INTRAOCULAR LENSES

Table of Contents

I-A. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

• Study reliability and reporting limitations I-1
• Disclaimers I-2
• Data interpretation & reporting level I-2
• Quantitative techniques & analytics I-3
• Product definitions and scope of study I-3
• Hard intraocular lenses (IOLs) I-3
• Foldable intraocular lenses (IOLs) I-3

I-B. GENERAL OVERVIEW OF MEDICAL DEVICES & DIAGNOSTICS INDUSTRY

II. EXECUTIVE SUMMARY

1. Industry Overview II-1

• Outlook II-1
• Global Market to Mirror Steady Growth... II-1
• Hard Intraocular Lenses: Out With the Old II-1
• Foldable Intraocular Lenses Transforming the Market II-1
• Market & Its Competitive Framework II-2
• Intraocular Lenses: A Market Primer II-2
• Competitive Environment... II-2
• Table 1: Global Intraocular Implant Market by Type - Cristallin (Cataracts),Cornea (Refractive Surgery), and Retina for 2003 & 2005(E) (includes corresponding Graph/Chart) II-3
• Table 2: Leading Players in the Global IOL Market (2003 & 2004): Percentage Shares of Revenues for Alcon, Advanced Medical Optics (AMO), Bausch and Lomb, and Others (includes corresponding Graph/Chart) II-4
• Table 3: Leading Players in the Worldwide Phacoemulsification Market: Percentage Market Share of Alcon, Bausch and Lomb, Advanced Medical Optics, and Others for 2003 & 2005(E) (includes corresponding Graph/Chart) II-4
• Product Line Up of Major IOL Manufacturers - Alcon,Advanced Medical Optics, Bausch & Lomb, Adatomed,CIBA Vision, Corneal, Domilens, Ioltech Iovision, ORC, and PFM for 2001 II-5
• Chief Phacoemulsion Systems from Leading Players II-5
• The Ophthalmic Market: An Overview II-6
• Ophthalmic Surgical Devices Market: A Review II-6
• Trends & Issues II-6
• Demand Trends... II-6
• Demographic Trends II-7
• Table 4: Percentage Share of Global Population by Age Group, Worldwide: 2003 & 2025(E) (includes corresponding Graph/Chart) II-7
• Shifting Trends in Cataract Surgery & IOLs II-8
• Hard to Foldable IOLs: A Change for the Better... II-8
• The Epic Transition from Nonfoldable toFoldable Continues... II-8
• Table 5: Transition from Rigid PMMA based IOLs to Foldable IOLs: % Market Penetration Breakdown by Region- The United States, Europe, and Japan for 2001 & 2008 (includes corresponding Graph/Chart) II-9
• Setback of Multifocals II-9
• Material Difference - A Key Consideration II-9
• Regulatory Issues & Approval Procedures... II-10
• Lucrativeness of Regional IOL MarketsAcross the Globe... II-10
• Target Customer Groups & their Requirement Patterns II-10
• Reimbursements: The Key to IOL Prices... II-11
• Price Wars: A Direct Influence on Market Conditions II-11
• IOL Prices in International Markets Marginally Higher II-12
• Technological Innovations: A Boon to the IOL Industry II-12
• New Product Innovations in AccommodativeIOLs Pep-Up the Market... II-12
• Flexibility of IOLs Leads to Better Implantations II-12
• Small-Incision Surgeries: The Reduction ofComplications II-13
• Lasers: The High-Tech Solution II-13
• Viscosurgery: A Safer Alternative II-13
• Low Energy Methods for Cataract Removal II-13
• IOL Material Substitutes II-14
• A Nostalgic Review of Historic Trends... II-14
• Table 6: Global Market for IOLs: A Retrospective Peek Into the Market Share Trends of Early Players- Iolab, Reccor/Olic, American Medical Optics, Pharmacia, Optical Radiation Company, CambiaVision, and Others for 1986 (includes corresponding Graph/Chart) II-14
• Factors Influencing the Market II-14
• Cataract In Tandem With Old Age II-14
• A Statistical Review... II-15
• Table 7: Cataract Related Blindness, Worldwide: Percentage Breakdown by Region - Africa, Asia (Ex India & China), India, China, Latin America, Middle East, and Other for 2000 and 2005(E) (includes corresponding Graph/Chart) II-15
• Table 8: Cataract Market Worldwide by Region - United States, Europe, Asia Pacific, and Rest of the World for 2001 & 2005(E) (includes corresponding Graph/Chart) II-16
• Table 9: Cataract Market Worldwide by Product Segment - Intraocular Lenses (IOLs), Viscoelastics, Equipment, Instruments, and Others for 2003 & 2005(E) (includes corresponding Graph/Chart) II-16
• Table 10: Leading Players in the Global Cataract Market (2003 & 2004): Percentage Shares of Revenues for Alcon, Bausch and Lomb, Advanced Medical Optics (AMO), STAAR Surgical and Others(includes corresponding Graph/Chart) II-17
• Rising Cataract & Refractive Surgeries Put IOLs onthe Right Growth Track II-17
• Conducive Demographics: A Key Driving Force II-18
• Other Market Drivers In a Capsule... II-18
• Major Markets II-19
• The United States II-19
• Canada II-20
• Japan II-20
• Europe II-20
• Asia-Pacific II-20

