The World Orthopaedic Market Report 2008

Table of Contents

ORTHOPAEDIC MARKET

• Global Orthopaedic Market by Segment, 2006
• 2006-2011 Worldwide Orthopaedic Market by Segment
• World Orthopaedic Market Forecasts, 2006-2011
  • Joint Replacement Market
    • Global Reconstruction Market Shares, 2006
    • Global Reconstruction Market by Product, 2006
  • Trauma Market
    • Global Trauma & Craniomaxillofacial Market, 2006
  • Spinal Market
    • Global Spinal Market Shares, 2006*
  • Arthroscopy Market
    • Global Arthroscopy Market (US$2 billion), 2006*
  • Orthobiologics
  • Key Players
    • Global Orthopaedic Market Shares, 2006

WORLD MARKET REVIEW

• Global Orthopaedic Market by Region, 2006 (US$ million)
• Global Orthopaedic Market by Region, 2006 (%)
• Projected CAGR (%) in the Global Orthopaedic Market by Region, 2006-2011
  • North America
    • United States
      • US Orthopaedic Market - Key Indicators 2006
      • Diagnoses by CCS Category, 2005
      • Clinical Procedures by CCS Code, 2000-05 (All Listed)
      • Discharges from Short Stay Hospitals by Sex & Diagnosis, 2001-05 (000s)
      • Procedures in Short-Stay Hospitals by Age, 2005 (000s)
    • Canada
      • Canadian Orthopaedic Market - Key Indicators 2006
      • Number of Hospitalisations for Hip and Knee Replacement Procedures,1994⁄1995-2004⁄2005
  • Western Europe
    • Western Europe Orthopaedic Market, 2006
    • Key Western Europe Orthopaedic Markets, 2006 (%)
    • Germany
      • German Orthopaedic Market - Key Indicators 2006
      • Inpatients by Diagnosis, 2000-2004
    • United Kingdom
      • UK Orthopaedic Market - Key Indicators 2006
      • Hip & Knee Joint Replacements in England & Wales, 2006
      • Primary Diagnosis in England by ICD10 Diagnosis Group, 2004⁄05
      • Operations performed in English Hospitals, 2004⁄05
    • Orthopaedic Manufacturers in Western Europe
      • Asia⁄Pacific
      • Asia⁄Pacific Orthopaedic Market, 2006
      • Key Asia⁄Pacific Orthopaedic Markets, 2006 (%)
    • Japan
      • Japanese Orthopaedic Market - Key Indicators 2006
    • Japanese Orthopaedic Activity
      • Daily Number of Inpatients per 100,000 population, 1990-2002
    • Australia
      • Australian Orthopaedic Market - Key Indicators 2006
      • Hospital Inpatient Separations by ICD Classification, 2004⁄05
      • Leading ICD Diagnoses, Public Hospitals, 2004⁄05
      • Leading ICD Diagnoses, Private Hospitals, 2004⁄05
      • Leading Procedures Performed in Public Hospitals, 2004⁄05
      • Leading Procedures Performed in Private Hospitals, 2004⁄05
  • Eastern Europe
    • East European Orthopaedic Market, 2006
    • Key East European Orthopaedic Markets, 2006 (%)
  • Middle East & Africa
    • Middle East⁄Africa Orthopaedic Market, 2006
  • Central & South America
    • Orthopaedic Market in Central & South America, 2006

GROWTH DRIVERS

• Ageing Population
  • Global Population Forecasts 2006-2020
  • National Life Expectancy at Birth Ranked by Female Life Expectancy
  • World Overview, Population, % Aged 65+, 2006-11
  • World Overview, Population, Number Aged 65+, 2006-11 (Millions)
• Improved Products & Surgical Advances
  • Key Advances
  • Hip Resurfacing
  • Gender⁄ethnic-specific Knees
  • Artificial Lumbar Discs
  • Cervical Total Disc Replacement
  • Nucleus Replacement
  • Posterior Dynamic Stabilisation
  • Interspinous Process Spacers
  • Facet Replacement
  • Cartilage Repair⁄Regeneration
  • Bone Morphogenetic Proteins
  • Demineralised Bone Matrix (DBM)
  • Minimally Invasive Surgery
• Obesity
  • Prevalence

