Chiral Technology

Table of Contents

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

• Study Reliability and Reporting Limitations
• Disclaimers
• Data Interpretation & Reporting Level
• Quantitative Techniques & Analytics
• Product Definitions and Scope of Study
• Chiral Technology Enabling Products
• Chiral Intermediates
• Analytical Products
• Other Products
• Chiral Technology End-Use Products
• Pharmaceuticals
• Agrochemicals

II. EXECUTIVE SUMMARY

1. Introduction

• An Insight into Chiral Technology
• Techniques Used for Achieving Single-Isomers
• Table 1: World Chiral Technology Market (2002 & 2010): Percentage Breakdown of Revenues by Techniques- Traditional Methods, Asymmetric Methods, and Biological Methods (includes corresponding Graph/Chart)
• Importance and Advancements

2. Global Market Overview

• Outlook and Trends
• Good Tidings for Chiral Technology
• Market Drivers
• Demand for Chiral-based Therapeutic Drugs Augments Growth
• New Legislations Push Chiral Technology Demand
• Key Trends
• Organizations Extend Approaches
• Companies' Association with Universities

3. Chiral Technology - An Overview

• Definitions
• Chiral Technology Enabling Products
• Chiral Intermediates
• Analytical Products
• Other Products
• Chiral Technology End-Use Markets
• Pharmaceuticals
• Agrochemicals
• Description
• Functioning of Chiral Molecules
• Chiral Preparation Process
• Traditional Methods
• Biological Methods
• Asymmetric Methods
• Chiral Separation
• Chromatography - The Widely Used Method for Separation
• How it Works?
• Chiral Mobile Phase Additive (CMPA)
• Chiral Stationary Phase (CSP)
• Chiral Recognition
• Protein Chiral Stationary Phases
• Carbohydrate Columns
• Pirkle Columns
• Crystallization
• Solvent Extraction
• Kinetic Resolution
• Capillary Electrophoresis
• Receptor Based Resolution
• Miscellaneous Separative Techniques
• Chiral Synthesis

4. Chiral Technology - Development vs. Acquisition

• In-House Creation & Development
• Acquisition of Technology
• "Economics" of Chiral Technology

5. Chiral Analysis Products

• Chiral Analytical Chromatography
• Chiral Liquid Chromatography
• Supercritical Fluid Chromatography - Substitute to LC for Enantiomer Separations
• Chiral Gas Chromatography
• Chiral Simulated Moving Bed Chromatography
• Partition Chromatography
• Adsorption Chromatography
• Computer Assisted Resolution
• Chiral Polarimetry
• Other Chiral Analytical Techniques
• Calorimetry
• Differential Scanning Calorimetry (DSC)
• Enzymatic Assay
• Immunoassay
• Isotope Dilution
• Nuclear Magnetic Resonance (NMR)
• X-Ray Crystallography

6. Application Markets

• Pharmaceuticals - The Largest Market
• Changing Face of the Pharmaceutical Industry
• Analysis of Chiral Drugs
• Select Companies Involved in Chiral Technology Market
• Table 2: Single-Enantiomer Drugs Market Worldwide (2006): Sales of Select Leading Brands (In US$ Billion) (includes corresponding Graph/Chart)
• Drugs Built on Chiral Technology
• Analgesics
• Anesthetics
• Anti-Infective Products
• Cardiovascular System (CVS) Products
• Angiotensin-Converting Enzyme (ACE) Inhibitors
• Beta-Blockers
• Calcium Channel Blockers
• Diuretics
• Vasodilators
• Central Nervous System (CNS) Agents
• Anticonvulsants
• Sedatives and Tranquilizers
• Stimulants and Antidepressants
• Oncogenic (Cancer-Treatment) Products
• Biochemicals
• Oligonucleotides
• Oxyacids
• Amino Acids
• Sugars and Other Oligosaccharides
• Vitamins
• Peptides
• Pesticides - A Thriving Market
• Herbicides
• Insecticides
• Fungicides
• Other Products
• Liquid Crystals
• Flavor and Aroma Chemicals

7. Chiral Isomerism

• Organic Chemical Isomerism Types
• Structural Isomerism
• Chain Isomerism
• Position Isomerism
• Functional Group Isomerism
• Stereoisomerism
• Dynamic Isomerism (Tautomerism)
• Patents

8. Regulatory & Environmental Issues

9. Product Introductions

• Degussa Develops Novel Processes to Synthesize (S) CAP
• Regis Technologies, Inc. Launches RegisPack Chiral
• Columns
• Sigma-Aldrich Introduces ChiroSolv(tm) Kits
• Sigma-Aldrich Launches Ascentis Express HPLC Columns
• Evolved Nanomaterial Releases Revolutionary Analytical Chiral Column
• BASF Develops Novel Process to Produce Chiral Intermediates
• Chiral Quest Launches C3 TunePhos