2. Product Overview II-22

• The Formation of Cataract II-22
• Cataract Extraction: The Only Remedy II-22
• Cataract Extraction Procedures II-22
• Intracapsular Cataract Extraction II-22
• Extracapsular Cataract Extraction (ECCE) II-22
• Phacoemulsification II-22
• Post Cataract Extraction: The Alternatives... II-22
• Intraocular Lenses: A Much Better Solution II-23
• A Retrospection II-23
• The Structure of an IOL II-24
• Types of Intraocular Lenses II-24
• Classification Based on Material Used II-24
• Hard IOLs II-24
• Foldable IOLs II-24
• Classification Based on In-Situ Location II-24
• Anterior Chamber Lenses II-24
• Iris-Clip Lenses II-24
• Posterior Chamber Lenses II-25
• Phakic IOLs II-25
• Accommodating IOLs - The Latest Entrants into the World of IOLs II-25
• The Location of the Implant II-25
• The Process of IOL Production II-26
• Machining II-26
• Molding II-26
• IOL Materials II-26
• Surgical Disposables II-27
• Surgical Lasers II-27
• Intraocular Tissue Removal II-27

3. Effects of Intraocular Lenses Implantations II-28

• Changes in the Size of Capsulorhexis following IOLImplantation... II-28
• Effect of Anterior Chamber Baikoff Phakic IOLs onthe Cornea II-28
• Posterior Chamber IOL Fixed Clerally for Children withMonocular Aphakia II-28
• Aging of the Ciliary Suclus on the Placement of PosteriorChamber IOLs II-28
• Cystic Epithelial Downgrowth: A Complication ofIntraocular Surgery II-28
• Evaluation of Visual Functions & Side Effects of Iris-Fixated Intraocular Lenses II-28
• Occurrence of Endophthalmitis After Secondary IOLImplantations II-29
• Effect of Implantation of Silicone IOLs through Different Types of Incisions II-29
• Width of the Anterior Capsule Opening After IOL Implantations II-29
• Evaluation of the Cellular Reaction on the Surface of PMMA IOLs II-29
• Incidence of Glaucoma in Children after Cataract Extraction & IOL Implantation II-29
• Effect of Incision Length During IOL Implantation on Corneal Astigmatism II-30
• Effects of Cataract Extraction on the Cornea II-30
• Occurrence of Capsular Capture During Silicone IOL Implants II-30
• Evaluation of the Anis Circular Lens II-30
• Effect of Foldable Intraocular Lens Insertion on Incision Width II-30
• Postoperative Mydriatics Effects II-31
• Corneal Complications After Cataract & IOL Surgery II-31
• Comparison of Silicone & PMMA IOLs II-31
• Loss of Corneal Endothelium Caused by Phacoemulsification & IOL Implantation II-31
• Side Effects of Oval IOLs Implantation II-31
• Effects of Phacoemulsification & Small-Incision IOLImplantation on Incision Width II-31
• Capsular Fibrotic Changes II-32
• Suitable Lens After Cataract Surgery: Multifocal orMonofocal ? II-32
• Aspheric IOL Improves Visual Performance II-32

