Impact of the PROactive Study on the Treatment of Type 2 Diabetes

Table of Contents

Introduction: Promising Results in the Recent PROactive Study

Type 2 Diabetes: Disease Background and Prevalence

• Pathophysiology and Risk Factors
• Type 2 Diabetes and Cardiovascular Disease
• Prevalence of Type 2 Diabetes

Overview of Current Drug Therapies

• Sulfonylureas
• Meglitinides
• Alpha-Glucosidase Inhibitors
• Biguanides
• Peroxisome Proliferator-Activated Receptor-Gamma Agonists
• Glucagon-Like Peptide-1 Analogues
• Amylin Analogues

The PROactive Study: Revealing a Potential Breakthrough Treatment for Cardiovascular Disease in

Type 2 Diabetes

• The Role of PPAR in Cardiovascular Disease
• PROactive Study Design
• PROactive Study Results
• Shortcomings of the PROactive Study

Outlook