2006⁄2007 IN REVIEW

• Leading Orthopaedic Companies Ranked by Orthopaedic Revenues, 2006
• Selected Leading Orthopaedic Companies Ranked by Growth in Orthopaedic Revenues, 2005-2006
• R&D Expenditure as % of Total Revenues, 2006
• USDOJ Investigation Results in Settlements
• Mergers & Acquisitions
  • Mergers & Acquisitions in the Orthopaedic Sector 01⁄2006 to 11⁄2007
• Agreements
  • Agreements in the Orthopaedic Sector 01⁄2006 to 11⁄2007

INDUSTRY CONSOLIDATION

• Significant Acquisitions in the Orthopaedic Sector 1997-2005
• A New Wave of Industry Consolidation, 2006-2007
  • Increasing Role of Private Equity
    • Recent Private Equity Investment in the Orthopaedics Industry

AAP IMPLANTATE

• Recent Key Events
  • aap Implantate - Published Patents 2006-07
  • aap Implantate - Products Awaiting Regulatory Approval
  • aap Implantate - US FDA 510(k) Marketing Clearances 2007
  • aap Implantate - Substantial Equivalence⁄Predicate Device(s) to US FDA 510(k) Marketing Clearances 2007
• Financials
  • aap Implantate - Key Financial Data 2003-2006
  • aap Implantate - Sales by Country⁄Region 2003-2006
  • aap Implantate - Sales by Business Segment 2005-2006

ADVANCED BIOMATERIAL SYSTEMS

• Recent Key Events
  • Advanced Biomaterial Systems - Published Patents 2006-07
• Financials

AESCULAP

• Recent Key Events
  • Aesculap - Published Patents 2007
  • Aesculap - US FDA 510(k) Marketing Clearances 2006-2007
• Financials
  • Aesculap - Revenues, 2004-2006

ALPHATEC SPINE

• Recent Key Events
  • Alphatec Spine - US FDA 510(k) Marketing Clearances 2006-07
  • Alphatec Spine - Substantial Equivalence⁄Predicate Device(s) to US FDA 510(k) Marketing Clearances 2006-07
  • Alphatec Spine - Published Patents 2006-07
• Financials
  • Alphatec Spine - Key Financial Data 2005-2006

ARTHROSURFACE

• Recent Key Events
  • Arthrosurface - US FDA 510(k) Marketing Clearances 2006-07
  • Arthrosurface - Substantial Equivalence⁄Predicate Device(s) to US FDA 510(k) Marketing Clearances 2006-07
  • Arthrosurface - Published Patents 2006-07
• Financials

ARTIMPLANT

• Recent Key Events
  • Artimplant - US FDA 510(k) Marketing Clearances 2006-07
  • Artimplant - Substantial Equivalence⁄Predicate Device(s) to US FDA 510(k) Marketing Clearances 2006-07
  • Artimplant - Published Patents 2006-07
• Financials
  • Artimplant - Key Financial Data 2004-2006
  • Artimplant - Revenues by Geographic Area, 2006

ASCENSION ORTHOPEDICS

• Recent Key Events
  • Ascension Orthopedics - US FDA 510(k) Marketing Clearances 2006-07
  • Ascension Orthopedics - Substantial Equivalence⁄Predicate Device(s) to US FDA 510(k) Marketing Clearances 2006-07
  • Ascension Orthopedics - Published Patents 2006-07
• Financials

BIOMET

• Recent Key Events
  • Biomet - US FDA 510(k) Marketing Clearances 2006-07
  • Biomet - Substantial Equivalence⁄Predicate Device(s) to US FDA 510(k) Marketing Clearances 2006-07
  • Biomet - Published Patents 2006-07
• Financials
  • Revenue by Product Type, 2005-2007 (US$ million)*
  • Revenue by Product Type, 1998-2007 (US$ million)
  • Percentage of Revenue by Product Type, 2007

BIORTHEX

• Recent Key Events
  • Biorthex - Published Patents 2006-07
• Financials
  • Biorthex - Selected Financial Data 2004-2006

