INFLAMMATORY DIRECTIONS: Strategies for Six Diseases with Unmet Needs

Table of Contents

Chapter 1 INTRODUCTION: THE IMMUNE SYSTEM AND THE INFLAMMATORY RESPONSE

• 1.1. The Immune System
• 1.2. Immune Dysfunction and Autoimmune Disease

Chapter 2 REVIEW OF THE INFLAMMATORY DISEASES: EPIDEMIOLOGY, PATHOLOGY, DIAGNOSIS, AND SYMPTOMS

• 2.1. Rheumatoid Arthritis
  • Pathology
  • Causes
  • Diagnosis
  • Epidemiology
• 2.2. Inflammatory Bowel Disease
  • Pathology
  • Causes
  • Diagnosis
  • Epidemiology
• 2.3. Psoriasis
  • Pathology
  • Causes
  • Diagnosis
  • Epidemiology
• 2.4. Lupus
  • Pathology
  • Causes
  • Diagnosis
  • Epidemiology
• 2.5. Multiple Sclerosis
  • Pathology
  • Causes
  • Diagnosis
  • Epidemiology
• 2.6. Asthma
  • Pathology
  • Causes
  • Diagnosis
  • Epidemiology

Chapter 3 CURRENT PHARMACOLOGICAL TREATMENT OPTIONS

• 3.1. Rheumatoid Arthritis
  • Analgesics and NSAIDS
  • Corticosteroids
  • Synthetic DMARDs
    • Methotrexate
    • Arava (Leflunomide)
    • Other DMARDs
  • Biological DMARDs
    • Enbrel (Etanercept)
    • Remicade (Infliximab)
    • Humira (Adalimumab)
    • Kineret (Anakinra)
    • Orencia (Abatacept)
    • Rituxan (Rituximab)
• 3.2. Inflammatory Bowel Disease
  • Aminosalicylates
  • Corticosteroids
  • Immunomodulators
    • Azathioprine, 6-Mercaptopurine, and 6-Thioguanine
    • Methotrexate
    • Cyclosporine
    • Remicade (Infliximab)
    • Humira (Adalimumab)
    • Tysabri (Natalizumab)
  • Antibiotics
• 3.3. Psoriasis
  • Topical Therapies
    • Corticosteroids
    • Vitamin D3 and A Compounds
    • Retinoids
    • Coal Tar
    • Anthralin
    • Salicylic Acid
  • Light Therapy
  • Systemic Therapy
    • Methotrexate
    • Cyclosporine
    • Oral Retinoids
    • Hydroxyurea
    • Amevive (Alefacept)
    • Raptiva (Efalizumab)
    • Enbrel (Etanercept)
    • Remicade (Infliximab)
    • Humira (Adalimumab)
• 3.4. Lupus
  • NSAIDs
  • Antimalarials
  • Corticosteroids
  • Immunomodulators
• 3.5. Multiple Sclerosis
  • Corticosteroids
  • Disease-Modifying Agents
    • Interferon Beta
    • Copaxone (Glatiramer Acetate)
    • Novantrone (Mitoxantrone)
    • Tysabri (Natalizumab)
  • Other Immunomodulators
• 3.6. Asthma
  • Quick-Relief Medications
    • Bronchodilators
    • Oral Corticosteroids
  • Long-Term Control Medications
    • Inhaled Corticosteroids
    • Bronchodilators
    • Mast Cell Stabilizers
    • Leukotriene Modifiers
    • Xolair (Omalizumab)

Chapter 4 COMPOUNDS IN DEVELOPMENT: THE NEXT GENERATION OF DRUGS FOR INFLAMMATORY DISEASES

• 4.1. New Approaches to Inflammatory Diseases
  • Tumor Necrosis Factor Family Inhibitors
  • Interleukin Inhibitors
  • Other Cytokine Inhibitors
  • Chemokine Receptor Antagonists
  • Anti-inflammatory Cytokines
  • Compounds Targeting T-Cell Antigens
  • Compounds Targeting B-Cell Antigens
  • Complement Inhibitors
  • Adhesion Molecule Blockers
  • Protease Inhibitors
    • TACE
    • ICE
    • Cathepsin S
  • Kinase Inhibitors
    • p38 MAP Kinase
    • JNK
    • NF-κB
  • Other Kinases
• 4.2. Setbacks
• 4.3. Rheumatoid Arthritis
  • TNF-alpha Inhibitors
    • UCB
    • Centocor
    • Targeted Genetics
    • Arana Therapeutics
    • Xencor
    • Meyer Pharmaceuticals
    • Pharmaxis
    • Ception Therapeutics
    • Ablynx
    • Nastech Pharmaceutical
    • Devgen
  • Interleukin Inhibitors
    • Amgen
  • Kinase Inhibitors
    • Rigel Pharmaceuticals
    • Plexxikon
• 4.4. Inflammatory Bowel Disease
  • Adhesion Molecule Blockers
    • Atlantic Healthcare
    • Millennium Pharmaceuticals
  • Other Compounds
    • InDex Pharmaceuticals
    • Genzyme
• 4.5. Psoriasis
  • TNF Inhibitors
    • Apollo Life Sciences
    • York Pharma
  • Interleukin Inhibitors
    • Centocor
    • Abbott Laboratories
  • Calcineurin Inhibitors
    • Isotechnika
    • Biogen Idec
    • CombinatoRx
    • Celgene
  • Vitamin D Analogs
    • CollaGenex Pharmaceuticals
    • Cytochroma
• 4.6. Lupus
  • Immunomodulators
    • La Jolla Pharmaceutical
    • Genelabs Technologies
  • BLyS Inhibitors
    • Human Genome Sciences
    • ZymoGenetics
    • Anthera Pharmaceuticals
    • Biogen Idec/Genentech
    • Xencor
  • Toll-like Receptor Antagonists
    • Coley Pharmaceutical Group
    • Dynavax Technologies
    • Idera Pharmaceuticals
• 4.7. Multiple Sclerosis
  • Immunomodulators
    • Biogen Idec
    • Genzyme/Bayer Schering Pharma
    • Novartis
  • Cytokines
    • Nastech Pharmaceutical
    • Syntonix Pharmaceuticals
    • Ichor Medical Systems
    • Nautilus Biotech
    • Flamel Technologies
    • Modigene
    • Bolder BioTechnology
    • CoGenesys
    • Allozyne
  • Peptide Vaccines and MBP-Base Therapeutics
    • Orchestra Therapeutics
    • BioMS Medical/Eli Lilly
    • Bayhill Therapeutics
  • Remyelinating Agents
    • Biogen Idec
    • Acorda Therapeutics
• 4.8. Asthma
  • Interleukin Inhibitors
    • GlaxoSmithKline
    • MedImmune/BioWa
    • Aerovance
    • Amgen
    • Genentech
    • Altair Therapeutics
    • CSL/Merck
    • Synairgen
  • Phosphodiesterase-4 Inhibitors
    • Nycomed
    • Glenmark Pharmaceuticals/Forest Laboratories
    • MediciNova
    • Other PDE4 Inhibitors
  • Toll-like Receptor Agonists
    • Coley Pharmaceutical Group/Sanofi-Aventis
    • Dynavax Technologies
    • Idera Pharmaceuticals
    • InDex Pharmaceuticals
  • CRTH2 Antagonists

References

Company Index with Web Addresses