[Report] Global Vaccines Market Research, Trends, Analysis TOC

Chapter One: Executive Summary

Scope and Methodology

Size and Growth of the Market

Market Trends

Industry Structure and Leading Competitors

Chapter Two: Introduction to Vaccines

A Brief History: The Development of Vaccines

The Immune Response

Mechanism of Action

Types of Vaccines

Attenuated (Weakened) Live Viruses
Killed Whole Vaccines
Toxoid Vaccines
Genetically Engineered/Modified Vaccines
Subunit Vaccines
Conjugate Vaccines
Vaccine Approval Process

DNA Vaccines

Mechanism of Action of DNA Vaccines
Advantages of DNA Vaccines

Therapeutic Vaccines to Treat Cancer

Chapter Three: Pediatric Preventive Vaccines

Overview

Childhood Immunization in the United States

Childhood Immunization Rates
Challenges to the Vaccine Delivery System
Recommended Childhood Immunization Schedule

Pediatric Vaccine Products

BCG Vaccines
Diphtheria, Tetanus, Pertussis, Hepatitis B and Polio Vaccines
Diphtheria
Pertussis
Tetanus
Hepatitis B
Poliomyelitis
Haemophilus Influenzae Type B Vaccines
Hepatitis A Vaccines
Measles, Mumps and Rubella Vaccines
- Measles
- Mumps
- Rubella
Pneumococcal Conjugate Vaccine
Rotavirus Vaccines
Varicella Vaccines

Cost of Vaccines in the United States

Pediatric Vaccines in Development

Global Initiatives for Vaccine Research
Diarrhea-Related Diseases
Rotavirus
Rotavirus Vaccines
Rotavirus Vaccines in Clinical Trials
Enterotoxigenic Escherichia coli
ETEC Vaccines in Clinical Trials
Acute Respiratory Infections
Streptococcus Pneumoniae
Pneumococcal Vaccines
Respiratory Syncytial Virus
RSV Vaccines in Clinical Trials
Parainfluenza Virus Type 3
PIV-3 Vaccines in Clinical Trials
The World Market for Pediatric Preventive Vaccines

Total Market Size and Forecast
DTP and DTaP Vaccine Market
Market Analysis
Leading Products and Competitors
Hepatitis Vaccine Market
Market Analysis
Leading Products and Competitors
Haemophilus Influenzae Type B Vaccine Market
Market Analysis
Leading Products and Competitors
Measles, Mumps and Rubella Vaccines
Market Analysis
Leading Products and Competitors
Combination Vaccines Market
Market Analysis
Leading Products and Competitors
Pneumococcal Vaccine
Market Analysis
Poliovirus Vaccine
Market Analysis
Leading Products and Competitors
Varicella Vaccines
Market Analysis
Leading Products and Competitors
Other Vaccines Market
Market Analysis
Leading Products and Competitors

Chapter Four: Adult Preventive Vaccines

Introduction

Adult Vaccine-Preventable Diseases: Facts and Figures

Global Virological Surveillance Program

Recommendations for Adult Immunizations

Vaccine Recommendations for International Travel
CDCs Revised Recommendations for Influenza Vaccination for 2004-05 Flu Season
Priority Groups for Influenza Vaccination
Other Vaccination Recommendations
Vaccination of Persons in Nonpriority Groups
Persons Who Should Not Receive Influenza Vaccine
CDCs Recommendations for Yellow Fever Vaccination
WHO International Health Regulations

Adult Vaccine Products

BCG Vaccines
Cholera Vaccines
Diphtheria-Tetanus Vaccines
Hepatitis Vaccines
Hepatitis A
Hepatitis B
Influenza Vaccines
Japanese Encephalitis Vaccine
Pneumococcal Disease Vaccines
Rabies Vaccine
Typhoid Vaccines
Yellow Fever Vaccines

Adult Vaccines in Development

Global Initiatives for Vaccine Research

Cholera Vaccines
Dengue Fever Vaccines
Epstein-Barr Virus Vaccines
HIV/AIDS
AIDS Vaccines
Helicobacter Pylori Vaccines
Hepatitis Vaccines
Hepatitis C
Hepatitis E
Herpesvirus Vaccines
Leishmaniasis
Severe Acute Respiratory Syndrome
Shigella Vaccine
West Nile Virus

The World Market for Adult Preventive Vaccines

Total Market Size and Forecast
Hepatitis Market
Market Analysis
Leading Products and Competitors
Influenza Vaccine Market
Market Analysis
Leading Products and Competitors
Pneumococcal Vaccine Market
Market Analysis
Leading Products and Competitors
Travel; DT; Miscellaneous Market
Market Analysis
Leading Products and Competitors

