Bioinformatics

Table of Contents

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

• Study Reliability and Reporting Limitations
• Disclaimers
• Data Interpretation & Reporting Level
• Quantitative Techniques & Analytics
• Product Definitions and Scope of Study
• Software
• Hardware
• Biocontent

II. EXECUTIVE SUMMARY

1. Industry Overview

• Revolution in Biology
• Outlook
• Analysis by Product Segment
• Software
• Biocontent
• Hardware
• Industry Structure
• Industry Challenges
• Consolidation- A Key to Success

2. Introduction to Bioinformatics

• Bioinformatics Assumes More Comprehensive Role
• Bioinformatics: Definition
• Bioinformatics: History in Brief
• Functions of Bioinformatics
• Major End-Users of Bioinformatics
• Interface of IT and Biosciences
• Venture Capital and Bioinformatics
• Branches Associated with Bioinformatics
• Emerging Clinical Genomics Industry
• Genomic Business Models
• Applications of Bioinformatics
• Bioinformatics: Crucial for New Drug Development
• Application of Bioinformatics to Oral Genomics
• Importance of IP Protection Systems in Bioinformatics

3. Insight into Bioinformatics Technology

• Protein Structure and its Determination
• Components of Bioinformatics
• Software
• Hardware
• Biocontent
• Proteins/ Proteomics Data and Databases
• DNA Sequences and Protein Sequencing
• Aligning Sequences
• Databases
• Nucleotide Databases
• EMBL Nucleotide Sequence Database
• DNA Database of Japan (DDBJ)
• GenBank
• Institute for Genomic Research (TIGR)
• Protein Databases
• SWISS-PROT
• TrEMBL
• IMGT/LIGM-DB
• PROSITE
• Design and Development of XML Bioinformatics Environment
• Biopolymer Markup Language (BioML)
• Bioinformatics Sequence Mark-Up Language - BSML
• Genome Annotation Markup Elements (GAME)
• Microarray Markup Language (MAML)
• Gene Expression Markup Language (GEML™)
• Hardware
• Technologies Involved
• Computer-Assisted Imaging, Mapping and High-Throughput Screening
• Database Engineering
• Computer Processing
• Computational Software

4. Product Innovations/Introductions

• Accelrys Rolls Out Three New Component Collections for its SciTegic Pipeline Pilot™
• Agilent Technologies Unveils Gene Expression Bioinformatics System, GeneSpring GX 9.0
• GeneBio and SIB Roll Out New Version of Melanie 2-D Gel Analysis Platform
• InforSense to Incorporate BioWisdom' s SRS software in its Workflow Analytics Platform
• BioWisdom Launches SRS 3D Technology, as a Free Software
• GeneGo Integrates Cytoscape Software on its Data Analysis Platform
• Applied Biosystems and Integromics Unveil Integrated Real- Time PCR Data Analysis Solution
• Applied Biosystems Rolls Out Advanced DNA Sequencing Platform, The SOLiD™ System
• GeneBio Introduces New Version of Phenyx Platform
• TCS to Introduce Enhanced Bioinformatics Software, BioAppliance
• Applied Biosystems Introduces Genotyping Service Provider Program
• Applied Biosystems Launches Variant Reporter™, Genetic Variation Data Analysis Software
• GeneBio Launches Online Platform of Phenyx, PhenyxOnline.
• InforSense Rolls Out a Statistical Genetics Solution, GenSense
• U. S. Department of Energy Joint Genome Institute Introduces IMG Version 2.1
  • CLC bio Launches CLC Bioinformatics Cell
  • Accelrys Unveils Imaging Software for SciTegic Pipeline Pilot
  • CLC bio Launches the Pioneering Customizable Bioinformatics Suite
  • Jalaja Technologies and The Institute of Genomics & Integrative Biology Devise GENO-CLUSTER Bioinformatics Software
  • CLC Bio Launches Four New Bioinformatics Software
  • Insightful Develops Bioinformatics Software for National Cancer Institute
  • 3rd Millennium Unveils 2.0 ARDAS™ Software
  • GeneBio Introduces Phenyx 2.1 for Proteomics MS Data Analysis
  • BioWisdom Unveils SRS 8.2
  • INCOGEN Releases Version 3.3 of VIBE Data Pipelining Software for Bioinformatics
  • INCOGEN Introduces VIBE 3.1 Bioinformatics Data Pipelining Software
  • InforSense Launches InforSense KDE, InforSense BioSense Grid on Mac OS X V 10.4
  • Massively Parallel Technologies Completes Early Beta Testing of Bioinformatics Tool
  • Kinexus Announces Launch of KiNET Functional Proteomics Database
  • Agilent Technologies Launches Search Tool for Cytoscape Bioinformatics Platform
  • Ocimum Develops DNA Analysis Software
  • Apple Computer Launches Bioinformatics Cluster
  • EBI, Swiss Institute of Bioinformatics and Georgetown University Launch UniProt

