Carotid Stents

Table of Contents

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

• Study Reliability and Reporting Limitations
• Disclaimers
• Data Interpretation & Reporting Level
• Quantitative Techniques & Analytics
• Product Definitions and Scope of Study
• Carotid Stents

II. EXECUTIVE SUMMARY

1. Global Market Overview and Analysis

• Carotid Stents - A Nascent Market
• Current and Future Analysis
• US - Picking Pace

2. Market Dynamics

• Factors Driving Carotid Stents Market
• Clinical Trials & Regulatory Approvals to Accelerate Adoption
• Broader Application of CAS
• Benefiting From Less-Invasive Nature of Procedure
• Acceptance by Various Medical Specialties
• Market Challenges
• Absence of Sufficient Clinical Data
• Surgeons Wary of High-Risk CAS Procedures
• Reimbursement Coverage Issue Hurdles Widespread Adoption
• Fighting for CAS Domain
• Training and Certification of Surgeons - A Major Hurdle
• Stenting Procedure for Transient Ischemic Attacks - A Continuing Dilemma

3. Competitive Scenario

• Table 1: Worldwide Carotid Stents Market (2006-2007E): Market Share of Leading Players by Revenues for Boston Scientific, Abbott Vascular/Guidant, Johnson & Johnson/Cordis, Medtronic and Others (includes corresponding Graph/Chart)

4. Product Overview

• Carotid Stents - An Introduction
• How is Carotid Stenting Helpful?
• Carotid Stents - A Viable Alternative to Surgical Procedures
• Carotid Stenting Lowers Depression Symptoms!!!
• Embolic Protection Devices
• Filter-Based EPD Systems
• Balloon Occlusion Devices
• Basic Carotid Stents Products
• Stent Design
• Carotid Stents of Major Companies Available in the Market
• Carotid Stents Under Development
• Diagnosis of Carotid Artery Blockage
• Eligibility Criteria for Carotid Stenting Procedure
• Potential Candidates for Carotid Stenting
• Patients with High Surgical Risk
• Non-Candidates for Carotid Stenting
• Risk Factors Associated with Carotid Stenting Procedures
• Carotid Artery Stenting (CAS) - The Procedure
• Catheter Insertion Via Femoral Artery
• Advantages of the Procedure
• Post-Stenting Complications

5. Overview of Cardiac Diseases

• Cerebrovascular Disease
• Carotid Artery Disease
• Major Symptoms
• Carotid Artery Stenosis
• Atherosclerosis
• Treatment Procedures for Carotid Artery Disease
• Carotid Endarterectomy (CEA)
• Drawbacks of CEA Procedure
• Carotid Artery Stenting (CAS)
• CAS Versus CEA
• Table 2: Worldwide Carotid Interventions (2006-2008E)): Percentage Breakdown of Number of Procedures for Carotid Endarterectomy and Carotid Stenting (includes corresponding Graph/Chart)
• Comparative Study of CAS and CEA Devices
• Benefits of CAS over CEA
• Drawbacks for CAS Penetration
• Risks Associated with CEA and CAS

6. Major Clinical Trials/Studies

• Clinical Trials - Key to Higher Adoption of Carotid Stents
• Major Clinical Trials & Stent Devices Used
• Guidant’s CAPTURE Study
• CAPTURE Study Results Hold Promise for Asymptomatic Patients
• Boston Scientific’s BEACH Trial
• Abbott’s ACT I Trial
• CREST Clinical Trial
• J&J’s SAPPHIRE Clinical Trial
• SAPPHIRE Study Proves Effectiveness of CAS in High-Risk Patients
• Other Trials
• Medtronic’s MAVErIC Trials Validate the Efficiency of Exponent Carotid Stent
• University of Massachusetts Conduct CAS Efficacy Study in Elderly Patients
• CaRESS Study

7. Product Launches/Approvals

• KNC Obtains Expanded CE Mark Clearance for TriActiv® ProGuard™
• FDA Approves Protege® RX Carotid Stent from ev3
• Abbott Introduces Emboshield® PRO Embolic Protection System in Europe
• Cordis Gains FDA Approval for PRECISE® & ANGIOGUARD® Devices
• Medtronic Obtains CE Mark Approval for Exponent® RX Carotid Stent
• FDA Approves Boston Scientific’s FilterWire EZ™ Embolic Protection System
• Abbott' s Xact® Carotid Stent Receives FDA Approval
• EndoTex’s NexStent™ Receives CE Mark Approval
• KNC Seeks FDA Approval for TriActiv LFX Trial
• Guidant' s RX ACCULINK™ Carotid Stent System Gets FDA Clearance
• ev3’s Protege GPS Receives CE Mark Approval
• Medtronic’s Interceptor® PLUS Carotid Filter System Receives CE Mark Approval
• Guidant Unveils RX Accunet Embolic Protection System in European Market
• Guidant Rolls Out ACCULINK™ Carotid Stent System for European Market

8. Recent Industry Activity

• Boston Scientific Acquires EndoTex
• Boston Scientific and Guidant Merge Operations; Abbott Acquires Guidant’s Vascular Business
• Lumen Commences EPIC Feasibility Study
• Boston Scientific Exclusively Distributes EndoTex’s NexStent™ Carotid Stent

