[Report] Acute Stroke Stakeholder Insight Market Research, Trends, Analysis TOC

ABOUT DATAMONITOR HEALTHCARE
- About the Cardiovascular pharmaceutical analysis team
CHAPTER 1 EXECUTIVE SUMMARY
- Scope of the analysis
- Contributing experts
  - Experts interviewed for this report (interviewed in October 2007)
  - Experts interviewed for Stakeholder Insight 2005: Acute Stroke, DMHC2058 (interviewed in 2005)
  - Experts interviewed for Pipeline Insight 2005: Antithrombotics, DMHC2084 (interviewed in 2005)
  - Experts interviewed for Pipeline Insight 2006: Acute Stroke, DMHC2167 (interviewed in February 2006)
- Datamonitor insight into the stroke market
- Related reports
CHAPTER 2 INTRODUCTION AND SCOPE
- Coverage of the Stakeholder Insight survey
  - Country level "treatment trees"
  - Supporting data sets
CHAPTER 3 COUNTRY TREATMENT TREES
- Introduction to the treatment trees
  - United States
  - Japan
  - France
  - Germany
  - Italy
  - Spain
  - United Kingdom
CHAPTER 4 EPIDEMIOLOGY AND PATIENT SEGMENTATION
- Disease definition and classification
  - Symptoms
    - Ischemic stroke
    - Hemorrhagic stroke
    - Transient ischemic attack
- Epidemiology of stroke
  - Epidemiology methodology
    - US
    - Japan
    - Europe
- Key patient segmentations
  - Patient age
  - Comorbidities, complications and risk factors
CHAPTER 5 DIAGNOSIS AND TREATMENT OPTIONS
- Presentation and diagnosis
  - Time to presentation
  - Diagnosis
    - Healthcare professionals involved in the diagnosis of stroke
    - Tests in emergency diagnosis of stroke
    - Secondary tests performed after initial diagnosis
- Influences on diagnosis and treatment rates
  - The National Stroke Association
  - STOP Stroke Act
  - The Stroke Association
- Treatment guidelines
  - Treatment of acute ischemic stroke
  - Treatment of hemorrhagic stroke
  - Stroke units
- Treatment pathways
CHAPTER 6 PRESCRIBING TRENDS AND INFLUENCING FACTORS
- Ischemic stroke treatment
  - Antiplatelets
  - Anticoagulants
  - Thrombolytics
- Hemorrhagic stroke treatment
CHAPTER 7 IMPROVING TREATMENT OUTCOMES
- Treatment outcomes
  - Length of stay
  - Mortality
  - Recovery
    - Recurrence of stroke
- Unmet needs
  - Physician education: tackling physician competence and attitude
  - Patient education: raising stroke-symptom awareness
  - Infrastructural unmet needs: establishing, maintaining and expanding the network of dedicated stroke units.
  - Unmet clinical needs
    - Procoagulation
    - Neuroprotection
    - Revascularization
    - Safety
    - Efficacy
    - Extended time window of treatment
    - Ease of use
- New product development
  - Prolyse
    - Clinical trials
  - Ancrod
    - Clinical trials
  - Danaparoid sodium
    - Clinical trials
  - Dabigatran etexilate
    - Clinical trials
  - Clazosentan
    - Clinical trials
  - Rivaroxaban
    - Clinical trials
  - Desmoteplase
    - Clinical trials
  - Conclusion
APPENDIX A BIBLIOGRAPHY
- Epidemiology
- General and clinical trial data
APPENDIX B
- Physician research methodology
  - Physician sample breakdown
  - US
  - Japan
  - France
  - Germany
  - Italy
  - Spain
  - UK
APPENDIX C
- The survey questionnaire
  - 1. Patient Segmentation
  - 2. Presentation And Referral
  - 3. Diagnosis
  - 4. Treatment
    - Treatment of ischemic stroke
    - Treatment of hemorrhagic stroke
  - 5. Treatment Outcomes
- Glossary
DISCLAIMER
- List of Tables
  - Table 1: Incidence of first-ever stroke, 2007
  - Table 2: All stroke patients with comorbidities and risk factors in the seven major markets, 2007
  - Table 3: Causes of hemorrhagic stroke experienced by patients, 2007
  - Table 4: Type of medical professional diagnosing stroke, 2007
  - Table 5: Emergency diagnosis tests carried out in stroke patients, 2007
  - Table 6: Percentage of patients undergoing each test following initial diagnosis, 2007
  - Table 7: Antiplatelets given to ischemic stroke patients in the acute phase, 2007
  - Table 8: Antiplatelets given to ischemic stroke patients in the post-acute phase, 2007
  - Table 9: Anticoagulants given to ischemic stroke patients in the acute phase, 2007
  - Table 10: Anticoagulants given to ischemic stroke patients in the post-acute phase, 2007
  - Table 11: Types of therapy received by Ischemic stroke patients to prevent recurrence, 2007
  - Table 12: Late-stage drugs in development for stroke, 2007
  - US physician sample breakdown, 2007
  - Japan physician sample breakdown, 2007