4. Regulations Governing the Production and

• Approval of IOLs II-33
• IOL Compressibility Test II-33
• IOL Vault Testing II-33
• Haptic Fatigue Testing II-33
• Dardenne Testing II-33
• Process of IOL Approval II-33

5. Product Innovations/Launches II-34

• New Intraocular Lenses Developed by US-Based Individuals II-34
• IOLs To Be Launched By Advanced Medical Optics in India II-34
• AMO Unveils ReZoom, a Multifocal Refractive IOL II-34
• New IOL from Alcon II-34
• Medennium Launches New Accommodative Lens II-34
• Calhoun Vision Develops New Adjustable IOL II-34
• New Aspheric IOLs in the US Market II-35
• Canon Contemplates to Promote Preset IOL System II-35
• Bausch & Lomb Introduces Hydroview Foldable AcrylicIntraocular Lens II-35
• Product Approvals II-35
• Alcon' s AcrySof ReSTOR Receives FDA Approval II-35
• AMO' s ReZoom Receives FDA Approval II-35
• Visiogen Obtains CE Mark for Dual-optic AIOL II-36
• CE Approval Granted for STAAR Surgical' s Preloaded IOL II-36
• OPHTEC Wins CE Approval for ARTIFLEX® Lens II-36
• FDA Grants Approval for VISIAN ICL(TM) of STAAR Surgical II-36
• Alcon Receives FDA Approval for AcrySof(R) Toric IOL II-36
• AMO Receives FDA Clearance for TECNIS® Foldable Acrylic IOL II-37
• Alcon' s AcrySof ReSTOR Receives FDA Approval II-37
• AMO' s ReZoom Receives FDA Approval II-37
• Pfizer Gains FDA Nod for Tecnis II-37
• Rayner Wins TGA Approval for the Sale of IOLs II-37
• AMO and OPHTEC Receives FDA Approval II-37
• ARTISAN® /Verisyse™ Phakic Intraocular Lens fromOPHTEC USA and AMO Receives PMA from FDA II-38
• FDA Approves Crystalens from Eyeonics II-38
• FDA Gives Marketing Approval to Alcon' s Natural Single-Piece IOL II-38

6. Recent Industry Activity II-39

• AMO Acquires VISX II-39
• Advanced Ocular Systems Merges with Regenera II-39
• AMO Pacts With Quest Vision II-39
• AMO Pacts With OPHTEC II-39
• AMO Acquires Ophthalmic Surgical Business of Pfizer II-40
• Carl Zeiss Acquires Majority Stake in IOLTECH II-40
• Santen to Terminate Ophthalmic Surgical Instruments Sales II-40
• Eyeonics Adds Presbyopia for Crystalens® II-40
• Presby Acquires Refocus II-40
• Morcher Appoints FCI Ophthalmics for the US Distribution Operations II-40
• STAAR Surgical Revamps Collamer Intraocular Lens II-41
• Bausch & Lomb and HLL Join Hands... II-41
• Advanced Medical Optics Spin-Off From Allergan II-41
• Medennium Divests PRL™ to CIBA Vision II-41
• Santen Buys Advanced Vision Science... II-41
• Pfizer Acquires Pharmacia... II-41
• Pharmacia Pacts with Suppleye.com II-41
• Merger Between Novartis and Wesley Jessen... II-42

7. Innovations & Developments in the IOL Market:

• A Historic Overview II-43
• IOL Medical Research Developments II-43
• Product Introductions II-56
• Acquisitions, Mergers, and Joint Ventures II-58

8. Focus on Select Global Players II-59

• Alcon, Inc. (Switzerland) II-59
• Advanced Medical Optics, Inc. (USA) II-59
• Bausch & Lomb, Inc. (USA) II-60
• CIBA Vision (USA) II-60
• Eurocrystal SA (France) II-60
• Eyeonics, Inc. (USA) II-61
• HumanOptics AG (Germany) II-61
• Morcher GmbH II-61
• OPHTEC BV (The Netherlands) II-61
• OPHTEC USA, Inc. (USA) II-61
• Staar Surgical Company (USA) II-61
• Advanced Vision Science, Inc. (USA) II-62

