Biochips

Table of Contents

I-A. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

• Study Reliability and Reporting Limitations I-1
• Disclaimers I-2
• Data Interpretation & Reporting Level I-2
• Quantitative Techniques & Analytics I-2
• Product Definitions and Scope of Study I-3
• A. DNA Chips I-3
• B. Protein Chips I-3

I-B. GENERAL OVERVIEW OF BIOTECH INDUSTRY

II. EXECUTIVE SUMMARY

1. Industry Overview II-1

• Promising Biochips Promote Biological Research II-1
• Market Scenario across Products and Regions II-1
• Probable Industry Directions II-2
• Biochip Technology Spreads beyond Pharma Industry II-3
• Protein Chips to Shape the Future II-3
• Proteomics " Chip" into Biochip Technology II-4
• Towards Increasing Minaturization II-4
• European Advancements Set Diagnostic Procedures II-4
• Competitive Scenario II-4
• Major Participants II-4
• Roche and Affymetrix Taste Success in theDiagnostics Market II-5
• Protein Chip Giants II-5
• Table 1: Leading Players in Worldwide Protein Biochips Market (2004 -2005E)- Percentage Share Breakdown of Value Sales for Biacore, Ciphergen, Clontech, Zyomyx and Others (includes corresponding Graph/Chart) II-6
• Growing Partnerships between Pharma and Biotech Companies II-6
• Tech Giants Join the Biochip Fray II-7

2. Product Overview II-8

• Biochips - Complex Blend of Biochemistry and Electronics II-8
• Historical Perspective II-8
• Lab-on-a-chip: An Enabled Technology II-10
• Utility II-10
• Evolution and Segmentation II-10
• Differing Perspectives II-10
• Classification of Biochips II-11
• Manufacturing Systems Used in Biochip Manufacture II-12
• Working of a Biochip II-12
• A Functional Model II-13
• Cocktail of Disparate Technically Specialized Applications II-13
• Biochips: By-product of Multi-disciplinary Sciences II-13
• Nanotechnology II-13
• BioMEMS II-14
• Microfluidics II-15
• Micro Total Analysis System II-15

3. Biochip And Microarray Construction II-16

• Chip Architecture II-16
• Essence of a Biochip II-16
• Concept of a Microarray II-16
• Microarray Modules II-16
• High Degree of Automation Spurs Biochips Use II-17
• Microfabrication Technology in Biochips made from Polymer and Plastics II-17
• Micro-optics in Biochips II-17
• Liquid Handling Through Micro-Dispensers II-18
• Capillary Electrophoresis and Electrochemical Detectors II-18
• Other Technologies II-18
• Management of Bio-information II-18
• Scanning II-18
• Microarray Database Management II-19
• Classification of DNA Chips II-19
• General Description of Spotted cDNA Microarrays II-19
• Spotted DNA Arrays II-19
• Spotted cDNA Versus Spotted Oligonucleotide Arrays II-19
• Limitations of Conventional cDNA Microarrays II-20
• Protein Biochips II-20
• General Applications of Protein Biochips II-21
• Challenges in the Design of a Protein Biochip II-21
• Limitations of Protein Chip Technology II-21
• Advances by Companies II-22
• Concluding Remarks for Protein Biochips II-22

4. Applications Of Biochips II-23

• Biochip Uses II-23
• Biochips and Pharmaceutical Investigation II-24
• Biochips and Medical Diagnostics II-24
• Advantages of Biosensor Chip Technology II-25
• Biochips and Forensics II-25
• Biochips and Transplantation Screening II-25
• Biochips and Identity Testing II-25
• Biochips and Water and Environmental Testing II-25
• Food Industry II-25

5. Trends II-26

• Industry Characteristics II-26
• New Products and Players to Drive Market II-26
• Key Forces Boosting the Industry II-26
• Industry Structure II-26
• Industry Challenges II-27
• Price Dearness Pauses Biochips Growth II-27
• Current Approaches to Biochips II-27
• The Business of Biochips II-28
• Technological Trends II-28
• Sensitivity II-28
• Microfabrication II-29
• Density II-29
• Integrated Chips II-29
• Patent Trends II-29
• Patent Applications II-30
• Table 2: Biochips Patent Applications (2003)-Percentage Breakdown by Geographic Region for US, China, Japan, Germany, South Korea, UK and Others (includes corresponding Graph/Chart) II-30

