How Insulin Resistance Diagnostics Can Expand the Market for Insulin-Sensitizing Agents

Table of Contents

• Executive Summary
  • Strategic Considerations
  • Stakeholder Implications
• Unmet Need in Insulin Resistance Testing
• An Overview of Insulin Resistance
  • Link Between Insulin Resistance and Other Diseases
  • Epidemiology of Insulin Resistance
• Current Diagnostics for Insulin Resistance
  • Euglycemic Hyperinsulinemic Clamp
  • Steady-State Plasma Glucose
  • Random Plasma Glucose
  • Fasting Plasma Glucose
  • Oral Glucose Tolerance Test
  • Frequently Sampled Intravenous Glucose Tolerance Test
  • Glycosylated Hemoglobin A1c
  • Fasting Insulin Measurements
  • Homeostasis Assessment Model
• New Diagnostic Techniques for Insulin Resistance
  • KineMed
  • Isotechnika
  • Syn X
  • LipoScience
  • Entelos
• Outlook
  • About the Authors
• Appendix A. Etiology and Pathophysiology of Insulin Resistance
  • Etiology
  • Pathophysiology
• Appendix B. Bibliography

Tables

• 1. Studies Demonstrating the Relationship Between Insulin Resistance, Diabetes, and Cardiovascular Diseases
• 2. Updated NCEP-ATP III Criteria for Metabolic Syndrome from the AHA and NHLBI
• 3. Prevalence of Insulin Resistance in Various Populations
• 4. Number of Total Prevalent Cases of Insulin Resistance Segmented by Type 2 Diabetic and Nondiabetic Subpopulations in the United States and Major European Markets, 2006-2016
• 5. Indexes Currently Used to Assess Insulin Resistance
• 6. Select Novel Tests and Indexes for Insulin Resistance
• 7. Select Companies with Diagnostics for Insulin Sensitivity/Resistance
• 8. Clinical Trials for the Pharmacological Prevention of Type 2 Diabetes
• A-1. Risk Factors for Insulin Resistance

Figures

• A-1. Clinical Progression of Insulin Resistance