BLOOD FLOW MEASUREMENT DEVICES

Table of Contents

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

• Study Reliability and Reporting Limitations
• Disclaimers
• Data Interpretation & Reporting Level
• Quantitative Techniques & Analytics
• Product Definitions and Scope of Study
• Doppler Flowmeters
• Laser Flowmeters
• Electromagnetic Flowmeters
• By Application Area
• By Site of Care

II. EXECUTIVE SUMMARY

1. Market Overview

• Outlook
• Table 1: World Market for Blood Flow Measurement Devices by Technology (2008): Percentage Share Breakdown of Value Sales for Doppler Flowmeters, Laser Flowmeters, and Electromagnetic Flowmeters (includes corresponding Graph/Chart)
• Market Drivers
• Rising Incidence of Peripheral Vascular Diseases Pace Demand for Blood Flow Meters-
• Product Innovations Sustain Market Momentum

2. Product Overview

• What' s Blood Flow and Why is it Measured?
• Blood Flow Theory - Similar to Electrical Current Theory
• Significance of Evaluating Blood Flow in Early Diagnosis of Disease
• How is Blood Flow Measured?
• Cutaneous Blood Flow Measurement
• Methods of Measuring Blood flow
• Clinical Applications of Blood Flowmeters
• Table 2: World Market for Blood Flow Measurement Devices by Site of Care (2008): Percentage Share Breakdown of Value Sales for Operating Units, Intensive Care Unit , Emergency Care Units , Vascular Laboratory, Dialysis Units , and Others (includes corresponding Graph/Chart)

3. Invasive Blood Flow Measurement Techniques

• Thermal Dilution
• Electromagnetic Flowmeters
• Implantable Ultrasonic Transmit-time Flowmeters
• Laser Doppler, Ultrasonic Doppler, Electromagnetic Tipped Catheters Velocimeters
• Implantable Doppler Velocimeters

4. Non Invasive Blood Flow Measurement

Techniques

• Doppler Velocimeters
• Doppler Velocimeters With Fast Fourier Spectrum Analyzers
• Doppler Ultrasound
• Plethysmography
• Impedance Plethysmography

5. Laser Doppler Flowmetry

• A Pioneering Technique in Blood Flow Measurement
• Variety of Applications
• Organs Other Than Skin in Which Tissue Capillary Blood Flow has been Studied by Laser Doppler Flowmetry
• Clinical Uses for Laser Doppler Flowmetry
• Skin Blood Flow
• Anesthesia
• Burns
• Angiology and Vascular Surgery
• General Medicine
• Dermatology
• Rehabilitation
• Occupational medicine
• Pharmacology
• Blood flow in other organs
• Gastroenterology
• General surgery
• Gynecology
• Plastic surgery
• Theory of Laser Doppler Flowmetry
• The Methodology
• Mechanism
• Laser Light Source and Probe
• Photodetectors

6. Ocular Blood Flow Measurement Techniques

• Ocular Blood Flow Analyzer (BFA)
• Clinical Benefits of the BFA

7. Cerebral Blood Flow Measurement Techniques II- 14

Intraoperative Cerebral Blood Flow Measurement

• Qualitative CBF Monitoring Techniques
• Electroencephalography and SSEP Monitoring
• Neurological Examination
• Intraoperative Angiography
• Transcranial Doppler Ultrasonography
• Quantitative CBF Monitoring Techniques
• Ultrasonic Perivascular Flow Probe
• Xenon-133 Study

8. Relevant Factors in Blood Flow Measurement

• Skin Anatomy
• Skin and Blood Flow
• Physiology of Skin Blood Flow
• Distribution

9. Product/Technology Developments

• NOVA Blood-Flow Measuring Technology
• New York Researchers Develop Tiny Implantable Sensors for Measuring Blood Flow
• Japanese Inventors Develop Wearable Micro Laser Bloodflow Meter
• Integra LifeSciences to Launch NeuroSensor Equipment