6. Next Generation Technology II-31

• Microfluidics Using CD-ROM Technology II-31

7. Product Innovations and Developments II-32

• Affymetrix Launches GeneChip(R) Scanner II-32
• Affymetrix Releases Chip-on-Chip Array II-32
• DNA Chip Research Launches High Sensitivity DNA Chip II-32
• DNA Chip Research and HitachiSoft Unveils AceGene II-32
• Hitachi Develops RFID Sensor Chip for DNA Analysis II-32
• Canon Develops DNA Chip on Inkjet Printer Technology II-33
• Biacore Introduces Array-Based Protein Interaction Analysis Systems II-33
• Caliper Launches Protein Express Assay for Electrophoresis System II-33
• Affymetrix Rolls Out GeneChip(R) Globin-Reduction Kits and Protocol II-33
• Biacore Introduces Next Generation System for Protein Interaction Analysis (Sweden) II-33
• Affymetrix and Invitrogen Launch Reagents for GeneChip Expression Array Platform II-34
• Amersham Biosciences Extends CodeLink Range II-34
• Ciphergen Showcases ProteinChip System-Series 4000 II-34
• Affymetrix Rolls Out Plasmodium/Anopheles Genome GeneChip(R) Array II-34
• SIRS-Lab Showcases Lab-Arraytor(R) II-35
• Affymetrix Unveils GeneChip(R) Array for Malaria Study II-35
• Caliper Extends Portfolio of LabChip Microfluidic Systems II-35
• Affymetrix Launches World' s First Diagnostic Microarray System (Europe) II-35
• Ushio' s biochip Machine for BioMEM and MicroTAS (Japan) II-36
• Invitrogen Unveils Yeast ProtoArray II-36
• Randox Showcases biochip Technology for Clinical Diagnostics (UK) II-36
• Zyomyx Introduces Murine Cytokine Biochip (US) II-36
• Invitrogen Launches ProtoArray Human Protein Microarray II-36
• Affymetrix Launches Plasmodium Genome GeneChip(R) II-37
• Recent Past Product Launches & Developments II-37

8. Recent Industry Activity II-40

• Toshiba Signs Licensing Agreement with Antara BioSciences II-40
• MUSC Signs LOI with Lumera II-40
• Biacore Expands Operations into Chinese Market II-40
• Nisshinbo to Replace Glass with Resin in DNA Production II-40
• OCIMUM Acquires a Division of MWG Biotech AG II-40
• Biacore Acquires FLEXChip from HTS BioSystems II-40
• Qiagen Acquires Assets of LumiCyte II-41
• BD Sells Clontech II-41
• Affymetrix Acquires ParAllele BioScience II-41
• Biacore Acquires FLEXChip System from HTS BioSystems II-41
• Caliper Signs Purchase Agreement with Amphora II-42
• Bio-Rad Inks Agreement with Caliper II-42
• Toray Enters Joint Research Agreement with DNA Chip Research II-42
• Ciphergen and Quest Diagnostics Partner for Proteomic Diagnostic Tests II-42
• Affymetrix and bioMerieux Extend Agreement II-42
• Agilent Technologies Licenses Caliper' s LabChip(R) Technology II-43
• Caliper and Predicant Biosciences Forge Licensing Agreement II-43
• IntegraGen Signs Agreement with La Ligue Nationale Contre le Cancer II-43
• Affymetrix Supplies GeneChip Technology to Veridex II-43
• GE Acquires Amersham PLC II-44
• ViroLogic Merges with Aclara Biosciences II-44
• Invitrogen Accredits Protein Chip Intellectual Property From Zyomyx II-44
• Toshiba Collaborates with Osaka University II-44
• Siemens, Infineon and Dr. Hintsche Plan Extended Alliance on Biochip Technology II-45
• Intel Eyes Biochips II-45
• APAF and LumiCyte Join Hands in Proteomic Discovery II-45
• Affymetrix and Caliper Life Sciences Join Forces for Target Preparation II-45
• Affymetrix and TGen Collaborate to Offer Genotyping Services II-46
• Affymetrix Licenses GeneChip Technology to Veridex II-46
• Affymetrix Grants Access to Aventis for GeneChip(R) Platform II-46
• GeneChip Technology to Aid Neurological Disease Detection II-46
• Affymetrix, ParAllele and Cambridge University Join Hands For Extensive Genotyping II-46
• Historic Review II-47

