF CONTENTS

Chapter 1. Introduction

• What Is Target Validation?
• Target Validation as a Critical Bottleneck in Global, Genomics-Based Drug Discovery Strategies
• Target Validation and Alternative Genomics-Based Drug Discovery Strategies
• Biology-Driven Strategies
• Chemistry First Chemical Genomics/Chemical Genetics Strategies

Chapter 2. Scientific Overview

• Role of Target Validation in Genomics-Based Drug Discovery
• Target Screening
• Target Identification
• Target Validation
• Biochemical Pathways and Target Identification and Validation

Chapter 3. Target Validation Technologies

• RNAi /Antisense/Ribozymes
• Other Downregulation Tools
• Model Organisms
• Genetic Approaches
• Cellular Assays
• Protein Inhibition
• Molecular Pathology
• Chemical Genetics

Chapter 4. Using Target Validation Technologies in Drug Discovery

Chapter 5. Business and Strategic Issues in Target Validation

• Deal-Making activity: From Targets to Drugs
• Target Validation Companies: Moving from Technology Companies to Drug Developers
• Outlook for the Target Validation Field: Making Genomics-Based Drug Discovery More Effective
• Expert Commentaries