9. Global Market Perspective II-63

• Table 11: World Recent Past, Current & Future Market Analysis for Intraocular Lenses by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) II-63
• Table 12: World Historic Market Review for Intraocular Lenses by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1991 through 2000 (includes corresponding Graph/Chart) II-63
• Table 13: World 20-Year Perspective for Intraocular Lenses by Geographic Region - Percentage Breakdown of Value Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets for Years 1991, 1995, 2005 & 2010 (includes corresponding Graph/Chart) II-64
• Table 14: World Recent Past, Current & Future Market Analysis for Hard Intraocular Lenses by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) II-65
• Table 15: World Historic Market Review for Hard Intraocular Lenses by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1991 through 2000 (includes corresponding Graph/Chart) II-65
• Table 16: World 20-Year Perspective for Hard Intraocular Lenses by Geographic Region - Percentage Breakdown of Value Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets for Years 1991, 1995, 2005 & 2010 (includes corresponding Graph/Chart) II-66
• Table 17: World Recent Past, Current & Future Market Analysis for Foldable Intraocular Lenses by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) II-67
• Table 18: World Historic Market Review for Foldable Intraocular Lenses by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1991 through 2000 (includes corresponding Graph/Chart) II-67
• Table 19: World 20-Year Perspective for Foldable Intraocular Lenses by Geographic Region - Percentage Breakdown of Value Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets for Years 1991, 1995, 2005 & 2010 (includes corresponding Graph/Chart) II-68

III. MARKET

1. The United States III-1

• A. Market Analysis III-1
• Outlook III-1
• The US IOL Market: An Overview III-1
• Imperative Need for Cataract Surgery III-1
• Phakic IOLs - An Emerging Way Out III-1
• The US IOL Market: Influenced by Medicare Reimbursements... III-2
• A Backdrop on Medicare Reimbursement III-2
• Market Share Trends III-3
• Table 20: Leading Players in the US IOL Market (2002 & 2004): Percentage Shares of Revenues for Alcon, Advanced Medical Optics (AMO), Bausch and Lomb, and Others (includes corresponding Graph/Chart) III-3
• Table 21: Leading Players in the US Foldable IOL Market: Percentage Market Share of Alcon, Advanced Medical Optics (AMO), Bausch and Lomb, and Others for 2003 & 2005(E) (Share in %) (includes corresponding Graph/Chart) III-3
• A Historic Perspective III-4
• Table 22: Number of Cataract Surgeries in the US: 1990-1995 - A Historical Perspective (includes corresponding Graph/Chart) III-4
• Table 23: Sales of Ophthalmic Surgical Devices- Intraocular Lenses, Intraocular Tissue Removal, Ophthalmic Disposables, Ophthalmic Lasers, and Ophthalmic Surgical Microscopes from 1993-1995 - A Historical Perspective (includes corresponding Graph/Chart) III-5
• Market for Viscoelastic Agents III-5
• Table 24: Volume Sales of Viscoelastic By End-Use Segment in the US: Sales of Cataract, Glaucoma,Keratoplasty, and Other from 2000 to 2002 (In ' 000 units) (includes corresponding Graph/Chart) III-5
• Table 25: US Viscoelastic Market By End-Use Segments: Market Share of Cataract, Glaucoma,Keratoplasty, and Other from 1999 to 2003(% Share) (includes corresponding Graph/Chart) III-6
• Product Launches III-6
• Product Approvals III-7
• Strategic Developments III-9
• Focus on Key Players III-12
• B. Market Analytics III-14
• Table 26: US Recent Past, Current & Future Market Analysis for Intraocular Lenses by Product Segment - Hard Intraocular Lenses and Foldable Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) III-14
• Table 27: US Recent Past, Current & Future Market Analysis for Intraocular Lenses by Product Segment - Hard Intraocular Lenses and Foldable Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in ' 000 Units for Years 2001 through 2010 (includes corresponding Graph/Chart) III-15
• Table 28: US Historic Market Review for Intraocular Lenses by Product Segment - Hard Intraocular Lenses and Foldable Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1991 through 2000 (includes corresponding Graph/Chart) III-15
• Table 29: US 20-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Value Sales for Hard Intraocular Lenses and Foldable Intraocular Lenses Markets for 1991, 1995, 2005 & 2010 III-16
• Table 30: US 10-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Volume Sales for Hard Intraocular Lenses and Foldable Intraocular Lenses Markets for 2001, 2005 & 2010 III-16

