The Market for Lead Optimization Tools and Services: Applying the new "-omics" to enhance drug discovery

Table of Contents

Chapter 1: EXECUTIVE SUMMARY

• Understanding Drug Discovery
• Role of Lead Optimization
• Report Objectives & Structure
• Results Summary

Chapter 2 LEAD OPTIMIZATIONS & "-OMICS"

• Understanding ADMET
• Structure Activity Relationships
• In-silico, In-vitro, In-vivo Approaches
• Genomics & Pharmaco-Genomics
• Proteomics
• Transcriptomics
• Metabonomics
• Toxicogenomics

Chapter 3: MARKETS FOR LEAD OPT TOOLS

• ADMET Assays
• In-silico Software
• Chemical Synthesis Instruments & Arrays

Chapter 4: MARKETS FOR LEAD OPT SERVICES

• Case Study: Evotec OAI
• Early ADMET
• Predictive Modeling
• Compound Synthesis
• Focused Libraries

Chapter 5: CUSTOMERS FOR LEADOPT

• Big Pharma Approaches to LeadOpt
• Biotech Approaches to LeadOpt
• How Suppliers are Selected

Chapter 6: FUTURE OF LEADOPT

• Customer Wants & Needs
• Service Suppliers
• Tools Suppliers
• Opportunities & Growth

Chapter 7. SUPPLIER PROFILES

• Service Suppliers
• Absorption Systems
• Albany Molecular
• Amedis
• Argenta
• ArQule,
• BioFocus
• CMT
• Cerep
• ChemBridge
• ComGenex
• Entelos
• Evotec OAI
• Gene Logic
• Inpharmatica
• Millennium
• NiKem
• NoAb
• Pharmacopeia
• Quintiles
• Upstate

Tools Suppliers:

• Accelyrs
• Aclara
• Affymetrix
• Amersham
• Biacore
• Bio-Rad
• CST
• Charles River Labs
• Gene Logic
• Invitrogen
• Lion
• MDS Sciex
• PHASE-1
• Pierce
• pION
• Promega
• Simulations Plus
• Tecan
• Tripos
• Xceleron

Appendix: DIRECTORY OF SUPPLIERS