The Global Orthobiologics Market

Table of Contents

Volume 1

GLOBAL ORTHOBIOLOGICS MARKET

• Orthobiologic Market Segments
  • Table 1: Global Orthobiologics Market by Product, 2007-2012 (US$ million)
  • Table 2: Global Orthobiologics Market by Geographic Region 2007-2012
  • Figure 1: Bone Graft Substitute Materials Market, 2007 US$2.4 Billion
• Orthobiologics Sector - Market Players
• Recent Industry Highlights
• Orthobiologics Market - Market Drivers
  • Figure 2: Population Aged 65 and Over, US and Europe (Millions)
  • Figure 3: Percentage of Population Aged 65 and Over, US and Europe
  • Figure 4: US Population Aged 65 and Over, 2000-2050
  • Table 3: Obesity (most recent) by Country
• Growth in Number of Orthopaedic Procedures
  • Table 4: United States, Diagnoses by CCS Category, 2005
  • Table 5: United States - Clinical Procedures by CCS Code, 2000-05 (All Listed)
  • Table 6: Most Common Musculoskeletal Procedures in US hospitals, 2004
  • Table 7: Number of Hospitalisations for Hip and Knee Replacement Procedures in Canada, 1994/1995-2004/2005
• Western Europe
  • Table 8: Germany; Inpatients by Diagnosis, 2000-2004
  • Table 9: Ambulatory Surgery Rates for Arthroscopies Performed in Public and Private Hospitals in France, 2001
  • Table 10: Inpatient Activity in Public Short-Stay Units in France, 2003
  • Table 11: Inpatient Activity in Private Short-Stay Units in France, 2003
  • Table 12: Hip & Knee Joint Replacements in England & Wales, 2005/2006
  • Table 13: Primary Diagnosis in England by ICD10 Diagnostic Group, Diseases of the Musculoskeletal System 2004/05 and 2005/06
  • Table 14: Orthopaedic Operations performed in English Hospitals, 2005/06
  • Table 15: Operations performed in English Hospitals, 2004/05
  • Table 16: Hospital Activity, Diseases of the Musculoskeletal System in Italy, 2004
  • Table 17: Orthopaedic & Traumatology Procedures in Italy, 2005
• Musculoskeletal Conditions
• The Need for Bone Substitute Materials
  • Table 18: Bone Graft Procedures/Indications
• Autograft
• Alternative Bone Substitute Materials
• ORTHOBIOLOGICALS - FDA REGULATORY ENVIRONMENT

ALLOGRAFT TISSUE MARKET

• Advantages of Allografts
• Disadvantages of Allografts
• Market Drivers
• Market Players
• Traditional Allografts
• Precision Machined Spinal Allografts
• Allograft Tissue Matrix
• Fresh Osteochondral Allografts

DEMINERALISED BONE MATRIX MARKET SEGMENT

• Advantages and Disadvantages of DBM
• DBM Market Size
• DBM Market Players

GROWTH FACTORS MARKET

• BONE MORPHOGENIC PROTEINS market
• Medtronic
• Stryker Biotech
• DePuy
• BioMimetic Therapeutics
• CeraPedics
• Tornier and BioSET
• Cost of BMPs
• InFUSE Bone Graft LT Cage - Economic Impact
  • Table 19: InFUSE Bone Graft - Economic Impact; Payor Model - Two-Year Time Period Results
  • Table 20: Cost of Lumbar Spinal Fusion without InFUSE Bone Graft (Anterior Approach)
  • Table 21: Cost of Lumbar Spinal Fusion with InFUSE Bone Graft (Anterior Approach)
• PLATELET-DERIVED GROWTH FACTORS
  • Platelet-Rich Plasma
  • Advantages of PRP
  • Disadvantages of PRP
• AUTOLOGOUS PLATELET GEL PREPARATION SYSTEMS
  • Harvest Technologies/DePuy
    • Table 22: Performance Summary of Platelet Gel Technology Platforms
  • Biomet
  • Medtronic
  • Smith & Nephew
  • Exactech/EmCyte
  • Erythrosave Ltd
  • Platelet-Rich Fibrin