2. Canada III-17

• A. Market Analysis III-17
• Table 31: Canadian Recent Past, Current & Future Market Analysis for Intraocular Lenses by Product Segment - Hard Intraocular Lenses and Foldable Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) III-17
• Table 32: Canadian Historic Market Review for Intraocular Lenses by Product Segment - Hard Intraocular Lenses and Foldable Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1991 through 2000 (includes corresponding Graph/Chart) III-18
• Table 33: Canadian 20-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Value Sales for Hard Intraocular Lenses and Foldable Intraocular Lenses Markets for 1991, 1995, 2005 & 2010 III-18

3. Japan III-19

• A. Market Analysis III-19
• Overview & Outlook III-19
• Santen Pharmaceutical Co III-19
• Strategic Corporate Developments III-19
• B. Market Analytics III-20
• Table 34: Japanese Recent Past, Current & Future Market Analysis for Intraocular Lenses by Product Segment - Hard Intraocular Lenses and Foldable Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) III-20
• Table 35: Japanese Recent Past, Current & Future Market Analysis for Intraocular Lenses by ProductSegment - Hard Intraocular Lenses and Foldable Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in ' 000 Units for Years 2001 through 2010 (includes corresponding Graph/Chart) III-21
• Table 36: Japanese Historic Market Review for Intraocular Lenses by Product Segment - Hard Intraocular Lenses and Foldable Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1991 through 2000 (includes corresponding Graph/Chart) III-21
• Table 37: Japanese 20-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Value Sales for Hard Intraocular Lenses and Foldable Intraocular Lenses Markets for 1991, 1995, 2005 & 2010 III-22
• Table 38: Japanese 10-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Volume Sales for Hard Intraocular Lenses and Foldable Intraocular Lenses Markets for 2001, 2005 & 2010 III-22

4. Europe III-23

• A. Market Analysis III-23
• Outlook III-23
• Market Share Trends III-23
• Table 39:Leading Players in the European Foldable IOL Market: Percentage Market Share of Alcon, AMO, Bausch and Lomb, and Others for 2001 & 2005(E) (Share in %) (includes corresponding Graph/Chart) III-23
• Strategic Corporate Developments III-24
• Calhoun Vision Develops New Adjustable IOL III-24
• Carl Zeiss to Acquire Majority Stake in IOLTECH III-24
• Alcon Inc. - A Swiss Leader in the Global IOLs Market III-24
• B. Market Analytics III-25
• Table 40: European Recent Past, Current & Future Market Analysis for Intraocular Lenses by Geographic Region - France, Germany, United Kingdom, Italy, Spain, Russia and Rest of European Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) III-25
• Table 41: European Recent Past, Current & Future Market Analysis for Intraocular Lenses by Product Segment - Hard Intraocular Lenses and Foldable Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) III-25
• Table 42: European Recent Past, Current & Future Market Analysis for Intraocular Lenses by Product Segment - Hard Intraocular Lenses and Foldable Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in ' 000 Units for Years 2001 through 2010 (includes corresponding Graph/Chart) III-26
• Table 43: European Historic Market Review for Intraocular Lenses by Geographic Region - France, Germany, United Kingdom, Italy, Spain, Russia and Rest of European Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1991 through 2000 (includes corresponding Graph/Chart) III-26
• Table 44: European Historic Market Review for Intraocular Lenses by Product Segment - Hard Intraocular Lenses and Foldable Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1991 through 2000 (includes corresponding Graph/Chart) III-27
• Table 45: European 20-Year Perspective for Intraocular Lenses by Geographic Region - Percentage Breakdown of Value Sales for France, Germany, United Kingdom, Italy, Spain, Russia and Rest of European Markets for 1991, 1995, 2005 & 2010 (includes corresponding Graph/Chart) III-27
• Table 46: European 20-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Value Sales for Hard Intraocular Lenses and Foldable Intraocular Lenses Markets for 1991, 1995, 2005 & 2010 III-28
• Table 47: European 10-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Volume Sales for Hard Intraocular Lenses and Foldable Intraocular Lenses Markets for 2001, 2005 & 2010 III-28

