Lead Optimization A Reinvention of the Process

The ability to generate a sufficient number of candidate compounds that can be taken into the formal stages of drug development has always been essential to the pharmaceutical industry. The industry's present productivity crisis can be traced to two causes: development processes take too long, and their attrition profile is far from optimal - with too many candidates failing during the later stages when considerable resources have already been spent on them. Lead optimization is the procedural hub that determines the chances for eventual success of a drug. Companies have already realized that improving R&D productivity is contingent on the full integration of lead optimization into discovery and development. Although this will not lead to the disappearance of lead optimization as a discrete step in the process, from the beginning all its requirements need to be considered.

D&MD's Technology Forecasting Report, Lead Optimization: A Reinvention of the Process, examines in detail how to successfully integrate intelligent lead optimization library design and synthesis, advanced screening technologies, and early involvement of in vivo testing. The Report discusses cutting-edge methods, such as computational ADME/Tox, cell-based systems, pharmacogenomics, and metabonomics, along with several case studies in lead optimization. In addition, this Report reviews companies that supply lead optimization tools/services plus assesses aspects of patenting, economics, and regulatory affairs where considerations impacting lead optimization are important.

This Report Will Help You to:

• Discover the five main factors driving the redefinition of the lead optimization process through an in-depth review of each.
• Learn effective data management and visualization resolutions via a review of key strengths of specific informatics software available as turn-key solutions.
• Obtain an all-encompassing picture of lead optimization via a thorough examination of intellectual property issues, regulatory affairs, and manufacturing obstacles influencing the process.
• Identify the most promising lead compounds with an assessment of emerging technologies that are adapting pre-established criteria to target development.
• Recognize often neglected matters in lead optimization - synthesis economics, patenting, and regulatory affairs - from an evaluation of their importance and affect on the process.
• In order to recognize potential solutions get a first-hand account of successful approaches to lead optimization from four descriptive case studies.
• Look inside 10 companies that are pioneering of today's lead discovery and optimization through a complete discussion of their product pipelines, alliances, business strategies, and more.