Obesity Drug Discoveries: what the future holds

While only recently identified as a major health concern, obesity levels have been growing steadily and the condition threatens to rank among the biggest causes of premature death in both the industrialised and emerging economies. With only three products approved worldwide for long-term treatment, and growing unmet clinical need, the treatment of obesity could present a major opportunity area for pharma companies.

Obesity has reached epidemic proportions worldwide. With 2005 estimates of approximately 1.6 billion adults (aged 15 years and over) overweight and at least 400 million adults obese, the World Health Organization predicts that by 2015, approximately 2.3 billion adults will be overweight and more than 700 million will be obese. These estimates do not even take into account a lower overweight threshold set for Asians. In the US and Canada half of all adults are likely to be obese within eight years, with only one in five people of healthy weight.

The market for weight-loss drugs in the US, Europe and Japan totalled around US$600 million in 2005, and is expected to rise globally to approximately US$2 billion by 2010. Current long-term treatments include: Abbott' s Meridia/Reductil (sibutramine), a monoamine reuptake inhibitor that is approved in the US and Europe; Roche' s Xenical (orlistat), a gastric lipase inhibitor that is approved in the US and Europe; and sanofi-aventis' Acomplia (rimonabant), a cannabinoid type 1 receptor blocker that is approved only in Europe.

No single major company dominates the obesity drug market, although sanofi-aventis, GSK, Merck & Co and Pfizer all have several compounds in development. The rewards are high for those who can bring effective treatments to market, but questions remain...

• What are the strengths and weaknesses for current therapy approaches?
• Which research approach is likely to achieve best clinical and commercial results and when are the resulting drugs likely to reach the market?
• What are the development and regulatory challenges companies must overcome?

The answers to these and many other questions can be found in this new 120+ page strategic management report Obesity Drug Discoveries: What the future holds (published August 2007). In addition, for those needing to monitor this developing area there is the Obesity Tracker, an online news service available for customers buying the web edition of the report.

Key areas addressed

• Sales forecasts for major launched products
• Obesity prevalence and trends
• Detailed appraisal of 20 therapies in research
• Estimation of launch
• Emerging trends and developments

Focus on leading strategies

• Beta3 adrenergic receptor modulators
• Cannabinoid receptor modulators
• Digestive inhibitors/lipid metabolism modulators
• Histaminergic system modulators
• Hormone analogues
• Monoamine reuptake inhibitors/5-HT receptor modulators
• Neuropeptide receptor modulators
• Combination therapies

UNIQUE COMPETITIVE ASSESSMENT SCORE

For each product reviewed, the report provides a critical competitor ratio analysis, based on our assessment of the following five criteria:

• novelty/rationale for mechanism of action
• proof of concept/clinical data
• management expertise
• competition within the marketplace
• risks associated with drug development in the therapeutic class