Chapter Five: Preventive Vaccines Market Summary

Trends Driving the Preventive Vaccines Market

Market Size and Forecast

Vaccine Market Competitors
Pediatric Vaccines
Major Manufacturers Market Share
Adult Vaccines
Major Manufacturers Market Share

Chapter Six: Therapeutic Cancer Vaccines

Cancer Vaccine Technology

Cancer Statistics

Available Cancer Vaccines

Bladder Cancer

Colorectal Cancer

Melanoma

Types of Cancers Susceptible to Vaccines

Breast Cancer
Cervical Cancer
Colorectal Cancer
Gastrointestinal Cancer
Stomach
Liver
Pancreas
Kidney
Leukemia
Lung Cancer
Lymphoma
Melanoma
Multiple Myeloma
Neuroblastoma
Ovarian Cancer
Prostate Cancer
Sarcoma

Cancer Vaccine Pipeline

Vaccine Candidates in Phase III
Vaccine Candidates in Phase II
Vaccine Candidates in Phase I

The Emerging Cancer Vaccine Market

Total Market Size and Forecast
Competitor Analysis

Chapter Seven: Issues and Trends

Vaccine Safety

Pre-licensure Evaluation
Post-Licensure Surveillance
Vaccine Adverse Event Reporting System
The Vaccine Safety Datalink Project
The Vaccine Injury Compensation Program
The Future of Vaccine Safety

Vaccine Shortages

Preventing Future Shortages in the U.S.
Financial incentives
Equitable pricing
Utilizing vaccine stockpiles

Impact of Product Divergence on Vaccine Supply in Developing Countries

Vaccines and Bioterrorism

Overview
Project Bioshield Act of 2004
Anthrax
Smallpox
Plague
Botulism
Tularemia
Viral Hemorrhagic Fevers

Innovations in Vaccine Delivery Systems

Edible Vaccines
Mucosal Delivery
Intranasal Delivery
Oral Vaccines
Vaccine Patches

Chapter Eight: Company Profiles

Acambis plc

History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information

AlphaVax, Inc.

History and Lines of Business
Strategic Alliances
Vaccine Products

Avant Immunotherapeutics

History and Lines of Business
Strategic Alliances
Vaccine Products

Aventis Pasteur

History and Lines of Business
Strategic Alliances
Vaccine products
Financial Information

Bavarian Nordic A/S

History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information

Baxter Healthcare

History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information

Berna Biotech AG

History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
BioPort Corporation

History and Lines of Business
Strategic Acquisition and Alliance
Vaccine Products

Chiron Corporation

History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
Corixa Corporation

History and Lines of Business
Strategic Alliances
Vaccine Products

Epimmune, Inc.

History and Development
Corporate Contract with NIH
Vaccine Products

GlaxoSmithKline

History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
ID Biomedical Corporation

History and Lines of Business
Vaccine Products

MedImmune, Inc.

History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information

Merck & Co Inc

History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information

Nabi Biopharmaceuticals

History and Lines of Business
Strategic Alliance
Vaccine Products
Financial Information

Vical Incorporated

History and Lines of Business
Strategic Alliances
Technology Platform
Therapeutic Cancer Vaccine Products in Clinical Trials
Financial Information

Wyeth

History and Lines of Business
Vaccine Products
Financial Information

Appendix A: Vaccine Products

Appendix B: Company Directory

list of exhibits

Chapter One: Executive Summary

Table 1-1: Impact of Vaccines in the 20th Century Table 1-2: The World Vaccines Market by Vaccine Target 2001-2005 Figure 1-1: World Market for Vaccines, by Type, 2001-2010 Figure 1-2: World Market for Vaccines, by Type, 2001, 2005 and 2010= Table 1-3: Major Manufacturers Shares of the World Vaccine Market 2003 Figure 1-3: World Vaccines Market Share by Leading Competitors 2003

Chapter Two: Introduction to Vaccines

Table 2-1: Impact of Vaccines in the 20th Century
Table 2-2: Vaccine-Preventable Diseases