9. Focus on Select Players

• Abbott Vascular (USA)
• Boston Scientific Corporation (USA)
• ev3, Inc. (USA)
• Johnson & Johnson (USA)
• Cordis Corporation (USA)
• Kensey Nash Corporation (USA)
• Medtronic, Inc. (USA)

10. Global Market Perspective

• Table 3: World Recent Past, Current & Future Analysis for Carotid Stents by Geographic Region - US, Europe and Rest of World Markets Independently Analyzed with Annual Number of Carotid Stent Procedures in Thousands for Years 2004 through 2012 (includes corresponding Graph/Chart)
• Table 4: World 9-Year Perspective for Carotid Stents by Geographic Region - Percentage Breakdown by Number of Carotid Stent Procedures for US, Europe and Rest of World Markets for Years 2004, 2007 & 2012 (includes corresponding Graph/Chart)
• Table 5: World Recent Past, Current & Future Analysis for Carotid Stents by Geographic Region - US, Europe and Rest of World Markets Independently Analyzed with Annual Revenues in US$ Million for Years 2004 through 2012 (includes corresponding Graph/Chart)
• Table 6: World 9-Year Perspective for Carotid Stents by Geographic Region - Percentage Breakdown by Annual Revenues for US, Europe and Rest of World Markets for Years 2004, 2007 & 2012 (includes corresponding Graph/Chart)

III. MARKET

1. The United States

• A. Market Analysis
  • Overview
  • Current and Future Analysis
  • Factors Affecting Growth
  • Reimbursement Scenario for CAS
  • Restricted Reimbursement Coverage Limits CASPenetration…
  • CMS Proposes Expanded Reimbursement Coveragefor Carotid Stenting
  • Absence of Regulatory Approvals - A MajorChallenge
  • Clinical Trials - Key to Higher Adoption ofCarotid Stents
  • Latent Demand
  • Key Statistics
  • Major Carotid Stents & EPDs in the Market
  • US Carotid Stents Market - A Gradual Growth
  • Table 7: Carotid Interventions in the US (2006-2008): Percentage Breakdown of Number of Procedures by Carotid Endarterectomy and Carotid Stenting (includes corresponding Graph/Chart)
  • Trends and Issues
  • Convenience in Deployment & Use - Critical forHigher Adoption
  • Rapid Exchange Capabilities Facilitate EffectiveControl Over Procedures
  • Carotid Stents Assume the Role of MemoryBoosters
  • Competitive Landscape
  • Table 8: US Carotid Stents Market (2006-2007): Market Share of Leading Players by Revenues for Boston Scientific, Guidant, Cordis/J&J, Medtronic and Others (includes corresponding Graph/Chart)
  • Product Launches/Approvals
  • Strategic Corporate Developments
  • Focus on Select Players
  • Abbott Vascular
  • Boston Scientific Corporation
  • ev3, Inc.
  • Johnson & Johnson
  • Cordis Corporation
  • Kensey Nash Corporation
  • Medtronic, Inc.
• B. Market Analysis
  • Table 9: US Recent Past, Current & Future Analysis for Carotid Stents Market Independently Analyzed with Annual Number of Carotid Stent Procedures in Thousands for Years 2004 through 2012 (includes corresponding Graph/Chart)
  • Table 10: US Recent Past, Current & Future Analysis for Carotid Stents Market Independently Analyzed with Annual Revenues in US$ Million for Years 2004 through 2012 (includes corresponding Graph/Chart)

2. Europe

• A. Market Analysis
  • Current and Future Analysis
  • European Carotid Stents Market - An Overview
  • ELOCAS Study
  • CEA Versus CAS
  • Table 11: European Vascular Interventions Market (2004-2006E): Percentage Breakdown by Number of Procedures for Carotid Artery Stenting and Carotid Endarterectomy (includes corresponding Graph/Chart)
  • Product Launches/Approvals
  • Strategic Corporate Development
• B. Market Analytics
  • Table 12: European Recent Past, Current & Future Analysis for Carotid Stents Market Independently Analyzed with Annual Number of Carotid Stent Procedures in Thousands for Years 2004 through 2012 (includes corresponding Graph/Chart)
  • Table 13: European Recent Past, Current & Future Analysis for Carotid Stents Market Independently Analyzed with Annual Revenues in US$ Million for Years 2004 through 2012 (includes corresponding Graph/Chart)

3. Rest of World

• A. Market Analysis
  • Current and Future Analysis
  • Carotid Stenting Scenario in India
• B. Market Analytics
  • Table 14: Rest of World Recent Past, Current & Future Analysis for Carotid Stents Market Independently Analyzed with Annual Number of Carotid Stent Procedures in Thousands for Years 2004 through 2012 (includes corresponding Graph/Chart)
  • Table 15: Rest of World Recent Past, Current & Future Analysis for Carotid Stents Market Independently Analyzed with Annual Revenues in US$ Million for Years 2004 through 2012 (includes corresponding Graph/Chart)