10. Recent Industry Activity

• Getinge Acquires Huntleigh Technology
• Cardinal Health Acquires VIASYS Healthcare
• ESTECH Extends Agreement with NeoProbe
• ESTECH, NeoProbe Ink Distribution Pact
• VIASYS Takes Over BioBeat Medical, Ltd
• Ostara Acquires Rheologics, Inc
• IVMD Files Generic Patent for Tissue Blood Flow
• Compumedics Acquires DWL
• Tec Factory Acquires HeartSTAT
• Volcano Acquires Jomed
• Huntleigh Healthcare Inc. Announces a Pact with MedAssets HSCA, Inc
• Neoprobe Corp Receives Marketing Clearance for Quantix/OR in the US
• Neoprobe Bags U.S. Patent for Blood Flow Measurement Technology for its Subsidiary, Cardiosonix

11. Focus on Select Players

• ArjoHuntleigh (Sweden)
• Atys Medical (France)
• Braemar, Inc. (US)
• Cardinal Health, Inc. (US)
• VIASYS Healthcare (US)
• Nicolet Vascular (US)
• Compumedics DWL (Germany)
• Flowtronics, Inc. (US)
• Neoprobe Corporation (US)
• Cardiosonix, Ltd., (Israel)
• Transonic Systems, Inc. (US)

12. Global Market Perspective

• Table 3: World Recent Past, Current & Future Analysis for Blood Flow Measurement Devices by Geographic Region/ Country - United States, Canada, Japan, Europe, Asia-Pacific, Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 4: World Long-term Projections for Blood Flow Measurement Devices by Geographic Region/Country - United States, Canada, Japan, Europe, Asia-Pacific, Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 5: World 10-Year Perspective for Blood Flow Measurement Devices by Geographic Region/Country - Percentage Breakdown of Value Sales for United States, Canada, Japan, Europe, Asia-Pacific, Latin America and Rest of World Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart)
• Analytics by Product Segment
• Table 6: World Recent Past, Current & Future Analysis for Doppler Flowmeters by Geographic Region/Country - US, Canada, Japan, Europe, Asia-Pacific, Latin America, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 7: World Long-term Projections for Doppler Flowmeters by Geographic Region/Country - United States, Canada, Japan, Europe, Asia-Pacific, Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 8: World 10-Year Perspective for Doppler Flowmeters by Geographic Region/Country - Percentage Breakdown of Value Sales for United States, Canada, Japan, Europe, Asia-Pacific, Latin America, and Rest of World Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart)
• Table 9: World Recent Past, Current & Future Analysis for Laser Flowmeters by Geographic Region/Country - United States, Canada, Japan, Europe, Asia-Pacific, Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 10: World Long-term Projections for Laser Flowmeters by Geographic Region/Country - United States, Canada, Japan, Europe, Asia-Pacific, Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 11: World 10-Year Perspective for Laser Flowmeters by Geographic Region/Country - Percentage Breakdown of Value Sales for United States, Canada, Japan, Europe, Asia-Pacific, Latin America and Rest of World Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart)
• Table 12: World Recent Past, Current & Future Analysis for Electromagnetic Flowmeters by Geographic Region/Country - US, Canada, Japan, Europe, Asia-Pacific, Latin America, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 13: World Long-term Projections for Electromagnetic Flowmeters by Geographic Region/Country - United States, Canada, Japan, Europe, Asia-Pacific, Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 14: World 10-Year Perspective for Electromagnetic Flowmeters by Geographic Region/Country - Percentage Breakdown of Value Sales for United States, Canada, Japan, Europe, Asia- Pacific, Latin America, and Rest of World Markets for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart)