SYNTHETIC BONE GRAFT MARKET

• CERAMIC-BASED BONE GRAFT SUBSTITUTES
• Calcium Phosphate Products
• Market Players
• Calcium-Sulphate based products
• Bioactive Glass
• Composite Grafts
• Collagen-based Materials

JOINT FLUID THERAPY MARKET

• HYALURONIC ACID VISCOSUPPLEMENTATION
  • Table 23: NSAID-related deaths and admissions to hospital, UK, USA and Canada
• Leading Market Players
  • Table 24: Level of Hyaluronate in Healthy and Osteoarthritic Synovial Fluid
  • Table 25: Comparison of Synvisc with Other Selected Viscosupplements
• HA Viscosupplementation Treatments
• Is Viscosupplementation Clinically Effective?

SOFT TISSUE REPAIR

• ARTICULAR CARTILAGE REPAIR MARKET
• Market Drivers
• Market Size and Potential
  • Figure 5: Global Cartilage Repair Market Potential, US$3 Billion*
• Cell-Based Cartilage Repair Therapies: ACI , MACI , AMIC , CACI
• Synthetic Cartilage Repair
• Combination Synthetic/ACI Cartilage Repair
• Future Cartilage Repair Technologies
• Acellular Cartilage Repair

STEM CELL THERAPIES

• Market Size
• Mesenchymal STEM CELLS - alternative to autograft
  • Bone Marrow Harvesting
• MESENCHYMAL STEM CELL products
  • Osiris / Blackstone Medical
  • Aastrom Biosciences
  • Osteotech
  • Smith & Nephew and RE MEDI
  • TiGenix
  • Mesoblast
  • BioE - Phillips Plastics
  • Massachusetts General Hospital and the Harvard Stem Cell Institute
• Amniotic Fluid-Derived Stem (AFS) Cells
  • Research at Wake Forest and Harvard Universities
• FAT-DERIVED STEM CELLS
  • Fat-derived stem cells could aid percutaneous spine therapies

GENE THERAPY

• Light Activated Gene Therapy
• Freeze-Dried Tendon Implants Loaded with Gene Therapy
• New Procedure for Creating Bone
• summing up
• FUTURE MARKET TRENDS