9. Focus on Select Global Players II-52

• Affymetrix (US) II-52
• GE Healthcare/Amersham Plc (UK) II-52
• Applied Biosystems Group (US) II-52
• Biacore International AB (Sweden) II-52
• Biomerieux (France) II-53
• Caliper Technologies Corp (US) II-53
• Cepheid (US) II-53
• Ciphergen Inc (USA) II-54
• Takara Bio, Inc. (Japan) II-54
• Zyomyx (US) II-54

10. Global Market Perspective II-55

• Table 3: World Recent Past, Current & Future Analysis for Biochips by Geographic Region - US, Canada, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Revenues Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-55
• Table 4: World 10-Year Perspective for Biochips by Geographic Region - Percentage Breakdown of Dollar Revenues for US, Canada, Japan, Europe, and Rest of World Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart) II-55
• Table 5: World Recent Past, Current & Future Analysis for DNA Chips by Geographic Region - US, Canada, Japan, Europe,and Rest of World Markets Independently Analyzed with Annual Revenues Figures in US$ Million for Years 2000 through 2010 (includescorresponding Graph/Chart) II-56
• Table 6: World 10-Year Perspective for DNA Chips by Geographic Region - Percentage Breakdown of Dollar Revenues for US, Canada, Japan, Europe, and Rest of World Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart) II-56
• Table 7: World Recent Past, Current & Future Analysis for Protein Chips by Geographic Region - US, Canada, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Revenues Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-57
• Table 8 : World 10-Year Perspective for Protein Chips by Geographic Region - Percentage Breakdown of Dollar Revenues for US, Canada, Japan, Europe, and Rest of World Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart) II-57

III. MARKET

1. The United States III-1

• A. Market Analysis III-1
• Outlook III-1
• Key Player Review III-1
• Affymetrix III-1
• Applied Biosystems Group III-1
• Clontech III-1
• Caliper Life Sciences, Inc. (Formerly Caliper Technologies Corp III-2
• Cepheid III-2
• Ciphergen, Inc III-2
• Zyomyx III-2
• Product Developments & Launches III-3
• Strategic Corporate Developments III-7
• B. Market Analytics III-15
• Table 9: US Recent Past, Current & Future Analysis for Biochips by Product Segments- DNA Chip and Protein chip Markets Independently Analyzed with AnnualRevenues Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-15
• Table 10 : US 10-Year Perspective for Biochips by Product Segment- Percentage Breakdown of Dollar Revenues for DNA Chip and Protein chip Markets for Years 2000, 2005 & 2010 III-15

2. Canada III-16

• A. Market Analysis III-16
• B. Market Analytics III-16
• Table 11: Canadian Recent Past, Current & Future Analysis for Biochips by Product Segments- DNA Chip and Protein chip Markets Independently Analyzed with Annual Revenues Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-16
• Table 12 : Canadian 10-Year Perspective for Biochips by Product Segment - Percentage Breakdown of Dollar Revenues for DNA Chip and Protein chip Markets for Years 2000, 2005 & 2010 III-16

3. Japan III-17

• A. Market Analysis III-17
• DNA Chip Based on Printing Technology III-17
• DNA Chips to Reveal Links Among Genes III-17
• A leading Japanese Biochip Player - Takara Shuzo III-18
• ICAN �ETechnology for Large-Scale Production of DNA Fragments III-18
• Recent Product Launches III-19
• Strategic Corporate Developments III-19
• Takara Bio Inc - A Key Player III-22
• B. Market Analytics III-23
• Table 13: Japanese Recent Past, Current & Future Analysis for Biochips by Product Segments- DNA Chip and Protein chip Markets Independently Analyzed with Annual Revenues Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-23
• Table 14: Japanese 10-Year Perspective for Biochips by Product Segment - Percentage Breakdown of Dollar Revenues for DNA Chip and Protein chip Markets for Years 2000, 2005 & 2010 III-23