III. MARKET

1. The United States

• A. Market Analysis
  • Product Launches/Developments
  • Strategic Corporate Developments
  • Leading Player
  • Braemar, Inc.
  • Cardinal Health, Inc.
  • VIASYS Healthcare
  • Nicolet Vascular
  • Crystal Biotech
  • Flowtronics, Inc.
  • Neoprobe Corporation
  • Transonic Systems, Inc.
• B. Market Analytics
  • By Product Segment
  • Table 15: US Recent Past, Current & Future Analysis for Blood Flow Measurement Devices by Product Segment - Doppler Flowmeters, Laser Flowmeters and Electromagnetic Flowmeters Markets Independently Analyzed with Annual sales Figures in US$ million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 16: US Long-term Projections for Blood Flow Measurement Devices by Product Segment - Doppler Flowmeters, Laser Flowmeters and Electromagnetic Flowmeters Markets Independently analyzed with Annual sales Figures in US$ million for Years 2011 through 2015 (includes corresponding Graph/Chart)
  • Table 17: US 10-Year Perspective for Blood Flow Measurement Devices by Product Segment - Percentage Breakdown of Value Sales for Doppler Flowmeters, Laser Flowmeters and Electromagnetic Flowmeters Market for 2003, 2008 & 2012 (includes corresponding Graph/Chart)
  • By Application Area
  • Table 18: US Recent Past, Current & Future Analysis for Blood Flow Measurement Devices by Application Area - Surgery, Post-Operative Care, Emergency Care, General Care and Other Markets Independently analyzed with Annual Sales Figures in US$ million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 19: US Long-term Projections for Blood Flow Measurement Devices by Application Area - Surgery, Post-Operative Care, Emergency Care, General Care and Other Markets Independently analyzed with Annual Sales Figures in US$ million for Years 2011 through 2015 (includes corresponding Graph/Chart)
  • Table 20: US 10-Year Perspective for Blood Flow Measurement Devices by Application Area -Percentage Breakdown of Value Sales for Surgery, Post-Operative Care, Emergency Care, General Care and Other Markets for 2003, 2008 & 2012 (includes corresponding Graph/Chart)
  • By Site of Care
  • Table 21: US Recent Past, Current & Future Analysis for Blood Flow Measurement Devices by Site of Care - Operating Units, Intensive Care Unit, Emergency Units, Vascular Laboratory, Dialysis Units and Other Markets Independently analyzed with Annual Sales Figures in US$ million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 22: US Long-term Projections for Blood Flow Measurement Devices by Site of Care - Operating Units, Intensive Care Unit, Emergency Care Units, Vascular Laboratory, Dialysis Units and Other Markets Independently analyzed with Annual Sales Figures in US$ million for Years 2011 through 2015 (includes corresponding Graph/Chart)
  • Table 23: US 10-Year Perspective for Blood Flow Measurement Devices by Site of Care - Operating Units, Intensive Care Unit, Emergency Units, Vascular Laboratory, Dialysis Units and Other Markets for 2003, 2008 & 2012 (includes corresponding Graph/Chart)

2. Canada

• Market Analysis
• Table 24: Canadian Recent Past, Current & Future Analysis for Blood Flow Measurement Devices by Product Segment - Doppler Flowmeters, Laser Flowmeters and Electromagnetic Flowmeters Markets Independently Analyzed with Annual Sales Figures in US$ million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 25: Canadian Long-term Projections for Blood Flow Measurement Devices by Product Segment - Doppler Flowmeters, Laser Flowmeters and Electromagnetic Flowmeters Markets Independently Analyzed with Annual Sales Figures in US$ million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 26: Canadian 10-Year Perspective for Blood Flow Measurement Devices by Product Segment-Percentage Breakdown of Value Sales for Doppler Flowmeters, Laser Flowmeters and Electromagnetic Flowmeters Market for 2003, 2008 & 2012 (includes corresponding Graph/Chart)

3. Japan

• A. Market Analysis
  • Select Player Review
  • Hadeco, Inc.
  • Research Development
• B. Market Analytics
  • Table 27: Japanese Recent Past, Current & Future Analysis for Blood Flow Measurement Devices by Product Segment - Doppler Flowmeters, Laser Flowmeters and Electromagnetic Flowmeters Markets Independently analyzed with Annual sales Figures in US$ million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 28: Japanese Long-term Projections for Blood Flow Measurement Devices by Product Segment - Doppler Flowmeters, Laser Flowmeters and Electromagnetic Flowmeters Markets Independently analyzed with Annual sales Figures in US$ million for Years 2011 through 2015 (includes corresponding Graph/Chart)
  • Table 29: Japanese 10-Year Perspective for Blood Flow Measurement Devices by Product Segment-Percentage Breakdown of value Sales for Doppler Flowmeters, Laser Flowmeters and Electromagnetic Flowmeters Market for 2003, 2008 & 2012 (includes corresponding Graph/Chart)

