Vaccines

TABLE OF CONTENTS

INTRODUCTION

I. EXECUTIVE SUMMARY

II. MARKET ENVIRONMENT

General

Economic Factors

Recent Economic Trends

Long-Term Economic Projections

Demographic Patterns

Diseases & Disorders

Medical Conditions

Acute Conditions

Chronic Conditions

Specified Reportable Diseases

AIDS

Lyme Disease

Varicella

Tuberculosis

Pertussis

Hepatitis

Other Specified Reportable Diseases

Health Care Trends

Health Insurance & Reimbursement Trends

National Health Expenditures

Medical Providers

Patient Procedures

Veterinary Health Care

Veterinary Demographic Trends

Veterinarians

Veterinary Health Expenditures

III. VACCINE TECHNOLOGIES

General

Component Vaccines

Biotechnology-Derived Vaccines

Recombinant DNA

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Monoclonal Antibodies

Vector Systems

Live Vaccines

Killed Bacterial & Viral Vaccines

IV. PRODUCT OVERVIEW

General

Major Product Groups

Human Vaccines

Veterinary Vaccines

Market Trends

Regulatory Considerations

Human Vaccine Regulation

Veterinary Vaccine Regulation

US Trade

International Markets

North America

Western Europe

Asia/Pacific

Other International Markets

V. HUMAN VACCINES

General

Pediatric Vaccines

RSV Antibodies

Pneumococcal Vaccines

DTaP Vaccines

Measles-Mumps-Rubella (M-M-R) Vaccines

Varicella Vaccines

Polio Vaccines

Haemophilus b Vaccines

Other Pediatric Vaccines

Hepatitis Vaccines

Hepatitis B Vaccines

Hepatitis A Vaccines

Other Hepatitis Vaccines

Biodefense Vaccines

Smallpox Vaccines

Anthrax Vaccines

Other Biodefense Vaccines

Botulinum

Brucellosis

Plague

Q Fever

Ricin

Tularemia

Influenza Vaccines

Travel Vaccines

Encephalitis Vaccines

Rabies Vaccines

SARS Vaccines

Other Travel Vaccines

Typhoid Fever

Yellow Fever

Dengue Fever

Malaria

Cholera

Other Human Vaccines

Meningococcal Vaccines

BCG Vaccines

Developmental Vaccines

Cancer Vaccines

AIDS Vaccines

Herpes Vaccines

West Nile Vaccines

Other Developmental Vaccines

VI. VETERINARY VACCINES

General

Livestock Vaccines

Bovine Vaccines

Swine Vaccines

Ovine Vaccines

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Companion Animal Vaccines

Canine Vaccines

Feline Vaccines

Equine Vaccines

Poultry Vaccines

Other Veterinary Vaccines

VII. INDUSTRY STRUCTURE

General

Market Share

Competitive Strategies

Mergers & Acquisitions

Licensing & Related Agreements

Research & Development

Manufacturing

Marketing & Distribution

Company Profiles

Acambis plc

Akzo Nobel NV

Avecia Group plc

Aventis SA

AVI BioPharma Incorporated

Baxter International Incorporated

Berna Biotech Limited

Berna Products Corporation, see Acambis plc

Biogen Idec Incorporated

BioProtein Technologies

CancerVax Corporation

Chiron Corporation

Covalent Group Incorporated

Dow Chemical Company

DynPort Vaccine Company LLC

Fort Dodge Animal Health, see Wyeth

GenVec Incorporated

Genzyme Corporation

GlaxoSmithKline plc

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Intervet Incorporated, see Akzo Nobel NV

Large Scale Biology Corporation

MedImmune Incorporated

Merck & Company Incorporated

Merial Limited

Nobilon, see Akzo Nobel NV

Pevion Biotech Limited, see Berna Biotech Limited

Pfizer Incorporated

PowderJect Pharmaceuticals plc, see Chiron Corporation

VaxGen Incorporated

VaxInnate Corporation

Wyeth

LIST OF TABLES

SECTION I -- EXECUTIVE SUMMARY

Summary Table

SECTION II -- MARKET ENVIRONMENT

1 Macroeconomic Indicators

2 Demographic Indicators

3 Acute Conditions by Type

4 Chronic Conditions by Type

5 Specified Reportable Diseases

6 National Health Expenditures by Type

7 Medical Providers by Type

8 Patient Procedures by Type

9 Veterinary Health Care Indicators

10 Veterinary Health Expenditures

SECTION III -- VACCINE TECHNOLOGIES

1 Vaccine Demand by Technology

SECTION IV -- PRODUCT OVERVIEW

1 Vaccines Demand by Major Product Group

2 Human Vaccines Licensed for US Sale

3 Vaccines -- Market Trends, 1993-2003

4 US Trade in Vaccines

5 World Vaccines Demand by Country/Region

6 Western Europe -- Vaccines Demand by Type & Selected Countries

SECTION V -- HUMAN VACCINES

1 Human Vaccines Demand

2 Pediatric Vaccines Demand by Type

3 RSV Antibodies Demand

4 Pneumococcal Vaccines Demand

5 DTaP (Diphtheria, Tetanus, Pertussis) Vaccines Demand

6 M-M-R (Measles-Mumps-Rubella) Vaccines Demand

7 Varicella Vaccines Demand

8 Polio Vaccines Demand

9 Haemophilus b (Hib) Vaccines Demand

10 Rotavirus Vaccines Demand

11 Hepatitis Vaccines Demand

12 Hepatitis B Vaccines Demand

13 Hepatitis A Vaccines Demand

14 Other Hepatitis Vaccines Demand

15 Biodefense Vaccines Demand

16 Smallpox Vaccines Demand

17 Anthrax Vaccines Demand

18 Other Biodefense Vaccines Demand

19 Influenza Vaccines Demand

20 Travel Vaccines Demand by Type

21 Encephalitis Vaccines Demand

22 Rabies Vaccines Demand

23 SARS Vaccines Demand

24 Other Travel Vaccines Demand

25 Other Human Vaccines Demand by Type

26 Meningococcal Vaccines Demand

27 BCG Vaccines Demand

28 Developmental Vaccines by Type

29 Cancer Vaccines Demand by Type

30 AIDS Vaccines Demand

31 Herpes Vaccines Demand

32 West Nile Virus Vaccines Demand

33 Other Developmental Vaccines Demand

SECTION VI -- VETERINARY VACCINES

1 Veterinary Vaccines Demand by Product Group

2 Livestock Vaccines Demand by Type

3 Companion Animal Vaccines Demand by Type

4 Poultry Vaccines Demand

5 Other Veterinary Vaccines Demand

SECTION VII -- INDUSTRY STRUCTURE

1 US Vaccine Revenues by Company, 2003

2 Selected Acquisitions & Divestitures

3 Selected Cooperative Agreements

LIST OF CHARTS

SECTION III -- VACCINE TECHNOLOGIES

1 Vaccines Demand by Technology, 2003

SECTION IV -- PRODUCT OVERVIEW

1 Vaccines Demand by Major Product Group, 2003

2 Recommended Childhood & Adolescent Immunization - United States, 2001

SECTION V -- HUMAN VACCINES

1 Human Vaccines Demand by Type, 2003

SECTION VI -- VETERINARY VACCINES

1 Veterinary Vaccines Demand by Type, 2003

SECTION VII -- INDUSTRY STRUCTURE

1 Human Vaccines US Market Share by Company, 2003

2 Veterinary Vaccines US Market Share by Company, 2003