10. Recent Industry Activity

• Cambrex to Buy ProSyntest AS
• Johnson Matthey and X-Zyme Sign Licensing Agreement
• Chiral Quest Starts a New Production Facility
• Chiral Quest Completes Reverse Merger with Surg II
• DSM and IEP Extend Partnership
• Shasun Chemicals Acquires Rhodia Pharma Solutions
• Sigma-Aldrich Corp Acquires Astec
• Solvias Receives License for MeOBIPHEP Catalyst Technology
• Codexis Acquires Juelich Fine Chemicals
• ChiroBlock Exits from Chiral Compounds Business
• Chiral Quest Opens New Facility in China
• Chiral Quest to Supply C3 TunePhos to Phoenix Chemicals
• Lonza and Codexis Sign Agreement for Biocatalysis Process
• DSM Signs Licensing Agreement with Chiral Quest
• Chiral Quest Signs Distribution Agreement with Aldrich Chemical
• BASF and Solvias to Collaborate on Chiral Molecule Development
• Chiral Quest and Avantium Enter into Partnership

11. Focus on Select Players

• Albemarle Corporation (USA)
• BASF AG (Germany)
• Cambrex Corp. (USA)
• Chiral Quest Inc (US)
• Dalco ChromTech AB (Sweden)
• Daicel Chemical Industries Ltd. (Japan)
• DSM Pharmaceutical Products (Netherlands)
• DowpharmaSM (USA)
• Johnson Matthey PLC (UK)
• Regis Technologies Inc (USA)
• Shasun Chemicals and Drugs Limited (India)
• Solvias (Switzerland)
• Sigma Aldrich Corp (USA)
• Suven Life Sciences Ltd. (USA)

12. Global Market Perspective

• Table 3: World Recent Past, Current & Future Analysis for Chiral Technology Enabling Products by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 4: World Long-term Projections for Chiral Technology Enabling Products by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 5: World 10-Year Perspective for Chiral Technology Enabling Products by Geographic Region - Percentage Breakdown of Value Sales for US, Japan, Europe, and Rest of World Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart)
• Table 6: World Recent Past, Current & Future Analysis for Chiral Intermediates by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 7: World Long-term Projections for Chiral Intermediates by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 8: World 10-Year Perspective for Chiral Intermediates by Geographic Region - Percentage Breakdown of Value Sales for US, Japan, Europe, and Rest of World Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart)
• Table 9: World Recent Past, Current & Future Analysis for Chiral Analytical Products by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 10: World Long-term Projections for Chiral Analytical Products by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• TABLE 11: World 10-Year Perspective for Chiral Analytical Products by Geographic Region - Percentage Breakdown of Value Sales for US, Japan, Europe, and Rest of World Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart)
• Table 12: World Recent Past, Current & Future Analysis for Other Chiral Technology Enabling Products by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 13: World Long-term Projections for Other Chiral Technology Enabling Products by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 14: World 10-Year Perspective for Other Chiral Technology Enabling Products by Geographic Region - Percentage Breakdown of Value Sales for US, Japan, Europe, and Rest of World Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart)
• Table 15: World Recent Past, Current & Future Analysis for Chiral Technology in Pharmaceuticals by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 16: World Long-term Projections for Chiral Technology in Pharmaceuticals by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 17: World 10-Year Perspective for Chiral Technology in Pharmaceuticals by Geographic Region - Percentage Breakdown of Value Sales for US, Japan, Europe, and Rest of World Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart)
• Table 18: World Recent Past, Current & Future Analysis for Chiral Technology in Agrochemicals by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 19: World Long-term Projections for Chiral Technology in Agrochemicals by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 20: World 10-Year Perspective for Chiral Technology in Agrochemicals by Geographic Region - Percentage Breakdown of Value Sales for US, Japan, Europe, and Rest of World Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart)