4. Europe III-24

• A. Market Analysis III-24
• Biochips Outlook in Europe III-24
• European Advancements Shape Diagnostic Procedures III-24
• Product Launches III-25
• B. Market Analytics III-26
• Table 15 : European Recent Past, Current & Future Analysis for Biochips by Geographic Region - France, Germany, UK, and Rest of Europe Markets Independently Analyzed with Annual Revenues Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-26
• Table 16 : European 10-Year Perspective for Biochips by Geographic Region - Percentage Breakdown of Dollar Revenues for France, Germany, UK, and Rest of Europe Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart) III-26
• Table 17 : European Recent Past, Current & Future Analysis for Biochips by Product Segments- DNA Chip and Protein chip Markets Independently Analyzed with Annual Revenues Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-27
• Table 18: European 10-Year Perspective for Biochips by Product Segment - Percentage Breakdown of Dollar Revenues for DNA Chip and Protein chip Markets for Years 2000, 2005 & 2010 III-27

4a. France III-28

• A. Market Analysis III-28
• Key Player Review III-28
• Biomerieux III-28
• B. Market Analytics III-28
• Table 19 : French Recent Past, Current & Future Analysis for Biochips by Product Segments- DNA Chip and Protein chip Markets Independently Analyzed with Annual Revenues Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-28
• Table 20 : French 10-Year Perspective for Biochips by Product Segment - Percentage Breakdown of Dollar Revenues for DNA Chip and Protein chip Markets for Years 2000, 2005 & 2010 III-29

4b. Germany III-30

• A. Market Analysis III-30
• Berlin, Brandenburg and Biochips III-30
• B. Market Analytics III-31
• Table 21 : German Recent Past, Current & Future Analysis for Biochips by Product Segments- DNA Chip and Protein chip Markets IndependentlyAnalyzed with Annual Revenues Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-31
• Table 22 : German 10-Year Perspective for Biochips by Product Segment - Percentage Breakdown of Dollar Revenues for DNA Chip and Protein chip Markets for Years 2000, 2005 & 2010 III-31

4c. The United Kingdom III-32

• A. Market Analysis III-32
• Product Launches III-32
• Key Player III-32
• GE Healthcare/Amersham Plc III-32
• Strategic Corporate Developments -Historic III-33
• B. Market Analytics III-33
• Table 23 : UK Recent Past, Current & Future Analysis for Biochips by Product Segments- DNA Chip and Protein chip Markets Independently Analyzed with Annual Revenues Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-33
• Table 24 : UK 10-Year Perspective for Biochips by Product Segment - Percentage Breakdown of Dollar Revenues for DNA Chip and Protein chip Markets for Years 2000, 2005 & 2010 III-33

4d. Rest of Europe III-34

• A. Market Analysis III-34
• Status of Proteomics in Finland III-34
• Key Player Review III-34
• Biacore International AB (Sweden) III-34
• Strategic Corporate Developments III-35
• B. Market Analytics III-36
• Table 25: Rest of Europe Recent Past, Current & Future Analysis for Biochips by Product Segments- DNA Chip and Protein chip Markets Independently Analyzed with Annual Revenues Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-36
• Table 26 : Rest of Europe10-Year Perspective for Biochips by Product Segment - Percentage Breakdown of Dollar Revenues for DNA Chip and Protein chip Markets for Years 2000, 2005 & 2010 III-36

5. Rest of World III-37

• A. Market Analysis III-37
• China III-37
• Basic Environment and Commercial Development III-37
• Biochip Research III-37
• Status of Biochip Industry in China III-38
• Historic Review - Chinese Government Chips in III-38
• Novel Technologies - Top on China' s Agenda III-39
• Taiwan III-39
• Taiwan Pursues Promise of Biochip Sector III-39
• International Advantage Sought III-39
• Strategic Corporate Developments III-40
• B. Market Analytics III-41
• Table 27 : Rest of World Recent Past, Current & Future Analysis for Biochips by Product Segments- DNA Chip and Protein chip Markets Independently Analyzed with Annual Revenues Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-41
• Table 28: Rest of World 10-Year Perspective for Biochips by Product Segment - Percentage Breakdown of Dollar Revenues for DNA Chip and Protein chip Markets for Years 2000, 2005 & 2010 III-41

