Multiplex Assays in Translational Medicine: Technologies, Applications, and Future Directions

Table of Contents

Chapter 1 INTRODUCTION: DEFINITION OF TRANSLATIONAL MEDICINE AND HOW ASSAY TECHNOLOGIES AFFECT ITS COURSE

• 1.1. Scope of the Report
• 1.2. Translational Medicine: Beginnings and Biomarkers
  • Historical Background
  • Biomarkers
  • Assay Technologies
  • Adoption of Translational Medicine
  • Experts' Views on Translational Medicine

Chapter 2 THE HISTORY OF ASSAY TECHNOLOGIES

• 2.1. Early Technologies
• 2.2. Mass Spectrometry
• 2.3. DNA Microarrays

Chapter 3 PRODUCTS AND APPLICATIONS OF MULTIPLEX ASSAYS FOR THE ADVANCEMENT OF TRANSLATIONAL MEDICINE

• 3.1. Microarrays
  • High-Throughput Microchips
  • Affymetrix' s GeneChip
  • Agendia' s MammaPrint
  • Extension Arrays
  • Asper Biotech' s APEX Technology
  • Electronic Platforms
  • Osmetech' s eSensor Detection Technology
  • PCR-Based Assays
  • Applied Biosystems' TaqMan Probes
  • Epigenomics' MethyLight
  • Genomic Health' s Oncotype DX
  • OncoMethylome Sciences' Methylation-Specific PCR (MSP)
  • Gene Express' StaRT-PCR
• 3.2. Protein Microarrays
  • Antibody Arrays
  • Biosite' s Protein Arrays
  • Biosite' s Triage Panel Products
  • Biacore' s Life Sciences Protein Microarray
  • BD Biosciences' Cytometric Bead Array
  • Zeptosens' ZeptoMark Capture Microarray and ZeptoMark CeLyA Reverse Microarray
  • High Throughput Genomics' ArrayPlate qNPA
  • Pierce' s Protein Array Kits
  • PamGene' s PamChip Microarray
  • Microsphere or Bead-Based Technologies
  • Luminex' s xMAP Technology
  • Molecular Probes' Qdot Nanocrystals
  • Oxonica' s Nanoplex Technology
  • Pronostics' UltraPlex Barcodes Molecules
  • Illumina' s BeadXpress Reader and VeraCode Technology
  • BioArray Solutions' BeadChip
  • Randox' s Evidence
  • Xceed Molecular' s Flow-Thru Chip and TipChip Technology
  • Decision Biomarkers' Avantra Q400 Biomarker Workstation
  • Meso Scale Discovery' s Platform
  • Bio-Rad' s BioPlex
• 3.3. Imaging Technologies
  • Stratos Biosystems' EC-Affinity Biochips
  • Blueshift Biotechnologies' IsoCyte
• 3.4. Miscellaneous Assay Technologies
  • Monogram Biosciences' eTag

Chapter 4 TWO CASE STUDIES INVOLVING MULTIPLEX ASSAY TECHNOLOGIES APPLIED TO TRANSLATIONAL MEDICINE

• 4.1. Blood Testing Technology to Discover Serum Protein Markers for Early Detection of Ovarian Cancer
• 4.2. StaRT-PCR to Assess Genes Associated with Cisplatin Chemoresistance

Chapter 5 FUTURE DIRECTIONS OF MULTIPLEX ASSAY TECHNOLOGIES APPLIED TO TRANSLATIONAL MEDICINE

• 5.1. Translating Discoveries Made in Animal Models to Humans
• 5.2. Discoveries in Pharmacogenomics
• 5.3. Assay Technologies in Disease Diagnosis
• 5.4. Translational Research to Help in Disease Prevention
• 5.5. More "System"-Oriented Assay Technologies
  • XB TransMed' s XB BioIntegration Suite
• 5.6. The Growth of Personalized Medicine Companies

Chapter 6 FDA PERSPECTIVE ON MULTIPLEX ASSAY TECHNOLOGIES IN TRANSLATIONAL MEDICINE

• 6.1. Critical Path Initiative (CPI)
• 6.2. Oncology Biomarker Qualification Initiative (OBQI)
• 6.3. Predictive Safety Testing Consortium (PSTC)

Chapter 7 EXPERT INTERVIEWS

• Guido Grentzmann, PhD, President, PBS PharmaBioServices, Verrières le Buisson, France
• David Lester, PhD, Senior Vice President of Strategy and Corporate Development, Gene Express, Inc., Toledo, OH
• Bruce Littman, MD, President, Translational Medicine Associates; Formerly Global Head of Translational Medicine, Pfizer Global Research and Development, New London, CT
• Francesco M. Marincola, MD, Chief, Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, National Institutes of Health, Bethesda, MD
• Gil Mor, MD, PhD, Associate Professor, Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven CT; Director of Yale Gynecologic Oncology' s program, Discovery to Cure: Advancing the Prevention, Early Detection and Treatment of Women' s Reproductive Cancers
• Deborah J. Neff, President and CEO, Pathwork Diagnostics, Sunnyvale, CA
• Scott Patterson, PhD, Executive Director of Medical Sciences, Amgen, Thousand Oaks, CA
• Wendy Sanhai, PhD, Senior Scientific Advisor, Office of the Commissioner, Food and Drug Administration

Chapter 8 SELECTED COMPANY PROFILES

• Affymetrix
• Agendia
• Asper Biotech
• Biosite
• Epigenomics
• Gene Express, Inc.
• Genomic Health
• High Throughput Genomics
• Luminex Corporation
• Monogram Biosciences
• OncoMethylome Sciences
• Osmetech
• PamGene
• Randox Laboratories
• Stratos Biosystems
• Xceed Molecular
• Zeptosens

Appendix

INSIGHT PHARMA REPORTS MULTIPLEX ASSAY SURVEY-DECEMBER 2007

References

Company Index with Web Addresses