5. Recent Industry Activity

• InforSense and Crosslinks Ink Research Alliance
• Chemizon and KRIBB Team Up to establish a New Biotech Company
• BIOBASE Establishes a New Japanese Subsidiary, Nihon BIOBASE KK
• Applied Biosystems Ropes in Geospiza® and GenomeQuest into Software Development Community for Developing Advanced Bioinformatics Tools
• InforSense and BioWisdom Enter Bioinformatics Agreement
• Gene Logic Completes Sale of its Genomic assets to Ocimum Biosolutions
• SGI Develops World' s Largest FPGA Supercomputer
• Progeniq Enrolls into BioIT Alliance
• Applied Biosystems Launches Software Development Community for Advancing Bioinformatics Applications for its SOLiD™ System
• Agilent and Strand Life Sciences Ink Software Development Agreement
• Cell Therapeutics to Acquire Systems Medicine
• SGI Enrolls into Bio-IT Alliance
• GenoLogic Joins Illumina' s Bioinformatics Program, Illumina Connect
• InApp Software to Establish a Bioinformatics Society in India
• Agilent Technologies Partners with Gene Logic for Research and iscovery Projects
• Thomson, Corp. Acquires Unleashed Informatics
• iHorizons Signs R&D Agreement With AREA Science Park and Cluster in Biomedicine
• GeneBio' s Software to be Integrated into Biozentrum' s Proteomics Cluster
• BioWisdom Signs Agreement with the European Bioinformatics Institute to Deliver SRS 8.2
• Genencor Licenses ERGO™ Software to Integrated Genomics
• Intelligent Business Systems Signs MOU to Establish a Biotechnology Solutions Venture in India
• Nonlinear Dynamics and Agilent Sign Co-Marketing Deal
• Agilent Technologies' Bioinformatics Solution Enables Platforms' Standardization at NCI
• LION Bioscience Divests Bioinformatics Business to BioWisdom
• Applied Biosystems Collaborates with GeneGo
• BioWisdom and AstraZeneca Extend Partnership for Intelligence Networks
• BioWisdom Extends SRS Licenses for Boehringer Ingelheim
• Sheba and Weizmann Attain Licenses for Partek' s Genomics Suite Software
• Sirna Gains Exclusive Worldwide License for miRNA Technology
• HSARPA to Commence Bioinformatics and Assay Development Programme
• Syngenta Selects InforSense® to Develop Bioinformatics Computational Platform
• Stratagene Partners with Strand Life Sciences for Advanced Bioinformatics Software Tools
• Nonlinear Dynamics Join Forces with Genedata Over Proteomics Research
• RTI International Bags Bioinformatics Contracts from the National Institutes of Health' s NCI
• Cold Spring Harbor Lab Kicks off Bioinformatics Expansion
• Iowa State Bags $3 Million IGERT Grant for Bioinformatics
• AMITY, MASCON Announce Partnership for Bioinformatics R&D
• BioTeam Teams Up InforSense to Develop Grid Computing Environment for Bioinformatics
• Nonlinear and Water Corp Ink Agreement
• Clarient Signs Bioinformatics Patent Licensing Agreement With HDC
• Gene-IT to Develop Bioinformatics Technology
• AstraZeneca Purchases License for Target Informatics Platform from Eidogen-Sertanty
• SRI International Expands BioCyc Database Collection
• JBRIC Selects United Device' s Grid MP
• India' s TCS Introduces Bioinformatics Software
• Japan' s Hitachi and the University of Tokyo Establish New Venture
• Sun Microsystems Launches Bioinformatics Cluster
• Sun Micro Establishes Medical Bioinformatics Center in India
• Expression Analysis forms Alliance with InPharmix
• W&G Offers Gene-Typing Service
• Health Discovery Acquires Fractal Genomics
• Celera Diagnostics Collaborates with Merck
• IBM and NIE Launch NBL
• Proteome Systems and CSIRO Team Up
• Ocimum Signs Life Sciences Deal
• Beckman Boosts up its Systems Biology Technologies