  - France physician sample breakdown, 2007
  - Germany physician sample breakdown, 2007
  - Italy physician sample breakdown, 2007
  - Spain physician sample breakdown, 2007
  - UK physician sample breakdown, 2007
- List of Figures
  - Figure 1: Diagrammatic overview of the coverage of the Stakeholder Insight: Stroke survey, 2007
  - Figure 2: Summary of stroke treatment in the US, 2007
  - Figure 3: Ischemic stroke treatment in the US (I), 2007
  - Figure 4: Ischemic stroke treatment in the US (II), 2007
  - Figure 5: Ischemic stroke treatment in the US (III), 2007
  - Figure 6: Hemorrhagic stroke treatment in the US, 2007
  - Figure 7: Summary of stroke treatment in Japan, 2007
  - Figure 8: Ischemic stroke treatment in Japan (I), 2007
  - Figure 9: Ischemic stroke treatment in Japan (II), 2007
  - Figure 10: Ischemic stroke treatment in Japan (III), 2007
  - Figure 11: Hemorrhagic stroke treatment in Japan, 2007
  - Figure 12: Summary of stroke treatment in France, 2007
  - Figure 13: Ischemic stroke treatment in France (I), 2007
  - Figure 14: Ischemic stroke treatment in France (II), 2007
  - Figure 15: Ischemic stroke treatment in France (III), 2007
  - Figure 16: Hemorrhagic stroke treatment in France, 2007
  - Figure 17: Summary of stroke treatment in Germany, 2007
  - Figure 18: Ischemic stroke treatment in Germany (I), 2007
  - Figure 19: Ischemic stroke treatment in Germany (II), 2007
  - Figure 20: Ischemic stroke treatment in Germany (III), 2007
  - Figure 21: Hemorrhagic stroke treatment in Germany, 2007
  - Figure 22: Summary of stroke treatment in Italy, 2007
  - Figure 23: Ischemic stroke treatment in Italy (I), 2007
  - Figure 24: Ischemic stroke treatment in Italy (II), 2007
  - Figure 25: Ischemic stroke treatment in Italy (III), 2007
  - Figure 26: Hemorrhagic stroke treatment in Italy, 2007
  - Figure 27: Summary of stroke treatment in Spain, 2007
  - Figure 28: Ischemic stroke treatment in Spain (I), 2007
  - Figure 29: Ischemic stroke treatment in Spain (II), 2007
  - Figure 30: Ischemic stroke treatment in Spain (III), 2007
  - Figure 31: Hemorrhagic stroke treatment in Spain, 2007
  - Figure 32: Summary of stroke treatment in the UK, 2007
  - Figure 33: Ischemic stroke treatment in the UK (I), 2007
  - Figure 34: Ischemic stroke treatment in the UK (II), 2007
  - Figure 35: Ischemic stroke treatment in the UK (III), 2007
  - Figure 36: Hemorrhagic stroke treatment in the UK, 2007
  - Figure 37: Average age of stroke patients, 2007
  - Figure 38: Time to presentation after the onset of symptoms, 2007
  - Figure 39: Time taken to obtain emergency test results, 2007
  - Figure 40: Secondary diagnostic tests carried out in stroke patients, 2007
  - Figure 41: Overview of treatment guidelines for acute ischemic stroke
  - Figure 42: Overview of treatment guidelines for ICH
  - Figure 43: Organization of an acute neurological stroke unit
  - Figure 44: Share of respondents whose hospital has an acute stroke unit, seven major markets, 2007
  - Figure 45: Treatment Pathways, 2007
  - Figure 46: Percentage of patients that are referred from other hospitals or admitted as emergencies to stroke units, 2007
  - Figure 47: Percentage of ischemic stroke patients treated by each healthcare professional, 2007
  - Figure 48: Stroke patients receiving initial drug therapy in the ambulance or emergency room, 2007
  - Figure 49: Ischemic stroke patients treated with acute drug therapy, 2007
  - Figure 50: Ischemic stroke patients treated in the post-acute phase, 2007
  - Figure 51: Ischemic stroke patients receiving specified thrombolytic (%), 2007
  - Figure 52: Hemorrhagic stroke patients receiving each specified therapy, 2007
  - Figure 53: Hemorrhagic stroke patients undergoing surgery, 2007
  - Figure 54: Hemorrhagic stroke patients undergoing the specified surgical procedures, 2007
  - Figure 55: Average length of hospital stay, 2007
  - Figure 56: Stroke patients who die before receiving medical attention, 2007
  - Figure 57: Stroke patients who die in hospital, 2007
  - Figure 58: Level of recovery achieved by ischemic stroke patients, 2007
  - Figure 59: Hemorrhagic stroke patients making each type of recovery (%), 2007
  - Figure 60: Stroke patients referred for rehabilitation, 2007
  - Figure 61: Stroke patients that go on to have recurrent stroke (%), 2007

Stakeholder Insight: Acute Stroke - TPA spurs infrastructure changes for the better

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