IV. COMPETITION

• 1. Abbott Molecular, Inc. (USA) IV-1
• 2. Advalytix AG (Germany) IV-1
• 3. Affymetrix, Inc. (USA) IV-2
• Table 29: First Quarter Sales Analysis: 2005-2006 (Q1) (In US$ million) IV-3
• Table 30: Annual Sales Analysis: 2004-2005 (In US$ million) IV-3
• 4. Agilent Technologies, Inc. (USA) IV-7
• 5. Antara Biosciences, Inc. (USA) IV-11
• 6. Applera Corporation (USA) IV-12
• Applied Biosystems (USA) IV-14
• Table 31: Nine Months Sales Analysis: 2005-2006 (Nine Months Ended, March) (In US$ billion) IV-15
• Table 32: Nine Months Sales Analysis by Quarter: 2005-2006 (Nine Months Ended, March) (In US$ billion) IV-15
• Table 33: Nine Months Sales Analysis by Product Segment: 2005-2006 (Nine Months Ended, March) (In US$ billion) IV-15
• Table 34: Nine Months Sales Analysis by Business Segment: 2005-2006 (Nine Months Ended, March) (In US$ billion) IV-15
• Table 35: Nine Months Sales Analysis by Geographic Region: 2005-2006 (Nine Months Ended, March) (In US$ billion) IV-15
• Table 36: Annual Sales Analysis: 2004-2005 (In US$ billion) IV-16
• Table 37: Quarterly Annual Sales Analysis: 2004-2005 (In US$ billion) IV-16
• Table 38: Annual Sales Analysis by Product Segment: 2004-2005 (In US$ billion) IV-16
• Table 39: Annual Sales Analysis by Business Segment: 2004-2005 (In US$ billion) IV-16
• Table 40: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ billion) (USA)) IV-16
• Celera Genomics Group (USA) IV-19
• 7. Array-On GmbH (Germany) IV-20
• 8. Aviva Bioscience Corporation (USA) IV-20
• 9. Biacore International AB (Sweden) IV-21
• Table 41: First Quarter Sales Analysis: 2005-2006 (Q1) (In SEK million) IV-21
• Table 42: Annual Sales Analysis: 2004-2005 (In SEK million) IV-22
• Biacore KK (Japan) IV-23
• 10. Bioarray Solutions LLC (USA) IV-24
• 11. Biochip-Imb Ltd. (Russia) IV-25
• 12. Biodiscovery, Inc. (USA) IV-26
• 13. Biomedical Photometrics, Inc. (Canada) IV-29
• 14. BioMérieux SA (France) IV-30
• Table 43: Nine Months Sales Analysis: 2004-2005 (In € million) IV-31
• Table 44: Nine Months Sales Analysis by Business Segment: 2004-2005 (In € million) IV-31
• Table 45: Nine Months Sales Analysis by Geographic Region: 2004-2005 (In € million) IV-31
• Table 46: Annual Sales Analysis: 2003-2004 (In € million) IV-31
• Biomerieux, Inc. (USA) IV-34
• 15. Bio Micro Systems (USA) IV-35
• 16. Bio-Rad Laboratories, Inc. (USA) IV-37
• Table 47: First Quarter Sales Analysis: 2005-2006 (Q1) (In US$ million) IV-38
• Table 48: First Quarter Sales Analysis by Segment: 2005-2006 (Q1) (In US$ million) IV-38
• Table 49: Annual Sales Analysis: 2004-2005 (In US$ million) IV-39
• Table 50: Quarterly Sales Analysis: 2004-2005 (In US$ million) IV-39
• Table 51: Annual Sales Analysis by Segment: 2004-2005 (In US$ million) IV-39
• Table 52: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million) IV-39
• 17. Caliper Life Sciences, Inc. (USA) IV-49
• Table 53: First Quarter Sales Analysis: 2005-2006 (Q1) (In US$ million) IV-50
• Table 54: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million) IV-50
• Table 55: Annual Sales Analysis: 2004-2005 (In US$ million) IV-50
• Table 56: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million) IV-50
• 18. Cambridge Antibody Technology (UK) IV-53
• 19. Cambridge Bioscience Ltd. (UK) IV-55
• 20. Canon Technology (Japan) IV-56
• 21. Cea-Leti (France) IV-59
• 22. Cepheid, Inc. (USA) IV-60
• Table 57: First Quarter Sales Analysis: 2005-2006 (Q1) (In US$ thousands) IV-60