4. Europe

• Market Analysis
• Table 30: European Recent Past, Current & Future Analysis for Blood Flow Measurement Devices by Geographic Region/Country - France, Germany, Italy, UK, and Rest of Europe Markets Independently analyzed with Annual Sales Figures in US$ million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 31: European Recent Past, Current & Future Analysis for Blood Flow Measurement Devices by Product Segment- Doppler Flowmeters, Laser Flowmeters and Electromagnetic Flowmeters Markets Independently Analyzed with Annual Sales Figures in US$ million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 32: European Long-term Projections for Blood Flow Measurement Devices by Geographic Region/Country - France, Germany, Italy, UK, and Rest of Europe Markets Independently analyzed with Annual sales Figures in US$ million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 33: European Long-term Projections for Blood Flow Measurement Devices by Product Segment- Doppler Flowmeters, Laser Flowmeters and Electromagnetic Flowmeters Markets Independently Analyzed with Annual Sales Figures in US$ million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 34: European 10-Year Perspective for Blood Flow Measurement Devices by Geographic Region/ Country -Percentage Breakdown of Value Sales for France, Germany, Italy, UK and Rest of Europe Market for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart)
• Table 35: European 10-Year Perspective for Blood Flow Measurement Devices by Product Segment-Percentage Breakdown of Value Sales for Doppler Flowmeters, Laser Flowmeters and Electromagnetic Flowmeters Market for Years 2003, 2008 & 2012 (includes corresponding Graph/Chart)

4a. France

• Market Analysis
• Atys Medical - A Key Player
• Table 36: French Recent Past, Current & Future Analysis for Blood Flow Measurement Devices by Product Segment - Doppler Flowmeters, Laser Flowmeters and Electromagnetic Flowmeters Markets Independently Analyzed with Annual Sales Figures in US$ million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 37: French Long-term Projections for Blood Flow Measurement Devices by Product Segment - Doppler Flowmeters, Laser Flowmeters and Electromagnetic Flowmeters Markets Independently Analyzed with Annual Sales Figures in US$ million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 38: French 10-Year Perspective for Blood Flow Measurement Devices by Product Segment-Percentage Breakdown of Value Sales for Doppler Flowmeters, Laser Flowmeters and Electromagnetic Flowmeters Market for 2003, 2008 & 2012 (includes corresponding Graph/Chart)

4b. Germany

• A. Market Analysis
  • Compumedics DWL - A Leading Player
• B. Market Analytics
  • Table 39: German Recent Past, Current & Future Analysis for Blood Flow Measurement Devices by Product Segment - Doppler Flowmeters, Laser Flowmeters and Electromagnetic Flowmeters Markets Independently analyzed with Annual sales Figures in US$ million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 40: German Long-term Projections for Blood Flow Measurement Devices by Product Segment - Doppler Flowmeters, Laser Flowmeters and Electromagnetic Flowmeters Markets Independently analyzed with Annual sales Figures in US$ million for Years 2011 through 2015 (includes corresponding Graph/Chart)
  • Table 41: German 10-Year Perspective for Blood Flow Measurement Devices by Product Segment-Percentage Breakdown of Value Sales for Doppler Flowmeters, Laser Flowmeters and Electromagnetic Flowmeters Market for 2003, 2008 & 2012 (includes corresponding Graph/Chart)

4c. Italy

• Market Analysis
• Table 42: Italian Recent Past, Current & Future Analysis for Blood Flow Measurement Devices by Product Segment - Doppler Flowmeters, Laser Flowmeters and Electromagnetic Flowmeters Markets Independently analyzed with Annual sales Figures in US$ million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 43: Italian Long-term Projections for Blood Flow Measurement Devices by Product Segment - Doppler Flowmeters, Laser Flowmeters and Electromagnetic Flowmeters Markets Independently analyzed with Annual sales Figures in US$ million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 44: Italian 10-Year Perspective for Blood Flow Measurement Devices by Product Segment-Percentage Breakdown of Value Sales for Doppler Flowmeters, Laser Flowmeters and Electromagnetic Flowmeters Market for 2003, 2008 & 2012 (includes corresponding Graph/Chart)

4d. The United Kingdom

• A. Market Analysis
  • Strategic Corporate Development
• B. Market Analytics
  • Table 45: UK Recent Past, Current & Future Analysis for Blood Flow Measurement Devices by Product Segment - Doppler Flowmeters, Laser Flowmeters and Electromagnetic Flowmeters Markets Independently Analyzed with Annual Sales Figures in US$ million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 46: UK Long-term Projections for Blood Flow Measurement Devices by Product Segment - Doppler Flowmeters, Laser Flowmeters and Electromagnetic Flowmeters Markets Independently Analyzed with Annual Sales Figures in US$ million for Years 2011 through 2015 (includes corresponding Graph/Chart)
  • Table 47: UK 10-Year Perspective for Blood Flow Measurement Devices by Product Segment-Percentage Breakdown of Value Sales for Doppler Flowmeters, Laser Flowmeters and Electromagnetic Flowmeters Market for 2003, 2008 & 2012 (includes corresponding Graph/Chart)