4a. France III-29

• A. Market Analysis III-29
• Outlook III-29
• Eurocrystal - A Key Player III-29
• B. Market Analytics III-29
• Table 48:French Recent Past, Current & Future Market Analysis for Intraocular Lenses by Product Segment - Hard Intraocular Lenses and Foldable Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) III-29
• Table 49: French Historic Market Review for Intraocular Lenses by Product Segment - Hard Intraocular Lensesand Foldable Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1991 through 2000 (includes corresponding Graph/Chart) III-30
• Table 50: French 20-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Value Sales for Hard Intraocular Lenses and Foldable Intraocular Lenses Markets for 1991, 1995, 2005 & 2010 (includes III-30

4b. Germany III-31

• A. Market Analysis III-31
• Outlook III-31
• Focus on Key Players III-31
• B. Market Analytics III-32
• Table 51: German Recent Past, Current & Future Market Analysis for Intraocular Lenses by Product Segment - Hard Intraocular Lenses and Foldable Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) III-32
• Table 52: German Historic Market Review for Intraocular Lenses by Product Segment - Hard Intraocular Lenses and Foldable Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1991 through 2000 (includes corresponding Graph/Chart) III-32
• Table 53: German 20-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Value Sales for Hard Intraocular Lenses and Foldable Intraocular Lenses Markets for 1991, 1995, 2005 & 2010 III-33

4c. The United Kingdom III-34

• A. Market Analysis III-34
• Table 54: UK Recent Past, Current & Future Market Analysis for Intraocular Lenses by Product Segment - Hard Intraocular Lenses and Foldable Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) III-34
• Table 55: UK Historic Market Review for Intraocular Lenses by Product Segment - Hard Intraocular Lenses and Foldable Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1991 through 2000 (includes corresponding Graph/Chart) III-35
• Table 56: UK 20-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Value Sales for Hard Intraocular Lenses and Foldable Intraocular Lenses Markets for 1991, 1995, 2005 & 2010 III-35

4d. Italy III-36

• A. Market Analysis III-36
• Table 57: Italian Recent Past, Current & Future Market Analysis for Intraocular Lenses by Product Segment - Hard Intraocular Lenses and Foldable Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) III-36
• Table 58: Italian Historic Market Review for Intraocular Lenses by Product Segment - Hard Intraocular Lenses and Foldable Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1991 through 2000 (includes corresponding Graph/Chart) III-37
• Table 59: Italian 20-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Value Sales for Hard Intraocular Lenses and Foldable Intraocular Lenses Markets for 1991, 1995, 2005 & 2010 III-37

4e. Spain III-38

• A. Market Analysis III-38
• Table 60: Spanish Recent Past, Current & Future Market Analysis for Intraocular Lenses by Product Segment - Hard Intraocular Lenses and Foldable Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) III-38
• Table 61: Spanish Historic Market Review for Intraocular Lenses by Product Segment - Hard Intraocular Lenses and Foldable Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1991 through 2000 (includes corresponding Graph/Chart) III-39
• Table 62: Spanish 20-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Value Sales for Hard Intraocular Lenses and Foldable Intraocular Lenses Markets for 1991, 1995, 2005 & 2010 III-39

4f. Russia III-40

• A. Market Analysis III-40
• Table 63: Russian Recent Past, Current & Future Market Analysis for Intraocular Lenses by Product Segment - Hard Intraocular Lenses and Foldable Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) III-40
• Table 64: Russian Historic Market Review for Intraocular Lenses by Product Segment - Hard Intraocular Lenses and Foldable Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1991 through 2000 (includes corresponding Graph/Chart) III-41
• Table 65: Russian 20-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Value Sales for Hard Intraocular Lenses and Foldable Intraocular Lenses Markets for 1991, 1995, 2005 & 2010 III-41

