Discoveries and Challenges in Early-Stage Apoptosis Drug Development

Table of Contents

Introduction

An Overview of Apoptosis

• Characteristics of Apoptosis
• Detecting Apoptosis
• Role of Apoptosis in Human Development
• Role of Apoptosis in Disease
• The Apoptotic Pathways

Apoptosis Activators in Development for Cancer

• Bcl-2 Inhibitors
• IAP Inhibitors
• TRAIL Receptor Agonists
• Other Intrinsic Pathway Drug Discovery Methods

Caspase Inhibitors as Antiapoptotic Agents

• Challenges to Caspase Inhibitor Development
• IDN-6556

Outlook