III. MARKET

1. The United States

• A. Market Analysis
  • Overview
  • Product Introductions/Developments
  • Strategic Corporate Developments
  • Select Players
  • Albemarle Corporation
  • Cambrex Corp.
  • Chiral Quest Inc
  • DowpharmaSM
  • Regis Technologies Inc
  • Sigma Aldrich Corp
  • Suven Life Sciences Ltd.
• B. Market Analytics
  • Table 21: US Recent Past, Current & Future Analysis for Chiral Technology Enabling Products by Product Segment - Intermediates, Analytical, and Other Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 22: US Long-term Projections for Chiral Technology Enabling Products by Product Segment - Intermediates, Analytical, and Other Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
  • TABLE 23: US 10-Year Perspective for Chiral Technology Enabling Products by Product Segment - Percentage Breakdown of Value Sales for Intermediates, Analytical, and Other Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart)
  • Table 24: US Recent Past, Current & Future Analysis for Chiral Technology by End-Use Segment - Pharmaceuticals, and Agrochemicals Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 25: US Long-term Projections for Chiral Technology by End-Use Segment - Pharmaceuticals, and Agrochemicals Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
  • Table 26: US 10-Year Perspective for Chiral Technology by End-Use Segment - Percentage Breakdown of Value Sales for Pharmaceuticals, and Agrochemicals Markets for Years 2003, 2008 & 2012

2. Japan

• A. Market Analysis
  • Outlook
  • Daicel Chemical Industries Ltd - A Major Player
• B. Market Analytics
  • Table 27: Japanese Recent Past, Current & Future Analysis for Chiral Technology Enabling Products by Product Segment - Intermediates, Analytical, and Other Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 28: Japanese Long-term Projections for Chiral Technology Enabling Products by Product Segment - Intermediates, Analytical, and Other Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
  • Table 29: Japanese 10-Year Perspective for Chiral Technology Enabling Products by Product Segment - Percentage Breakdown of Value Sales for Intermediates, Analytical, and Other Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart)
  • Table 30: Japanese Recent Past, Current & Future Analysis for Chiral Technology by End-Use Segment - Pharmaceuticals, and Agrochemicals Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 31: Japanese Long-term Projections for Chiral Technology by End-Use Segment - Pharmaceuticals, and Agrochemicals Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
  • Table 32: Japanese 10-Year Perspective for Chiral Technology by End-Use Segment - Percentage Breakdown of Value Sales for Pharmaceuticals and Agrochemicals Markets for Years 2003, 2008 & 2012

3. Europe

• A. Market Analysis
  • Overview
  • Product Introductions
  • Strategic Corporate Developments
  • Select Players
  • BASF AG (Germany)
  • Dalco ChromTech AB (Sweden)
  • DSM Pharmaceutical Products (Netherlands)
  • Johnson Matthey PLC (UK)
  • Solvias (Switzerland)
• B. Market Analytics
  • Table 33: European Recent Past, Current & Future Analysis for Chiral Technology Enabling Products by Product Segment - Intermediates, Analytical, and Other Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 34: European Long-term Projections for Chiral Technology Enabling Products by Product Segment - Intermediates, Analytical, and Other Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
  • Table 35: European 10-Year Perspective for Chiral Technology Enabling Products by Product Segment - Percentage Breakdown of Value Sales for Intermediates, Analytical, and Other Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart)
  • Table 36: European Recent Past, Current & Future Analysis for Chiral Technology by End-Use Segment - Pharmaceuticals, and Agrochemicals Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 37: European Long-term Projections for Chiral Technology by End-Use Segment - Pharmaceuticals, and Agrochemicals Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
  • Table 38: European 10-Year Perspective for Chiral Technology by End-Use Segment - Percentage Breakdown of Value Sales for Pharmaceuticals, and Agrochemicals Markets for Years 2003, 2008 & 2012

4. Rest of World

• A. Market Analysis
  • Outlook
  • India
  • Chiral Drugs in Indian Market
  • China-A Hub for Pharmaceutical Manufacturing
  • Strategic Corporate Development
  • Shasun Chemicals and Drugs Limited - A Major Indian Player
• B. Market Analytics
  • Table 39: Rest of World Recent Past, Current & Future Analysis for Chiral Technology Enabling Products by Product Segment - Intermediates, Analytical, and Other Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 40: Rest of World Long-term Projections for Chiral Technology Enabling Products by Product Segment - Intermediates, Analytical, and Other Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
  • Table 41: Rest of World 10-Year Perspective for Chiral Technology Enabling Products by Product Segment - Percentage Breakdown of Value Sales for Intermediates, Analytical, and Other Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart)
  • Table 42: Rest of World Recent Past, Current & Future Analysis for Chiral Technology by End-Use Segment - Pharmaceuticals, and Agrochemicals Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 43: Rest of World Long-term Projections for Chiral Technology by End-Use Segment - Pharmaceuticals, and Agrochemicals Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
  • Table 44: Rest of World 10-Year Perspective for Chiral Technology by End-Use Segment - Percentage Breakdown of Value Sales for Pharmaceuticals, and Agrochemicals Markets for Years 2003, 2008 & 2012