6. Focus on Select Players

• 3rd Millennium, Inc (US)
• Accelrys, Inc. (US)
• Affymetrix (US)
• Agilent Technologies (US)
• Applied Biosystems (US)
• BioWisdom Ltd (UK)
• Celera Group (US)
• Gene Logic (US)
• Geneva Bioinformatics S.A (Switzerland)
• IBM Life Sciences (US)
• InforSense Ltd (UK)
• InPharmix Incorporated (US)
• Invitrogen Corp.(US)
• Kinexus Bioinformatics Corporation (Canada)
• Nonlinear Dynamics Ltd (UK)
• Rosetta Inpharmatics (US)

7. Global Market Perspective

• Table 1: World Recent Past, Current & Future Market Analysis for Bioinformatics by Geographic Region - the US, Canada, Japan, Europe, Asia-Pacific and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 2: World Long-term Projections for Bioinformatics by Geographic Region - the US, Canada, Japan, Europe, Asia-Pacific and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 3: World 10-Year Perspective for Bioinformatics by Geographic Region - Percentage Breakdown of Dollar Sales for the US, Canada, Japan, Europe, Asia-Pacific and Rest of World for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart)
• Analytics by Product Segment
• Table 4: World Recent Past, Current & Future Market Analysis for Software (Bioinformatics) by Geographic Region - the US, Canada, Japan, Europe, Asia-Pacific andRest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 5: World Long-term Projections for Software (Bioinformatics) by Geographic Region - the US, Canada, Japan, Europe, Asia-Pacific and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 6: World 10-Year Perspective for Software (Bioinformatics) by Geographic Region - Percentage Breakdown of Dollar Sales for the US, Canada, Japan, Europe, Asia-Pacific and Rest of World for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart)
• Table 7: World Recent Past, Current & Future Market Analysis for Biocontent (Bioinformatics) by Geographic Region - the US, Canada, Japan, Europe, Asia-Pacific and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000through 2010 (includes corresponding Graph/Chart)
• Table 8: World Long-term Projections for Biocontent (Bioinformatics) by Geographic Region - the US, Canada, Japan, Europe, Asia-Pacific and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 9: World 10-Year Perspective for Biocontent (Bioinformatics) by Geographic Region - Percentage Breakdown of Dollar Sales for the US, Canada, Japan, Europe, Asia-Pacific and Rest of World for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart)
• Table 10: World Recent Past, Current & Future Market Analysis for Hardware (Bioinformatics) by Geographic Region - the US, Canada, Japan, Europe, Asia-Pacific and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 11: World Long-term Projections for Hardware (Bioinformatics) by Geographic Region - the US, Canada, Japan, Europe, Asia-Pacific and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015(includes corresponding Graph/Chart)
• Table 12: World 10-Year Perspective for Hardware (Bioinformatics) by Geographic Region - Percentage Breakdown of Dollar Sales for the US, Canada, Japan, Europe, Asia-Pacific and Rest of World for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart)