MERGERS & ACQUISITIONS IN THE ORTHOBIOLOGICS SECTOR

AGREEMENTS IN THE ORTHOBIOLOGICS SECTOR

REFERENCES

Volume 2

MANUFACTURERS OF ORTHOBIOLOGIC PRODUCTS

• 3DM
  • PuraMatrix Hydrogels
• AAP IMPLANTATE
  • Orthobiologics
  • Mergers and Acquisitions
  • Agreements
  • Financial Results
    • Table 1: aap Implantate 2006-2007 Sales
• AASTROM BIOSCIENCES
  • Financial Results
• ABBOTT SPINE
  • Biologics
  • Agreements
• ALLOGRAFT TISSUE SYSTEMS INC (ATSI)
  • Allograft Products
  • Agreements
• ALLOSOURCE
• ALPHATEC SPINE
  • Allograft Systems
  • Bone Grafting Materials
  • Acquisitions
  • Agreements
  • Financial Results
• APATECH
• ARTHRO KINETICS
  • Development Projects
  • Business Rationale
  • Agreements
• BERKELEY ADVANCED BIOMATERIALS
  • Ostetic Hydroxyapatite Products
  • GenerOs
  • Demineralised Bone Matrix
  • Agreements
• BIOMET
  • Biomaterials and Biologics
  • Agreements
  • Financial Results
    • Table 2: Biomet Revenue by Product Type, 2005-2007 (US$ million)*
• BIOMIMETIC THERAPEUTICS
  • Recombinant Protein Therapeutics with Tissue Specific Scaffolds
• BIONICHE PHARMA
• BIOSYNTECH
  • BST -Gel
  • Financial Results
• CO.DON AG
  • Orthopaedic Products
  • Agreements
  • Financial Results
• COLLAGEN MATRIX
  • Orthopaedic/Spine Applications
• CSIRO
  • Articular Cartilage Repair
• CURASAN AG
  • Synthetic Bone Graft Substitute
  • Joint Fluid Therapy
  • Agreements
  • Financial Results
    • Table 3: Curasan, Key Financial Results, 2004-2006
• DEPUY
  • Orthobiologic Products
  • Acquisitions
  • Agreements
  • Financial Results
    • Figure 1: DePuy Sales, 2004-2006 (US$ million)
• ETEX CORPORATION
  • Bone Substitute Materials
  • Carrier for Cells and Therapeutic Agents
  • Resorbable Orthopaedic Devices
  • Implant Surface Angstrom Coatings
  • Agreements
• EXACTECH
  • Biologics
  • Optecure DB M
  • Opteform and Optefil
  • OpteMx
  • Accelerate Platelet Concentrate System
  • Altiva Products
  • Acquisitions
  • Direct Distribution Operation in Japan
  • Licence Agreement - Cartilage Repair
  • Financial Results
• FERRING PHARMACEUTICALS
  • Non-Avian Sourced HA Viscosupplement
  • Mergers and Acquisitions
  • Financials
• FIDIA ADVANCED BIOPOLYMERS
  • Hyaluronan-Based Tissue-Engineered Cartilage
• GEISTLICH BIOMATERIALS
  • Regenerative Orthopaedic Products
  • Financial Results
  • Company Aims
• GENZYME
  • Biosurgery Products
  • Articular Cartilage Repair
  • New R&D Facility - China
  • Financial Results
• GRAFTYS
  • Graftys BCP Synthetic Bone Substitute
  • Resorbable Bioactive Cement
  • Combination Technologies
• HISTOGENICS
  • Cartilage Repair Products
  • Intellectual Property
  • Funding
• INTEGRA LIFESCIENCES
  • Orthobiologic Products
  • Agreements
  • Financial Results
    • Table 4: Integra LifeSciences Fiscal 2007 Revenue (US$ thousands)
    • Table 5: Integra LifeSciences 2008 Outlook
    • Table 6: Integra LifeSciences: Financial Indicators, 2002-2006
• ISTO TECHNOLOGIES
  • InQu Synthetic Bone Graft Substitute
  • Cartilage Regeneration Products
  • Agreements
• KASIOS
  • Kasios TCP Synthetic Bone Substitute
  • JectOS Injectable Bone Substitute
  • JectOS + Radiopaque Injectable Synthetic Bone Substitute
  • KAGE and KG Bone Cervical Cage with Synthetic Bone Substitute
  • TCH Synthetic Bone Substitute
• KINAMED
  • Allograft Tissue Products
• LIFECELL
  • KCI to Acquire LifeCell
  • LifeCell' s Orthopaedic Tissue Products
    • Table 7: Estimated Market Data for LifeCell' s Major Product Applications in the US
  • Financial Results
• LIFENET HEALTH
  • Allograft Tissue Products
• MAGNECELL
  • Magnetic Nanoparticles Cartilage Repair Technology
• MEDTRONIC
  • Biologics
  • Agreements
  • Mergers and Acquisitions
  • Financials
    • Table 8: Medtronic - Key Financial Data 2005-2007 (US$ million)