CO.DON

• Recent Key Events
• Financials
  • co.don - Key Financial Data 2001-2006

CORIN

• Recent Key Events
  • Corin Medical - US FDA 510(k) Marketing Clearances 2006-07
  • Corin Medical - Substantial Equivalence⁄Predicate Device(s) to US FDA 510(k) Marketing Clearances 2006-07
  • Corin - Published Patents 2006-07
• Financials
  • Corin Group - Key Financial Data 2002-2006
  • Corin Group - Revenue by Customer Location 2005-2006 (£ million)

DEPUY

• Recent Key Events
  • DePuy Spine - Published Patents 2007
  • DePuy Ireland - Published Patents 2007
  • DePuy Products - Published Patents 2007
  • DePuy Orthopaedics - Published Patents 2007
  • DePuy International Ltd. - Published Patents 2007
  • DePuy - US FDA 510(k) Marketing Clearances 2006-07
• Financials
  • DePuy Sales, 2004-2006 (US$ million)*

ENCORE MEDICAL

• Recent Key Events
  • Encore Medical - Published Patents 2006-07
  • Encore Medical - US FDA 510(k) Marketing Clearances 2006-07
• Financials
  • Encore Medical Revenues 2004-2006 (US$000s)

EXACTECH

• Recent Key Events
  • Exactech - US FDA 510(k) Marketing Clearances 2006-07
  • Exactech - Substantial Equivalence⁄Predicate Device(s) to US FDA 510(k) Marketing Clearances 2006-07
  • Exactech - Published Patents 2006-07
• Financials
  • Exactech - Key Financial Data 2003-2006
  • Exactech - Revenues by Product Line 2005-2006

GLOBUS MEDICAL

• Recent Key Events
  • Globus Medical - US FDA 510(k) Marketing Clearances 2006-07
  • Globus Medical - Substantial Equivalence⁄Predicate Device(s) to US FDA 510(k) Marketing Clearances 2006-07
  • Globus Medical - Published Patents 2006-07
• Financials
  • Globus Medical Revenues, 2003-2006

INTEGRA LIFESCIENCES

• Recent Key Events
  • Integra LifeSciences - US FDA 510(k) Marketing Clearances 2006-07
  • Integra LifeSciences - Published Patents 2007
• Financials
  • Integra LifeSciences - Key Financial Data 2003-2006
  • Integra LifeSciences - Revenues by Product Line 2005-2006
  • Integra LifeSciences - Revenues by Geographic Location 2003-2006

KYPHON

• Recent Key Events
  • Kyphon - Worldwide Patents 2003-2007
  • Kyphon - Published Patents 2007
• Financials
  • Kyphon - Key Financial Data 2003-2006
  • Kyphon - Revenues by Geographic Location 2004-2006

MEDTRONIC

• Recent Key Events
  • Recent Medtronic Sofamor Danek Patents
  • Medtronic Sofamor Danek - US FDA 510(k) Marketing Clearances 2006-07
• Financials
  • Medtronic - Key Financial Data 2005-2007 (US$ million)
  • Medtronic - Revenue by Operating Segment, 2005-2007 (US$ million)
  • Medtronic - Spinal & Navigation Revenues 2005-2007 (US$ million)

NUVASIVE

• Recent Key Events
  • NuVasive - US FDA 510(k) Marketing Clearances 2006-07
  • NuVasive - 510(k) Clearances 2003-2007*
  • NuVasive - Published Patents 2007
  • NuVasive - Patents in EPO Worldwide Database, 2003-2007
• FINANCIALS
  • NuVasive - Key Financial Data 2003-2006

ORTHOFIX

• Recent Key Events
  • Orthofix - Published Patents 2006-07
  • Orthofix - US FDA 510(k) Marketing Clearances 2006-07
• Financials
  • Orthofix - Key Financial Data 2004-2006 (US$ million)
  • Orthofix - Revenues by Geographic Location 2004-2006 (US$ million)
  • Orthofix - Revenue by Market Sector 2004-2006 (US$ million)
  • Orthofix Revenue by Business Segment 2004-2006 (US$ million)

