Abstract
Introduction
Protein biomarkers are appealing to drug developers because they can be used
early in the drug research pipeline, which allows early elimination of
ineffective or toxic compounds. Although the promise of these biomarkers is
clear, the path to successful implementation of protein biomarkers is not.
Perhaps the discovery-based approach is not the best way to tap the potential
of protein biomarkers.
Get the Answers You Need to Shape Your Strategy
- Despite scientifi c advancements, protein biomarker discovery is slowing.
What are the challenges facing companies and researchers that are hindering
the discovery process?
- Researchers are rethinking the discovery-based approach. What other
options and innovations are available? What companies are leading the way?
- The future of protein biomarkers is extremely promising for a multitude of
businesses. What benefi ts are available for technology vendors, Big Pharma
companies, researchers, and regulatory agencies? Can collaboration between any
or all of these stakeholders ensure the success of protein biomarkers?
Scope
- Proteomics technologies: 2D PAGE, mass spectrometry, antibody
microarrays, microfl uidics, label-free technologies.
- Alternatives to discovery-based approach: hypothesis-based
approach, engineering better biomarkers, systems biology.
- Major players in protein biomarker discovery: Bayer, Eli Lilly,
Novartis, Pfi zer, Roche.
- Outlook: The path toward successful protein biomarker discovery may
include multiplexing strategies, collaborations among researchers and
developers, and support from regulatory bodies.
Companies Mentioned in This Spectrum Report
- Applied Biosystems
- Axis Shield
- Bayer Pharmaceuticals
- Beyond Genomics
- Biacore
- Bioforce Nanoscience
- Bio-Rad
- Biosite
- Bruker Daltonics
- Cantion
- Clontech
- CODA Genomics
- Eisai
- Eli Lilly
- Fujirebio
- Gene News
- Genedata
- GeneProt
- Geneva Proteomics
- Genomic Solutions
- Genoptics
- GenTel Biosciences
- Integrated Genomics
- Invitrogen
- Johnson & Johnson
- Lumera
- Matritech
- Microfl uidics
- Millennium Pharmaceuticals
- Pfi zer
- Phadia US
- Power3 Medical Products
- Predictive Diagnostics
- Proteome Systems
- Quadraspec
- RBM
- Roche
- Rosetta Inpharmatics
- Sareum
- Shimadzu
- Target Discovery
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