    • Table 9: Medtronic - Revenue by Operating Segment, 2005-2007 (US$ million)
    • Table 10: Medtronic - Spinal & Navigation Revenues, 2005-2007 (US$ million)
• MESOBLAST
  • Orthopaedic Applications
• MUSCULOSKELETAL TRANSPLANT FOUNDATION (MTF)
  • DB X: Demineralised Bone Matrix
  • Bone Void Fillers: Orthopaedic Allografts
  • Osteochondral Grafts for Cartilage Repair
  • Meniscal Transplantation
  • Large Grafts: Structural Repair Allografts
  • Synthes Spine: Precision Spinal Allografts
  • NovaBone
• NANOCOATINGS PTY LTD
  • BioAlmog Synthetic Bone Graft Material
• NANOTHERAPEUTICS
  • Origen DB M with Bioactive Glass
• OLYMPUS TERUMO BIOMATERIALS CORP
  • Company Background
  • Products
• ORTHOFIX
  • Biologics
  • Blackstone Medical Products
  • Financial Results
    • Table 11: Orthofix' Net Sales by Business Segment, 2005-2007
    • Table 12: Orthofix' Net sales by Market Sector, 2005-2007 (US$ million)
    • Table 13: Orthofix Sales by Market Sector for the Three Month Period Ended 31st March 2008
    • Table 14: Orthofix Sales by Market Sector for the Three Month Period Ended 31st March 2007
• ORTHOMIMETICS
  • Tissue Regeneration Scaffolds
  • TSB Award
• ORTHOVITA
  • Synthetic Bone Graft Materials
  • Agreements
  • Financial Results
    • Table 15: Orthovita' s Product Sales 2006-2007
• OSIRIS
  • Orthobiologic Products
  • Agreements
  • Financial Results
• OSSACUR
  • Synthetic Bone Graft Material
  • Biological Bone Void Fillers
• OSTEOTECH
  • Grafton DBM
  • Spinal Allografts
  • Plexur Biocomposites
  • Traditional Allograft Tissue
  • Xenograft Bone Tissue Products
  • Agreements
  • Purchasing Contract
  • Research and Development
  • Financial Results
    • Table 16: Osteotech Consolidated Segment Revenue Fiscal 2006-7 (in US$ thousand)
• PEGASUS BIOLOGICS
  • Collagen Scaffolds
  • Product Pipeline
  • Financing
• PIONEER SURGICAL TECHNOLOGY
  • E-Matrix
  • NanOss
• Q-MED AB
  • Durolane HA Viscosupplement
• REGEN BIOLOGICS
  • Menaflex Collagen Meniscus Implant
• RTI BIOLOGICS
  • Fresh-stored Osteochondral OC Allografts
  • Agreements
  • Tutogen Medical Agreements
  • Financial Results
    • Table 17: RTI Biologics, Amount and Percentage of Revenue 2005-2007
• SMITH & NEPHEW
  • Joint Fluid Therapy
  • Platelet Concentration System
  • Articular Cartilage Repair
  • Synthetic Bone Graft Substitutes
  • Development Agreements
  • Distribution Agreements
  • Mergers and Acquisitions
  • OsteoBiologics
  • Financial Results
• SPINAL RESTORATION
  • Biostat Disc Augmentation System
  • Agreements
• SPINEOVATIONS
  • DiscSeal
  • Acquisitions
• STELLAR PHARMACEUTICALS
  • Joint Fluid therapy
  • Synthetic Bone Graft
  • Financial Results
    • Table 18: Stellar Pharmaceuticals - Key Financial Data 2004-2006 (Canadian dollars)
• STRYKER
  • OP -1 (Osteogenic Protein-1, BMP-7)
  • Spinal Allografts
  • Synthetics
  • Financial Results
    • Table 19: Stryker' s Net sales 2005-2007 (US$ millions)
• SYNTHES
  • chronOS Synthetic Bone Grafts
  • Demineralised Bone Matrix
  • Allograft Chips and Blocks
  • Norian Craniofacial Repair System
  • Norian SRS (Skeletal Repair System)
  • Porous Polyethylene Implants
  • Agreements
  • Financial Results
    • Table 20: Synthes' Consolidated Net Sales (First Quarter 2008, January to March)
• TIGENIX
  • ChondroCelect
  • Partnership with Fidia Advanced Biopolymers
  • Research and Development - Product Pipeline
• TRB CHEMEDICA
  • Joint Fluid Therapy
  • Synovial Fluid Replacement after Arthroscopy
• WRIGHT MEDICAL
  • Biologics Products
  • Financial Results
    • Table 21: Wright Medical' s Net Sales by Product Line, 2005-2007
• ZIMMER
  • Puros Allograft Products
  • Bone Graft Substitutes
  • Cartilage Repair
  • Agreements