III. MARKET

1. The United States

• A. Market Analysis
  • Outlook
  • Market Overview
  • Patents in Bioinformatics
  • Product Launches
  • Strategic Corporate Developments
  • Focus on Select Players
• B. Market Analytics
  • Table 13: US Recent Past, Current & Future Market Analysis for Bioinformatics by Product Segment - Software, Biocontent and Hardware Markets IndependentlyAnalyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 14: US Long-term Projections for Bioinformatics by Product Segment - Software, Biocontent and Hardware Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
  • Table 15: US 10-Year Perspective for Bioinformatics by Product Segment - Percentage Breakdown of Dollar Sales for Software, Biocontent and Hardware Markets for 2003, 2008 & 2012 (includes corresponding Graph/Chart)

2. Canada

• A. Market Analysis
  • Outlook
  • Canadian Bioinformatics Industry
  • Strategic Corporate Developments
  • Kinexus Bioinformatics Corporation-Key Canadian Player
• B. Market Analytics
  • Table 16: Canadian Recent Past, Current & Future Market Analysis for Bioinformatics by Product Segment - Software, Biocontent and Hardware Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 17: Canadian Long-term Projections for Bioinformatics by Product Segment - Software, Biocontent and Hardware Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015(includes corresponding Graph/Chart)
  • Table 18: Canadian 10-Year Perspective for Bioinformatics by Product Segment Percentage Breakdown of Dollar Sales for Software Biocontent and Hardware Markets for 2003, 2008 & 2012 (includes corresponding Graph/Chart)

3. Japan

• A. Market Analysis
  • Overview
  • An Update on Japanese Bioinformatics Industry
  • JbiC Drives Japanese Bioinformatics Industry
  • Strategic Corporate Developments
• B. Market Analytics
  • Table 19: Japanese Recent Past, Current & Future Market Analysis for Bioinformatics by Product Segment - Software, Biocontent and Hardware Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 20: Japanese Long-term Projections for Bioinformatics by Product Segment - Software, Biocontent and Hardware Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015(includes corresponding Graph/Chart)
  • Table 21: Japanese 10-Year Perspective for Bioinformatics by Product Segment - Percentage Breakdown of Dollar Sales for Software, Biocontent and Hardware Markets for 2003, 2008 & 2012 (includes corresponding Graph/Chart)

4. Europe

• A. Market Analysis
  • Outlook
  • European Bioinformatics Market
  • Major Public Science Institutes
  • Regulatory Environment
• B. Market Analytics
  • Table 22: European Recent Past, Current & Future Market Analysis for Bioinformatics by Geographic Region -France, Germany, Italy, UK and Rest of Europe Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 23: European Long-term Projections for Bioinformatics by Geographic Region -France, Germany, Italy, UK and Rest of Europe Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015(includes corresponding Graph/Chart)
  • Table 24: European 10-Year Perspective for Bioinformatics by Geographic Region - Percentage Breakdown of Dollar Sales for France, Germany, UK, Italy and Rest of Europe for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart)
  • Table 25: European Recent Past, Current & Future Market Analysis for Bioinformatics by Product Segment - Software, Biocontent and Hardware Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 26: European Long-term Projections for Bioinformatics by Product Segment - Software, Biocontent and Hardware Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
  • Table 27: European 10-Year Perspective for Bioinformatics by Product Segment - Percentage Breakdown of Dollar Sales for Software, Biocontent and Hardware Markets for 2003, 2008 & 2012 (includes corresponding Graph/Chart)

4a. France

• Market Analysis
• Table 28: French Recent Past, Current & Future Market Analysis for Bioinformatics by Product Segments - Software, Biocontent and Hardware Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 29: French Long-term Projections for Bioinformatics by Product Segment - Software, Biocontent and Hardware Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 30: French 10-Year Perspective for Bioinformatics by Product Segment - Percentage Breakdown of Dollar Sales for Software, Biocontent and Hardware Markets for 2003, 2008 & 2012 (includes corresponding Graph/Chart)