4e. Rest of Europe

• Market Analysis
• Key Players
• Medi-Stim AS (Norway)
• ArjoHuntleigh (Sweden)
• Table 48: Rest of Europe Recent Past, Current & Future Market Analysis for Blood Flow Measurement Devices by Product Segment - Doppler Flowmeters, Laser Flowmeters and Electromagnetic Flowmeters Markets Independently Analyzed with Annual Sales Figures in US$ million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 49: Rest of Europe Long-term Projections for Blood Flow Measurement Devices by Product Segment - Doppler Flowmeters, Laser Flowmeters and Electromagnetic Flowmeters Markets Independently Analyzed with Annual Sales Figures in US$ million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 50: Rest of Europe 10-Year Perspective for Blood Flow Measurement Devices by Product Segment - Percentage Breakdown of Value Sales for Doppler Flowmeters, Laser Flowmeters and Electromagnetic Flowmeters Market for 2003, 2008 & 2012 (includes corresponding Graph/Chart)

5. Asia-Pacific

• Market Analysis
• Table 51: Asia-Pacific Recent Past, Current & Future Analysis for Blood Flow Measurement Devices by Product Segment - Doppler Flowmeters, Laser Flowmeters and Electromagnetic Flowmeters Markets Independently Analyzed with Annual Sales Figures in US$ million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 52: Asia-Pacific Long-term Projections for Blood Flow Measurement Devices by Product Segment - Doppler Flowmeters, Laser Flowmeters and Electromagnetic Flowmeters Markets Independently Analyzed with Annual Sales Figures in US$ million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 53: Asia-Pacific 10-Year Perspective for Blood Flow Measurement Devices by Product Segment - Percentage Breakdown of Value Sales for Doppler Flowmeters, Laser Flowmeters and Electromagnetic Flowmeters Market for 2003, 2008 & 2012 (includes corresponding Graph/Chart)

6. Latin America

• Market Analysis
• Table 54: Latin American Recent Past, Current & Future Market Analysis for Blood Flow Measurement Devices by Product Segment -Doppler Flowmeters, Laser Flowmeters and Electromagnetic Flowmeters Markets Independently Analyzed with Annual Sales Figures in US$ million for Years 2000 through 2010 (includes corresponding Graph/Chart)
• Table 55: Latin American Long-term Projections for Blood Flow Measurement Devices by Product Segment - Doppler Flowmeters, Laser Flowmeters and Electromagnetic Flowmeters Markets Independently Analyzed with Annual Sales Figures in US$ million for Years 2011 through 2015 (includes corresponding Graph/Chart)
• Table 56: Latin American 10-Year Perspective for Blood Flow Measurement Devices by Product Segment - Percentage Breakdown of Value Sales for Doppler Flowmeters, Laser Flowmeters and Electromagnetic Flowmeters Market s for 2003, 2008 & 2012 (includes corresponding Graph/Chart)

7. Rest of World

• A. Market Analysis
  • Strategic Corporate Developments
  • Cardiosonix, Ltd., (Israel) - A Leading Player
• B. Market Analytics
  • Table 57: Rest of World Recent Past, Current & Future Market Analysis for Blood Flow Measurement Devices by Product Segment - Doppler Flowmeters, Laser Flowmeters and Electromagnetic Flowmeters Markets Independently Analyzed with Annual Sales Figures in US$ million for Years 2000 through 2010 (includes corresponding Graph/Chart)
  • Table 58: Rest of World Long-term Projections for Blood Flow Measurement Devices by Product Segment - Doppler Flowmeters, Laser Flowmeters and Electromagnetic Flowmeters Markets Independently Analyzed with Annual Sales Figures in US$ million for Years 2011 through 2015 (includes corresponding Graph/Chart)
  • Table 59: Rest of World 10-Year Perspective for Blood Flow Measurement Devices by Product Segment - Percentage Breakdown of Value Sales for Doppler Flowmeters, Laser Flowmeters and Electromagnetic Flowmeters Market s for 2003, 2008 & 2012 (includes corresponding Graph/Chart)