• Table 58: First Quarter Sales Analysis by Segment: 2005-2006 (Q1) (In US$ thousands) IV-61
• Table 59: Annual Sales Analysis: 2004-2005 (In US$ thousands) IV-61
• Table 60: Annual Sales Analysis by Segment: 2004-2005 (In US$ thousands) IV-61
• 23. Chemogenix GmbH (Germany) IV-64
• 24. Ciphergen Biosystems, Inc. (USA) IV-65
• 25. Combimatrix Corporation (USA) IV-68
• 26. Compugen Ltd. (Israel) IV-69
• 27. DNA Chip Research, Inc. (Japan) IV-71
• 28. Epigenomics AG (Germany) IV-72
• 29. Febit GmbH (Germany) IV-74
• 30. GE Health Care - Life Sciences (USA) IV-75
• 31. Genescan Europe AG (Germany) IV-76
• Genescan USA, Inc. (USA) IV-81
• 32. Genetix Ltd. (UK) IV-82
• Genetix USA, Inc. (USA) IV-83
• 33. Genomic Solutions, Inc. (USA) IV-84
• 34. GenTel Biosurfaces, Inc. (USA) IV-85
• 35. Greiner Bio-One GmbH (Germany) IV-86
• 36. Hitachi Software Engineering Co., Limited (Japan) IV-87
• Table 61: Annual Sales Analysis: 2004-2005 (In ¥ (Yen) billion) IV-88
• Table 62: Annual Sales Analysis by Business Segment: 2004-2005 (In ¥ billion) IV-88
• 37. IBM Research - Nanoscale Science Department (USA) IV-92
• 38. Illumina, Inc. (USA) IV-93
• 39. Infineon Technologies AG (Germany) IV-95
• 40. Invitrogen Corporation (USA) IV-97
• 41. Jerini AG (Germany) IV-108
• 42. Lumera Corporation (USA) IV-109
• Table 63: First Quarter Sales Analysis: 2005-2006 (Q1) (In US$ million) IV-110
• Table 64: Annual Sales Analysis: 2004-2005 (In US$ million) IV-110
• Table 65: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million) IV-110
• 43. MDS Pharma Services (USA) IV-112
• 44. Metrigenix, Inc. (USA) IV-113
• 45. Micronit Microfluidics BV (The Netherlands) IV-114
• 46. Mitsubishi Rayon Co., Ltd. (Japan) IV-115
• 47. Mobidiag Oy (Finland) IV-117
• 48. Motorola Biochip System (USA) IV-117
• 49. MWG Biotech AG (Germany) IV-118
• Table 66: First Quarter Sales Analysis: 2004-2005 (Q1) (In € million) IV-118
• 50. Nanogen, Inc. (USA) IV-120
• 51. Nimblegen Systems, Inc. (USA) IV-122
• 52. Nisshinbo Industries, Inc. (Japan) IV-125
• Table 67: Annual Sales Analysis: 2004-2005 (In ¥ million) IV-126
• Table 68: Annual Sales Analysis by Business Segment: 2004-2005 (In ¥ million) IV-127
• Table 69: Annual Sales Analysis by Geographical Region: 2004-2005 (In ¥ million) IV-127
• 53. Ocimum Biosolutions LLC (USA) IV-127
• 54. Origene Technologies, Inc. (USA) IV-128
• 55. Oxford Gene Technology (UK) IV-129
• 56. Perkinelmer, Inc. (USA) IV-130
• Perkinelmer Life Sciences (USA) IV-135
• 57. Procognia Limited (UK) IV-136
• 58. Qiagen NV (The Netherlands) IV-137
• Qiagen, Inc. (USA) IV-138
• 59. Randox Laboratories Ltd. (UK) IV-139
• 60. Samsung Advanced Institute Of Technology (Korea) IV-140
• 61. Scandinavian Micro Biodevices A/S (Denmark) IV-143
• 62. Sequenom, Inc. (USA) IV-144
• 63. Takara Bio, Inc. (Japan) IV-146
• Table 70: Annual Sales Analysis: 2004-2005 (In ¥ billion) IV-146
• Clontech Laboratories, Inc. (USA) IV-148
• Takara Bio Europe SA (France) IV-150
• 64. Telechem International, Inc. (USA) IV-151
• 65. TM Bioscience (Canada) IV-154
• 66. Toray Industries, Inc. (Japan) IV-155
• Table 71: Annual Sales Analysis: 2004-2005 (In ¥ billion) IV-155
• Table 72: Annual Sales Analysis By Business Segments: 2004-2005 (In ¥ billion) IV-156
• Table 73: Annual Sales Analysis By Geographical Regions: 2004-2005 (In ¥ billion) IV-156
• 67. Toshiba Corporation (Japan) IV-159
• Table 74: Annual Sales Analysis: 2004-2005 (In Us$ Billion) IV-162
• 68. Zyomyx, Inc. (USA) IV-173