Chapter Three: Pediatric Preventive Vaccines

Table 3-1: Global Immunization Score Card: Percentage of Countries and Population Left to Reach by WHO Objective
Table 3-2: Immunization Profile of the United States
Table 3-3: U.S. Recommended Childhood Immunization Schedule, July through December 2004
Table 3-4: Cost of Vaccines: Private Sector Versus Public Sector: Prices Last Reviewed/Updated, August 2004
Table 3-5: Selected Pediatric Vaccines in Development
Table 3-6: World Market for Pediatric Vaccines by Type 2001-2010
Figure 3-1: Market Share of Pediatric Vaccines by Type 2004
Figure 3-2: Market Share of Pediatric Vaccines by Type 2010
Table 3-7: World DTP and DTaP Vaccine Market 2001-2010
Table 3-8: World Pediatric Hepatitis Vaccine Market 2001-2010
Table 3-9: World Hib Vaccine Market, 2001-2010
Table 3-10: World MMR Vaccines Market 2001-2010
Table 3-11: World Combination Vaccines Market 2001-2010
Table 3-12: World Pediatric Pneumococcal Vaccine Market 2001-2010
Table 3-13: World Poliovirus Vaccine Market 2001-2010
Table 3-14: World Varicella Vaccine Market 2001-2010
Table 3-15: World Travel & Other Vaccines Market 2001-2010

Chapter Four: Adult Preventive Vaccines

Table 4-1: Low Adult Vaccination: A Costly Heath care Burden Number of Vaccine-Preventable Deaths in the United States vs Five Other Causes
Table 4-2: Universal Adult Immunization Schedule 2004
Table 4-3: Adult Immunization Schedule for Populations with Special Medical Conditions, 2004
Table 4-4: Selected Adult Preventive Vaccines in Development, 2004
Table 4-5: World Market for Adult Preventive Vaccines, 2001-2010
Figure 4-1: Market Share of Adult Vaccines, by Type, 2004
Figure 4-2: Market Share of Adult Vaccines, by Type, 2010
Table 4-6: World Hepatitis Vaccine Market 2001-2010
Table 4-8: World Influenza Vaccine Market 2001-2010
Figure 4-3: Immunization Rates of Persons Receiving Influenza Vaccine in 2002 by Age Group
Table 4-8: CDC Goal to Double Flu Immunization by 2010
Table 4-9: 2003 Estimated Population by Region and Selected Age Group
Table 4-10: World Pneumococcal Vaccine Market 2001-2010
Figure 4-5: European 65+ Population: Percent by Country
Table 4-11: World Travel; Diphtheria-Tetanus; Miscellaneous Vaccines Market 2001-2010

Chapter Five: Preventive Vaccines Market Summary

Table 5-1: The World Vaccines Market by Vaccine Type 2001-2010
Figure 5-1: World Market for Vaccines by Type 2001-2010
Figure 5-2: World Market for Vaccines Share by Type, 2001, 2005 and 2010
Table 5-2: Major Manufacturers Shares of the World Vaccine Market, 2003
Figure 5-3: 2003 World Vaccines Market Share, by Leading Competitors
Figure 5-4: Global Market Share of Leading Competitors by Region, 2003
Table 5-3: Major Manufacturers Shares of the World Pediatric Vaccine Market 2003
Figure 5-5: Market Share of Pediatric Vaccines Market, 2003
Table 5-4: Major Manufacturers Shares of the World Adult Vaccine Market 2003. 145
Figure 5-6: Market Share of Adult Vaccines Market 2003

Chapter Six: Therapeutic Cancer Vaccines

Table 6-1: Estimated and Projected World Cancer Incidence by Common Type of Cancer, 2003 and 2020
Figure 6-1: Estimated and Projected World Cancer Incidence by Common Type of Cancer, 2003 and 2020
Table 6-2: Estimated and Projected World Cancer Mortality by Common Type of Cancer, 2003 and 2020
Figure 6-2: Estimated and Projected World Cancer Mortality by Common Type of Cancer, 2003 and 2020152
Table 6-3: Cancer Vaccines in the Pipeline
Table 6-4: World Market Cancer Vaccines by Current and Emerging Markets 2001-2008
Figure 6-3: Cancer Vaccines by Current and Emerging Market Revenues and Percent Distribution, 2001-2008

Chapter Seven: Issues and Trends

Table 7-1: Impact of Vaccines in the 20th Century
Table 7-2: Tailored Products: Divergence of Vaccine Products Between Industrialized and Developing Countries
Table 7-3: Selected Companies/Laboratories Developing Biodefense Vaccines

Appendix A: Vaccine Products

Table A-1: Selected Vaccines Currently Available Worldwide Table A-2: Vaccines Licensed for Immunizations and Distributed in the United States as of January 2004

The World Market for Vaccines

Table of Contents

list of exhibits