Abstract
Proteases are a superfamily of enzymes with important roles in the regulation
of cellular protein activity. There are at least 475 known and putative
proteases and 103 homologs to known proteases in humans, and it is estimated
that up to 1,200 human genes encode proteases. Successful established protease
inhibitor drugs on the market act by inhibiting key proteases. Their success has
led to proteases being increasingly viewed as valuable drug targets in disease
treatment and a range of protease inhibitors are in various stages of commercial
development.
Scope
This Report offers a comprehensive review of the global protease market. The
Report discusses strategies to design peptidomimetic and non-peptidomimetic
competitive inhibitors, as well as other types of inhibitors. The main disease
areas where proteases or their inhibitors are involved include infectious
diseases, inflammation and wounds, cancer, cardiovascular conditions,
neurodegenerative diseases, and more are examined. In addition, this report
profiles key companies active in the protease drug discovery area.
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