4b. Germany

• Market Analysis
• Table 31: German Recent Past, Current & Future Market Analysis for Bioinformatics by Product Segments -Software, Biocontent and Hardware Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 32: German Long-term Projections for Bioinformatics by Product Segment - Software, Biocontent and Hardware Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 33: German 10-Year Perspective for Bioinformatics by Product Segment - Percentage Breakdown of Dollar Sales for Software, Biocontent and Hardware Markets for 2003, 2008 & 2012 (includes corresponding Graph/Chart)

4c. The United Kingdom

• A. Market Analysis
  • Overview
  • Research Entities
  • Product Launches
  • Strategic Corporate Developments
  • Key Players
• B. Market Analytics
  • Table 34: UK Recent Past, Current & Future Market Analysis for Bioinformatics by Product Segment - Software, Biocontent and Hardware Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 35: UK Long-term Projections for Bioinformatics by Product Segment - Software, Biocontent and Hardware Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
  • Table 36: UK 10-Year Perspective for Bioinformatics by Product Segment - Percentage Breakdown of Dollar Sales for Software, Biocontent and Hardware Markets for 2003, 2008 & 2012 (includes corresponding Graph/Chart)

4d. Italy

• Market Analysis
• Strategic Corporate Developments
• Table 37: Italian Recent Past, Current & Future Market Analysis for Bioinformatics by Product Segments - Software, Biocontent and Hardware Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 38: Italian Long-term Projections for Bioinformatics by Product Segment - Software, Biocontent and Hardware Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 39: Italian 10-Year Perspective for Bioinformatics by Product Segment - Percentage Breakdown of Dollar Sales for Software, Biocontent and Hardware Markets for 2003, 2008 & 2012 (includes corresponding Graph/Chart)

4e. Rest of Europe

• A. Market Analysis
  • Outlook
  • National Service Center for Bioinformatics in Netherlands
  • Key Player Review
  • Product Launches
  • Strategic Corporate Developments
• B. Market Analytics
  • Table 40: Rest of Europe Market Analysis for Bioinformatics by Product Segment - Recent Past, Current & Future Market Analysis for Software, Biocontent and Hardware Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 41: Rest of Europe Long-term Projections for Bioinformatics by Product Segment - Software, Biocontent and Hardware Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
  • Table 42: Rest of Europe 10-Year Perspective for Bioinformatics by Product Segment - Percentage Breakdown of Dollar Sales for Software, Biocontent and Hardware Markets for 2003, 2008 & 2012 (includes corresponding Graph/Chart)

5. Asia-Pacific

• A. Market Analysis
  • Outlook
  • Bioinformatics in Asia-Pacific
  • India
  • Taiwan
  • Australia
  • Market Drivers
  • Market Inhibitors
  • Singapore
  • Korea
  • Product Innovations
  • Strategic Corporate Developments
• B. Market Analytics
  • Table 43: Asia-Pacific Market Analysis for Bioinformatics by Product Segment - Recent Past, Current & Future Analysis for Software, Biocontent and Hardware Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 44: Asia-Pacific Long-term Projections for Bioinformatics by Product Segment - Software, Biocontent and Hardware Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015(includes corresponding Graph/Chart)
  • Table 45: Asia-Pacific 10-Year Perspective for Bioinformatics by Product Segment - Percentage Breakdown of Dollar Sales for Software, Biocontent and Hardware Markets for 2003, 2008 & 2012 (includes corresponding Graph/Chart)

6. Rest of World

• A. Market Analysis
  • Outlook
  • Strategic Corporate Developments
• B. Market Analytics
  • Table 46: Rest of World Market Analysis for Bioinformatics by Product Segment - Recent Past, Current & Future Analysis for Software, Biocontent and Hardware Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 47: Rest of World Long-term Projections for Bioinformatics by Product Segment - Software, Biocontent and Hardware Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
  • Table 48: Rest of World 10-Year Perspective for Bioinformatics by Product Segment - Percentage Breakdown of Dollar Sales for Software, Biocontent and Hardware Markets for 2003, 2008 & 2012 (includes corresponding Graph/Chart)