Abstract
Introduction
The peroxisome proliferator-activated receptor (PPAR)-gamma agonist class of
drugs is the fastest-growing drug class in the type 2 diabetes market. Sales
of the two PPAR-gamma agonists, GlaxoSmithKline' s Avandia and Takeda' s Actos,
are signifi cant drivers of type 2 diabetes market sales. However, a recent
study has questioned the safety of Avandia and has triggered a debate about
the use of PPAR-gamma agonists, thereby presenting commercial opportunities
for new agents in the treatment of type 2 diabetes.
Questions Answered in This Spectrum Report
- PPAR-gamma agonists are among the most popular therapies in the treatment
of type 2 diabetes. However, a recent meta-analysis has highlighted the
potential for cardiovascular side effects with Avandia and has affected both
sales of the agent and GlaxoSmithKline' s stock price. What are the strengths
and weaknesses of the Avandia study? Are the safety concerns raised by the
study relevant only to Avandia or to the entire PPAR-gamma agonist class?
- The safety concerns about PPAR-gamma agonists present a commercial
opportunity for new agents that offer a unique mechanism of action, an
improved safety profi le, and evidence of effi cacy. Which newly launched
agents threaten to compete with the PPAR-gamma agonists for the position of
preferred third-line therapy in type 2 diabetes? What advantages-and
shortcomings-do these new agents have?
- Novartis is developing a drug that that promises to compete heavily with
newly launched agents and further change the landscape of the type 2 diabetes
market. How will this agent differentiate itself from the currently available
type 2 diabetes therapies?
Scope
- Overview of PPAR-gamma agonists: mechanism of action, side effects, role
in the treatment of type 2 diabetes.
- Avandia controversy: safety concerns, the response to the recent
meta-analysis, implications for the PPAR-gamma agonist drug class.
- Commercial opportunities for new agents: description of agents that are
newly launched or in development.
- Outlook: how recent developments will affect the PPAR-gamma agonist drug
class and the type 2 diabetes market.
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