Repositioning ADME Studies: A Strategy to Reduce Drug Attrition

Table of Contents

• Executive Summary
  • Strategic Considerations
  • Stakeholder Implications
• Introduction
• ADME Properties and Drug-Likeness
• Positioning ADME in the R&D Process
• Absorption
  • Experimental Methods
    • Cell-Culture Assays
    • Cell-Free Assays
  • Computational Methods
• Distribution
  • Protein Binding
  • Blood-Brain-Barrier Penetration
• Metabolism
  • Experimental Methods
  • Computational Methods
• Excretion
• Company Profi les
  • Apredica
  • Creative Research Solutions
  • Cyprotex
  • Inpharmatica
  • Nimbus Biotechnology
  • Novamass Analytical
  • Quest Pharmaceutical Services
  • Solvo Biotechnology
  • TechElan
• Outlook for Early-Stage ADME Studies

Tables

• 1. Lipinski' s Rules
• 2. Suppliers of Computational ADME Packages
• 3. Providers of ADME Services

Figures

• 1 Success Rates as Compounds Advance Through Stages of Development
• 2. New Positioning of ADME Studies During Drug Discovery