4g. Rest of Europe III-42

• A. Market Analysis III-42
• Outlook III-42
• Product Approvals III-42
• OPHTEC BV - A Key Player in The Netherlands III-42
• B. Market Analytics III-43
• Table 66: Rest of European Recent Past, Current & Future Market Analysis for Intraocular Lenses by Product Segment - Hard Intraocular Lenses and Foldable Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010(includes corresponding Graph/Chart) III-43
• Table 67: Rest of European Historic Market Review for Intraocular Lenses by Product Segment - Hard Intraocular Lenses and Foldable Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1991 through 2000(includes corresponding Graph/Chart) III-44
• Table 68: Rest of European 20-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Value Sales for Hard Intraocular Lenses and Foldable Intraocular Lenses Markets for 1991, 1995, 2005 & 2010 III-44

5. Asia-Pacific III-45

• A. Market Analysis III-45
• Outlook III-45
• An Overview III-45
• Taiwan III-45
• Historical Perspective III-46
• Product Launch III-46
• Strategic Corporate Developments III-46
• B. Market Analytics III-47
• Table 69: Asia-Pacific Recent Past, Current & Future Market Analysis for Intraocular Lenses by Product Segment - Hard Intraocular Lenses and Foldable Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010(includes corresponding Graph/Chart) III-47
• Table 70: Asia-Pacific Historic Market Review for Intraocular Lenses by Product Segment - Hard Intraocular Lenses and Foldable Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1991 through 2000(includes corresponding Graph/Chart) III-47
• Table 71: Asia-Pacific 20-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Value Sales for Hard Intraocular Lenses and Foldable Intraocular Lenses Markets for 1991, 1995, 2005 & 2010 III-48

6. Latin America III-49

• A. Market Analysis III-49
• Table 72: Latin American Recent Past, Current & Future Market Analysis for Intraocular Lenses by Product Segment - Hard Intraocular Lenses and Foldable Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) III-49
• Table 73: Latin American Historic Market Review for Intraocular Lenses by Product Segment - Hard Intraocular Lenses and Foldable Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1991 through 2000 (includes corresponding Graph/Chart) III-50
• Table 74: Latin American 20-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Value Sales for Hard Intraocular Lenses and Foldable Intraocular Lenses Markets for 1991, 1995, 2005 & 2010 III-50

7. Rest of World III-51

• A. Market Analysis III-51
• Table 75: Rest of World Recent Past, Current & Future Market Analysis for Intraocular Lenses by Product Segment - Hard Intraocular Lenses and Foldable Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart) III-51
• Table 76: Rest of World Historic Market Review for Intraocular Lenses by Product Segment - Hard Intraocular Lenses and Foldable Intraocular Lenses Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 1991 through 2000 (includes corresponding Graph/Chart) III-52
• Table 77: Rest of World 20-Year Perspective for Intraocular Lenses by Product Segment - Percentage Breakdown of Value Sales for Hard Intraocular Lenses and Foldable Intraocular Lenses Markets for 1991, 1995, 2005 & 2010 III-52