REGENERATION TECHNOLOGIES

• Recent Key Events
  • Regeneration Technologies - US FDA 510(k) Marketing Clearances 2006-07
  • Regeneration Technologies - Substantial Equivalence⁄Predicate Device(s) to US FDA 510(k) Marketing Clearances 2006-07
  • Regeneration Technologies - Published Patents 2006-07
• Financials
  • Regeneration Technologies - Key Financial Data 2003-2006 (US$ millions)
  • Regeneration Technologies - Revenue by Product Type 2004-2006 (US$ millions)

SMALL BONE INNOVATIONS

• Recent Key Events
  • Small Bone Innovations - US FDA 510(k) Marketing Clearances 2006-07
  • Small Bone Innovations - Published Patents 2006-07
• Financials

SMITH & NEPHEW

• Recent Key Events
  • Smith & Nephew - Selected Published Orthopaedic Patents 2007
  • Smith & Nephew - US FDA 510(k) Marketing Clearances 2006-07
• Financials
  • Smith & Nephew - Key Financials 2003-2006
  • Smith & Nephew Revenue by Division, 2004-2006 (US$ million)
  • Smith & Nephew Revenue by Division, 2006

STRYKER

• Recent Key Events
  • Stryker - Selected Published Orthopaedic Patents 2006-07
  • Stryker - US FDA 510(k) Marketing Clearances 2006-07
• Financials
  • Stryker - Key Financial Indicators 2002-2006 (US$ million)
  • Stryker - Revenue by Operating Division, 2004-2005 (US$ million)

SYMMETRY MEDICAL

• Recent Key Events
  • Symmetry Medical - Worldwide Patents 2003-2007
• Financials
  • Symmetry Medical - Key Financial Data 2003-2006
  • Symmetry Medical - Revenue by Business Segment 2004-2006

SYNTHES

• Recent Key Events
  • Synthes - Published Patents 2006-07
  • Synthes - US FDA 510(k) Marketing Clearances 2006-07
• Financials
  • Synthes Key Financial Indicators - 2002-2006
  • Synthes - Revenues by Geographic Area 2005-2006 (US$ million)

TORNIER

• Recent Key Events
  • Tornier - Published Patents 2007
  • Tornier - US FDA 510(k) Marketing Clearances 2006-07
• Financials

TUTOGEN MEDICAL

• Recent Key Events
• Financials
  • Tutogen Medical - Key Financial Data 2003-2006
  • Tutogen Medical - Revenues by Geographic Location 2004-2006

WRIGHT MEDICAL GROUP

• Recent Key Events
  • Wright Medical Group - Published Patents 2006-07
  • Wright Medical Group - US FDA 510(k) Marketing Clearances 2006-07
• Financials
  • Wright Medical Technology - Key Financial Data 2005-2006 (US$ million)
  • Wright Medical Technology - Sales by Country⁄Region 2004-2006 (US$ million)
  • Wright Medical Technology - Sales by Business Segment 2004-2006 (US$ million)

ZIMMER

• Recent Key Events
  • Zimmer Tech - Selected Published Orthopaedic Patents 2007
  • Zimmer Spine - Selected Published Orthopaedic Patents 2007
  • Zimmer GmbH - Selected Published Orthopaedic Patents 2007
  • Zimmer Inc - Selected Published Orthopaedic Patents 2007
  • Zimmer Trabecular Metal Technology - Selected Published Orthopaedic Patents 2007
  • Zimmer Orthobiologics - Selected Published Orthopaedic Patents 2007
  • Zimmer - US FDA 510(k) Marketing Clearances 2007
• Financials
  • Zimmer - Key Financials 2004-2006 (US$ million)
  • Zimmer - Revenues by Product Segment 2002-2006 (US$ million)
  • Zimmer - Revenues by Geographic Area 2002-2006 (US$ million)

REPORT METHODOLOGY & BIBLIOGRAPHY

• Secondary Sources
• Primary Sources:
• Market forecasts
• Patents

DEFINITIONS

• Orthopaedic Market
• Orthopaedic Device⁄Medical Device