Chemical Genomics Commercial Applications in Drug Discovery and Development

Table of Contents

Chapter 1: Executive Summary

Chapter 2: The Preface to Chemical Genomics and Chemogenomics

• The Traditional Drug Discovery and Development Process
  • Drug Discovery and Development: A Complex Process
  • Drug Discovery and Development: A Lengthy Process
  • Drug Discovery and Development: An Expensive Process
• Drug Discovery and Development: Bottlenecks
  • Discovery/Preclinical Bottleneck
  • Clinical/Drug Development Bottlenecks
• The Role of Chemistry

Chapter 3: Defining Chemical Genomics and Chemogenomics

• Context Leading to Chemical Genomics and Chemogenomics
• Defining Chemical Genomics.
  • Selected Definitions of Chemical Genomics
  • Classical Genetics to Chemical Genomics
  • Forward Genetics
  • Reverse Genetics
• Chemical Genomics and Chemogenomics Technologies
  • Company Technologies
  • Acadia Pharmaceuticals
  • Amphora Discovery Corp.
  • Current target classes under investigation by Amphora include:
  • Chemical Genomics Application:
  • Avalon Pharmaceuticals
  • Chemical Genomics Application:
  • Astex
  • Chemical Genomics Application:
  • ChemGenex Therapeutics
  • Chemical Genomics Application:
  • Graffinity Pharmaceuticals
  • Chemical Genomics Application:
  • Iconix Pharmaceuticals
  • Chemical Genomics Application:
  • Infinity Pharmaceuticals, Inc.
  • Chemical Genomics Application:
  • Morphochem
  • Chemical Genomics Application:
  • NeoGenesis
  • Chemical Genomics Application:
  • Vertex Pharmaceuticals
  • Chemical Genomics Application:
  • Definitions Revisited

Chapter 4: Role of Chemistry in Chemical Genomics

• Use of Small Molecules to Explore Biology
• Examples of Utilizing Chemical Genomic and Chemogenomic Approaches
  • Utilizing Yeast Deletion Strains in Chemical Genomics
  • Tools for Successful Chemical Genomics and Chemogenomics
  • Applying Combinatorial and Synthesis Chemistry in Chemical Genomics
  • Probing Biology with Chemistry
  • Calcium-calcineurin-NFAT signaling pathway
  • Small-molecule Dimerizers
  • TOR and the Nutrient Response-signaling Network
  • HDACs and Chromatin
  • Access to Chemical Diversity
  • Access to Chemical Genomics Data -The ChemBank Connection
• Applying Chemical Genomics in Anticancer Drug Discovery and Development
• Summary and Conclusions

Chapter 5: Opinions from Industry Experts

• Reinhard Ebner, Ph.D.
• Bill Heilman, PhD
• Alan Engelberg
• Martin F. Haslanger, Ph.D.,
• Guri Giaever
• Andrew W. Stern, Ph.D.

Chapter 6: Company Profiles

• ACADIA Pharmaceuticals Inc.
• Amphora
• Astex Technology
• Avalon Pharmaceutical
  • Technology, Research and Development
• ComGenex International
• Graffinity.
• Iconix Pharmaceuticals.
• Infinity Pharmaceuticals
• NeoGenesis

Chapter 7: Recommended Reading

TABLE OF EXHIBITS

• Exhibit 1.1 Publications in the Chemical Genomics Field
• Exhibit 1.2 Drug Discovery and Development: Comparison of Traditional with Chemical Genomics Approach
• Exhibit 2.1 Drug Discovery and Development: Time and Money
• Exhibit 2.2 Drug Discovery and Development: Bottlenecks
• Exhibit 2.3 Schematic Segmentation of Drug Targets Depicted from Human Genome Sequencing
• Exhibit 2.4 From Discovery to Fruition. Comparing Sequence, Gene Discovery, Targets, and Chemistry
• Exhibit 2.5 How Chemistry and Screening Fits into the Big Picture of Discovery and Development
• Exhibit 3.1 Defining Chemical Genomics.
• Exhibit 3.2 Comparing Drug Discovery and Development between Pharmaceutical and Biotechnology Companies
• Exhibit 3.3 Schematic Defining different Aspects of Chemical Genomics
• Exhibit 3.4 Definitions Associated with Chemical/chemo-genomics Paradigm
• Exhibit 3.5 Schematic Showing Drug Discovery Linear Process and Chemical Genomics Based Parallel Fashion
• Exhibit 3.6 Defining and Comparing Forward Genetics, Reverse Genetics, Forward Chemical Genetics and Reverse Chemical Genetics
• Exhibit 3.7 Acadias Chemical Genomics Approach
• Exhibit 3.8 Avalon Pharmaceuticals Chemical Genomics Approach.
• Exhibit 3.9 Iconix Pharmaceuticals Chemogenomics Approach
• Exhibit 3.10 Schematic of Morphochems Chemical Genomics Approach.
• Exhibit 3.11 Schematic of Neogenesis Approach for Drug Target Based Small Molecule Identification
• Exhibit 3.12 Schematic of Comparing Traditional Approach with Chemical Genomics Approach
• Exhibit 4.1 Schematic of Drug Discovery Approach for Anti-cancer Drug Discovery.
• Exhibit 4.2 Schematic of the Comparison of Conventional Small Molecule Drug Discovery Approach with Chemical Genomics Approach
• Exhibit 4.3 Applications of Chemical Genomics
• Exhibit 6.1. Schematic of Acadias Drug Discovery Approach
• Exhibit 6.2 Schematic of Avalon Pharmaceuticals Therapeutics Anti-cancer Drugs