IV. COMPETITION

• 1. Advanced Medical Optics, Inc. (USA) IV-1
• Table 78: First Half Sales Analysis by Quarter: 2005-2006 (In US$ million) IV-2
• Table 79: First Half Sales Analysis by Segment: 2005-2006 (In US$ million) IV-2
• Table 80: First Half Sales Analysis by Geographic Region: 2005-2006 (In US$ million) IV-2
• Table 81: Annual Sales Analysis by Product Segment: 2004-2005 (In US$ million) IV-2
• Table 82: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million) IV-3
• Table 83: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million) IV-3
• Advanced Medical Optics India Private Limited (India) IV-5
• 2. Advanced Ocular Systems Ltd. (Australia) IV-6
• 3. Advanced Vision Science, Inc. (USA) IV-6
• 4. Alcon, Inc. (Switzerland) IV-7
• Alcon Laboratories, Inc. (USA) IV-8
• Alcon Sa Laboratoires (France) IV-13
• 5. Allergan, Inc. (USA) IV-14
• Table 84: Half Yearly Sales Analysis by Quarter: 2005-2006 (H1) (In US$ million) IV-15
• Table 85: Half Yearly Sales Analysis by Business Segment: 2005-2006 (H1) (In US$ million) IV-15
• Table 86: Half Yearly Sales Analysis By Product Segment: 2005-2006 (H1) (In US$ million) IV-15
• Table 87: Half Yearly Sales Analysis By Geographic Region: 2005-2006 (H1) (In US$ Million) IV-15
• Table 88: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million) IV-16
• Table 89: Annual Sales Analysis By Product Segment: 2004-2005 (In US$ million) IV-16
• Table 90: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million) IV-16
• 6. Bausch and Lomb, Inc. (USA) IV-20
• Bausch and Lomb Surgical (USA) IV-26
• Bausch and Lomb Surgical GmbH (Germany) IV-28
• 7. Brazosport Eye Institute (USA) IV-30
• 8. Calhoun Vision, Inc. (USA) IV-31
• 9. Carl Zeiss Meditec AG (Germany) IV-32
• Table 91: Half Yearly Sales Analysis: 2005-2006 (H1) (In € million) IV-32
• Table 92: Annual Sales Analysis by Business Segment: 2004-2005 (In € million) IV-33
• Table 93: Annual Sales Analysis by Geographical Region: 2004-2005 (In € million) IV-33
• Carl Zeiss Meditec, Inc. (USA) IV-34
• 10. CIBA Vision Corporation (USA) IV-35
• 11. Eurocrystal SA (France) IV-37
• 12. EyeKon Medical (USA) IV-38
• 13. Eyeonics, Inc. (USA) IV-39
• 14. Gelflex Laboratories (Australia) IV-40
• 15. Gulden Ophthalmics (USA) IV-41
• 16. Hanita Lenses (Israel) IV-59
• 17. Henan Universe Intraocular Lens Research and Manufacture Company Limited (China) IV-60
• 18. Hoya Corporation (Japan) IV-61
• 19. HumanOptics Ag (Germany) IV-62
• 20. IOL International (USA) IV-62
• 21. Ioltech Laboratories (France) IV-63
• 22. Medennium, Inc. (USA) IV-64
• 23. Menicon Co., Ltd. (Japan) IV-65
• Menicon Europe (France) IV-68
• Morcher GmbH (Germany) IV-68
• 24. Nidek Co., Ltd. (Japan) IV-69
• Nidek Inc. (USA) IV-71
• 25. Ophtec BV (The Netherlands) IV-72
• Ophtec USA, Inc. (USA) IV-75
• 26. Ophthalmic Innovations International, Inc. (USA) IV-76
• 27. Pfizer, Inc. (USA) IV-78
• Table 94: Half Yearly Sales Analysis: 2005-2006 (H1) (In US$ million) IV-79
• Table 95: Half Yearly Sales Analysis by Segment: 2005-2006 (H1) (In US$ million) IV-80
• 28. Physiol SA (Belgium) IV-83
• 29. Rayner Intraocular Lenses Ltd. (UK) IV-84
• 30. Santen Pharmaceutical Co., Ltd. (Japan) IV-85
• Table 96: Annual Sales Analysis: 2004-2006 (In ¥ billion) IV-86
• Table 97: Annual Sales Analysis by Segment: 2004-2005 (In ¥ billion) IV-87
• Table 98: Annual Sales Analysis by Geographic Region: 2004-2005 (In ¥ billion) IV-87
• 31. Staar Surgical Company (USA) IV-90
• Table 99: Half Yearly Sales Analysis: 2005-2006 (H1) (In US$ million) IV-90
• Table 100: Half Yearly Sales Analysis by Product Segment: 2005-2006 (H1) (In US$ million) IV-90
• Table 101: Half Yearly Sales Analysis by Geographic Region: 2005-2006 (H1) (In US$ million) IV-91
• Table 102: Annually Sales Analysis by Product Segment: 2004-2005 (In US$ million) IV-91
• Table 103: Annually Sales Analysis by Geographic Region: 2004-2005 (In US$ million) IV-91
• Table 104: Annually Sales Analysis by Quarters: 2004-2005 (In US$ million) IV-91
• 32. Suzhou Medical Apparatus and Instrument (China) IV-95
• 33. Us Iol, Inc. (USA) IV-96
• 34. Visiogen, Inc. (USA) IV-97