Abstract
Introduction
Despite 25 years of extensive research, an HIV vaccine remains an elusive
target. More-innovative approaches to vaccine development are urgently needed.
Although this high-risk, high-profi le area of development is crucial to world
health, it is unlikely to offer fi nancial rewards for Big Pharma. Therefore,
smaller biotechs and charitable organizations also play key roles.
Get the Answers You Need to Shape Your Strategy
- The recent failure of Merck' s T-cell vaccine for HIV may mark a turning
point in HIV development across the industry. Which other HIV vaccines in
the pipeline use this same approach? What other approaches to vaccine
development might offer greater potential for success in the future?
- Despite the critical importance of addressing the HIV pandemic, the market
potential of a vaccine will be limited in the near term. Where is the
greatest market potential? What strategies are pharmaceutical and biotech
companies pursuing to solve this world health problem while also maximizing
returns?
- Given the market limitations associated with HIV vaccine development,
government and charitable organizations are funding many of the development
efforts. Which organizations are providing the greatest amount of funding?
How is the pharmaceutical industry working with these organizations to achieve
scientifi c breakthroughs and gain a competitive advantage?
Scope
- Understanding HIV: background on the virus, the immune response,
the need for a vaccine.
- HIV market: market potential, possible target populations,
challenges, strategic considerations.
- Current approaches to vaccine design: neutralizing antibodies,
cell-mediated immunity.
- Current vaccine candidates: recombinant viral vectors, DNA
vaccines, recombinant proteins, peptides and lipopeptides.
- Future approaches to vaccine design: mucosal immunity, recombinant
vectors, virus-like particles, live attenuated vaccines, whole inactivated
viral vaccines, synthetic peptide immunogens, gene therapy, antisense
oligonucleotides.
- Outlook: Big Pharma, biotech companies, governments, charitable
organizations.
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